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Molecule Parameter List for CaMKII-thr305-PSD

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by color.
Statistics
CaMKII-thr305-PSD participated asMoleculeSum total ofEnzymeSubstrate of an enzymeProduct of an enzymeSubstrate in ReactionProduct in Reaction
No. of occurrences1101110

Accession and Pathway Details
Accession NameAccession No.Accession TypePathway Link
CaMKII_model363Network
Shared_Object_CaMKII_model3,  CaMKII,  CaM,  
PP1,  PP2B,  PP1_PSD,  
AC,  PKA 
This is the complete model of CaMKII bistability, model 3. It exhibits bistability in CaMKII activation due to autophosphorylation at the PSD and local saturation of PP1. This version of model 3 includes PKA regulatory input. This has little effect on the deterministic calculations, but the PKA pathway introduces a lot of noise which causes a difference in stochastic runs.

CaMKII-thr305-PSD acting as a Molecule in  CaMKII_model3 Network
NameAccession NamePathway NameInitial Conc.
(uM)		Volume
(fL)		Buffered
CaMKII-thr305-PSDCaMKII_model3
Accession No. : 63
  • Shared_Object_
    CaMKII_model3
    Pathway No. : 263
    		• 00.01No

    CaMKII-thr305-PSD acting as a Summed Molecule in      CaMKII_model3 Network
    Accession NamePathway NameTargetInput
    CaMKII_model3
    Accession No. : 63
  • Shared_Object_
    CaMKII_model3
    Pathway No. : 263
    		• tot_CaMKII_PSDactCaMKII-PSD
    CaMKII-PSD
  • CaMKII-thr305-PS
    D

    • CaMKII-thr305-PSD acting as a Substrate for an Enzyme in      CaMKII_model3 Network
    Enzyme Molecule /
    Enzyme Activity    		Accession NamePathway NameKm (uM)kcat (s^-1)RatioEnzyme TypeReagents
    PP1-active_PSD  /
    Deph-thr305a    		CaMKII_model3
    Accession No. : 63
  • Shared_Object_
    CaMKII_model3
    Pathway No. : 263
    		• 2.000010.24explicit E-S complexSubstrate
  • CaMKII-thr305-PS
    D

    Product
    CaMKII-PSD

    • CaMKII-thr305-PSD acting as a Product of an Enzyme in      CaMKII_model3 Network
    Enzyme Molecule /
    Enzyme Activity    		Accession NamePathway NameKm (uM)kcat (s^-1)RatioEnzyme TypeReagents
    PP1-active_PSD  /
    Deph-thr286c    		CaMKII_model3
    Accession No. : 63
  • Shared_Object_
    CaMKII_model3
    Pathway No. : 263
    		• 2.000010.24explicit E-S complexSubstrate
    CaMKII***-PSD

    Product
  • CaMKII-thr305-PS
    D

    • CaMKII-thr305-PSD acting as a Substrate in a reaction in      CaMKII_model3 Network
    Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.
    NameAccession NamePathway NameKfKbKdtauReagents
    back_2CaMKII_model3
    Accession No. : 63
  • Shared_Object_
    CaMKII_model3
    Pathway No. : 263
    		• 0.3
    (s^-1)    		0
    (#^-1 s^-1)    		Not applicable**-Substrate
  • CaMKII-thr305-PS
    D

    Product
    CaMK-thr305
    NMDAR
    • Same as for back_1
    ** This is a trasport reation between compartments of different volumes. Therefore Kd is not applicable. Please Note Kf, Kb units are in number of molecules instead of concentration


    Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
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