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Molecule Parameter List for GDP-Ras | The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by  color. | | Statistics |
Accession and Pathway Details | |
| Accession Name | Accession No. | Accession Type | Pathway Link | Ajay_bhalla_
2007_ReacDiff1_
1e-12 | 81 | Network | Shared_Object_Ajay_bhalla_2007_ReacDiff1_1e-12,
PKC, MAPK, Ras, CaM, PKM, chain, kinetics, PKC, MAPK, Ras, CaM, PKM, kinetics[1],
PKC, MAPK, Ras, CaM, PKM, kinetics[2], PKC, MAPK, Ras, CaM, PKM, kinetics[3],
PKC, MAPK, MAPK, Ras, CaM, PKM, kinetics[4], PKC, MAPK, Ras, CaM, PKM,
kinetics[5], PKC, MAPK, Ras, kinetics[6], CaM, PKM, PKC, MAPK, Ras,
CaM, PKM, kinetics[7], PKC, Ras, CaM, PKM, kinetics[8], PKC, MAPK,
Ras, CaM, PKM, kinetics[9], PKC, MAPK, Ras, CaM, PKM, kinetics[10],
PKC, MAPK, Ras, CaM, PKM, kinetics[11], PKC, MAPK, Ras, CaM, PKM, kinetics[12],
PKC, MAPK, Ras, CaM, PKM, kinetics[13], PKC, MAPK, Ras, CaM, PKM, kinetics[14],
PKC, MAPK, Ras, CaM, PKM, kinetics[15], PKC, MAPK, Ras, CaM, PKM, kinetics[16],
PKC, MAPK, Ras, CaM, PKM, kinetics[17], PKC, MAPK, Ras, CaM, PKM, kinetics[18],
PKC, MAPK, Ras, CaM, PKM, kinetics[19], PKC, MAPK, Ras, CaM, PKM, kinetics[20],
PKC, MAPK, Ras, CaM, PKM, kinetics[21], PKC, MAPK, Ras, CaM, PKM, kinetics[22],
PKC, MAPK, Ras, CaM, PKM, kinetics[23], PKC, MAPK, Ras, CaM, PKM | This is a 25-compartment reaction-diffusion version of the Ajay_Bhalla_2007_PKM model. The original single-compartment model is repeated 25 times. In addition, a subset (27 out of 42) molecules can diffuse between compartments. Diffusion is implemented as a reaction between corresponding molecules in neighboring compartments. For D = 1e-12 m^2/sec (i.e., 1 micron^2/sec ) the kf and kb of this reaction for these 10 micron compartments are both 0.01/sec. For D = 1e-13 m^2/sec (i.e., 0.1 micron^2/sec ) the kf and kb are 0.001/sec.
The stimulus file pkm_mapk22_diff_1e-12_Fig4A which was used for the model to replicate Figure 4A from the paper.
This stimulus file pkm_mapk22_diff_1e-12_Fig4G which was used for the model to replicate Figure 4G from the paper |
GDP-Ras acting as a Molecule in Ajay_bhalla_2007_ReacDiff1_1e-12 Network
| Name | Accession Name | Pathway Name | Initial Conc.
(uM) | Volume
(fL) | Buffered | | GDP-Ras | Ajay_bhalla_
2007_ReacDiff1_
1e-12
Accession No. : 81 | Ras
Pathway No. : 378 | 0.5 | 1.5 | No | | GDP bound form. See Rosen et al Neuron 12 1207-1221 June 1994. the activation loop is based on Boguski and McCormick Nature 366 643-654 93 Assume Ras is present at about the same level as craf-1, 0.2 uM. Hallberg et al JBC 269:6 3913-3916 1994 estimate upto 5-10% of cellular Raf is assoc with Ras. Given that only 5-10% of Ras is GTP-bound, we need similar amounts of Ras as Raf. | | GDP-Ras | Ajay_bhalla_
2007_ReacDiff1_
1e-12
Accession No. : 81 | Ras
Pathway No. : 385 | 0.5 | 1.5 | No | | GDP bound form. See Rosen et al Neuron 12 1207-1221 June 1994. the activation loop is based on Boguski and McCormick Nature 366 643-654 93 Assume Ras is present at about the same level as craf-1, 0.2 uM. Hallberg et al JBC 269:6 3913-3916 1994 estimate upto 5-10% of cellular Raf is assoc with Ras. Given that only 5-10% of Ras is GTP-bound, we need similar amounts of Ras as Raf. | | GDP-Ras | Ajay_bhalla_
2007_ReacDiff1_
1e-12
Accession No. : 81 | Ras
Pathway No. : 391 | 0.5 | 1.5 | No | | GDP bound form. See Rosen et al Neuron 12 1207-1221 June 1994. the activation loop is based on Boguski and McCormick Nature 366 643-654 93 Assume Ras is present at about the same level as craf-1, 0.2 uM. Hallberg et al JBC 269:6 3913-3916 1994 estimate upto 5-10% of cellular Raf is assoc with Ras. Given that only 5-10% of Ras is GTP-bound, we need similar amounts of Ras as Raf. | | GDP-Ras | Ajay_bhalla_
2007_ReacDiff1_
1e-12
Accession No. : 81 | Ras
Pathway No. : 397 | 0.5 | 1.5 | No | | GDP bound form. See Rosen et al Neuron 12 1207-1221 June 1994. the activation loop is based on Boguski and McCormick Nature 366 643-654 93 Assume Ras is present at about the same level as craf-1, 0.2 uM. Hallberg et al JBC 269:6 3913-3916 1994 estimate upto 5-10% of cellular Raf is assoc with Ras. Given that only 5-10% of Ras is GTP-bound, we need similar amounts of Ras as Raf. | | GDP-Ras | Ajay_bhalla_
2007_ReacDiff1_
1e-12
Accession No. : 81 | Ras
Pathway No. : 404 | 0.5 | 1.5 | No | | GDP bound form. See Rosen et al Neuron 12 1207-1221 June 1994. the activation loop is based on Boguski and McCormick Nature 366 643-654 93 Assume Ras is present at about the same level as craf-1, 0.2 uM. Hallberg et al JBC 269:6 3913-3916 1994 estimate upto 5-10% of cellular Raf is assoc with Ras. Given that only 5-10% of Ras is GTP-bound, we need similar amounts of Ras as Raf. | | GDP-Ras | Ajay_bhalla_
2007_ReacDiff1_
1e-12
Accession No. : 81 | Ras
Pathway No. : 410 | 0.5 | 1.5 | No | | GDP bound form. See Rosen et al Neuron 12 1207-1221 June 1994. the activation loop is based on Boguski and McCormick Nature 366 643-654 93 Assume Ras is present at about the same level as craf-1, 0.2 uM. Hallberg et al JBC 269:6 3913-3916 1994 estimate upto 5-10% of cellular Raf is assoc with Ras. Given that only 5-10% of Ras is GTP-bound, we need similar amounts of Ras as Raf. | | GDP-Ras | Ajay_bhalla_
2007_ReacDiff1_
1e-12
Accession No. : 81 | Ras
Pathway No. : 416 | 0.5 | 1.5 | No | | GDP bound form. See Rosen et al Neuron 12 1207-1221 June 1994. the activation loop is based on Boguski and McCormick Nature 366 643-654 93 Assume Ras is present at about the same level as craf-1, 0.2 uM. Hallberg et al JBC 269:6 3913-3916 1994 estimate upto 5-10% of cellular Raf is assoc with Ras. Given that only 5-10% of Ras is GTP-bound, we need similar amounts of Ras as Raf. | | GDP-Ras | Ajay_bhalla_
2007_ReacDiff1_
1e-12
Accession No. : 81 | Ras
Pathway No. : 422 | 0.5 | 1.5 | No | | GDP bound form. See Rosen et al Neuron 12 1207-1221 June 1994. the activation loop is based on Boguski and McCormick Nature 366 643-654 93 Assume Ras is present at about the same level as craf-1, 0.2 uM. Hallberg et al JBC 269:6 3913-3916 1994 estimate upto 5-10% of cellular Raf is assoc with Ras. Given that only 5-10% of Ras is GTP-bound, we need similar amounts of Ras as Raf. | | GDP-Ras | Ajay_bhalla_
2007_ReacDiff1_
1e-12
Accession No. : 81 | Ras
Pathway No. : 427 | 0.5 | 1.5 | No | | GDP bound form. See Rosen et al Neuron 12 1207-1221 June 1994. the activation loop is based on Boguski and McCormick Nature 366 643-654 93 Assume Ras is present at about the same level as craf-1, 0.2 uM. Hallberg et al JBC 269:6 3913-3916 1994 estimate upto 5-10% of cellular Raf is assoc with Ras. Given that only 5-10% of Ras is GTP-bound, we need similar amounts of Ras as Raf. | | GDP-Ras | Ajay_bhalla_
2007_ReacDiff1_
1e-12
Accession No. : 81 | Ras
Pathway No. : 433 | 0.5 | 1.5 | No | | GDP bound form. See Rosen et al Neuron 12 1207-1221 June 1994. the activation loop is based on Boguski and McCormick Nature 366 643-654 93 Assume Ras is present at about the same level as craf-1, 0.2 uM. Hallberg et al JBC 269:6 3913-3916 1994 estimate upto 5-10% of cellular Raf is assoc with Ras. Given that only 5-10% of Ras is GTP-bound, we need similar amounts of Ras as Raf. | | GDP-Ras | Ajay_bhalla_
2007_ReacDiff1_
1e-12
Accession No. : 81 | Ras
Pathway No. : 439 | 0.5 | 1.5 | No | | GDP bound form. See Rosen et al Neuron 12 1207-1221 June 1994. the activation loop is based on Boguski and McCormick Nature 366 643-654 93 Assume Ras is present at about the same level as craf-1, 0.2 uM. Hallberg et al JBC 269:6 3913-3916 1994 estimate upto 5-10% of cellular Raf is assoc with Ras. Given that only 5-10% of Ras is GTP-bound, we need similar amounts of Ras as Raf. | | GDP-Ras | Ajay_bhalla_
