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Molecule Parameter List for PLA2-Ca*

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by

color.

Statistics

PLA2-Ca* participated as	Molecule	Sum total of	Enzyme	Substrate of an enzyme	Product of an enzyme	Substrate in Reaction	Product in Reaction
No. of occurrences	1	0	1	0	0	2	1

Accession and Pathway Details

Accession Name	Accession No.	Accession Type	Pathway Link
3d_fold_model	8	Network	Shared_Object_3d_fold_model, PKC, MAPK, PLA2, Ras
This model is an annotated version of the synaptic signaling network. The primary reference is Bhalla US and Iyengar R. Science (1999) 283(5400):381-7 but several of the model pathways have been updated Bhalla US, Ram PT, Iyengar R. Science. 2002 Aug 9;297(5583):1018-23.

PLA2-Ca* acting as a Molecule in 3d_fold_model Network

Name	Accession Name	Pathway Name	Initial Conc. (uM)	Volume (fL)	Buffered
PLA2-Ca*	3d_fold_model Accession No. : 8	PLA2 Pathway No. : 57	0	1000	No

PLA2-Ca* acting as an Enzyme in 3d_fold_model Network

Enzyme Molecule / Enzyme Activity	Accession Name	Pathway Name	Km (uM)	kcat (s^-1)	Ratio	Enzyme Type	Reagents
PLA2-Ca* / kenz	3d_fold_model Accession No. : 8	PLA2 Pathway No. : 57	20	5.4	4	explicit E-S complex	Substrate APC Product AA
10 x raise oct22 12 x oct 24, set k2 = 4 k3*

PLA2-Ca* acting as a Substrate in a reaction in 3d_fold_model Network

Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.

	Name	Accession Name	Pathway Name	Kf	Kb	Kd	tau	Reagents
1	PIP2-Ca-PLA2-act	3d_fold_model Accession No. : 8	PLA2 Pathway No. : 57	0.012 (uM^-1 s^-1)	0.1 (s^-1)	Kd(bf) = 8.3333(uM)	-	Substrate PLA2-Ca* temp-PIP2 Product PIP2-Ca-PLA2*
2	DAG-Ca-PLA2-act	3d_fold_model Accession No. : 8	PLA2 Pathway No. : 57	0.003 (uM^-1 s^-1)	4 (s^-1)	Kd(bf) = 1333.3333(uM)	-	Substrate DAG PLA2-Ca* Product DAG-Ca-PLA2*
	27 June 1996 Scaled kf down by 0.015 from 3.33e-7 to 5e-9 to fit with revised DAG estimates and use of mole-fraction to calculate eff on PLA2.

PLA2-Ca* acting as a Product in a reaction in 3d_fold_model Network

Name	Accession Name	Pathway Name	Kf	Kb	Kd	tau	Reagents
PLA2-Ca-act	3d_fold_model Accession No. : 8	PLA2 Pathway No. : 57	1 (uM^-1 s^-1)	0.1 (s^-1)	Kd(bf) = 0.1(uM)	-	Substrate Ca PLA2-cytosolic Product PLA2-Ca*
Leslie and Channon BBA 1045 (1990) 261-270 fig6 pp267.

Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
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