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Molecule Parameter List for CaMKII-PSD

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by

color.

Statistics

*CaMKII-PSD* participated as	Molecule	Sum total of	Enzyme	Substrate of an enzyme	Product of an enzyme	Substrate in Reaction	Product in Reaction
No. of occurrences	1	1	0	2	2	2	1

Accession and Pathway Details

Accession Name	Accession No.	Accession Type	Pathway Link
CaMKII_model3	63	Network	Shared_Object_CaMKII_model3, CaMKII, CaM, PP1, PP2B, PP1_PSD, AC, PKA
This is the complete model of CaMKII bistability, model 3. It exhibits bistability in CaMKII activation due to autophosphorylation at the PSD and local saturation of PP1. This version of model 3 includes PKA regulatory input. This has little effect on the deterministic calculations, but the PKA pathway introduces a lot of noise which causes a difference in stochastic runs.

CaMKII-PSD acting as a Molecule in CaMKII_model3 Network

Name	Accession Name	Pathway Name	Initial Conc. (uM)	Volume (fL)	Buffered
CaMKII-PSD	CaMKII_model3 Accession No. : 63	Shared_Object_ CaMKII_model3 Pathway No. : 263	0	0.01	No

CaMKII-PSD acting as a Summed Molecule in CaMKII_model3 Network

Accession Name	Pathway Name	Target	Input
CaMKII_model3 Accession No. : 63	Shared_Object_ CaMKII_model3 Pathway No. : 263	tot_CaMKII_PSD	actCaMKII-PSD CaMKII-PSD CaMKII-thr305-PS D

CaMKII-PSD acting as a Substrate for an Enzyme in CaMKII_model3 Network

	Enzyme Molecule / Enzyme Activity	Accession Name	Pathway Name	Km (uM)	kcat (s^-1)	Ratio	Enzyme Type	Reagents
1	tot-auto-PSD / auton-autoph	CaMKII_model3 Accession No. : 63	Shared_Object_ CaMKII_model3 Pathway No. : 263	500.005	2	4	explicit E-S complex	Substrate CaMKII-PSD Product CaMKII-thr286-PS D
2	tot-CaM-CaMKII-P SD / CaM_act_autoph	CaMKII_model3 Accession No. : 63	Shared_Object_ CaMKII_model3 Pathway No. : 263	320.002	2	4	explicit E-S complex	Substrate CaMKII-PSD Product CaMKII-thr286-PS D

CaMKII-PSD acting as a Product of an Enzyme in CaMKII_model3 Network

	Enzyme Molecule / Enzyme Activity	Accession Name	Pathway Name	Km (uM)	kcat (s^-1)	Ratio	Enzyme Type	Reagents
1	PP1-active_PSD / Deph-thr286b	CaMKII_model3 Accession No. : 63	Shared_Object_ CaMKII_model3 Pathway No. : 263	2.00001	0.2	4	explicit E-S complex	Substrate CaMKII-thr286-PS D Product CaMKII-PSD
2	PP1-active_PSD / Deph-thr305a	CaMKII_model3 Accession No. : 63	Shared_Object_ CaMKII_model3 Pathway No. : 263	2.00001	0.2	4	explicit E-S complex	Substrate CaMKII-thr305-PS D Product CaMKII-PSD

CaMKII-PSD acting as a Substrate in a reaction in CaMKII_model3 Network

Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.

	Name	Accession Name	Pathway Name	Kf	Kb	Kd	tau	Reagents
1	CaMKII-bind-CaM- PSD	CaMKII_model3 Accession No. : 63	Shared_Object_ CaMKII_model3 Pathway No. : 263	49.9998 (uM^-1 s^-1)	0 (s^-1)	-	-	Substrate CaM-Ca4-PSD CaMKII-PSD Product CaMKII-CaM-PSD
2	back_1	CaMKII_model3 Accession No. : 63	Shared_Object_ CaMKII_model3 Pathway No. : 263	0.3 (s^-1)	0 (#^-1 s^-1)	Not applicable**	-	Substrate CaMKII-PSD Product CaMKII NMDAR
	Rates set by the translocation experiments of Shen and Meyer, Science 1999.

** This is a trasport reation between compartments of different volumes. Therefore Kd is not applicable. Please Note Kf, Kb units are in number of molecules instead of concentration

CaMKII-PSD acting as a Product in a reaction in CaMKII_model3 Network

Name	Accession Name	Pathway Name	Kf	Kb	Kd	tau	Reagents
CaMKII-diss-CaM	CaMKII_model3 Accession No. : 63	Shared_Object_ CaMKII_model3 Pathway No. : 263	5 (s^-1)	0 (uM^-1 s^-1)	-	-	Substrate CaMKII-CaM-PSD Product CaM-Ca4-PSD CaMKII-PSD

Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
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