2007_ReacDiff1_
1e-12
Accession No. : 81 | Ras
Pathway No. : 445 | 0.5 | 1.5 | No | | GDP bound form. See Rosen et al Neuron 12 1207-1221 June 1994. the activation loop is based on Boguski and McCormick Nature 366 643-654 93 Assume Ras is present at about the same level as craf-1, 0.2 uM. Hallberg et al JBC 269:6 3913-3916 1994 estimate upto 5-10% of cellular Raf is assoc with Ras. Given that only 5-10% of Ras is GTP-bound, we need similar amounts of Ras as Raf. | | GDP-Ras | Ajay_bhalla_
2007_ReacDiff1_
1e-12
Accession No. : 81 | Ras
Pathway No. : 451 | 0.5 | 1.5 | No | | GDP bound form. See Rosen et al Neuron 12 1207-1221 June 1994. the activation loop is based on Boguski and McCormick Nature 366 643-654 93 Assume Ras is present at about the same level as craf-1, 0.2 uM. Hallberg et al JBC 269:6 3913-3916 1994 estimate upto 5-10% of cellular Raf is assoc with Ras. Given that only 5-10% of Ras is GTP-bound, we need similar amounts of Ras as Raf. | | GDP-Ras | Ajay_bhalla_
2007_ReacDiff1_
1e-12
Accession No. : 81 | Ras
Pathway No. : 457 | 0.5 | 1.5 | No | | GDP bound form. See Rosen et al Neuron 12 1207-1221 June 1994. the activation loop is based on Boguski and McCormick Nature 366 643-654 93 Assume Ras is present at about the same level as craf-1, 0.2 uM. Hallberg et al JBC 269:6 3913-3916 1994 estimate upto 5-10% of cellular Raf is assoc with Ras. Given that only 5-10% of Ras is GTP-bound, we need similar amounts of Ras as Raf. | | GDP-Ras | Ajay_bhalla_
2007_ReacDiff1_
1e-12
Accession No. : 81 | Ras
Pathway No. : 463 | 0.5 | 1.5 | No | | GDP bound form. See Rosen et al Neuron 12 1207-1221 June 1994. the activation loop is based on Boguski and McCormick Nature 366 643-654 93 Assume Ras is present at about the same level as craf-1, 0.2 uM. Hallberg et al JBC 269:6 3913-3916 1994 estimate upto 5-10% of cellular Raf is assoc with Ras. Given that only 5-10% of Ras is GTP-bound, we need similar amounts of Ras as Raf. | | GDP-Ras | Ajay_bhalla_
2007_ReacDiff1_
1e-12
Accession No. : 81 | Ras
Pathway No. : 469 | 0.5 | 1.5 | No | | GDP bound form. See Rosen et al Neuron 12 1207-1221 June 1994. the activation loop is based on Boguski and McCormick Nature 366 643-654 93 Assume Ras is present at about the same level as craf-1, 0.2 uM. Hallberg et al JBC 269:6 3913-3916 1994 estimate upto 5-10% of cellular Raf is assoc with Ras. Given that only 5-10% of Ras is GTP-bound, we need similar amounts of Ras as Raf. | | GDP-Ras | Ajay_bhalla_
2007_ReacDiff1_
1e-12
Accession No. : 81 | Ras
Pathway No. : 475 | 0.5 | 1.5 | No | | GDP bound form. See Rosen et al Neuron 12 1207-1221 June 1994. the activation loop is based on Boguski and McCormick Nature 366 643-654 93 Assume Ras is present at about the same level as craf-1, 0.2 uM. Hallberg et al JBC 269:6 3913-3916 1994 estimate upto 5-10% of cellular Raf is assoc with Ras. Given that only 5-10% of Ras is GTP-bound, we need similar amounts of Ras as Raf. | | GDP-Ras | Ajay_bhalla_
2007_ReacDiff1_
1e-12
Accession No. : 81 | Ras
Pathway No. : 481 | 0.5 | 1.5 | No | | GDP bound form. See Rosen et al Neuron 12 1207-1221 June 1994. the activation loop is based on Boguski and McCormick Nature 366 643-654 93 Assume Ras is present at about the same level as craf-1, 0.2 uM. Hallberg et al JBC 269:6 3913-3916 1994 estimate upto 5-10% of cellular Raf is assoc with Ras. Given that only 5-10% of Ras is GTP-bound, we need similar amounts of Ras as Raf. | | GDP-Ras | Ajay_bhalla_
2007_ReacDiff1_
1e-12
Accession No. : 81 | Ras
Pathway No. : 487 | 0.5 | 1.5 | No | | GDP bound form. See Rosen et al Neuron 12 1207-1221 June 1994. the activation loop is based on Boguski and McCormick Nature 366 643-654 93 Assume Ras is present at about the same level as craf-1, 0.2 uM. Hallberg et al JBC 269:6 3913-3916 1994 estimate upto 5-10% of cellular Raf is assoc with Ras. Given that only 5-10% of Ras is GTP-bound, we need similar amounts of Ras as Raf. | | GDP-Ras | Ajay_bhalla_
2007_ReacDiff1_
1e-12
Accession No. : 81 | Ras
Pathway No. : 493 | 0.5 | 1.5 | No | | GDP bound form. See Rosen et al Neuron 12 1207-1221 June 1994. the activation loop is based on Boguski and McCormick Nature 366 643-654 93 Assume Ras is present at about the same level as craf-1, 0.2 uM. Hallberg et al JBC 269:6 3913-3916 1994 estimate upto 5-10% of cellular Raf is assoc with Ras. Given that only 5-10% of Ras is GTP-bound, we need similar amounts of Ras as Raf. | | GDP-Ras | Ajay_bhalla_
2007_ReacDiff1_
1e-12
Accession No. : 81 | Ras
Pathway No. : 499 | 0.5 | 1.5 | No | | GDP bound form. See Rosen et al Neuron 12 1207-1221 June 1994. the activation loop is based on Boguski and McCormick Nature 366 643-654 93 Assume Ras is present at about the same level as craf-1, 0.2 uM. Hallberg et al JBC 269:6 3913-3916 1994 estimate upto 5-10% of cellular Raf is assoc with Ras. Given that only 5-10% of Ras is GTP-bound, we need similar amounts of Ras as Raf. | | GDP-Ras | Ajay_bhalla_
2007_ReacDiff1_
1e-12
Accession No. : 81 | Ras
Pathway No. : 505 | 0.5 | 1.5 | No | | GDP bound form. See Rosen et al Neuron 12 1207-1221 June 1994. the activation loop is based on Boguski and McCormick Nature 366 643-654 93 Assume Ras is present at about the same level as craf-1, 0.2 uM. Hallberg et al JBC 269:6 3913-3916 1994 estimate upto 5-10% of cellular Raf is assoc with Ras. Given that only 5-10% of Ras is GTP-bound, we need similar amounts of Ras as Raf. | | GDP-Ras | Ajay_bhalla_
2007_ReacDiff1_
1e-12
Accession No. : 81 | Ras
Pathway No. : 511 | 0.5 | 1.5 | No | | GDP bound form. See Rosen et al Neuron 12 1207-1221 June 1994. the activation loop is based on Boguski and McCormick Nature 366 643-654 93 Assume Ras is present at about the same level as craf-1, 0.2 uM. Hallberg et al JBC 269:6 3913-3916 1994 estimate upto 5-10% of cellular Raf is assoc with Ras. Given that only 5-10% of Ras is GTP-bound, we need similar amounts of Ras as Raf. | | GDP-Ras | Ajay_bhalla_
2007_ReacDiff1_
1e-12
Accession No. : 81 | Ras
Pathway No. : 517 | 0.5 | 1.5 | No | | GDP bound form. See Rosen et al Neuron 12 1207-1221 June 1994. the activation loop is based on Boguski and McCormick Nature 366 643-654 93 Assume Ras is present at about the same level as craf-1, 0.2 uM. Hallberg et al JBC 269:6 3913-3916 1994 estimate upto 5-10% of cellular Raf is assoc with Ras. Given that only 5-10% of Ras is GTP-bound, we need similar amounts of Ras as Raf. | | GDP-Ras | Ajay_bhalla_
2007_ReacDiff1_
1e-12
Accession No. : 81 | Ras
Pathway No. : 523 | 0.5 | 1.5 | No | | GDP bound form. See Rosen et al Neuron 12 1207-1221 June 1994. the activation loop is based on Boguski and McCormick Nature 366 643-654 93 Assume Ras is present at about the same level as craf-1, 0.2 uM. Hallberg et al JBC 269:6 3913-3916 1994 estimate upto 5-10% of cellular Raf is assoc with Ras. Given that only 5-10% of Ras is GTP-bound, we need similar amounts of Ras as Raf. |
GDP-Ras acting as a Substrate for an Enzyme in Ajay_bhalla_2007_ReacDiff1_1e-12 Network
| | Enzyme Molecule /
Enzyme Activity | Accession Name | Pathway Name | Km (uM) | kcat (s^-1) | Ratio | Enzyme Type | Reagents | | 1 | inact-GEF /
basal_GEF_
activity
| Ajay_bhalla_
2007_ReacDiff1_
1e-12
Accession No. : 81 | Ras
Pathway No. : 378 | 10.1015 | 0.02 | 4 | explicit E-S complex | Substrate
GDP-Ras
Product
GTP-Ras
| | | | | 2 | GEF* /
GEF*-act-ras | Ajay_bhalla_
2007_ReacDiff1_
1e-12
Accession No. : 81 | Ras
Pathway No. : 378 | 0.505057 | 0.02 | 4 | explicit E-S complex | Substrate
GDP-Ras
Product
GTP-Ras
| | | Kinetics same as GEF-bg-act-ras | | 3 | CaM-GEF /
CaM-GEF-act-ras | Ajay_bhalla_
2007_ReacDiff1_
1e-12
Accession No. : 81 | Ras
Pathway No. : 378 | 0.505057 | 0.2 | 4 | explicit E-S complex | Substrate
GDP-Ras
Product
