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Molecule Parameter List for craf-1 | The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by  color. | | Statistics |
Accession and Pathway Details | |
| Accession Name | Accession No. | Accession Type | Pathway Link | Ajay_Bhalla_
2007_ReacDiff1_
1e-13 | 82 | Network | Shared_Object_Ajay_Bhalla_2007_ReacDiff1_1e-13,
PKC, MAPK, Ras, CaM, PKM, chain, kinetics, PKC, MAPK, Ras, CaM, PKM, kinetics[1],
PKC, MAPK, Ras, CaM, PKM, kinetics[2], PKC, MAPK, Ras, CaM, PKM, kinetics[3],
PKC, MAPK, Ras, CaM, PKM, kinetics[4], PKC, MAPK, Ras, CaM, PKM, kinetics[5],
PKC, MAPK, Ras, kinetics[6], CaM, PKM, PKC, MAPK, Ras, CaM, PKM, kinetics[7],
PKC, MAPK, Ras, CaM, PKM, kinetics[8], PKC, MAPK, Ras, CaM, PKM, kinetics[9],
PKC, MAPK, Ras, CaM, PKM, kinetics[10], PKC, MAPK, Ras, CaM, PKM, kinetics[11],
PKC, MAPK, Ras, CaM, PKM, kinetics[12], PKC, MAPK, Ras, CaM, PKM, kinetics[13],
PKC, MAPK, Ras, CaM, PKM, kinetics[14], PKC, MAPK, Ras, CaM, PKM, kinetics[15],
PKC, MAPK, Ras, CaM, PKM, kinetics[16], PKC, MAPK, Ras, CaM, PKM, kinetics[17],
PKC, MAPK, Ras, CaM, PKM, kinetics[18], PKC, MAPK, Ras, CaM, PKM, kinetics[19],
PKC, MAPK, Ras, CaM, PKM, kinetics[20], PKC, MAPK, Ras, CaM, PKM, kinetics[21],
PKC, MAPK, Ras, CaM, PKM, kinetics[22], PKC, MAPK, Ras, CaM, PKM, kinetics[23],
PKC, MAPK, Ras, CaM, PKM | This is a 25-compartment reaction-diffusion version of the Ajay_Bhalla_2007_PKM model. The original single-compartment model is repeated 25 times. In addition, a subset (27 out of 42) molecules can diffuse between compartments. Diffusion is implemented as a reaction between corresponding molecules in neighboring compartments. For D = 1e-12 m^2/sec (i.e., 1 micron^2/sec ) the kf and kb of this reaction for these 10 micron compartments are both 0.01/sec. For D = 1e-13 m^2/sec (i.e., 0.1 micron^2/sec ) the kf and kb are 0.001/sec.
The stimulus file pkm_mapk22_diff_1e-13_Fig4B which was used for the model to replicate Figure 4B from the paper.
pkm_mapk22_diff_1e-13_Fig4H replicate Figure 4H.
pkm_mapk22_diff_1e-13_Fig4I replicate Figure 4I.
|
craf-1 acting as a Molecule in Ajay_Bhalla_2007_ReacDiff1_1e-13 Network
| Name | Accession Name | Pathway Name | Initial Conc.
(uM) | Volume
(fL) | Buffered | | craf-1 | Ajay_Bhalla_
2007_ReacDiff1_
1e-13
Accession No. : 82 | MAPK
Pathway No. : 528 | 0.5 | 1.5 | No | | Couldn't find any ref to the actual conc of craf-1 but I should try Strom et al Oncogene 5 pp 345 In line with the other kinases in the cascade, I estimate the conc to be 0.2 uM. To init we use 0.15, which is close to equil 16 May 2003: Changing to synaptic levels. Increasing 2.5 fold to 0.5 uM. See Mihaly et al 1991 Brain Res 547(2):309-14 and Morice et al 1999 Eur J Neurosci 11(6):1995-2006 | | craf-1 | Ajay_Bhalla_
2007_ReacDiff1_
1e-13
Accession No. : 82 | MAPK
Pathway No. : 535 | 0.5 | 1.5 | No | | Couldn't find any ref to the actual conc of craf-1 but I should try Strom et al Oncogene 5 pp 345 In line with the other kinases in the cascade, I estimate the conc to be 0.2 uM. To init we use 0.15, which is close to equil 16 May 2003: Changing to synaptic levels. Increasing 2.5 fold to 0.5 uM. See Mihaly et al 1991 Brain Res 547(2):309-14 and Morice et al 1999 Eur J Neurosci 11(6):1995-2006 | | craf-1 | Ajay_Bhalla_
2007_ReacDiff1_
1e-13
Accession No. : 82 | MAPK
Pathway No. : 541 | 0.5 | 1.5 | No | | Couldn't find any ref to the actual conc of craf-1 but I should try Strom et al Oncogene 5 pp 345 In line with the other kinases in the cascade, I estimate the conc to be 0.2 uM. To init we use 0.15, which is close to equil 16 May 2003: Changing to synaptic levels. Increasing 2.5 fold to 0.5 uM. See Mihaly et al 1991 Brain Res 547(2):309-14 and Morice et al 1999 Eur J Neurosci 11(6):1995-2006 | | craf-1 | Ajay_Bhalla_
2007_ReacDiff1_
1e-13
Accession No. : 82 | MAPK
Pathway No. : 547 | 0.5 | 1.5 | No | | Couldn't find any ref to the actual conc of craf-1 but I should try Strom et al Oncogene 5 pp 345 In line with the other kinases in the cascade, I estimate the conc to be 0.2 uM. To init we use 0.15, which is close to equil 16 May 2003: Changing to synaptic levels. Increasing 2.5 fold to 0.5 uM. See Mihaly et al 1991 Brain Res 547(2):309-14 and Morice et al 1999 Eur J Neurosci 11(6):1995-2006 | | craf-1 | Ajay_Bhalla_
