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Molecule Parameter List for PP1-I1* | The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by  color. | | Statistics |
Accession and Pathway Details | |
| Accession Name | Accession No. | Accession Type | Pathway Link | AMPAR_traff_
model0 | 59 | Network |
Shared_Object_AMPAR_traff_model0, CaMKII, CaM,
PP1, PP2B, PP1_PSD,
PKA, AC, AMPAR,
AMPAR_memb | | This is model 0 from Hayer and Bhalla, PLoS Comput Biol 2005. It has a bistable model of AMPAR traffick, plus a
non-bistable model of CaMKII. This differs from the reference model (model 1) in that model0 lacks degradation and turno
ver reactions for AMPAR. |
PP1-I1* acting as a Molecule in AMPAR_traff_model0 Network
PP1-I1* acting as a Substrate for an Enzyme in AMPAR_traff_model0 Network
| | Enzyme Molecule /
Enzyme Activity | Accession Name | Pathway Name | Km (uM) | kcat (s^-1) | Ratio | Enzyme Type | Reagents | | 1 | PP2A /
PP2A-dephosph-PP
1-I*
| AMPAR_traff_
model0
Accession No. : 59 | PP1
Pathway No. : 237 | 15.9999 | 2 | 4.1667 | explicit E-S complex | Substrate
PP1-I1*
Product
PP1-I1
| | | k1 changed from 3.3e-6 to 6.6e-6 | | 2 | PP2A /
PP2A-dephosph-PP
1-I*_
PSD
| AMPAR_traff_
model0
Accession No. : 59 | PP1
Pathway No. : 237 | 15.9999 | 2 | 4.1667 | explicit E-S complex | Substrate
PP1-I1*
Product
PP1-I1
| | | k1 changed from 3.3e-6 to 6.6e-6 | | 3 | CaM_Ca_n-CaNAB /
dephosph-PP1-I* | AMPAR_traff_
model0
Accession No. : 59 | PP2B
Pathway No. : 238 | 4.97079 | 0.34 | 4 | explicit E-S complex | Substrate
PP1-I1*
Product
PP1-I1
| | 4 | CaM_Ca_n-CaNAB /
dephosph-PP1-I*_
PSD
| AMPAR_traff_
model0
Accession No. : 59 | PP2B
Pathway No. : 238 | 4.97071 | 0.34 | 4 | explicit E-S complex | Substrate
PP1-I1*
Product
PP1-I1
|
PP1-I1* acting as a Product in a reaction in AMPAR_traff_model0 Network
| Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated.
Kd for higher order reaction are not consider. |
| | Name | Accession Name | Pathway Name | Kf | Kb | Kd | tau | Reagents | | 1 | Inact-PP1 | AMPAR_traff_
model0
Accession No. : 59 | PP1
Pathway No. : 237 | 499.981
(uM^-1 s^-1) | 0.1
(s^-1) | Kd(bf) = 0.0002(uM) | - | Substrate
I1*
PP1-active
Product
PP1-I1*
| | | K inhib = 1nM from Cohen Ann Rev Bioch 1989, 4 nM from Foukes et al Assume 2 nM. kf /kb = 8.333e-4 | | 2 | Inact-PP1 | AMPAR_traff_
model0
Accession No. : 59 | PP1_PSD
Pathway No. : 239 | 499.98
(uM^-1 s^-1) | 0.1
(s^-1) | Kd(bf) = 0.0002(uM) | - | Substrate
I1*
PP1-active_PSD
Product
PP1-I1*
| | | K inhib = 1nM from Cohen Ann Rev Bioch 1989, 4 nM from Foukes et al Assume 2 nM. kf /kb = 8.333e-4 |
| Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
This Copyright is applied to ensure that the contents of this database remain freely available. Please see FAQ for details. |
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