GTP-Ras
| | | Kinetics same as GEF-bg_act-ras, but as of March 17, 2006, the kcat is scaled from 0.02 to 0.2 to have a stronger Ca response for the direct MAPK input. | | 4 | inact-GEF /
basal_GEF_
activity
| Ajay_bhalla_
2007_ReacDiff1_
1e-12
Accession No. : 81 | Ras
Pathway No. : 385 | 10.1015 | 0.02 | 4 | explicit E-S complex | Substrate
GDP-Ras
Product
GTP-Ras
| | | | | 5 | GEF* /
GEF*-act-ras | Ajay_bhalla_
2007_ReacDiff1_
1e-12
Accession No. : 81 | Ras
Pathway No. : 385 | 0.505057 | 0.02 | 4 | explicit E-S complex | Substrate
GDP-Ras
Product
GTP-Ras
| | | Kinetics same as GEF-bg-act-ras | | 6 | CaM-GEF /
CaM-GEF-act-ras | Ajay_bhalla_
2007_ReacDiff1_
1e-12
Accession No. : 81 | Ras
Pathway No. : 385 | 0.505057 | 0.2 | 4 | explicit E-S complex | Substrate
GDP-Ras
Product
GTP-Ras
| | | Kinetics same as GEF-bg_act-ras, but as of March 17, 2006, the kcat is scaled from 0.02 to 0.2 to have a stronger Ca response for the direct MAPK input. | | 7 | inact-GEF /
basal_GEF_
activity
| Ajay_bhalla_
2007_ReacDiff1_
1e-12
Accession No. : 81 | Ras
Pathway No. : 391 | 10.1015 | 0.02 | 4 | explicit E-S complex | Substrate
GDP-Ras
Product
GTP-Ras
| | | | | 8 | GEF* /
GEF*-act-ras | Ajay_bhalla_
2007_ReacDiff1_
1e-12
Accession No. : 81 | Ras
Pathway No. : 391 | 0.505057 | 0.02 | 4 | explicit E-S complex | Substrate
GDP-Ras
Product
GTP-Ras
| | | Kinetics same as GEF-bg-act-ras | | 9 | CaM-GEF /
CaM-GEF-act-ras | Ajay_bhalla_
2007_ReacDiff1_
1e-12
Accession No. : 81 | Ras
Pathway No. : 391 | 0.505057 | 0.2 | 4 | explicit E-S complex | Substrate
GDP-Ras
Product
GTP-Ras
| | | Kinetics same as GEF-bg_act-ras, but as of March 17, 2006, the kcat is scaled from 0.02 to 0.2 to have a stronger Ca response for the direct MAPK input. | | 10 | inact-GEF /
basal_GEF_
activity
| Ajay_bhalla_
2007_ReacDiff1_
1e-12
Accession No. : 81 | Ras
Pathway No. : 397 | 10.1015 | 0.02 | 4 | explicit E-S complex | Substrate
GDP-Ras
Product
GTP-Ras
| | | | | 11 | GEF* /
GEF*-act-ras | Ajay_bhalla_
2007_ReacDiff1_
1e-12
Accession No. : 81 | Ras
Pathway No. : 397 | 0.505057 | 0.02 | 4 | explicit E-S complex | Substrate
GDP-Ras
Product
GTP-Ras
| | | Kinetics same as GEF-bg-act-ras | | 12 | CaM-GEF /
CaM-GEF-act-ras | Ajay_bhalla_
2007_ReacDiff1_
1e-12
Accession No. : 81 | Ras
Pathway No. : 397 | 0.505057 | 0.2 | 4 | explicit E-S complex | Substrate
GDP-Ras
Product
GTP-Ras
| | | Kinetics same as GEF-bg_act-ras, but as of March 17, 2006, the kcat is scaled from 0.02 to 0.2 to have a stronger Ca response for the direct MAPK input. | | 13 | inact-GEF /
basal_GEF_
activity
| Ajay_bhalla_
2007_ReacDiff1_
1e-12
Accession No. : 81 | Ras
Pathway No. : 404 | 10.1015 | 0.02 | 4 | explicit E-S complex | Substrate
GDP-Ras
Product
GTP-Ras
| | | | | 14 | GEF* /
GEF*-act-ras | Ajay_bhalla_
2007_ReacDiff1_
1e-12
Accession No. : 81 | Ras
Pathway No. : 404 | 0.505057 | 0.02 | 4 | explicit E-S complex | Substrate
GDP-Ras
Product
GTP-Ras
| | | Kinetics same as GEF-bg-act-ras | | 15 | CaM-GEF /
CaM-GEF-act-ras | Ajay_bhalla_
2007_ReacDiff1_
1e-12
Accession No. : 81 | Ras
Pathway No. : 404 | 0.505057 | 0.2 | 4 | explicit E-S complex | Substrate
GDP-Ras
Product
GTP-Ras
| | | Kinetics same as GEF-bg_act-ras, but as of March 17, 2006, the kcat is scaled from 0.02 to 0.2 to have a stronger Ca response for the direct MAPK input. | | 16 | inact-GEF /
basal_GEF_
activity
| Ajay_bhalla_
2007_ReacDiff1_
1e-12
Accession No. : 81 | Ras
Pathway No. : 410 | 10.1015 | 0.02 | 4 | explicit E-S complex | Substrate
GDP-Ras
Product
GTP-Ras
| | | | | 17 | GEF* /
GEF*-act-ras | Ajay_bhalla_
2007_ReacDiff1_
1e-12
Accession No. : 81 | Ras
Pathway No. : 410 | 0.505057 | 0.02 | 4 | explicit E-S complex | Substrate
GDP-Ras
Product
GTP-Ras
| | | Kinetics same as GEF-bg-act-ras | | 18 | CaM-GEF /
CaM-GEF-act-ras | Ajay_bhalla_
2007_ReacDiff1_
1e-12
Accession No. : 81 | Ras
Pathway No. : 410 | 0.505057 | 0.2 | 4 | explicit E-S complex | Substrate
GDP-Ras
Product
GTP-Ras
| | | Kinetics same as GEF-bg_act-ras, but as of March 17, 2006, the kcat is scaled from 0.02 to 0.2 to have a stronger Ca response for the direct MAPK input. | | 19 | inact-GEF /
basal_GEF_
activity
| Ajay_bhalla_
2007_ReacDiff1_
1e-12
Accession No. : 81 | Ras
Pathway No. : 416 | 10.1015 | 0.02 | 4 | explicit E-S complex | Substrate
GDP-Ras
Product
GTP-Ras
| | | | | 20 | GEF* /
GEF*-act-ras | Ajay_bhalla_
2007_ReacDiff1_
1e-12
Accession No. : 81 | Ras
Pathway No. : 416 | 0.505057 | 0.02 | 4 | explicit E-S complex | Substrate
GDP-Ras
Product
GTP-Ras
| | | Kinetics same as GEF-bg-act-ras | | 21 | CaM-GEF /
CaM-GEF-act-ras | Ajay_bhalla_
2007_ReacDiff1_
1e-12
Accession No. : 81 | Ras
Pathway No. : 416 | 0.505057 | 0.2 | 4 | explicit E-S complex | Substrate
GDP-Ras
Product
GTP-Ras
| | | Kinetics same as GEF-bg_act-ras, but as of March 17, 2006, the kcat is scaled from 0.02 to 0.2 to have a stronger Ca response for the direct MAPK input. | | 22 | inact-GEF /
basal_GEF_
activity
| Ajay_bhalla_
2007_ReacDiff1_
1e-12
Accession No. : 81 | Ras
Pathway No. : 422 | 10.1015 | 0.02 | 4 | explicit E-S complex | Substrate
GDP-Ras
Product
GTP-Ras
| | | | | 23 | GEF* /
GEF*-act-ras | Ajay_bhalla_
2007_ReacDiff1_
1e-12
Accession No. : 81 | Ras
Pathway No. : 422 | 0.505057 | 0.02 | 4 | explicit E-S complex | Substrate
GDP-Ras
Product
GTP-Ras
| | | Kinetics same as GEF-bg-act-ras | | 24 | CaM-GEF /
CaM-GEF-act-ras | Ajay_bhalla_
2007_ReacDiff1_
1e-12
Accession No. : 81 | Ras
Pathway No. : 422 | 0.505057 | 0.2 | 4 | explicit E-S complex | Substrate
GDP-Ras
Product
GTP-Ras
| | | Kinetics same as GEF-bg_act-ras, but as of March 17, 2006, the kcat is scaled from 0.02 to 0.2 to have a stronger Ca response for the direct MAPK input. | | 25 | inact-GEF /
basal_GEF_
activity
| Ajay_bhalla_
2007_ReacDiff1_
1e-12
Accession No. : 81 | Ras
Pathway No. : 427 | 10.1015 | 0.02 | 4 | explicit E-S complex | Substrate
GDP-Ras
Product
GTP-Ras
| | | | | 26 | GEF* /
GEF*-act-ras | Ajay_bhalla_
2007_ReacDiff1_
1e-12
Accession No. : 81 | Ras
Pathway No. : 427 | 0.505057 | 0.02 | 4 | explicit E-S complex | Substrate
GDP-Ras
Product
GTP-Ras
| | | Kinetics same as GEF-bg-act-ras | | 27 | CaM-GEF /
CaM-GEF-act-ras | Ajay_bhalla_
2007_ReacDiff1_
1e-12
Accession No. : 81 | Ras
Pathway No. : 427 | 0.505057 | 0.2 | 4 | explicit E-S complex | Substrate
GDP-Ras
Product
GTP-Ras
| | | Kinetics same as GEF-bg_act-ras, but as of March 17, 2006, the kcat is scaled from 0.02 to 0.2 to have a stronger Ca response for the direct MAPK input. | | 28 | inact-GEF /
basal_GEF_
activity
| Ajay_bhalla_
2007_ReacDiff1_
1e-12
Accession No. : 81 | Ras
Pathway No. : 433 | 10.1015 | 0.02 | 4 | explicit E-S complex | Substrate
GDP-Ras
Product
GTP-Ras
| | | | | 29 | GEF* /
GEF*-act-ras | Ajay_bhalla_
2007_ReacDiff1_
1e-12
Accession No. : 81 | Ras
Pathway No. : 433 | 0.505057 | 0.02 | 4 | explicit E-S complex | Substrate
GDP-Ras
Product
GTP-Ras
| | | Kinetics same as GEF-bg-act-ras | | 30 | CaM-GEF /
CaM-GEF-act-ras | Ajay_bhalla_
2007_ReacDiff1_
1e-12
Accession No. : 81 | Ras
Pathway No. : 433 | 0.505057 | 0.2 | 4 | explicit E-S complex | Substrate
GDP-Ras
Product
GTP-Ras
| | | Kinetics same as GEF-bg_act-ras, but as of March 17, 2006, the kcat is scaled from 0.02 to 0.2 to have a stronger Ca response for the direct MAPK input. | | 31 | inact-GEF /
basal_GEF_
activity
| Ajay_bhalla_
2007_ReacDiff1_
1e-12
Accession No. : 81 | Ras
Pathway No. : 439 | 10.1015 | 0.02 | 4 | explicit E-S complex | Substrate
GDP-Ras
Product
GTP-Ras
| | | | | 32 | GEF* /
GEF*-act-ras | Ajay_bhalla_
2007_ReacDiff1_
1e-12
Accession No. : 81 | Ras
Pathway No. : 439 | 0.505057 | 0.02 | 4 | explicit E-S complex | Substrate
GDP-Ras
Product
GTP-Ras
| | | Kinetics same as GEF-bg-act-ras | | 33 | CaM-GEF /
CaM-GEF-act-ras | Ajay_bhalla_