2007_ReacDiff1_
1e-13
Accession No. : 82 | MAPK
Pathway No. : 553 | 0.5 | 1.5 | No | | Couldn't find any ref to the actual conc of craf-1 but I should try Strom et al Oncogene 5 pp 345 In line with the other kinases in the cascade, I estimate the conc to be 0.2 uM. To init we use 0.15, which is close to equil 16 May 2003: Changing to synaptic levels. Increasing 2.5 fold to 0.5 uM. See Mihaly et al 1991 Brain Res 547(2):309-14 and Morice et al 1999 Eur J Neurosci 11(6):1995-2006 | | craf-1 | Ajay_Bhalla_
2007_ReacDiff1_
1e-13
Accession No. : 82 | MAPK
Pathway No. : 559 | 0.5 | 1.5 | No | | Couldn't find any ref to the actual conc of craf-1 but I should try Strom et al Oncogene 5 pp 345 In line with the other kinases in the cascade, I estimate the conc to be 0.2 uM. To init we use 0.15, which is close to equil 16 May 2003: Changing to synaptic levels. Increasing 2.5 fold to 0.5 uM. See Mihaly et al 1991 Brain Res 547(2):309-14 and Morice et al 1999 Eur J Neurosci 11(6):1995-2006 | | craf-1 | Ajay_Bhalla_
2007_ReacDiff1_
1e-13
Accession No. : 82 | MAPK
Pathway No. : 565 | 0.5 | 1.5 | No | | Couldn't find any ref to the actual conc of craf-1 but I should try Strom et al Oncogene 5 pp 345 In line with the other kinases in the cascade, I estimate the conc to be 0.2 uM. To init we use 0.15, which is close to equil 16 May 2003: Changing to synaptic levels. Increasing 2.5 fold to 0.5 uM. See Mihaly et al 1991 Brain Res 547(2):309-14 and Morice et al 1999 Eur J Neurosci 11(6):1995-2006 | | craf-1 | Ajay_Bhalla_
2007_ReacDiff1_
1e-13
Accession No. : 82 | MAPK
Pathway No. : 571 | 0.5 | 1.5 | No | | Couldn't find any ref to the actual conc of craf-1 but I should try Strom et al Oncogene 5 pp 345 In line with the other kinases in the cascade, I estimate the conc to be 0.2 uM. To init we use 0.15, which is close to equil 16 May 2003: Changing to synaptic levels. Increasing 2.5 fold to 0.5 uM. See Mihaly et al 1991 Brain Res 547(2):309-14 and Morice et al 1999 Eur J Neurosci 11(6):1995-2006 | | craf-1 | Ajay_Bhalla_
2007_ReacDiff1_
1e-13
Accession No. : 82 | MAPK
Pathway No. : 577 | 0.5 | 1.5 | No | | Couldn't find any ref to the actual conc of craf-1 but I should try Strom et al Oncogene 5 pp 345 In line with the other kinases in the cascade, I estimate the conc to be 0.2 uM. To init we use 0.15, which is close to equil 16 May 2003: Changing to synaptic levels. Increasing 2.5 fold to 0.5 uM. See Mihaly et al 1991 Brain Res 547(2):309-14 and Morice et al 1999 Eur J Neurosci 11(6):1995-2006 | | craf-1 | Ajay_Bhalla_
2007_ReacDiff1_
1e-13
Accession No. : 82 | MAPK
Pathway No. : 583 | 0.5 | 1.5 | No | | Couldn't find any ref to the actual conc of craf-1 but I should try Strom et al Oncogene 5 pp 345 In line with the other kinases in the cascade, I estimate the conc to be 0.2 uM. To init we use 0.15, which is close to equil 16 May 2003: Changing to synaptic levels. Increasing 2.5 fold to 0.5 uM. See Mihaly et al 1991 Brain Res 547(2):309-14 and Morice et al 1999 Eur J Neurosci 11(6):1995-2006 | | craf-1 | Ajay_Bhalla_
2007_ReacDiff1_
1e-13
Accession No. : 82 | MAPK
Pathway No. : 589 | 0.5 | 1.5 | No | | Couldn't find any ref to the actual conc of craf-1 but I should try Strom et al Oncogene 5 pp 345 In line with the other kinases in the cascade, I estimate the conc to be 0.2 uM. To init we use 0.15, which is close to equil 16 May 2003: Changing to synaptic levels. Increasing 2.5 fold to 0.5 uM. See Mihaly et al 1991 Brain Res 547(2):309-14 and Morice et al 1999 Eur J Neurosci 11(6):1995-2006 | | craf-1 | Ajay_Bhalla_
2007_ReacDiff1_
1e-13
Accession No. : 82 | MAPK
Pathway No. : 595 | 0.5 | 1.5 | No | | Couldn't find any ref to the actual conc of craf-1 but I should try Strom et al Oncogene 5 pp 345 In line with the other kinases in the cascade, I estimate the conc to be 0.2 uM. To init we use 0.15, which is close to equil 16 May 2003: Changing to synaptic levels. Increasing 2.5 fold to 0.5 uM. See Mihaly et al 1991 Brain Res 547(2):309-14 and Morice et al 1999 Eur J Neurosci 11(6):1995-2006 | | craf-1 | Ajay_Bhalla_
2007_ReacDiff1_
1e-13
Accession No. : 82 | MAPK
