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Molecule Parameter List for CaMKII-thr286-PSD

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by color.
Statistics
CaMKII-thr286-PSD participated asMoleculeSum total ofEnzymeSubstrate of an enzymeProduct of an enzymeSubstrate in ReactionProduct in Reaction
No. of occurrences1203310

Accession and Pathway Details
Accession NameAccession No.Accession TypePathway Link
CaMKII_model363Network
Shared_Object_CaMKII_model3 CaMKII CaM 
PP1 PP2B PP1_PSD 
AC PKA 
This is the complete model of CaMKII bistability, model 3. It exhibits bistability in CaMKII activation due to autophosphorylation at the PSD and local saturation of PP1. This version of model 3 includes PKA regulatory input. This has little effect on the deterministic calculations, but the PKA pathway introduces a lot of noise which causes a difference in stochastic runs.

CaMKII-thr286-PSD acting as a Molecule in  
CaMKII_model3 Network
NameAccession NamePathway NameInitial Conc.
(uM)
Volume
(fL)
Buffered
CaMKII-thr286-PSDCaMKII_model3
Accession No. : 63
  • Shared_Object_
    CaMKII_model3

    Pathway No. : 263
  • 00.01No

    CaMKII-thr286-PSD acting as a Summed Molecule in  
    CaMKII_model3 Network
     Accession NanePathway NameTargetInput
    1CaMKII_model3
    Accession No. : 63
  • Shared_Object_
    CaMKII_model3

    Pathway No. : 263
  • tot-auto-PSD
  • CaMKII-thr286-PS
    D

    CaMKII***-PSD
  • basal_CaMKII_
    PSD

  • 2CaMKII_model3
    Accession No. : 63
  • Shared_Object_
    CaMKII_model3

    Pathway No. : 263
  • 286P-PSD
  • CaMKII-thr286-Ca
    M-PSD

  • CaMKII-thr286-PS
    D


  • CaMKII-thr286-PSD acting as a Substrate for an Enzyme in  
    CaMKII_model3 Network
     Enzyme Molecule /
    Enzyme Activity
    Accession NamePathway NameKm (uM)kcat (s^-1)RatioEnzyme TypeReagents
    1tot-auto-PSD  /
    auton-305-PSD
    CaMKII_model3
    Accession No. : 63
  • Shared_Object_
    CaMKII_model3

    Pathway No. : 263
  • 50064explicit E-S complexSubstrate
  • CaMKII-thr286-PS
    D


    Product
    CaMKII***-PSD
  • 2PP1-active_PSD  /
    Deph-thr286b
    CaMKII_model3
    Accession No. : 63
  • Shared_Object_
    CaMKII_model3

    Pathway No. : 263
  • 2.000010.24explicit E-S complexSubstrate
  • CaMKII-thr286-PS
    D


    Product
    CaMKII-PSD
  • 3
  • tot-CaM-CaMKII-P
    SD
      /
    CaM-act-305-PSD
  • CaMKII_model3
    Accession No. : 63
  • Shared_Object_
    CaMKII_model3

    Pathway No. : 263
  • 32064explicit E-S complexSubstrate
  • CaMKII-thr286-PS
    D


    Product
    CaMKII***-PSD

  • CaMKII-thr286-PSD acting as a Product of an Enzyme in  
    CaMKII_model3 Network
     Enzyme Molecule /
    Enzyme Activity
    Accession NamePathway NameKm (uM)kcat (s^-1)RatioEnzyme TypeReagents
    1tot-auto-PSD  /
    auton-autoph
    CaMKII_model3
    Accession No. : 63
  • Shared_Object_
    CaMKII_model3

    Pathway No. : 263
  • 500.00524explicit E-S complexSubstrate
    CaMKII-PSD

    Product
  • CaMKII-thr286-PS
    D

  • 2PP1-active_PSD  /
    Deph-thr305
    CaMKII_model3
    Accession No. : 63
  • Shared_Object_
    CaMKII_model3

    Pathway No. : 263
  • 2.000010.24explicit E-S complexSubstrate
    CaMKII***-PSD

    Product
  • CaMKII-thr286-PS
    D

  • 3
  • tot-CaM-CaMKII-P
    SD
      /
    CaM_act_autoph
  • CaMKII_model3
    Accession No. : 63
  • Shared_Object_
    CaMKII_model3

    Pathway No. : 263
  • 320.00224explicit E-S complexSubstrate
    CaMKII-PSD

    Product
  • CaMKII-thr286-PS
    D


  • CaMKII-thr286-PSD acting as a Substrate in a reaction in  
    CaMKII_model3 Network
    Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.
    NameAccession NamePathway NameKfKbKdtauReagents
  • CaMKII-thr286-bi
    nd-CaM-PSD
  • CaMKII_model3
    Accession No. : 63
  • Shared_Object_
    CaMKII_model3

    Pathway No. : 263
  • 1000.02
    (uM^-1 s^-1)
    0.1
    (s^-1)
    Kd(bf) = 0.0001(uM)-Substrate
    CaM-Ca4-PSD
  • CaMKII-thr286-PS
    D


    Product
  • CaMKII-thr286-Ca
    M-PSD

  • Same values as for the main compartment Can the main compartment pool of Ca/CaM be used?



    Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
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