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Molecule Parameter List for RasGTP

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network. The text color of a molecule is highlighted by color.

Statistics

RasGTP participated as	Molecule	Sum total of	Enzyme	Substrate of an enzyme	Product of an enzyme	Substrate in Reaction	Product in Reaction
No. of occurrences	1	0	0	0	0	1	0

Accession and Pathway Details

Accession Name	Accession No.	Accession Type	Pathway Link
RasGTPase	71	Pathway	RasGTPase
Ras is an important regulator of cell growth in all eukaryotic cells. The model represent hydrolysis of active Ras-bound GTP to give inactive Ras-bound GDP catalyzed by GTPase activating proteins i.e NF1. The inactive Ras-bound GDP turns signalling protein off.

RasGTP acting as a Molecule in  RasGTPase Network

Name	Accession Name	Pathway Name	Initial Conc. (uM)	Volume (fL)	Buffered
RasGTP	RasGTPase Accession No. : 71	RasGTPase Pathway No. : 307	1	523.6	No
The concentration of Ras GTP is 1 um. Ref: Fig-2 Phillips RA et al Biochemistry 2003, 42, 3956-3965.

RasGTP acting as a Substrate in a reaction in  RasGTPase Network

Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.

Name	Accession Name	Pathway Name	Kf	Kb	Kd	tau	Reagents
NF1_binding	RasGTPase Accession No. : 71	RasGTPase Pathway No. : 307	1.2 (uM^-1 s^-1)	6.36 (s^-1)	Kd(bf) = 5.3(uM)	-	Substrate NF1 RasGTP Product RasGTP-NF1
Binding of NF1 to Ras.GTP NF1 is a mammalian GAP Kd = 5.3 uM Table 3, Phillips RA et al 2003 Biochemistry 42: 3956-3965