2007_ReacDiff1_
1e-12
Accession No. : 81 | Ras
Pathway No. : 439 | 0.505057 | 0.2 | 4 | explicit E-S complex | Substrate
GDP-Ras
Product
GTP-Ras
| | | Kinetics same as GEF-bg_act-ras, but as of March 17, 2006, the kcat is scaled from 0.02 to 0.2 to have a stronger Ca response for the direct MAPK input. | | 34 | inact-GEF /
basal_GEF_
activity
| Ajay_bhalla_
2007_ReacDiff1_
1e-12
Accession No. : 81 | Ras
Pathway No. : 445 | 10.1015 | 0.02 | 4 | explicit E-S complex | Substrate
GDP-Ras
Product
GTP-Ras
| | | | | 35 | GEF* /
GEF*-act-ras | Ajay_bhalla_
2007_ReacDiff1_
1e-12
Accession No. : 81 | Ras
Pathway No. : 445 | 0.505057 | 0.02 | 4 | explicit E-S complex | Substrate
GDP-Ras
Product
GTP-Ras
| | | Kinetics same as GEF-bg-act-ras | | 36 | CaM-GEF /
CaM-GEF-act-ras | Ajay_bhalla_
2007_ReacDiff1_
1e-12
Accession No. : 81 | Ras
Pathway No. : 445 | 0.505057 | 0.2 | 4 | explicit E-S complex | Substrate
GDP-Ras
Product
GTP-Ras
| | | Kinetics same as GEF-bg_act-ras, but as of March 17, 2006, the kcat is scaled from 0.02 to 0.2 to have a stronger Ca response for the direct MAPK input. | | 37 | inact-GEF /
basal_GEF_
activity
| Ajay_bhalla_
2007_ReacDiff1_
1e-12
Accession No. : 81 | Ras
Pathway No. : 451 | 10.1015 | 0.02 | 4 | explicit E-S complex | Substrate
GDP-Ras
Product
GTP-Ras
| | | | | 38 | GEF* /
GEF*-act-ras | Ajay_bhalla_
2007_ReacDiff1_
1e-12
Accession No. : 81 | Ras
Pathway No. : 451 | 0.505057 | 0.02 | 4 | explicit E-S complex | Substrate
GDP-Ras
Product
GTP-Ras
| | | Kinetics same as GEF-bg-act-ras | | 39 | CaM-GEF /
CaM-GEF-act-ras | Ajay_bhalla_
2007_ReacDiff1_
1e-12
Accession No. : 81 | Ras
Pathway No. : 451 | 0.505057 | 0.2 | 4 | explicit E-S complex | Substrate
GDP-Ras
Product
GTP-Ras
| | | Kinetics same as GEF-bg_act-ras, but as of March 17, 2006, the kcat is scaled from 0.02 to 0.2 to have a stronger Ca response for the direct MAPK input. | | 40 | inact-GEF /
basal_GEF_
activity
| Ajay_bhalla_
2007_ReacDiff1_
1e-12
Accession No. : 81 | Ras
Pathway No. : 457 | 10.1015 | 0.02 | 4 | explicit E-S complex | Substrate
GDP-Ras
Product
GTP-Ras
| | | | | 41 | GEF* /
GEF*-act-ras | Ajay_bhalla_
2007_ReacDiff1_
1e-12
Accession No. : 81 | Ras
Pathway No. : 457 | 0.505057 | 0.02 | 4 | explicit E-S complex | Substrate
GDP-Ras
Product
GTP-Ras
| | | Kinetics same as GEF-bg-act-ras | | 42 | CaM-GEF /
CaM-GEF-act-ras | Ajay_bhalla_
2007_ReacDiff1_
1e-12
Accession No. : 81 | Ras
Pathway No. : 457 | 0.505057 | 0.2 | 4 | explicit E-S complex | Substrate
GDP-Ras
Product
GTP-Ras
| | | Kinetics same as GEF-bg_act-ras, but as of March 17, 2006, the kcat is scaled from 0.02 to 0.2 to have a stronger Ca response for the direct MAPK input. | | 43 | inact-GEF /
basal_GEF_
activity
| Ajay_bhalla_
2007_ReacDiff1_
1e-12
Accession No. : 81 | Ras
Pathway No. : 463 | 10.1015 | 0.02 | 4 | explicit E-S complex | Substrate
GDP-Ras
Product
GTP-Ras
| | | | | 44 | GEF* /
GEF*-act-ras | Ajay_bhalla_
2007_ReacDiff1_
1e-12
Accession No. : 81 | Ras
Pathway No. : 463 | 0.505057 | 0.02 | 4 | explicit E-S complex | Substrate
GDP-Ras
Product
GTP-Ras
| | | Kinetics same as GEF-bg-act-ras | | 45 | CaM-GEF /
CaM-GEF-act-ras | Ajay_bhalla_
2007_ReacDiff1_
1e-12
Accession No. : 81 | Ras
Pathway No. : 463 | 0.505057 | 0.2 | 4 | explicit E-S complex | Substrate
GDP-Ras
Product
GTP-Ras
| | | Kinetics same as GEF-bg_act-ras, but as of March 17, 2006, the kcat is scaled from 0.02 to 0.2 to have a stronger Ca response for the direct MAPK input. | | 46 | inact-GEF /
basal_GEF_
activity
| Ajay_bhalla_
2007_ReacDiff1_
1e-12
Accession No. : 81 | Ras
Pathway No. : 469 | 10.1015 | 0.02 | 4 | explicit E-S complex | Substrate
GDP-Ras
Product
GTP-Ras
| | | | | 47 | GEF* /
GEF*-act-ras | Ajay_bhalla_
2007_ReacDiff1_
1e-12
Accession No. : 81 | Ras
Pathway No. : 469 | 0.505057 | 0.02 | 4 | explicit E-S complex | Substrate
GDP-Ras
Product
GTP-Ras
| | | Kinetics same as GEF-bg-act-ras | | 48 | CaM-GEF /
CaM-GEF-act-ras | Ajay_bhalla_
2007_ReacDiff1_
1e-12
Accession No. : 81 | Ras
Pathway No. : 469 | 0.505057 | 0.2 | 4 | explicit E-S complex | Substrate
GDP-Ras
Product
GTP-Ras
| | | Kinetics same as GEF-bg_act-ras, but as of March 17, 2006, the kcat is scaled from 0.02 to 0.2 to have a stronger Ca response for the direct MAPK input. | | 49 | inact-GEF /
basal_GEF_
activity
| Ajay_bhalla_
2007_ReacDiff1_
1e-12
Accession No. : 81 | Ras
Pathway No. : 475 | 10.1015 | 0.02 | 4 | explicit E-S complex | Substrate
GDP-Ras
Product
GTP-Ras
| | | | | 50 | GEF* /
GEF*-act-ras | Ajay_bhalla_
2007_ReacDiff1_
1e-12
Accession No. : 81 | Ras
Pathway No. : 475 | 0.505057 | 0.02 | 4 | explicit E-S complex | Substrate
GDP-Ras
Product
GTP-Ras
| | | Kinetics same as GEF-bg-act-ras | | 51 | CaM-GEF /
CaM-GEF-act-ras | Ajay_bhalla_
2007_ReacDiff1_
1e-12
Accession No. : 81 | Ras
Pathway No. : 475 | 0.505057 | 0.2 | 4 | explicit E-S complex | Substrate
GDP-Ras
Product
GTP-Ras
| | | Kinetics same as GEF-bg_act-ras, but as of March 17, 2006, the kcat is scaled from 0.02 to 0.2 to have a stronger Ca response for the direct MAPK input. | | 52 | inact-GEF /
basal_GEF_
activity
| Ajay_bhalla_
2007_ReacDiff1_
1e-12
Accession No. : 81 | Ras
Pathway No. : 481 | 10.1015 | 0.02 | 4 | explicit E-S complex | Substrate
GDP-Ras
Product
GTP-Ras
| | | | | 53 | GEF* /
GEF*-act-ras | Ajay_bhalla_
2007_ReacDiff1_
1e-12
Accession No. : 81 | Ras
Pathway No. : 481 | 0.505057 | 0.02 | 4 | explicit E-S complex | Substrate
GDP-Ras
Product
GTP-Ras
| | | Kinetics same as GEF-bg-act-ras | | 54 | CaM-GEF /
CaM-GEF-act-ras | Ajay_bhalla_
2007_ReacDiff1_
1e-12
Accession No. : 81 | Ras
Pathway No. : 481 | 0.505057 | 0.2 | 4 | explicit E-S complex | Substrate
GDP-Ras
Product
GTP-Ras
| | | Kinetics same as GEF-bg_act-ras, but as of March 17, 2006, the kcat is scaled from 0.02 to 0.2 to have a stronger Ca response for the direct MAPK input. | | 55 | inact-GEF /
basal_GEF_
activity
| Ajay_bhalla_
2007_ReacDiff1_
1e-12
Accession No. : 81 | Ras
Pathway No. : 487 | 10.1015 | 0.02 | 4 | explicit E-S complex | Substrate
GDP-Ras
Product
GTP-Ras
| | | | | 56 | GEF* /
GEF*-act-ras | Ajay_bhalla_
2007_ReacDiff1_
1e-12
Accession No. : 81 | Ras
Pathway No. : 487 | 0.505057 | 0.02 | 4 | explicit E-S complex | Substrate
GDP-Ras
Product
GTP-Ras
| | | Kinetics same as GEF-bg-act-ras | | 57 | CaM-GEF /
CaM-GEF-act-ras | Ajay_bhalla_
2007_ReacDiff1_
1e-12
Accession No. : 81 | Ras
Pathway No. : 487 | 0.505057 | 0.2 | 4 | explicit E-S complex | Substrate
GDP-Ras
Product
GTP-Ras
| | | Kinetics same as GEF-bg_act-ras, but as of March 17, 2006, the kcat is scaled from 0.02 to 0.2 to have a stronger Ca response for the direct MAPK input. | | 58 | inact-GEF /
basal_GEF_
activity
| Ajay_bhalla_
2007_ReacDiff1_
1e-12
Accession No. : 81 | Ras
Pathway No. : 493 | 10.1015 | 0.02 | 4 | explicit E-S complex | Substrate
GDP-Ras
Product
GTP-Ras
| | | | | 59 | GEF* /
GEF*-act-ras | Ajay_bhalla_
2007_ReacDiff1_
1e-12
Accession No. : 81 | Ras
Pathway No. : 493 | 0.505057 | 0.02 | 4 | explicit E-S complex | Substrate
GDP-Ras
Product
GTP-Ras
| | | Kinetics same as GEF-bg-act-ras | | 60 | CaM-GEF /
CaM-GEF-act-ras | Ajay_bhalla_
2007_ReacDiff1_
1e-12
Accession No. : 81 | Ras
Pathway No. : 493 | 0.505057 | 0.2 | 4 | explicit E-S complex | Substrate
GDP-Ras
Product
GTP-Ras
| | | Kinetics same as GEF-bg_act-ras, but as of March 17, 2006, the kcat is scaled from 0.02 to 0.2 to have a stronger Ca response for the direct MAPK input. | | 61 | inact-GEF /
basal_GEF_
activity
| Ajay_bhalla_
2007_ReacDiff1_
1e-12
Accession No. : 81 | Ras
Pathway No. : 499 | 10.1015 | 0.02 | 4 | explicit E-S complex | Substrate
GDP-Ras
Product
GTP-Ras
| | | | | 62 | GEF* /
GEF*-act-ras | Ajay_bhalla_
2007_ReacDiff1_
1e-12
Accession No. : 81 | Ras
