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Molecule Parameter List for PP1-active

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network. The text color of a molecule is highlighted by color.

Statistics

PP1-active participated as	Molecule	Sum total of	Enzyme	Substrate of an enzyme	Product of an enzyme	Substrate in Reaction	Product in Reaction
No. of occurrences	1	0	5	0	0	1	1

Accession and Pathway Details

Accession Name	Accession No.	Accession Type	Pathway Link
AMPAR_traff_ model0	59	Network	Shared_Object_AMPAR_traff_model0,  CaMKII,  CaM,   PP1,  PP2B,  PP1_PSD,   PKA,  AC,  AMPAR,   AMPAR_memb
This is model 0 from Hayer and Bhalla, PLoS Comput Biol 2005. It has a bistable model of AMPAR traffick, plus a non-bistable model of CaMKII. This differs from the reference model (model 1) in that model0 lacks degradation and turno ver reactions for AMPAR.

PP1-active acting as a Molecule in  AMPAR_traff_model0 Network

Name	Accession Name	Pathway Name	Initial Conc. (uM)	Volume (fL)	Buffered
PP1-active	AMPAR_traff_ model0 Accession No. : 59	PP1 Pathway No. : 237	1.8	0.09	No
Cohen et al Meth Enz 159 390-408 is main source of info conc = 1.8 uM

PP1-active acting as an Enzyme in  AMPAR_traff_model0 Network

	Enzyme Molecule / Enzyme Activity	Accession Name	Pathway Name	Km (uM)	kcat (s^-1)	Ratio	Enzyme Type	Reagents
1	PP1-active / Deph-thr286	AMPAR_traff_ model0 Accession No. : 59	PP1 Pathway No. : 237	5.09905	2.5	4	explicit E-S complex	Substrate CaMKII-thr286*-C aM Product CaMKII-CaM
2	PP1-active / Deph-thr286b	AMPAR_traff_ model0 Accession No. : 59	PP1 Pathway No. : 237	5.09905	2.5	4	explicit E-S complex	Substrate CaMKII-thr286 Product CaMKII
3	PP1-active / Deph-thr305	AMPAR_traff_ model0 Accession No. : 59	PP1 Pathway No. : 237	5.09905	2.5	4	explicit E-S complex	Substrate CaMKII*** Product CaMKII-thr286
4	PP1-active / Deph-thr286c	AMPAR_traff_ model0 Accession No. : 59	PP1 Pathway No. : 237	5.09905	2.5	4	explicit E-S complex	Substrate CaMKII*** Product CaMK-thr305
5	PP1-active / Deph-thr305a	AMPAR_traff_ model0 Accession No. : 59	PP1 Pathway No. : 237	5.09905	2.5	4	explicit E-S complex	Substrate CaMK-thr305 Product CaMKII

PP1-active acting as a Substrate in a reaction in  AMPAR_traff_model0 Network

Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.

Name	Accession Name	Pathway Name	Kf	Kb	Kd	tau	Reagents
Inact-PP1	AMPAR_traff_ model0 Accession No. : 59	PP1 Pathway No. : 237	499.981 (uM^-1 s^-1)	0.1 (s^-1)	Kd(bf) = 0.0002(uM)	-	Substrate I1* PP1-active Product PP1-I1*
K inhib = 1nM from Cohen Ann Rev Bioch 1989, 4 nM from Foukes et al Assume 2 nM. kf /kb = 8.333e-4

PP1-active acting as a Product in a reaction in  AMPAR_traff_model0 Network

Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.

Name	Accession Name	Pathway Name	Kf	Kb	Kd	tau	Reagents
dissoc-PP1-I1	AMPAR_traff_ model0 Accession No. : 59	PP1 Pathway No. : 237	1 (s^-1)	0 (uM^-1 s^-1)	-	-	Substrate PP1-I1 Product I1 PP1-active
Let us assume that the equil in this case is very far over to the right. This is probably safe.