Pathway No. : 601 | 0.5 | 1.5 | No | | Couldn't find any ref to the actual conc of craf-1 but I should try Strom et al Oncogene 5 pp 345 In line with the other kinases in the cascade, I estimate the conc to be 0.2 uM. To init we use 0.15, which is close to equil 16 May 2003: Changing to synaptic levels. Increasing 2.5 fold to 0.5 uM. See Mihaly et al 1991 Brain Res 547(2):309-14 and Morice et al 1999 Eur J Neurosci 11(6):1995-2006 | | craf-1 | Ajay_Bhalla_
2007_ReacDiff1_
1e-13
Accession No. : 82 | MAPK
Pathway No. : 607 | 0.5 | 1.5 | No | | Couldn't find any ref to the actual conc of craf-1 but I should try Strom et al Oncogene 5 pp 345 In line with the other kinases in the cascade, I estimate the conc to be 0.2 uM. To init we use 0.15, which is close to equil 16 May 2003: Changing to synaptic levels. Increasing 2.5 fold to 0.5 uM. See Mihaly et al 1991 Brain Res 547(2):309-14 and Morice et al 1999 Eur J Neurosci 11(6):1995-2006 | | craf-1 | Ajay_Bhalla_
2007_ReacDiff1_
1e-13
Accession No. : 82 | MAPK
Pathway No. : 613 | 0.5 | 1.5 | No | | Couldn't find any ref to the actual conc of craf-1 but I should try Strom et al Oncogene 5 pp 345 In line with the other kinases in the cascade, I estimate the conc to be 0.2 uM. To init we use 0.15, which is close to equil 16 May 2003: Changing to synaptic levels. Increasing 2.5 fold to 0.5 uM. See Mihaly et al 1991 Brain Res 547(2):309-14 and Morice et al 1999 Eur J Neurosci 11(6):1995-2006 | | craf-1 | Ajay_Bhalla_
2007_ReacDiff1_
1e-13
Accession No. : 82 | MAPK
Pathway No. : 619 | 0.5 | 1.5 | No | | Couldn't find any ref to the actual conc of craf-1 but I should try Strom et al Oncogene 5 pp 345 In line with the other kinases in the cascade, I estimate the conc to be 0.2 uM. To init we use 0.15, which is close to equil 16 May 2003: Changing to synaptic levels. Increasing 2.5 fold to 0.5 uM. See Mihaly et al 1991 Brain Res 547(2):309-14 and Morice et al 1999 Eur J Neurosci 11(6):1995-2006 | | craf-1 | Ajay_Bhalla_
2007_ReacDiff1_
1e-13
Accession No. : 82 | MAPK
Pathway No. : 625 | 0.5 | 1.5 | No | | Couldn't find any ref to the actual conc of craf-1 but I should try Strom et al Oncogene 5 pp 345 In line with the other kinases in the cascade, I estimate the conc to be 0.2 uM. To init we use 0.15, which is close to equil 16 May 2003: Changing to synaptic levels. Increasing 2.5 fold to 0.5 uM. See Mihaly et al 1991 Brain Res 547(2):309-14 and Morice et al 1999 Eur J Neurosci 11(6):1995-2006 | | craf-1 | Ajay_Bhalla_
2007_ReacDiff1_
1e-13
Accession No. : 82 | MAPK
Pathway No. : 631 | 0.5 | 1.5 | No | | Couldn't find any ref to the actual conc of craf-1 but I should try Strom et al Oncogene 5 pp 345 In line with the other kinases in the cascade, I estimate the conc to be 0.2 uM. To init we use 0.15, which is close to equil 16 May 2003: Changing to synaptic levels. Increasing 2.5 fold to 0.5 uM. See Mihaly et al 1991 Brain Res 547(2):309-14 and Morice et al 1999 Eur J Neurosci 11(6):1995-2006 | | craf-1 | Ajay_Bhalla_
2007_ReacDiff1_
1e-13
Accession No. : 82 | MAPK
Pathway No. : 637 | 0.5 | 1.5 | No | | Couldn't find any ref to the actual conc of craf-1 but I should try Strom et al Oncogene 5 pp 345 In line with the other kinases in the cascade, I estimate the conc to be 0.2 uM. To init we use 0.15, which is close to equil 16 May 2003: Changing to synaptic levels. Increasing 2.5 fold to 0.5 uM. See Mihaly et al 1991 Brain Res 547(2):309-14 and Morice et al 1999 Eur J Neurosci 11(6):1995-2006 | | craf-1 | Ajay_Bhalla_
2007_ReacDiff1_
1e-13
Accession No. : 82 | MAPK
Pathway No. : 643 | 0.5 | 1.5 | No | | Couldn't find any ref to the actual conc of craf-1 but I should try Strom et al Oncogene 5 pp 345 In line with the other kinases in the cascade, I estimate the conc to be 0.2 uM. To init we use 0.15, which is close to equil 16 May 2003: Changing to synaptic levels. Increasing 2.5 fold to 0.5 uM. See Mihaly et al 1991 Brain Res 547(2):309-14 and Morice et al 1999 Eur J Neurosci 11(6):1995-2006 | | craf-1 | Ajay_Bhalla_
2007_ReacDiff1_
1e-13
Accession No. : 82 | MAPK
Pathway No. : 649 | 0.5 | 1.5 | No | | Couldn't find any ref to the actual conc of craf-1 but I should try Strom et al Oncogene 5 pp 345 In line with the other kinases in the cascade, I estimate the conc to be 0.2 uM. To init we use 0.15, which is close to equil 16 May 2003: Changing to synaptic levels. Increasing 2.5 fold to 0.5 uM. See Mihaly et al 1991 Brain Res 547(2):309-14 and Morice et al 1999 Eur J Neurosci 11(6):1995-2006 | | craf-1 | Ajay_Bhalla_
