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Molecule Parameter List for Transcription_comp2 | The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by  color. | | Statistics |
| Transcription_comp2 participated as | Molecule | Sum total of | Enzyme | Substrate of an enzyme | Product of an enzyme | Substrate in Reaction | Product in Reaction | | No. of occurrences | 1 | 0 | 1 | 0 | 0 | 0 | 0 |
Accession and Pathway Details | |
| Accession Name | Accession No. | Accession Type | Pathway Link | | SOCS1_knockout | 67 | Pathway |
SOCS1_knockout | This model was taken from the Yamada S et al. FEBS Letters 2003 Jan 16;534(1-3):190-6
This model shows the control mechanism of Jak-Stat pathway, here SOCS1 (Suppressor of cytokine signaling-I) was identified as the negative regulator of Jak and STAT signal transduction pathway. This is the knockout version of Jak-Stat pathway in this model the SOCS1 has been knocked out i.e it formation is not shown.
The graphs are almost similar to the graphs as shown in the paper but STAT1n graph has some ambiguities. Thanks to Dr Satoshi Yamada for clarifying some of those ambiguities and providing the values used in the simulations. |
Transcription_comp2 acting as a Molecule in SOCS1_knockout Network
| Name | Accession Name | Pathway Name | Initial Conc.
(uM) | Volume
(fL) | Buffered | | Transcription_comp2 | SOCS1_knockout
Accession No. : 67 | SOCS1_knockout
Pathway No. : 294 | 0.001 | 0.0016667 | Yes | | Transcription complex for mRNAVn Appendix, Satoshi Yamada et al 2003 FEBS Letters 534:190-196. |
Transcription_comp2 acting as an Enzyme in SOCS1_knockout Network
Enzyme Molecule /
Enzyme Activity | Accession Name | Pathway Name | Km (uM) | kcat (s^-1) | Ratio | Enzyme Type | Reagents | Transcription_
comp2 /
DNA
| SOCS1_knockout
Accession No. : 67 | SOCS1_knockout
Pathway No. : 294 | 0.4 | 0.01 | 4 | Classical Michaelis-Menten
V = Etot.S.Kcat/Km+S | Substrate
dup_
STAT1n*-STAT1n*
Product
mRNAVn
| | DNA Km = 0.4uM kcat = 0.01/sec Appendix, Satoshi Yamada et al 2003 FEBS Letters 534;190-196. |
| Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
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