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Molecule Parameter List for PP2A

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by color.
Statistics
PP2A participated asMoleculeSum total ofEnzymeSubstrate of an enzymeProduct of an enzymeSubstrate in ReactionProduct in Reaction
No. of occurrences1040000

Accession and Pathway Details
Accession NameAccession No.Accession TypePathway Link
  • AMPAR_CaMKII_
    weak_coupling
    		• 65Network
    Shared_Object_AMPAR_CaMKII_weak_coupling,  CaMKII,  CaM,  
    PP1,  PP2B,  PP1_PSD,  
    AMPAR,  PKA,  AC,  
    AMPAR_memb,  PP1_CaMKII_PSD,  CaMKII_PSD 
    This is a model of weak coupling between the AMPAR traffikcing bistability, and the CaMKII autophosphorylation bistability. In this model, there are three stable states: Both off, AMPAR on, or both on. The fourth possible state: CaMKII on but AMPAR off, is not truly stable, since over the course of hours the AMPAR also turns on.

    PP2A acting as a Molecule in      AMPAR_CaMKII_weak_coupling Network
    NameAccession NamePathway NameInitial Conc.
    (uM)    		Volume
    (fL)    		Buffered
    PP2A
  • AMPAR_CaMKII_
    weak_coupling
    Accession No. : 65
  • Shared_Object_
    AMPAR_CaMKII_
    weak_coupling
    Pathway No. : 281
    		• 0.11110.09No

    PP2A acting as an Enzyme in      AMPAR_CaMKII_weak_coupling Network
     Enzyme Molecule /
    Enzyme Activity    		Accession NamePathway NameKm (uM)kcat (s^-1)RatioEnzyme TypeReagents
    1PP2A /
  • PP2A-dephosph-I1
  • AMPAR_CaMKII_
    weak_coupling
    Accession No. : 65
  • Shared_Object_
    AMPAR_CaMKII_
    weak_coupling
    Pathway No. : 281
    		• 15.999924.1667explicit E-S complexSubstrate
    I1*

    Product
    I1
        PP2A does most of the dephosph of I1 at basal Ca levels. See the review by Cohen in Ann Rev Biochem 1989. For now, lets halve Km. k1 was 3.3e-6, now 6.6e-6
    2PP2A /
  • PP2A-dephosph-PP
    1-I*
  • AMPAR_CaMKII_
    weak_coupling
    Accession No. : 65
  • Shared_Object_
    AMPAR_CaMKII_
    weak_coupling
    Pathway No. : 281
    		• 15.999924.1667explicit E-S complexSubstrate
    PP1-I1*

    Product
    PP1-I1
        k1 changed from 3.3e-6 to 6.6e-6
    3PP2A /

  • PP2A-dephosph-I1
    _
    PSD
  • AMPAR_CaMKII_
    weak_coupling
    Accession No. : 65
  • Shared_Object_
    AMPAR_CaMKII_
    weak_coupling
    Pathway No. : 281
    		• 15.999924.1667explicit E-S complexSubstrate
    I1*

    Product
    I1
        PP2A does most of the dephosph of I1 at basal Ca levels. See the review by Cohen in Ann Rev Biochem 1989. For now, lets halve Km. k1 was 3.3e-6, now 6.6e-6
    4PP2A /

  • PP2A-dephosph-PP
    1-I*_
    PSD
  • AMPAR_CaMKII_
    weak_coupling
    Accession No. : 65
  • Shared_Object_
    AMPAR_CaMKII_
    weak_coupling
    Pathway No. : 281
    		• 15.999924.1667explicit E-S complexSubstrate
    PP1-I1*

    Product
    PP1-I1
        k1 changed from 3.3e-6 to 6.6e-6


    Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
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