2007_ReacDiff1_
1e-13
Accession No. : 82 | MAPK
Pathway No. : 655 | 0.5 | 1.5 | No | | Couldn't find any ref to the actual conc of craf-1 but I should try Strom et al Oncogene 5 pp 345 In line with the other kinases in the cascade, I estimate the conc to be 0.2 uM. To init we use 0.15, which is close to equil 16 May 2003: Changing to synaptic levels. Increasing 2.5 fold to 0.5 uM. See Mihaly et al 1991 Brain Res 547(2):309-14 and Morice et al 1999 Eur J Neurosci 11(6):1995-2006 | | craf-1 | Ajay_Bhalla_
2007_ReacDiff1_
1e-13
Accession No. : 82 | MAPK
Pathway No. : 661 | 0.5 | 1.5 | No | | Couldn't find any ref to the actual conc of craf-1 but I should try Strom et al Oncogene 5 pp 345 In line with the other kinases in the cascade, I estimate the conc to be 0.2 uM. To init we use 0.15, which is close to equil 16 May 2003: Changing to synaptic levels. Increasing 2.5 fold to 0.5 uM. See Mihaly et al 1991 Brain Res 547(2):309-14 and Morice et al 1999 Eur J Neurosci 11(6):1995-2006 | | craf-1 | Ajay_Bhalla_
2007_ReacDiff1_
1e-13
Accession No. : 82 | MAPK
Pathway No. : 667 | 0.5 | 1.5 | No | | Couldn't find any ref to the actual conc of craf-1 but I should try Strom et al Oncogene 5 pp 345 In line with the other kinases in the cascade, I estimate the conc to be 0.2 uM. To init we use 0.15, which is close to equil 16 May 2003: Changing to synaptic levels. Increasing 2.5 fold to 0.5 uM. See Mihaly et al 1991 Brain Res 547(2):309-14 and Morice et al 1999 Eur J Neurosci 11(6):1995-2006 | | craf-1 | Ajay_Bhalla_
2007_ReacDiff1_
1e-13
Accession No. : 82 | MAPK
Pathway No. : 673 | 0.5 | 1.5 | No | | Couldn't find any ref to the actual conc of craf-1 but I should try Strom et al Oncogene 5 pp 345 In line with the other kinases in the cascade, I estimate the conc to be 0.2 uM. To init we use 0.15, which is close to equil 16 May 2003: Changing to synaptic levels. Increasing 2.5 fold to 0.5 uM. See Mihaly et al 1991 Brain Res 547(2):309-14 and Morice et al 1999 Eur J Neurosci 11(6):1995-2006 |
craf-1 acting as a Substrate for an Enzyme in Ajay_Bhalla_2007_ReacDiff1_1e-13 Network
| | Enzyme Molecule /
Enzyme Activity | Accession Name | Pathway Name | Km (uM) | kcat (s^-1) | Ratio | Enzyme Type | Reagents | | 1 | PKC-active /
PKC-act-raf | Ajay_Bhalla_
2007_ReacDiff1_
1e-13
Accession No. : 82 | Shared_Object_
Ajay_Bhalla_
2007_ReacDiff1_
1e-13
Pathway No. : 526 | 20.0005 | 4 | 4 | explicit E-S complex | Substrate
craf-1
Product
craf-1*
| | | Rate consts from Chen et al Biochem 32, 1032 (1993) k3 = k2 = 4 k1 = 9e-5 recalculated gives 1.666e-5, which is not very different. Looks like k3 is rate-limiting in this case: there is a huge amount of craf locked up in the enz complex. Let us assume a 10x higher Km, ie, lower affinity. k1 drops by 10x. Also changed k2 to 4x k3. Lowerd k1 to 1e-6 to balance 10X DAG sensitivity of PKC | | 2 | PKC-active /
PKC-act-raf | Ajay_Bhalla_
2007_ReacDiff1_
1e-13
Accession No. : 82 | kinetics
Pathway No. : 533 | 20.0005 | 4 | 4 | explicit E-S complex | Substrate
craf-1
Product
craf-1*
| | | Rate consts from Chen et al Biochem 32, 1032 (1993) k3 = k2 = 4 k1 = 9e-5 recalculated gives 1.666e-5, which is not very different. Looks like k3 is rate-limiting in this case: there is a huge amount of craf locked up in the enz complex. Let us assume a 10x higher Km, ie, lower affinity. k1 drops by 10x. Also changed k2 to 4x k3. Lowerd k1 to 1e-6 to balance 10X DAG sensitivity of PKC | | 3 | PKC-active /
PKC-act-raf | Ajay_Bhalla_
2007_ReacDiff1_
1e-13
Accession No. : 82 | kinetics[1]
Pathway No. : 539 | 20.0005 | 4 | 4 | explicit E-S complex | Substrate
craf-1
Product
craf-1*
| | | Rate consts from Chen et al Biochem 32, 1032 (1993) k3 = k2 = 4 k1 = 9e-5 recalculated gives 1.666e-5, which is not very different. Looks like k3 is rate-limiting in this case: there is a huge amount of craf locked up in the enz complex. Let us assume a 10x higher Km, ie, lower affinity. k1 drops by 10x. Also changed k2 to 4x k3. Lowerd k1 to 1e-6 to balance 10X DAG sensitivity of PKC | | 4 | PKC-active /
PKC-act-raf | Ajay_Bhalla_
2007_ReacDiff1_
1e-13
Accession No. : 82 | kinetics[2]
Pathway No. : 545 | 20.0005 | 4 | 4 | explicit E-S complex | Substrate
craf-1
Product
craf-1*
