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Molecule Parameter List for CaMKII-thr286*-CaM

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by color.
Statistics
CaMKII-thr286*-CaM participated asMoleculeSum total ofEnzymeSubstrate of an enzymeProduct of an enzymeSubstrate in ReactionProduct in Reaction
No. of occurrences1201211

Accession and Pathway Details
Accession NameAccession No.Accession TypePathway Link
CaMKII_model363Network
Shared_Object_CaMKII_model3,  CaMKII,  CaM,  
PP1,  PP2B,  PP1_PSD,  
AC,  PKA 
This is the complete model of CaMKII bistability, model 3. It exhibits bistability in CaMKII activation due to autophosphorylation at the PSD and local saturation of PP1. This version of model 3 includes PKA regulatory input. This has little effect on the deterministic calculations, but the PKA pathway introduces a lot of noise which causes a difference in stochastic runs.

CaMKII-thr286*-CaM acting as a Molecule in  CaMKII_model3 Network
NameAccession NamePathway NameInitial Conc.
(uM)		Volume
(fL)		Buffered
CaMKII-thr286*-CaMCaMKII_model3
Accession No. : 63		CaMKII
Pathway No. : 264		00.09No
From Hanson and Schulman, the thr286 is responsible for autonomous activation of CaMKII.

CaMKII-thr286*-CaM acting as a Summed Molecule in  CaMKII_model3 Network
 Accession NanePathway NameTargetInput
1CaMKII_model3
Accession No. : 63		CaMKII
Pathway No. : 264		tot_CaM_CaMKIICaMKII-CaM
  • CaMKII-thr286*-C
    aM
    • 2CaMKII_model3
    Accession No. : 63
  • Shared_Object_
    CaMKII_model3
    Pathway No. : 263
    		• tot_CaMKII_cytCaMKII-CaM
  • CaMKII-thr286*-C
    aM
    CaMKII-thr286
    CaMKII***
    CaMK-thr305
    CaMKII
  • basal_CaMKII_
    cyt

    • CaMKII-thr286*-CaM acting as a Substrate for an Enzyme in      CaMKII_model3 Network
    Enzyme Molecule /
    Enzyme Activity    		Accession NamePathway NameKm (uM)kcat (s^-1)RatioEnzyme TypeReagents
    PP1-active  /
    Deph-thr286    		CaMKII_model3
    Accession No. : 63
  • Shared_Object_
    CaMKII_model3
    Pathway No. : 263
    		• 5.099052.54explicit E-S complexSubstrate
  • CaMKII-thr286*-C
    aM

    Product
    CaMKII-CaM

    • CaMKII-thr286*-CaM acting as a Product of an Enzyme in      CaMKII_model3 Network
     Enzyme Molecule /
    Enzyme Activity    		Accession NamePathway NameKm (uM)kcat (s^-1)RatioEnzyme TypeReagents
    1tot_CaM_CaMKII  /
    CaM_act_286    		CaMKII_model3
    Accession No. : 63    		CaMKII
    Pathway No. : 264    		226.9980.54explicit E-S complexSubstrate
    CaMKII-CaM

    Product
  • CaMKII-thr286*-C
    aM
    • 2
  • tot_autonomous_
    CaMKII      /
    auton_286
    		• CaMKII_model3
    Accession No. : 63    		CaMKII
    Pathway No. : 264    		349.9870.54explicit E-S complexSubstrate
    CaMKII-CaM

    Product
  • CaMKII-thr286*-C
    aM

    • CaMKII-thr286*-CaM acting as a Substrate in a reaction in      CaMKII_model3 Network
    Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.
    NameAccession NamePathway NameKfKbKdtauReagents
    transloc_2CaMKII_model3
    Accession No. : 63
  • Shared_Object_
    CaMKII_model3
    Pathway No. : 263
    		• 0
    (#^-1 s^-1)    		0
    (s^-1)    		Not applicable**-Substrate
  • CaMKII-thr286*-C
    aM
    NMDAR

    Product
  • CaMKII-thr286-Ca
    M-PSD
    • Same as for transloc_1
    ** This is a trasport reation between compartments of different volumes. Therefore Kd is not applicable. Please Note Kf, Kb units are in number of molecules instead of concentration

    CaMKII-thr286*-CaM acting as a Product in a reaction in      CaMKII_model3 Network
    Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.
    NameAccession NamePathway NameKfKbKdtauReagents
  • CaMK-thr286-bind
    -CaM
    		• CaMKII_model3
    Accession No. : 63    		CaMKII
    Pathway No. : 264    		1000.19
    (uM^-1 s^-1)    		0.1
    (s^-1)    		Kd(bf) = 0.0001(uM)-Substrate
    CaM-Ca4
    CaMKII-thr286

    Product
  • CaMKII-thr286*-C
    aM
    • Affinity is up 1000X. Time to release is about 20 sec, so the kb is OK at 0.1 This makes Kf around 1.6666e-3


    Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
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