Pathway No. : 499 | 0.505057 | 0.02 | 4 | explicit E-S complex | Substrate
GDP-Ras
Product
GTP-Ras
| | | Kinetics same as GEF-bg-act-ras | | 63 | CaM-GEF /
CaM-GEF-act-ras | Ajay_bhalla_
2007_ReacDiff1_
1e-12
Accession No. : 81 | Ras
Pathway No. : 499 | 0.505057 | 0.2 | 4 | explicit E-S complex | Substrate
GDP-Ras
Product
GTP-Ras
| | | Kinetics same as GEF-bg_act-ras, but as of March 17, 2006, the kcat is scaled from 0.02 to 0.2 to have a stronger Ca response for the direct MAPK input. | | 64 | inact-GEF /
basal_GEF_
activity
| Ajay_bhalla_
2007_ReacDiff1_
1e-12
Accession No. : 81 | Ras
Pathway No. : 505 | 10.1015 | 0.02 | 4 | explicit E-S complex | Substrate
GDP-Ras
Product
GTP-Ras
| | | | | 65 | GEF* /
GEF*-act-ras | Ajay_bhalla_
2007_ReacDiff1_
1e-12
Accession No. : 81 | Ras
Pathway No. : 505 | 0.505057 | 0.02 | 4 | explicit E-S complex | Substrate
GDP-Ras
Product
GTP-Ras
| | | Kinetics same as GEF-bg-act-ras | | 66 | CaM-GEF /
CaM-GEF-act-ras | Ajay_bhalla_
2007_ReacDiff1_
1e-12
Accession No. : 81 | Ras
Pathway No. : 505 | 0.505057 | 0.2 | 4 | explicit E-S complex | Substrate
GDP-Ras
Product
GTP-Ras
| | | Kinetics same as GEF-bg_act-ras, but as of March 17, 2006, the kcat is scaled from 0.02 to 0.2 to have a stronger Ca response for the direct MAPK input. | | 67 | inact-GEF /
basal_GEF_
activity
| Ajay_bhalla_
2007_ReacDiff1_
1e-12
Accession No. : 81 | Ras
Pathway No. : 511 | 10.1015 | 0.02 | 4 | explicit E-S complex | Substrate
GDP-Ras
Product
GTP-Ras
| | | | | 68 | GEF* /
GEF*-act-ras | Ajay_bhalla_
2007_ReacDiff1_
1e-12
Accession No. : 81 | Ras
Pathway No. : 511 | 0.505057 | 0.02 | 4 | explicit E-S complex | Substrate
GDP-Ras
Product
GTP-Ras
| | | Kinetics same as GEF-bg-act-ras | | 69 | CaM-GEF /
CaM-GEF-act-ras | Ajay_bhalla_
2007_ReacDiff1_
1e-12
Accession No. : 81 | Ras
Pathway No. : 511 | 0.505057 | 0.2 | 4 | explicit E-S complex | Substrate
GDP-Ras
Product
GTP-Ras
| | | Kinetics same as GEF-bg_act-ras, but as of March 17, 2006, the kcat is scaled from 0.02 to 0.2 to have a stronger Ca response for the direct MAPK input. | | 70 | inact-GEF /
basal_GEF_
activity
| Ajay_bhalla_
2007_ReacDiff1_
1e-12
Accession No. : 81 | Ras
Pathway No. : 517 | 10.1015 | 0.02 | 4 | explicit E-S complex | Substrate
GDP-Ras
Product
GTP-Ras
| | | | | 71 | GEF* /
GEF*-act-ras | Ajay_bhalla_
2007_ReacDiff1_
1e-12
Accession No. : 81 | Ras
Pathway No. : 517 | 0.505057 | 0.02 | 4 | explicit E-S complex | Substrate
GDP-Ras
Product
GTP-Ras
| | | Kinetics same as GEF-bg-act-ras | | 72 | CaM-GEF /
CaM-GEF-act-ras | Ajay_bhalla_
2007_ReacDiff1_
1e-12
Accession No. : 81 | Ras
Pathway No. : 517 | 0.505057 | 0.2 | 4 | explicit E-S complex | Substrate
GDP-Ras
Product
GTP-Ras
| | | Kinetics same as GEF-bg_act-ras, but as of March 17, 2006, the kcat is scaled from 0.02 to 0.2 to have a stronger Ca response for the direct MAPK input. | | 73 | inact-GEF /
basal_GEF_
activity
| Ajay_bhalla_
2007_ReacDiff1_
1e-12
Accession No. : 81 | Ras
Pathway No. : 523 | 10.1015 | 0.02 | 4 | explicit E-S complex | Substrate
GDP-Ras
Product
GTP-Ras
| | | | | 74 | GEF* /
GEF*-act-ras | Ajay_bhalla_
2007_ReacDiff1_
1e-12
Accession No. : 81 | Ras
Pathway No. : 523 | 0.505057 | 0.02 | 4 | explicit E-S complex | Substrate
GDP-Ras
Product
GTP-Ras
| | | Kinetics same as GEF-bg-act-ras | | 75 | CaM-GEF /
CaM-GEF-act-ras | Ajay_bhalla_
2007_ReacDiff1_
1e-12
Accession No. : 81 | Ras
Pathway No. : 523 | 0.505057 | 0.2 | 4 | explicit E-S complex | Substrate
GDP-Ras
Product
GTP-Ras
| | | Kinetics same as GEF-bg_act-ras, but as of March 17, 2006, the kcat is scaled from 0.02 to 0.2 to have a stronger Ca response for the direct MAPK input. |
GDP-Ras acting as a Product of an Enzyme in Ajay_bhalla_2007_ReacDiff1_1e-12 Network
| | Enzyme Molecule /
Enzyme Activity | Accession Name | Pathway Name | Km (uM) | kcat (s^-1) | Ratio | Enzyme Type | Reagents | | 1 | GAP /
GAP-inact-ras | Ajay_bhalla_
2007_ReacDiff1_
1e-12
Accession No. : 81 | Ras
Pathway No. : 378 | 1.0104 | 10 | 4 | explicit E-S complex | Substrate
GTP-Ras
Product
GDP-Ras
| | | From Eccleston et al JBC 268(36)pp27012-19 get Kd < 2uM, kcat - 10/sec From Martin et al Cell 63 843-849 1990 get Kd ~ 250 nM, kcat = 20/min I will go with the Eccleston figures as there are good error bars (10%). In general the values are reasonably close. k1 = 1.666e-3/sec, k2 = 1000/sec, k3 = 10/sec (note k3 is rate-limiting) 5 Nov 2002: Changed ratio term to 4 from 100. Now we have k1=8.25e-5; k2=40, k3=10. k3 is still rate-limiting. | | 2 | GAP /
GAP-inact-ras | Ajay_bhalla_
2007_ReacDiff1_
1e-12
Accession No. : 81 | Ras
Pathway No. : 385 | 1.0104 | 10 | 4 | explicit E-S complex | Substrate
GTP-Ras
Product
GDP-Ras
| | | From Eccleston et al JBC 268(36)pp27012-19 get Kd < 2uM, kcat - 10/sec From Martin et al Cell 63 843-849 1990 get Kd ~ 250 nM, kcat = 20/min I will go with the Eccleston figures as there are good error bars (10%). In general the values are reasonably close. k1 = 1.666e-3/sec, k2 = 1000/sec, k3 = 10/sec (note k3 is rate-limiting) 5 Nov 2002: Changed ratio term to 4 from 100. Now we have k1=8.25e-5; k2=40, k3=10. k3 is still rate-limiting. | | 3 | GAP /
GAP-inact-ras | Ajay_bhalla_
2007_ReacDiff1_
1e-12
Accession No. : 81 | Ras
Pathway No. : 391 | 1.0104 | 10 | 4 | explicit E-S complex | Substrate
GTP-Ras
Product
GDP-Ras
| | | From Eccleston et al JBC 268(36)pp27012-19 get Kd < 2uM, kcat - 10/sec From Martin et al Cell 63 843-849 1990 get Kd ~ 250 nM, kcat = 20/min I will go with the Eccleston figures as there are good error bars (10%). In general the values are reasonably close. k1 = 1.666e-3/sec, k2 = 1000/sec, k3 = 10/sec (note k3 is rate-limiting) 5 Nov 2002: Changed ratio term to 4 from 100. Now we have k1=8.25e-5; k2=40, k3=10. k3 is still rate-limiting. | | 4 | GAP /
GAP-inact-ras | Ajay_bhalla_
2007_ReacDiff1_
1e-12
Accession No. : 81 | Ras
Pathway No. : 397 | 1.0104 | 10 | 4 | explicit E-S complex | Substrate
GTP-Ras
Product
GDP-Ras
| | | From Eccleston et al JBC 268(36)pp27012-19 get Kd < 2uM, kcat - 10/sec From Martin et al Cell 63 843-849 1990 get Kd ~ 250 nM, kcat = 20/min I will go with the Eccleston figures as there are good error bars (10%). In general the values are reasonably close. k1 = 1.666e-3/sec, k2 = 1000/sec, k3 = 10/sec (note k3 is rate-limiting) 5 Nov 2002: Changed ratio term to 4 from 100. Now we have k1=8.25e-5; k2=40, k3=10. k3 is still rate-limiting. | | 5 | GAP /
GAP-inact-ras | Ajay_bhalla_
2007_ReacDiff1_
1e-12
Accession No. : 81 | Ras
Pathway No. : 404 | 1.0104 | 10 | 4 | explicit E-S complex | Substrate
GTP-Ras
Product
GDP-Ras
| | | From Eccleston et al JBC 268(36)pp27012-19 get Kd < 2uM, kcat - 10/sec From Martin et al Cell 63 843-849 1990 get Kd ~ 250 nM, kcat = 20/min I will go with the Eccleston figures as there are good error bars (10%). In general the values are reasonably close. k1 = 1.666e-3/sec, k2 = 1000/sec, k3 = 10/sec (note k3 is rate-limiting) 5 Nov 2002: Changed ratio term to 4 from 100. Now we have k1=8.25e-5; k2=40, k3=10. k3 is still rate-limiting. | | 6 | GAP /
GAP-inact-ras | Ajay_bhalla_
2007_ReacDiff1_
1e-12
Accession No. : 81 | Ras
Pathway No. : 410 | 1.0104 | 10 | 4 | explicit E-S complex | Substrate
GTP-Ras
Product
GDP-Ras
| | | From Eccleston et al JBC 268(36)pp27012-19 get Kd < 2uM, kcat - 10/sec From Martin et al Cell 63 843-849 1990 get Kd ~ 250 nM, kcat = 20/min I will go with the Eccleston figures as there are good error bars (10%). In general the values are reasonably close. k1 = 1.666e-3/sec, k2 = 1000/sec, k3 = 10/sec (note k3 is rate-limiting) 5 Nov 2002: Changed ratio term to 4 from 100. Now we have k1=8.25e-5; k2=40, k3=10. k3 is still rate-limiting. | | 7 | GAP /
GAP-inact-ras | Ajay_bhalla_
2007_ReacDiff1_
1e-12
Accession No. : 81 | Ras