| | | Rate consts from Chen et al Biochem 32, 1032 (1993) k3 = k2 = 4 k1 = 9e-5 recalculated gives 1.666e-5, which is not very different. Looks like k3 is rate-limiting in this case: there is a huge amount of craf locked up in the enz complex. Let us assume a 10x higher Km, ie, lower affinity. k1 drops by 10x. Also changed k2 to 4x k3. Lowerd k1 to 1e-6 to balance 10X DAG sensitivity of PKC | | 5 | PKC-active /
PKC-act-raf | Ajay_Bhalla_
2007_ReacDiff1_
1e-13
Accession No. : 82 | kinetics[3]
Pathway No. : 551 | 20.0005 | 4 | 4 | explicit E-S complex | Substrate
craf-1
Product
craf-1*
| | | Rate consts from Chen et al Biochem 32, 1032 (1993) k3 = k2 = 4 k1 = 9e-5 recalculated gives 1.666e-5, which is not very different. Looks like k3 is rate-limiting in this case: there is a huge amount of craf locked up in the enz complex. Let us assume a 10x higher Km, ie, lower affinity. k1 drops by 10x. Also changed k2 to 4x k3. Lowerd k1 to 1e-6 to balance 10X DAG sensitivity of PKC | | 6 | PKC-active /
PKC-act-raf | Ajay_Bhalla_
2007_ReacDiff1_
1e-13
Accession No. : 82 | kinetics[4]
Pathway No. : 557 | 20.0005 | 4 | 4 | explicit E-S complex | Substrate
craf-1
Product
craf-1*
| | | Rate consts from Chen et al Biochem 32, 1032 (1993) k3 = k2 = 4 k1 = 9e-5 recalculated gives 1.666e-5, which is not very different. Looks like k3 is rate-limiting in this case: there is a huge amount of craf locked up in the enz complex. Let us assume a 10x higher Km, ie, lower affinity. k1 drops by 10x. Also changed k2 to 4x k3. Lowerd k1 to 1e-6 to balance 10X DAG sensitivity of PKC | | 7 | PKC-active /
PKC-act-raf | Ajay_Bhalla_
2007_ReacDiff1_
1e-13
Accession No. : 82 | kinetics[5]
Pathway No. : 563 | 20.0005 | 4 | 4 | explicit E-S complex | Substrate
craf-1
Product
craf-1*
| | | Rate consts from Chen et al Biochem 32, 1032 (1993) k3 = k2 = 4 k1 = 9e-5 recalculated gives 1.666e-5, which is not very different. Looks like k3 is rate-limiting in this case: there is a huge amount of craf locked up in the enz complex. Let us assume a 10x higher Km, ie, lower affinity. k1 drops by 10x. Also changed k2 to 4x k3. Lowerd k1 to 1e-6 to balance 10X DAG sensitivity of PKC | | 8 | PKC-active /
PKC-act-raf | Ajay_Bhalla_
2007_ReacDiff1_
1e-13
Accession No. : 82 | kinetics[6]
Pathway No. : 567 | 20.0005 | 4 | 4 | explicit E-S complex | Substrate
craf-1
Product
craf-1*
| | | Rate consts from Chen et al Biochem 32, 1032 (1993) k3 = k2 = 4 k1 = 9e-5 recalculated gives 1.666e-5, which is not very different. Looks like k3 is rate-limiting in this case: there is a huge amount of craf locked up in the enz complex. Let us assume a 10x higher Km, ie, lower affinity. k1 drops by 10x. Also changed k2 to 4x k3. Lowerd k1 to 1e-6 to balance 10X DAG sensitivity of PKC | | 9 | PKC-active /
PKC-act-raf | Ajay_Bhalla_
2007_ReacDiff1_
1e-13
Accession No. : 82 | kinetics[7]
Pathway No. : 575 | 20.0005 | 4 | 4 | explicit E-S complex | Substrate
craf-1
Product
craf-1*
| | | Rate consts from Chen et al Biochem 32, 1032 (1993) k3 = k2 = 4 k1 = 9e-5 recalculated gives 1.666e-5, which is not very different. Looks like k3 is rate-limiting in this case: there is a huge amount of craf locked up in the enz complex. Let us assume a 10x higher Km, ie, lower affinity. k1 drops by 10x. Also changed k2 to 4x k3. Lowerd k1 to 1e-6 to balance 10X DAG sensitivity of PKC | | 10 | PKC-active /
PKC-act-raf | Ajay_Bhalla_
2007_ReacDiff1_
1e-13
Accession No. : 82 | kinetics[8]
Pathway No. : 581 | 20.0005 | 4 | 4 | explicit E-S complex | Substrate
craf-1
Product
craf-1*
| | | Rate consts from Chen et al Biochem 32, 1032 (1993) k3 = k2 = 4 k1 = 9e-5 recalculated gives 1.666e-5, which is not very different. Looks like k3 is rate-limiting in this case: there is a huge amount of craf locked up in the enz complex. Let us assume a 10x higher Km, ie, lower affinity. k1 drops by 10x. Also changed k2 to 4x k3. Lowerd k1 to 1e-6 to balance 10X DAG sensitivity of PKC | | 11 | PKC-active /
PKC-act-raf | Ajay_Bhalla_
2007_ReacDiff1_
1e-13
Accession No. : 82 | kinetics[9]
Pathway No. : 587 | 20.0005 | 4 | 4 | explicit E-S complex | Substrate
craf-1
Product
craf-1*
| | | Rate consts from Chen et al Biochem 32, 1032 (1993) k3 = k2 = 4 k1 = 9e-5 recalculated gives 1.666e-5, which is not very different. Looks like k3 is rate-limiting in this case: there is a huge amount of craf locked up in the enz complex. Let us assume a 10x higher Km, ie, lower affinity. k1 drops by 10x. Also changed k2 to 4x k3. Lowerd k1 to 1e-6 to balance 10X DAG sensitivity of PKC | | 12 | PKC-active /
