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Molecule Parameter List for PP1-I1

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by

color.

Statistics

*PP1-I1* participated as	Molecule	Sum total of	Enzyme	Substrate of an enzyme	Product of an enzyme	Substrate in Reaction	Product in Reaction
No. of occurrences	2	0	0	0	4	2	0

Accession and Pathway Details

Accession Name	Accession No.	Accession Type	Pathway Link
AMPAR_traff_ model1	60	Network	Shared_Object_AMPAR_traff_model1, CaMKII, CaM, PP1, PP2B, PP1_PSD, PKA, AC, AMPAR, AMPAR_memb
This is the basic model of AMPAR trafficking bistability. It is based on Hayer and Bhalla, PLoS Comput. Biol. 2005. It includes the degradation and turnover of AMPARs. The CaMKII portion of the model is not bistable.

PP1-I1 acting as a Molecule in AMPAR_traff_model1 Network

Name	Accession Name	Pathway Name	Initial Conc. (uM)	Volume (fL)	Buffered
PP1-I1	AMPAR_traff_ model1 Accession No. : 60	PP1 Pathway No. : 247	0	0.09	No

PP1-I1	AMPAR_traff_ model1 Accession No. : 60	PP1_PSD Pathway No. : 249	0	0.01	No

PP1-I1 acting as a Product of an Enzyme in AMPAR_traff_model1 Network

	Enzyme Molecule / Enzyme Activity	Accession Name	Pathway Name	Km (uM)	kcat (s^-1)	Ratio	Enzyme Type	Reagents
1	PP2A / PP2A-dephosph-PP 1-I*	AMPAR_traff_ model1 Accession No. : 60	PP1 Pathway No. : 247	15.9999	2	4.1667	explicit E-S complex	Substrate PP1-I1* Product PP1-I1
	k1 changed from 3.3e-6 to 6.6e-6
2	PP2A / PP2A-dephosph-PP 1-I*_ PSD	AMPAR_traff_ model1 Accession No. : 60	PP1 Pathway No. : 247	15.9999	2	4.1667	explicit E-S complex	Substrate PP1-I1* Product PP1-I1
	k1 changed from 3.3e-6 to 6.6e-6
3	CaM_Ca_n-CaNAB / dephosph-PP1-I*	AMPAR_traff_ model1 Accession No. : 60	PP2B Pathway No. : 248	4.97079	0.34	4	explicit E-S complex	Substrate PP1-I1* Product PP1-I1
4	CaM_Ca_n-CaNAB / dephosph-PP1-I*_ PSD	AMPAR_traff_ model1 Accession No. : 60	PP2B Pathway No. : 248	4.97071	0.34	4	explicit E-S complex	Substrate PP1-I1* Product PP1-I1

PP1-I1 acting as a Substrate in a reaction in AMPAR_traff_model1 Network

Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.

	Name	Accession Name	Pathway Name	Kf	Kb	Kd	tau	Reagents
1	dissoc-PP1-I1	AMPAR_traff_ model1 Accession No. : 60	PP1 Pathway No. : 247	1 (s^-1)	0 (uM^-1 s^-1)	-	-	Substrate PP1-I1 Product I1 PP1-active
	Let us assume that the equil in this case is very far over to the right. This is probably safe.
2	dissoc-PP1-I1	AMPAR_traff_ model1 Accession No. : 60	PP1_PSD Pathway No. : 249	1 (s^-1)	0 (uM^-1 s^-1)	-	-	Substrate PP1-I1 Product I1 PP1-active_PSD
	Let us assume that the equil in this case is very far over to the right. This is probably safe.

Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
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