Pathway No. : 416 | 1.0104 | 10 | 4 | explicit E-S complex | Substrate
GTP-Ras
Product
GDP-Ras
| | | From Eccleston et al JBC 268(36)pp27012-19 get Kd < 2uM, kcat - 10/sec From Martin et al Cell 63 843-849 1990 get Kd ~ 250 nM, kcat = 20/min I will go with the Eccleston figures as there are good error bars (10%). In general the values are reasonably close. k1 = 1.666e-3/sec, k2 = 1000/sec, k3 = 10/sec (note k3 is rate-limiting) 5 Nov 2002: Changed ratio term to 4 from 100. Now we have k1=8.25e-5; k2=40, k3=10. k3 is still rate-limiting. | | 8 | GAP /
GAP-inact-ras | Ajay_bhalla_
2007_ReacDiff1_
1e-12
Accession No. : 81 | Ras
Pathway No. : 422 | 1.0104 | 10 | 4 | explicit E-S complex | Substrate
GTP-Ras
Product
GDP-Ras
| | | From Eccleston et al JBC 268(36)pp27012-19 get Kd < 2uM, kcat - 10/sec From Martin et al Cell 63 843-849 1990 get Kd ~ 250 nM, kcat = 20/min I will go with the Eccleston figures as there are good error bars (10%). In general the values are reasonably close. k1 = 1.666e-3/sec, k2 = 1000/sec, k3 = 10/sec (note k3 is rate-limiting) 5 Nov 2002: Changed ratio term to 4 from 100. Now we have k1=8.25e-5; k2=40, k3=10. k3 is still rate-limiting. | | 9 | GAP /
GAP-inact-ras | Ajay_bhalla_
2007_ReacDiff1_
1e-12
Accession No. : 81 | Ras
Pathway No. : 427 | 1.0104 | 10 | 4 | explicit E-S complex | Substrate
GTP-Ras
Product
GDP-Ras
| | | From Eccleston et al JBC 268(36)pp27012-19 get Kd < 2uM, kcat - 10/sec From Martin et al Cell 63 843-849 1990 get Kd ~ 250 nM, kcat = 20/min I will go with the Eccleston figures as there are good error bars (10%). In general the values are reasonably close. k1 = 1.666e-3/sec, k2 = 1000/sec, k3 = 10/sec (note k3 is rate-limiting) 5 Nov 2002: Changed ratio term to 4 from 100. Now we have k1=8.25e-5; k2=40, k3=10. k3 is still rate-limiting. | | 10 | GAP /
GAP-inact-ras | Ajay_bhalla_
2007_ReacDiff1_
1e-12
Accession No. : 81 | Ras
Pathway No. : 433 | 1.0104 | 10 | 4 | explicit E-S complex | Substrate
GTP-Ras
Product
GDP-Ras
| | | From Eccleston et al JBC 268(36)pp27012-19 get Kd < 2uM, kcat - 10/sec From Martin et al Cell 63 843-849 1990 get Kd ~ 250 nM, kcat = 20/min I will go with the Eccleston figures as there are good error bars (10%). In general the values are reasonably close. k1 = 1.666e-3/sec, k2 = 1000/sec, k3 = 10/sec (note k3 is rate-limiting) 5 Nov 2002: Changed ratio term to 4 from 100. Now we have k1=8.25e-5; k2=40, k3=10. k3 is still rate-limiting. | | 11 | GAP /
GAP-inact-ras | Ajay_bhalla_
2007_ReacDiff1_
1e-12
Accession No. : 81 | Ras
Pathway No. : 439 | 1.0104 | 10 | 4 | explicit E-S complex | Substrate
GTP-Ras
Product
GDP-Ras
| | | From Eccleston et al JBC 268(36)pp27012-19 get Kd < 2uM, kcat - 10/sec From Martin et al Cell 63 843-849 1990 get Kd ~ 250 nM, kcat = 20/min I will go with the Eccleston figures as there are good error bars (10%). In general the values are reasonably close. k1 = 1.666e-3/sec, k2 = 1000/sec, k3 = 10/sec (note k3 is rate-limiting) 5 Nov 2002: Changed ratio term to 4 from 100. Now we have k1=8.25e-5; k2=40, k3=10. k3 is still rate-limiting. | | 12 | GAP /
GAP-inact-ras | Ajay_bhalla_
2007_ReacDiff1_
1e-12
Accession No. : 81 | Ras
Pathway No. : 445 | 1.0104 | 10 | 4 | explicit E-S complex | Substrate
GTP-Ras
Product
GDP-Ras
| | | From Eccleston et al JBC 268(36)pp27012-19 get Kd < 2uM, kcat - 10/sec From Martin et al Cell 63 843-849 1990 get Kd ~ 250 nM, kcat = 20/min I will go with the Eccleston figures as there are good error bars (10%). In general the values are reasonably close. k1 = 1.666e-3/sec, k2 = 1000/sec, k3 = 10/sec (note k3 is rate-limiting) 5 Nov 2002: Changed ratio term to 4 from 100. Now we have k1=8.25e-5; k2=40, k3=10. k3 is still rate-limiting. | | 13 | GAP /
GAP-inact-ras | Ajay_bhalla_
2007_ReacDiff1_
1e-12
Accession No. : 81 | Ras
Pathway No. : 451 | 1.0104 | 10 | 4 | explicit E-S complex | Substrate
GTP-Ras
Product
GDP-Ras
| | | From Eccleston et al JBC 268(36)pp27012-19 get Kd < 2uM, kcat - 10/sec From Martin et al Cell 63 843-849 1990 get Kd ~ 250 nM, kcat = 20/min I will go with the Eccleston figures as there are good error bars (10%). In general the values are reasonably close. k1 = 1.666e-3/sec, k2 = 1000/sec, k3 = 10/sec (note k3 is rate-limiting) 5 Nov 2002: Changed ratio term to 4 from 100. Now we have k1=8.25e-5; k2=40, k3=10. k3 is still rate-limiting. | | 14 | GAP /
GAP-inact-ras | Ajay_bhalla_
2007_ReacDiff1_
1e-12
Accession No. : 81 | Ras
Pathway No. : 457 | 1.0104 | 10 | 4 | explicit E-S complex | Substrate
GTP-Ras
Product
GDP-Ras
| | | From Eccleston et al JBC 268(36)pp27012-19 get Kd < 2uM, kcat - 10/sec From Martin et al Cell 63 843-849 1990 get Kd ~ 250 nM, kcat = 20/min I will go with the Eccleston figures as there are good error bars (10%). In general the values are reasonably close. k1 = 1.666e-3/sec, k2 = 1000/sec, k3 = 10/sec (note k3 is rate-limiting) 5 Nov 2002: Changed ratio term to 4 from 100. Now we have k1=8.25e-5; k2=40, k3=10. k3 is still rate-limiting. | | 15 | GAP /
GAP-inact-ras | Ajay_bhalla_
2007_ReacDiff1_
1e-12
Accession No. : 81 | Ras
Pathway No. : 463 | 1.0104 | 10 | 4 | explicit E-S complex | Substrate
GTP-Ras
Product
GDP-Ras
| | | From Eccleston et al JBC 268(36)pp27012-19 get Kd < 2uM, kcat - 10/sec From Martin et al Cell 63 843-849 1990 get Kd ~ 250 nM, kcat = 20/min I will go with the Eccleston figures as there are good error bars (10%). In general the values are reasonably close. k1 = 1.666e-3/sec, k2 = 1000/sec, k3 = 10/sec (note k3 is rate-limiting) 5 Nov 2002: Changed ratio term to 4 from 100. Now we have k1=8.25e-5; k2=40, k3=10. k3 is still rate-limiting. | | 16 | GAP /
GAP-inact-ras | Ajay_bhalla_
2007_ReacDiff1_
1e-12
Accession No. : 81 | Ras
Pathway No. : 469 | 1.0104 | 10 | 4 | explicit E-S complex | Substrate
GTP-Ras
Product
GDP-Ras
| | | From Eccleston et al JBC 268(36)pp27012-19 get Kd < 2uM, kcat - 10/sec From Martin et al Cell 63 843-849 1990 get Kd ~ 250 nM, kcat = 20/min I will go with the Eccleston figures as there are good error bars (10%). In general the values are reasonably close. k1 = 1.666e-3/sec, k2 = 1000/sec, k3 = 10/sec (note k3 is rate-limiting) 5 Nov 2002: Changed ratio term to 4 from 100. Now we have k1=8.25e-5; k2=40, k3=10. k3 is still rate-limiting. | | 17 | GAP /
GAP-inact-ras | Ajay_bhalla_
2007_ReacDiff1_
1e-12
Accession No. : 81 | Ras
Pathway No. : 475 | 1.0104 | 10 | 4 | explicit E-S complex | Substrate
GTP-Ras
Product
GDP-Ras
| | | From Eccleston et al JBC 268(36)pp27012-19 get Kd < 2uM, kcat - 10/sec From Martin et al Cell 63 843-849 1990 get Kd ~ 250 nM, kcat = 20/min I will go with the Eccleston figures as there are good error bars (10%). In general the values are reasonably close. k1 = 1.666e-3/sec, k2 = 1000/sec, k3 = 10/sec (note k3 is rate-limiting) 5 Nov 2002: Changed ratio term to 4 from 100. Now we have k1=8.25e-5; k2=40, k3=10. k3 is still rate-limiting. | | 18 | GAP /
GAP-inact-ras | Ajay_bhalla_
2007_ReacDiff1_
1e-12
Accession No. : 81 | Ras
Pathway No. : 481 | 1.0104 | 10 | 4 | explicit E-S complex | Substrate
GTP-Ras
Product
GDP-Ras
| | | From Eccleston et al JBC 268(36)pp27012-19 get Kd < 2uM, kcat - 10/sec From Martin et al Cell 63 843-849 1990 get Kd ~ 250 nM, kcat = 20/min I will go with the Eccleston figures as there are good error bars (10%). In general the values are reasonably close. k1 = 1.666e-3/sec, k2 = 1000/sec, k3 = 10/sec (note k3 is rate-limiting) 5 Nov 2002: Changed ratio term to 4 from 100. Now we have k1=8.25e-5; k2=40, k3=10. k3 is still rate-limiting. | | 19 | GAP /
GAP-inact-ras | Ajay_bhalla_
2007_ReacDiff1_
1e-12
Accession No. : 81 | Ras
Pathway No. : 487 | 1.0104 | 10 | 4 | explicit E-S complex | Substrate
GTP-Ras
Product
GDP-Ras