PKC-act-raf | Ajay_Bhalla_
2007_ReacDiff1_
1e-13
Accession No. : 82 | kinetics[10]
Pathway No. : 593 | 20.0005 | 4 | 4 | explicit E-S complex | Substrate
craf-1
Product
craf-1*
| | | Rate consts from Chen et al Biochem 32, 1032 (1993) k3 = k2 = 4 k1 = 9e-5 recalculated gives 1.666e-5, which is not very different. Looks like k3 is rate-limiting in this case: there is a huge amount of craf locked up in the enz complex. Let us assume a 10x higher Km, ie, lower affinity. k1 drops by 10x. Also changed k2 to 4x k3. Lowerd k1 to 1e-6 to balance 10X DAG sensitivity of PKC | | 13 | PKC-active /
PKC-act-raf | Ajay_Bhalla_
2007_ReacDiff1_
1e-13
Accession No. : 82 | kinetics[11]
Pathway No. : 599 | 20.0005 | 4 | 4 | explicit E-S complex | Substrate
craf-1
Product
craf-1*
| | | Rate consts from Chen et al Biochem 32, 1032 (1993) k3 = k2 = 4 k1 = 9e-5 recalculated gives 1.666e-5, which is not very different. Looks like k3 is rate-limiting in this case: there is a huge amount of craf locked up in the enz complex. Let us assume a 10x higher Km, ie, lower affinity. k1 drops by 10x. Also changed k2 to 4x k3. Lowerd k1 to 1e-6 to balance 10X DAG sensitivity of PKC | | 14 | PKC-active /
PKC-act-raf | Ajay_Bhalla_
2007_ReacDiff1_
1e-13
Accession No. : 82 | kinetics[12]
Pathway No. : 605 | 20.0005 | 4 | 4 | explicit E-S complex | Substrate
craf-1
Product
craf-1*
| | | Rate consts from Chen et al Biochem 32, 1032 (1993) k3 = k2 = 4 k1 = 9e-5 recalculated gives 1.666e-5, which is not very different. Looks like k3 is rate-limiting in this case: there is a huge amount of craf locked up in the enz complex. Let us assume a 10x higher Km, ie, lower affinity. k1 drops by 10x. Also changed k2 to 4x k3. Lowerd k1 to 1e-6 to balance 10X DAG sensitivity of PKC | | 15 | PKC-active /
PKC-act-raf | Ajay_Bhalla_
2007_ReacDiff1_
1e-13
Accession No. : 82 | kinetics[13]
Pathway No. : 611 | 20.0005 | 4 | 4 | explicit E-S complex | Substrate
craf-1
Product
craf-1*
| | | Rate consts from Chen et al Biochem 32, 1032 (1993) k3 = k2 = 4 k1 = 9e-5 recalculated gives 1.666e-5, which is not very different. Looks like k3 is rate-limiting in this case: there is a huge amount of craf locked up in the enz complex. Let us assume a 10x higher Km, ie, lower affinity. k1 drops by 10x. Also changed k2 to 4x k3. Lowerd k1 to 1e-6 to balance 10X DAG sensitivity of PKC | | 16 | PKC-active /
PKC-act-raf | Ajay_Bhalla_
2007_ReacDiff1_
1e-13
Accession No. : 82 | kinetics[14]
Pathway No. : 617 | 20.0005 | 4 | 4 | explicit E-S complex | Substrate
craf-1
Product
craf-1*
| | | Rate consts from Chen et al Biochem 32, 1032 (1993) k3 = k2 = 4 k1 = 9e-5 recalculated gives 1.666e-5, which is not very different. Looks like k3 is rate-limiting in this case: there is a huge amount of craf locked up in the enz complex. Let us assume a 10x higher Km, ie, lower affinity. k1 drops by 10x. Also changed k2 to 4x k3. Lowerd k1 to 1e-6 to balance 10X DAG sensitivity of PKC | | 17 | PKC-active /
PKC-act-raf | Ajay_Bhalla_
2007_ReacDiff1_
1e-13
Accession No. : 82 | kinetics[15]
Pathway No. : 623 | 20.0005 | 4 | 4 | explicit E-S complex | Substrate
craf-1
Product
craf-1*
| | | Rate consts from Chen et al Biochem 32, 1032 (1993) k3 = k2 = 4 k1 = 9e-5 recalculated gives 1.666e-5, which is not very different. Looks like k3 is rate-limiting in this case: there is a huge amount of craf locked up in the enz complex. Let us assume a 10x higher Km, ie, lower affinity. k1 drops by 10x. Also changed k2 to 4x k3. Lowerd k1 to 1e-6 to balance 10X DAG sensitivity of PKC | | 18 | PKC-active /
PKC-act-raf | Ajay_Bhalla_
2007_ReacDiff1_
1e-13
Accession No. : 82 | kinetics[16]
Pathway No. : 629 | 20.0005 | 4 | 4 | explicit E-S complex | Substrate
craf-1
Product
craf-1*
| | | Rate consts from Chen et al Biochem 32, 1032 (1993) k3 = k2 = 4 k1 = 9e-5 recalculated gives 1.666e-5, which is not very different. Looks like k3 is rate-limiting in this case: there is a huge amount of craf locked up in the enz complex. Let us assume a 10x higher Km, ie, lower affinity. k1 drops by 10x. Also changed k2 to 4x k3. Lowerd k1 to 1e-6 to balance 10X DAG sensitivity of PKC | | 19 | PKC-active /
PKC-act-raf | Ajay_Bhalla_
2007_ReacDiff1_
