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Molecule Parameter List for *CaMKII***-PSD*

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by

color.

Statistics

*CaMKII-PSD** participated as	Molecule	Sum total of	Enzyme	Substrate of an enzyme	Product of an enzyme	Substrate in Reaction	Product in Reaction
No. of occurrences	1	1	0	2	2	0	0

Accession and Pathway Details

Accession Name	Accession No.	Accession Type	Pathway Link
CaMKII_model3	63	Network	Shared_Object_CaMKII_model3, CaMKII, CaM, PP1, PP2B, PP1_PSD, AC, PKA
This is the complete model of CaMKII bistability, model 3. It exhibits bistability in CaMKII activation due to autophosphorylation at the PSD and local saturation of PP1. This version of model 3 includes PKA regulatory input. This has little effect on the deterministic calculations, but the PKA pathway introduces a lot of noise which causes a difference in stochastic runs.

CaMKII***-PSD acting as a Molecule in CaMKII_model3 Network

Name	Accession Name	Pathway Name	Initial Conc. (uM)	Volume (fL)	Buffered
CaMKII*-PSD	CaMKII_model3 Accession No. : 63	Shared_Object_ CaMKII_model3 Pathway No. : 263	0	0.01	No

CaMKII***-PSD acting as a Summed Molecule in CaMKII_model3 Network

Accession Name	Pathway Name	Target	Input
CaMKII_model3 Accession No. : 63	Shared_Object_ CaMKII_model3 Pathway No. : 263	tot-auto-PSD	CaMKII-thr286-PS D CaMKII*-PSD basal_CaMKII_ PSD

CaMKII***-PSD acting as a Substrate for an Enzyme in CaMKII_model3 Network

	Enzyme Molecule / Enzyme Activity	Accession Name	Pathway Name	Km (uM)	kcat (s^-1)	Ratio	Enzyme Type	Reagents
1	PP1-active_PSD / Deph-thr305	CaMKII_model3 Accession No. : 63	Shared_Object_ CaMKII_model3 Pathway No. : 263	2.00001	0.2	4	explicit E-S complex	Substrate CaMKII*-PSD Product CaMKII-thr286-PS D
2	PP1-active_PSD / Deph-thr286c	CaMKII_model3 Accession No. : 63	Shared_Object_ CaMKII_model3 Pathway No. : 263	2.00001	0.2	4	explicit E-S complex	Substrate CaMKII*-PSD Product CaMKII-thr305-PS D

CaMKII***-PSD acting as a Product of an Enzyme in CaMKII_model3 Network

	Enzyme Molecule / Enzyme Activity	Accession Name	Pathway Name	Km (uM)	kcat (s^-1)	Ratio	Enzyme Type	Reagents
1	tot-auto-PSD / auton-305-PSD	CaMKII_model3 Accession No. : 63	Shared_Object_ CaMKII_model3 Pathway No. : 263	500	6	4	explicit E-S complex	Substrate CaMKII-thr286-PS D Product CaMKII*-PSD
2	tot-CaM-CaMKII-P SD / CaM-act-305-PSD	CaMKII_model3 Accession No. : 63	Shared_Object_ CaMKII_model3 Pathway No. : 263	320	6	4	explicit E-S complex	Substrate CaMKII-thr286-PS D Product CaMKII*-PSD

Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
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Molecule Parameter List for CaMKII***-PSD

Molecule Parameter List for *CaMKII***-PSD*