| | | From Eccleston et al JBC 268(36)pp27012-19 get Kd < 2uM, kcat - 10/sec From Martin et al Cell 63 843-849 1990 get Kd ~ 250 nM, kcat = 20/min I will go with the Eccleston figures as there are good error bars (10%). In general the values are reasonably close. k1 = 1.666e-3/sec, k2 = 1000/sec, k3 = 10/sec (note k3 is rate-limiting) 5 Nov 2002: Changed ratio term to 4 from 100. Now we have k1=8.25e-5; k2=40, k3=10. k3 is still rate-limiting. | | 20 | GAP /
GAP-inact-ras | Ajay_bhalla_
2007_ReacDiff1_
1e-12
Accession No. : 81 | Ras
Pathway No. : 493 | 1.0104 | 10 | 4 | explicit E-S complex | Substrate
GTP-Ras
Product
GDP-Ras
| | | From Eccleston et al JBC 268(36)pp27012-19 get Kd < 2uM, kcat - 10/sec From Martin et al Cell 63 843-849 1990 get Kd ~ 250 nM, kcat = 20/min I will go with the Eccleston figures as there are good error bars (10%). In general the values are reasonably close. k1 = 1.666e-3/sec, k2 = 1000/sec, k3 = 10/sec (note k3 is rate-limiting) 5 Nov 2002: Changed ratio term to 4 from 100. Now we have k1=8.25e-5; k2=40, k3=10. k3 is still rate-limiting. | | 21 | GAP /
GAP-inact-ras | Ajay_bhalla_
2007_ReacDiff1_
1e-12
Accession No. : 81 | Ras
Pathway No. : 499 | 1.0104 | 10 | 4 | explicit E-S complex | Substrate
GTP-Ras
Product
GDP-Ras
| | | From Eccleston et al JBC 268(36)pp27012-19 get Kd < 2uM, kcat - 10/sec From Martin et al Cell 63 843-849 1990 get Kd ~ 250 nM, kcat = 20/min I will go with the Eccleston figures as there are good error bars (10%). In general the values are reasonably close. k1 = 1.666e-3/sec, k2 = 1000/sec, k3 = 10/sec (note k3 is rate-limiting) 5 Nov 2002: Changed ratio term to 4 from 100. Now we have k1=8.25e-5; k2=40, k3=10. k3 is still rate-limiting. | | 22 | GAP /
GAP-inact-ras | Ajay_bhalla_
2007_ReacDiff1_
1e-12
Accession No. : 81 | Ras
Pathway No. : 505 | 1.0104 | 10 | 4 | explicit E-S complex | Substrate
GTP-Ras
Product
GDP-Ras
| | | From Eccleston et al JBC 268(36)pp27012-19 get Kd < 2uM, kcat - 10/sec From Martin et al Cell 63 843-849 1990 get Kd ~ 250 nM, kcat = 20/min I will go with the Eccleston figures as there are good error bars (10%). In general the values are reasonably close. k1 = 1.666e-3/sec, k2 = 1000/sec, k3 = 10/sec (note k3 is rate-limiting) 5 Nov 2002: Changed ratio term to 4 from 100. Now we have k1=8.25e-5; k2=40, k3=10. k3 is still rate-limiting. | | 23 | GAP /
GAP-inact-ras | Ajay_bhalla_
2007_ReacDiff1_
1e-12
Accession No. : 81 | Ras
Pathway No. : 511 | 1.0104 | 10 | 4 | explicit E-S complex | Substrate
GTP-Ras
Product
GDP-Ras
| | | From Eccleston et al JBC 268(36)pp27012-19 get Kd < 2uM, kcat - 10/sec From Martin et al Cell 63 843-849 1990 get Kd ~ 250 nM, kcat = 20/min I will go with the Eccleston figures as there are good error bars (10%). In general the values are reasonably close. k1 = 1.666e-3/sec, k2 = 1000/sec, k3 = 10/sec (note k3 is rate-limiting) 5 Nov 2002: Changed ratio term to 4 from 100. Now we have k1=8.25e-5; k2=40, k3=10. k3 is still rate-limiting. | | 24 | GAP /
GAP-inact-ras | Ajay_bhalla_
2007_ReacDiff1_
1e-12
Accession No. : 81 | Ras
Pathway No. : 517 | 1.0104 | 10 | 4 | explicit E-S complex | Substrate
GTP-Ras
Product
GDP-Ras
| | | From Eccleston et al JBC 268(36)pp27012-19 get Kd < 2uM, kcat - 10/sec From Martin et al Cell 63 843-849 1990 get Kd ~ 250 nM, kcat = 20/min I will go with the Eccleston figures as there are good error bars (10%). In general the values are reasonably close. k1 = 1.666e-3/sec, k2 = 1000/sec, k3 = 10/sec (note k3 is rate-limiting) 5 Nov 2002: Changed ratio term to 4 from 100. Now we have k1=8.25e-5; k2=40, k3=10. k3 is still rate-limiting. | | 25 | GAP /
GAP-inact-ras | Ajay_bhalla_
2007_ReacDiff1_
1e-12
Accession No. : 81 | Ras
Pathway No. : 523 | 1.0104 | 10 | 4 | explicit E-S complex | Substrate
GTP-Ras
Product
GDP-Ras
| | | From Eccleston et al JBC 268(36)pp27012-19 get Kd < 2uM, kcat - 10/sec From Martin et al Cell 63 843-849 1990 get Kd ~ 250 nM, kcat = 20/min I will go with the Eccleston figures as there are good error bars (10%). In general the values are reasonably close. k1 = 1.666e-3/sec, k2 = 1000/sec, k3 = 10/sec (note k3 is rate-limiting) 5 Nov 2002: Changed ratio term to 4 from 100. Now we have k1=8.25e-5; k2=40, k3=10. k3 is still rate-limiting. |
GDP-Ras acting as a Product in a reaction in Ajay_bhalla_2007_ReacDiff1_1e-12 Network
| Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated.
Kd for higher order reaction are not consider. |
| | Name | Accession Name | Pathway Name | Kf | Kb | Kd | tau | Reagents | | 1 | Ras-intrinsic-GT
Pase | Ajay_bhalla_
2007_ReacDiff1_
1e-12
Accession No. : 81 | Ras
Pathway No. : 378 | 0.0001
(s^-1) | 0
(s^-1) | - | - | Substrate
GTP-Ras
Product
GDP-Ras
| | | This is extremely slow (1e-4), but it is significant as so little GAP actually gets complexed with it that the total GTP turnover rises only by 2-3 X (see Gibbs et al, JBC 265(33) 20437-20422) and Eccleston et al JBC 268(36) 27012-27019 kf = 1e-4 | | 2 | Ras-intrinsic-GT
Pase | Ajay_bhalla_
2007_ReacDiff1_
1e-12
Accession No. : 81 | Ras
Pathway No. : 385 | 0.0001
(s^-1) | 0
(s^-1) | - | - | Substrate
GTP-Ras
Product
GDP-Ras
| | | This is extremely slow (1e-4), but it is significant as so little GAP actually gets complexed with it that the total GTP turnover rises only by 2-3 X (see Gibbs et al, JBC 265(33) 20437-20422) and Eccleston et al JBC 268(36) 27012-27019 kf = 1e-4 | | 3 | Ras-intrinsic-GT
Pase | Ajay_bhalla_
2007_ReacDiff1_
1e-12
Accession No. : 81 | Ras
Pathway No. : 391 | 0.0001
(s^-1) | 0
(s^-1) | - | - | Substrate
GTP-Ras
Product
GDP-Ras
| | | This is extremely slow (1e-4), but it is significant as so little GAP actually gets complexed with it that the total GTP turnover rises only by 2-3 X (see Gibbs et al, JBC 265(33) 20437-20422) and Eccleston et al JBC 268(36) 27012-27019 kf = 1e-4 | | 4 | Ras-intrinsic-GT
Pase | Ajay_bhalla_
2007_ReacDiff1_
1e-12
Accession No. : 81 | Ras
Pathway No. : 397 | 0.0001
(s^-1) | 0
(s^-1) | - | - | Substrate
GTP-Ras
Product
GDP-Ras
| | | This is extremely slow (1e-4), but it is significant as so little GAP actually gets complexed with it that the total GTP turnover rises only by 2-3 X (see Gibbs et al, JBC 265(33) 20437-20422) and Eccleston et al JBC 268(36) 27012-27019 kf = 1e-4 | | 5 | Ras-intrinsic-GT
Pase | Ajay_bhalla_
2007_ReacDiff1_
1e-12
Accession No. : 81 | Ras
Pathway No. : 404 | 0.0001
(s^-1) | 0
(s^-1) | - | - | Substrate
GTP-Ras
Product
GDP-Ras
| | | This is extremely slow (1e-4), but it is significant as so little GAP actually gets complexed with it that the total GTP turnover rises only by 2-3 X (see Gibbs et al, JBC 265(33) 20437-20422) and Eccleston et al JBC 268(36) 27012-27019 kf = 1e-4 | | 6 | Ras-intrinsic-GT
Pase | Ajay_bhalla_
2007_ReacDiff1_
1e-12
Accession No. : 81 | Ras
Pathway No. : 410 | 0.0001
(s^-1) | 0
(s^-1) | - | - | Substrate
GTP-Ras
Product
GDP-Ras
| | | This is extremely slow (1e-4), but it is significant as so little GAP actually gets complexed with it that the total GTP turnover rises only by 2-3 X (see Gibbs et al, JBC 265(33) 20437-20422) and Eccleston et al JBC 268(36) 27012-27019 kf = 1e-4 | | 7 | Ras-intrinsic-GT
Pase | Ajay_bhalla_
2007_ReacDiff1_
1e-12
Accession No. : 81 | Ras
Pathway No. : 416 | 0.0001
(s^-1) | 0
(s^-1) | - | - | Substrate
GTP-Ras
Product
GDP-Ras
| | | This is extremely slow (1e-4), but it is significant as so little GAP actually gets complexed with it that the total GTP turnover rises only by 2-3 X (see Gibbs et al, JBC 265(33) 20437-20422) and Eccleston et al JBC 268(36) 27012-27019 kf = 1e-4 | | 8 | Ras-intrinsic-GT
Pase | Ajay_bhalla_
2007_ReacDiff1_
1e-12
Accession No. : 81 | Ras
Pathway No. : 422 | 0.0001
(s^-1) | 0
(s^-1) | - | - | Substrate
GTP-Ras
Product
GDP-Ras