1e-13
Accession No. : 82 | kinetics[17]
Pathway No. : 635 | 20.0005 | 4 | 4 | explicit E-S complex | Substrate
craf-1
Product
craf-1*
| | | Rate consts from Chen et al Biochem 32, 1032 (1993) k3 = k2 = 4 k1 = 9e-5 recalculated gives 1.666e-5, which is not very different. Looks like k3 is rate-limiting in this case: there is a huge amount of craf locked up in the enz complex. Let us assume a 10x higher Km, ie, lower affinity. k1 drops by 10x. Also changed k2 to 4x k3. Lowerd k1 to 1e-6 to balance 10X DAG sensitivity of PKC | | 20 | PKC-active /
PKC-act-raf | Ajay_Bhalla_
2007_ReacDiff1_
1e-13
Accession No. : 82 | kinetics[18]
Pathway No. : 641 | 20.0005 | 4 | 4 | explicit E-S complex | Substrate
craf-1
Product
craf-1*
| | | Rate consts from Chen et al Biochem 32, 1032 (1993) k3 = k2 = 4 k1 = 9e-5 recalculated gives 1.666e-5, which is not very different. Looks like k3 is rate-limiting in this case: there is a huge amount of craf locked up in the enz complex. Let us assume a 10x higher Km, ie, lower affinity. k1 drops by 10x. Also changed k2 to 4x k3. Lowerd k1 to 1e-6 to balance 10X DAG sensitivity of PKC | | 21 | PKC-active /
PKC-act-raf | Ajay_Bhalla_
2007_ReacDiff1_
1e-13
Accession No. : 82 | kinetics[19]
Pathway No. : 647 | 20.0005 | 4 | 4 | explicit E-S complex | Substrate
craf-1
Product
craf-1*
| | | Rate consts from Chen et al Biochem 32, 1032 (1993) k3 = k2 = 4 k1 = 9e-5 recalculated gives 1.666e-5, which is not very different. Looks like k3 is rate-limiting in this case: there is a huge amount of craf locked up in the enz complex. Let us assume a 10x higher Km, ie, lower affinity. k1 drops by 10x. Also changed k2 to 4x k3. Lowerd k1 to 1e-6 to balance 10X DAG sensitivity of PKC | | 22 | PKC-active /
PKC-act-raf | Ajay_Bhalla_
2007_ReacDiff1_
1e-13
Accession No. : 82 | kinetics[20]
Pathway No. : 653 | 20.0005 | 4 | 4 | explicit E-S complex | Substrate
craf-1
Product
craf-1*
| | | Rate consts from Chen et al Biochem 32, 1032 (1993) k3 = k2 = 4 k1 = 9e-5 recalculated gives 1.666e-5, which is not very different. Looks like k3 is rate-limiting in this case: there is a huge amount of craf locked up in the enz complex. Let us assume a 10x higher Km, ie, lower affinity. k1 drops by 10x. Also changed k2 to 4x k3. Lowerd k1 to 1e-6 to balance 10X DAG sensitivity of PKC | | 23 | PKC-active /
PKC-act-raf | Ajay_Bhalla_
2007_ReacDiff1_
1e-13
Accession No. : 82 | kinetics[21]
Pathway No. : 659 | 20.0005 | 4 | 4 | explicit E-S complex | Substrate
craf-1
Product
craf-1*
| | | Rate consts from Chen et al Biochem 32, 1032 (1993) k3 = k2 = 4 k1 = 9e-5 recalculated gives 1.666e-5, which is not very different. Looks like k3 is rate-limiting in this case: there is a huge amount of craf locked up in the enz complex. Let us assume a 10x higher Km, ie, lower affinity. k1 drops by 10x. Also changed k2 to 4x k3. Lowerd k1 to 1e-6 to balance 10X DAG sensitivity of PKC | | 24 | PKC-active /
PKC-act-raf | Ajay_Bhalla_
2007_ReacDiff1_
1e-13
Accession No. : 82 | kinetics[22]
Pathway No. : 665 | 20.0005 | 4 | 4 | explicit E-S complex | Substrate
craf-1
Product
craf-1*
| | | Rate consts from Chen et al Biochem 32, 1032 (1993) k3 = k2 = 4 k1 = 9e-5 recalculated gives 1.666e-5, which is not very different. Looks like k3 is rate-limiting in this case: there is a huge amount of craf locked up in the enz complex. Let us assume a 10x higher Km, ie, lower affinity. k1 drops by 10x. Also changed k2 to 4x k3. Lowerd k1 to 1e-6 to balance 10X DAG sensitivity of PKC | | 25 | PKC-active /
PKC-act-raf | Ajay_Bhalla_
2007_ReacDiff1_
1e-13
Accession No. : 82 | kinetics[23]
Pathway No. : 671 | 20.0005 | 4 | 4 | explicit E-S complex | Substrate
craf-1
Product
craf-1*
| | | Rate consts from Chen et al Biochem 32, 1032 (1993) k3 = k2 = 4 k1 = 9e-5 recalculated gives 1.666e-5, which is not very different. Looks like k3 is rate-limiting in this case: there is a huge amount of craf locked up in the enz complex. Let us assume a 10x higher Km, ie, lower affinity. k1 drops by 10x. Also changed k2 to 4x k3. Lowerd k1 to 1e-6 to balance 10X DAG sensitivity of PKC |
craf-1 acting as a Product of an Enzyme in Ajay_Bhalla_2007_ReacDiff1_1e-13 Network
craf-1 acting as a Substrate in a reaction in Ajay_Bhalla_2007_ReacDiff1_1e-13 Network
| Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated.
