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Molecule Parameter List for AC2 | The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by  color. | | Statistics |
Accession and Pathway Details | |
| Accession Name | Accession No. | Accession Type | Pathway Link | AMPAR_CaMKII_
weak_coupling | 65 | Network |
Shared_Object_AMPAR_CaMKII_weak_coupling, CaMKII, CaM,
PP1, PP2B, PP1_PSD,
AMPAR, PKA, AC,
AMPAR_memb, PP1_CaMKII_PSD, CaMKII_PSD | | This is a model of weak coupling between the AMPAR traffikcing bistability, and the CaMKII autophosphorylation bistability. In this model, there are three stable states: Both off, AMPAR on, or both on. The fourth possible state: CaMKII on but AMPAR off, is not truly stable, since over the course of hours the AMPAR also turns on. |
AC2 acting as a Molecule in AMPAR_CaMKII_weak_coupling Network
| Name | Accession Name | Pathway Name | Initial Conc.
(uM) | Volume
(fL) | Buffered | | AC2 | AMPAR_CaMKII_
weak_coupling
Accession No. : 65 | AC
Pathway No. : 289 | 0.0741 | 0.09 | No | | Starting at 0.015 uM. 17 Feb 2005: Raised slightly so as to have integer number of molecules. 18 Feb 2005: Doubled, to compensate for reduced ATP. |
AC2 acting as a Substrate for an Enzyme in AMPAR_CaMKII_weak_coupling Network
Enzyme Molecule /
Enzyme Activity | Accession Name | Pathway Name | Km (uM) | kcat (s^-1) | Ratio | Enzyme Type | Reagents | PKC-active /
phosph-AC2 | AMPAR_CaMKII_
weak_coupling
Accession No. : 65 | Shared_Object_
AMPAR_CaMKII_
weak_coupling
Pathway No. : 281 | 33.3337 | 4 | 4 | explicit E-S complex | Substrate
AC2
Product
AC2*
| | Phorbol esters have little effect on AC1 or on the Gs-stimulation of AC2. So in this model we are only dealing with the increase in basal activation of AC2 induced by PKC k1 = 1.66e-6 k2 = 16 k3 =4 |
AC2 acting as a Product in a reaction in AMPAR_CaMKII_weak_coupling Network
| Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated.
Kd for higher order reaction are not consider. |
| Name | Accession Name | Pathway Name | Kf | Kb | Kd | tau | Reagents | | dephosph-AC2 | AMPAR_CaMKII_
weak_coupling
Accession No. : 65 | AC
Pathway No. : 289 | 0.1
(s^-1) | 0
(s^-1) | - | - | Substrate
AC2*
Product
AC2
| | Random rate. |
| Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
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