| | | This is extremely slow (1e-4), but it is significant as so little GAP actually gets complexed with it that the total GTP turnover rises only by 2-3 X (see Gibbs et al, JBC 265(33) 20437-20422) and Eccleston et al JBC 268(36) 27012-27019 kf = 1e-4 | | 9 | Ras-intrinsic-GT
Pase | Ajay_bhalla_
2007_ReacDiff1_
1e-12
Accession No. : 81 | Ras
Pathway No. : 427 | 0.0001
(s^-1) | 0
(s^-1) | - | - | Substrate
GTP-Ras
Product
GDP-Ras
| | | This is extremely slow (1e-4), but it is significant as so little GAP actually gets complexed with it that the total GTP turnover rises only by 2-3 X (see Gibbs et al, JBC 265(33) 20437-20422) and Eccleston et al JBC 268(36) 27012-27019 kf = 1e-4 | | 10 | Ras-intrinsic-GT
Pase | Ajay_bhalla_
2007_ReacDiff1_
1e-12
Accession No. : 81 | Ras
Pathway No. : 433 | 0.0001
(s^-1) | 0
(s^-1) | - | - | Substrate
GTP-Ras
Product
GDP-Ras
| | | This is extremely slow (1e-4), but it is significant as so little GAP actually gets complexed with it that the total GTP turnover rises only by 2-3 X (see Gibbs et al, JBC 265(33) 20437-20422) and Eccleston et al JBC 268(36) 27012-27019 kf = 1e-4 | | 11 | Ras-intrinsic-GT
Pase | Ajay_bhalla_
2007_ReacDiff1_
1e-12
Accession No. : 81 | Ras
Pathway No. : 439 | 0.0001
(s^-1) | 0
(s^-1) | - | - | Substrate
GTP-Ras
Product
GDP-Ras
| | | This is extremely slow (1e-4), but it is significant as so little GAP actually gets complexed with it that the total GTP turnover rises only by 2-3 X (see Gibbs et al, JBC 265(33) 20437-20422) and Eccleston et al JBC 268(36) 27012-27019 kf = 1e-4 | | 12 | Ras-intrinsic-GT
Pase | Ajay_bhalla_
2007_ReacDiff1_
1e-12
Accession No. : 81 | Ras
Pathway No. : 445 | 0.0001
(s^-1) | 0
(s^-1) | - | - | Substrate
GTP-Ras
Product
GDP-Ras
| | | This is extremely slow (1e-4), but it is significant as so little GAP actually gets complexed with it that the total GTP turnover rises only by 2-3 X (see Gibbs et al, JBC 265(33) 20437-20422) and Eccleston et al JBC 268(36) 27012-27019 kf = 1e-4 | | 13 | Ras-intrinsic-GT
Pase | Ajay_bhalla_
2007_ReacDiff1_
1e-12
Accession No. : 81 | Ras
Pathway No. : 451 | 0.0001
(s^-1) | 0
(s^-1) | - | - | Substrate
GTP-Ras
Product
GDP-Ras
| | | This is extremely slow (1e-4), but it is significant as so little GAP actually gets complexed with it that the total GTP turnover rises only by 2-3 X (see Gibbs et al, JBC 265(33) 20437-20422) and Eccleston et al JBC 268(36) 27012-27019 kf = 1e-4 | | 14 | Ras-intrinsic-GT
Pase | Ajay_bhalla_
2007_ReacDiff1_
1e-12
Accession No. : 81 | Ras
Pathway No. : 457 | 0.0001
(s^-1) | 0
(s^-1) | - | - | Substrate
GTP-Ras
Product
GDP-Ras
| | | This is extremely slow (1e-4), but it is significant as so little GAP actually gets complexed with it that the total GTP turnover rises only by 2-3 X (see Gibbs et al, JBC 265(33) 20437-20422) and Eccleston et al JBC 268(36) 27012-27019 kf = 1e-4 | | 15 | Ras-intrinsic-GT
Pase | Ajay_bhalla_
2007_ReacDiff1_
1e-12
Accession No. : 81 | Ras
Pathway No. : 463 | 0.0001
(s^-1) | 0
(s^-1) | - | - | Substrate
GTP-Ras
Product
GDP-Ras
| | | This is extremely slow (1e-4), but it is significant as so little GAP actually gets complexed with it that the total GTP turnover rises only by 2-3 X (see Gibbs et al, JBC 265(33) 20437-20422) and Eccleston et al JBC 268(36) 27012-27019 kf = 1e-4 | | 16 | Ras-intrinsic-GT
Pase | Ajay_bhalla_
2007_ReacDiff1_
1e-12
Accession No. : 81 | Ras
Pathway No. : 469 | 0.0001
(s^-1) | 0
(s^-1) | - | - | Substrate
GTP-Ras
Product
GDP-Ras
| | | This is extremely slow (1e-4), but it is significant as so little GAP actually gets complexed with it that the total GTP turnover rises only by 2-3 X (see Gibbs et al, JBC 265(33) 20437-20422) and Eccleston et al JBC 268(36) 27012-27019 kf = 1e-4 | | 17 | Ras-intrinsic-GT
Pase | Ajay_bhalla_
2007_ReacDiff1_
1e-12
Accession No. : 81 | Ras
Pathway No. : 475 | 0.0001
(s^-1) | 0
(s^-1) | - | - | Substrate
GTP-Ras
Product
GDP-Ras
| | | This is extremely slow (1e-4), but it is significant as so little GAP actually gets complexed with it that the total GTP turnover rises only by 2-3 X (see Gibbs et al, JBC 265(33) 20437-20422) and Eccleston et al JBC 268(36) 27012-27019 kf = 1e-4 | | 18 | Ras-intrinsic-GT
Pase | Ajay_bhalla_
2007_ReacDiff1_
1e-12
Accession No. : 81 | Ras
Pathway No. : 481 | 0.0001
(s^-1) | 0
(s^-1) | - | - | Substrate
GTP-Ras
Product
GDP-Ras
| | | This is extremely slow (1e-4), but it is significant as so little GAP actually gets complexed with it that the total GTP turnover rises only by 2-3 X (see Gibbs et al, JBC 265(33) 20437-20422) and Eccleston et al JBC 268(36) 27012-27019 kf = 1e-4 | | 19 | Ras-intrinsic-GT
Pase | Ajay_bhalla_
2007_ReacDiff1_
1e-12
Accession No. : 81 | Ras
Pathway No. : 487 | 0.0001
(s^-1) | 0
(s^-1) | - | - | Substrate
GTP-Ras
Product
GDP-Ras
| | | This is extremely slow (1e-4), but it is significant as so little GAP actually gets complexed with it that the total GTP turnover rises only by 2-3 X (see Gibbs et al, JBC 265(33) 20437-20422) and Eccleston et al JBC 268(36) 27012-27019 kf = 1e-4 | | 20 | Ras-intrinsic-GT
Pase | Ajay_bhalla_
2007_ReacDiff1_
1e-12
Accession No. : 81 | Ras
Pathway No. : 493 | 0.0001
(s^-1) | 0
(s^-1) | - | - | Substrate
GTP-Ras
Product
GDP-Ras
| | | This is extremely slow (1e-4), but it is significant as so little GAP actually gets complexed with it that the total GTP turnover rises only by 2-3 X (see Gibbs et al, JBC 265(33) 20437-20422) and Eccleston et al JBC 268(36) 27012-27019 kf = 1e-4 | | 21 | Ras-intrinsic-GT
Pase | Ajay_bhalla_
2007_ReacDiff1_
1e-12
Accession No. : 81 | Ras
Pathway No. : 499 | 0.0001
(s^-1) | 0
(s^-1) | - | - | Substrate
GTP-Ras
Product
GDP-Ras
| | | This is extremely slow (1e-4), but it is significant as so little GAP actually gets complexed with it that the total GTP turnover rises only by 2-3 X (see Gibbs et al, JBC 265(33) 20437-20422) and Eccleston et al JBC 268(36) 27012-27019 kf = 1e-4 | | 22 | Ras-intrinsic-GT
Pase | Ajay_bhalla_
2007_ReacDiff1_
1e-12
Accession No. : 81 | Ras
Pathway No. : 505 | 0.0001
(s^-1) | 0
(s^-1) | - | - | Substrate
GTP-Ras
Product
GDP-Ras
| | | This is extremely slow (1e-4), but it is significant as so little GAP actually gets complexed with it that the total GTP turnover rises only by 2-3 X (see Gibbs et al, JBC 265(33) 20437-20422) and Eccleston et al JBC 268(36) 27012-27019 kf = 1e-4 | | 23 | Ras-intrinsic-GT
Pase | Ajay_bhalla_
2007_ReacDiff1_
1e-12
Accession No. : 81 | Ras
Pathway No. : 511 | 0.0001
(s^-1) | 0
(s^-1) | - | - | Substrate
GTP-Ras
Product
GDP-Ras
| | | This is extremely slow (1e-4), but it is significant as so little GAP actually gets complexed with it that the total GTP turnover rises only by 2-3 X (see Gibbs et al, JBC 265(33) 20437-20422) and Eccleston et al JBC 268(36) 27012-27019 kf = 1e-4 | | 24 | Ras-intrinsic-GT
Pase | Ajay_bhalla_
2007_ReacDiff1_
1e-12
Accession No. : 81 | Ras
Pathway No. : 517 | 0.0001
(s^-1) | 0
(s^-1) | - | - | Substrate
GTP-Ras
Product
GDP-Ras
| | | This is extremely slow (1e-4), but it is significant as so little GAP actually gets complexed with it that the total GTP turnover rises only by 2-3 X (see Gibbs et al, JBC 265(33) 20437-20422) and Eccleston et al JBC 268(36) 27012-27019 kf = 1e-4 | | 25 | Ras-intrinsic-GT
Pase | Ajay_bhalla_
2007_ReacDiff1_
1e-12
Accession No. : 81 | Ras
Pathway No. : 523 | 0.0001
(s^-1) | 0
(s^-1) | - | - | Substrate
GTP-Ras
Product
GDP-Ras
| | | This is extremely slow (1e-4), but it is significant as so little GAP actually gets complexed with it that the total GTP turnover rises only by 2-3 X (see Gibbs et al, JBC 265(33) 20437-20422) and Eccleston et al JBC 268(36) 27012-27019 kf = 1e-4 |
| Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
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