Kd for higher order reaction are not consider. |
| | Name | Accession Name | Pathway Name | Kf | Kb | Kd | tau | Reagents | | 1 | Ras-act-unphosph
-raf | Ajay_Bhalla_
2007_ReacDiff1_
1e-13
Accession No. : 82 | Shared_Object_
Ajay_Bhalla_
2007_ReacDiff1_
1e-13
Pathway No. : 526 | 0
(uM^-1 s^-1) | 0
(s^-1) | - | - | Substrate
GTP-Ras
craf-1
Product
Raf-GTP-Ras
| | | 18 May 2003. This reaction is here to provide basal activity for MAPK as well as the potential for direct EGF stimulus without PKC activation. Based on model from FB/fb28c.g: the model used for MKP-1 turnover. The rates there were constrained by basal activity values. | | 2 | Ras-act-unphosph
-raf | Ajay_Bhalla_
2007_ReacDiff1_
1e-13
Accession No. : 82 | kinetics
Pathway No. : 533 | 0
(uM^-1 s^-1) | 0
(s^-1) | - | - | Substrate
GTP-Ras
craf-1
Product
Raf-GTP-Ras
| | | 18 May 2003. This reaction is here to provide basal activity for MAPK as well as the potential for direct EGF stimulus without PKC activation. Based on model from FB/fb28c.g: the model used for MKP-1 turnover. The rates there were constrained by basal activity values. | | 3 | Ras-act-unphosph
-raf | Ajay_Bhalla_
2007_ReacDiff1_
1e-13
Accession No. : 82 | kinetics[1]
Pathway No. : 539 | 0
(uM^-1 s^-1) | 0
(s^-1) | - | - | Substrate
GTP-Ras
craf-1
Product
Raf-GTP-Ras
| | | 18 May 2003. This reaction is here to provide basal activity for MAPK as well as the potential for direct EGF stimulus without PKC activation. Based on model from FB/fb28c.g: the model used for MKP-1 turnover. The rates there were constrained by basal activity values. | | 4 | Ras-act-unphosph
-raf | Ajay_Bhalla_
2007_ReacDiff1_
1e-13
Accession No. : 82 | kinetics[2]
Pathway No. : 545 | 0
(uM^-1 s^-1) | 0
(s^-1) | - | - | Substrate
GTP-Ras
craf-1
Product
Raf-GTP-Ras
| | | 18 May 2003. This reaction is here to provide basal activity for MAPK as well as the potential for direct EGF stimulus without PKC activation. Based on model from FB/fb28c.g: the model used for MKP-1 turnover. The rates there were constrained by basal activity values. | | 5 | Ras-act-unphosph
-raf | Ajay_Bhalla_
2007_ReacDiff1_
1e-13
Accession No. : 82 | kinetics[3]
Pathway No. : 551 | 0
(uM^-1 s^-1) | 0
(s^-1) | - | - | Substrate
GTP-Ras
craf-1
Product
Raf-GTP-Ras
| | | 18 May 2003. This reaction is here to provide basal activity for MAPK as well as the potential for direct EGF stimulus without PKC activation. Based on model from FB/fb28c.g: the model used for MKP-1 turnover. The rates there were constrained by basal activity values. | | 6 | Ras-act-unphosph
-raf | Ajay_Bhalla_
2007_ReacDiff1_
1e-13
Accession No. : 82 | kinetics[4]
Pathway No. : 557 | 0
(uM^-1 s^-1) | 0
(s^-1) | - | - | Substrate
GTP-Ras
craf-1
Product
Raf-GTP-Ras
| | | 18 May 2003. This reaction is here to provide basal activity for MAPK as well as the potential for direct EGF stimulus without PKC activation. Based on model from FB/fb28c.g: the model used for MKP-1 turnover. The rates there were constrained by basal activity values. | | 7 | Ras-act-unphosph
-raf | Ajay_Bhalla_
2007_ReacDiff1_
1e-13
Accession No. : 82 | kinetics[5]
Pathway No. : 563 | 0
(uM^-1 s^-1) | 0
(s^-1) | - | - | Substrate
GTP-Ras
craf-1
Product
Raf-GTP-Ras
| | | 18 May 2003. This reaction is here to provide basal activity for MAPK as well as the potential for direct EGF stimulus without PKC activation. Based on model from FB/fb28c.g: the model used for MKP-1 turnover. The rates there were constrained by basal activity values. | | 8 | Ras-act-unphosph
-raf | Ajay_Bhalla_
2007_ReacDiff1_
1e-13
Accession No. : 82 | kinetics[6]
Pathway No. : 567 | 0
(uM^-1 s^-1) | 0
(s^-1) | - | - | Substrate
GTP-Ras
craf-1
Product
Raf-GTP-Ras
| | | 18 May 2003. This reaction is here to provide basal activity for MAPK as well as the potential for direct EGF stimulus without PKC activation. Based on model from FB/fb28c.g: the model used for MKP-1 turnover. The rates there were constrained by basal activity values. | | 9 | Ras-act-unphosph
-raf | Ajay_Bhalla_
2007_ReacDiff1_
1e-13
Accession No. : 82 | kinetics[7]
Pathway No. : 575 | 0
(uM^-1 s^-1) | 0
(s^-1) | - | - | Substrate
GTP-Ras
craf-1
Product
Raf-GTP-Ras
| | | 18 May 2003. This reaction is here to provide basal activity for MAPK as well as the potential for direct EGF stimulus without PKC activation. Based on model from FB/fb28c.g: the model used for MKP-1 turnover. The rates there were constrained by basal activity values. | | 10 | Ras-act-unphosph
-raf | Ajay_Bhalla_
2007_ReacDiff1_
1e-13
Accession No. : 82 | kinetics[8]
Pathway No. : 581 | 0
(uM^-1 s^-1) | 0
(s^-1) | - | - | Substrate
GTP-Ras
craf-1
Product
Raf-GTP-Ras
| | | 18 May 2003. This reaction is here to provide basal activity for MAPK as well as the potential for direct EGF stimulus without PKC activation. Based on model from FB/fb28c.g: the model used for MKP-1 turnover. The rates there were constrained by basal activity values. | | 11 | Ras-act-unphosph
-raf | Ajay_Bhalla_
2007_ReacDiff1_
1e-13
Accession No. : 82 | kinetics[9]
Pathway No. : 587 | 0
(uM^-1 s^-1) | 0
(s^-1) | - | - | Substrate
GTP-Ras
craf-1
Product
Raf-GTP-Ras
| | | 18 May 2003. This reaction is here to provide basal activity for MAPK as well as the potential for direct EGF stimulus without PKC activation. Based on model from FB/fb28c.g: the model used for MKP-1 turnover. The rates there were constrained by basal activity values. | | 12 | Ras-act-unphosph
-raf | Ajay_Bhalla_
2007_ReacDiff1_
1e-13
Accession No. : 82 | kinetics[10]
Pathway No. : 593 | 0
(uM^-1 s^-1) | 0
(s^-1) | - | - | Substrate
GTP-Ras
craf-1
Product
Raf-GTP-Ras
| | | 18 May 2003. This reaction is here to provide basal activity for MAPK as well as the potential for direct EGF stimulus without PKC activation. Based on model from FB/fb28c.g: the model used for MKP-1 turnover. The rates there were constrained by basal activity values. | | 13 | Ras-act-unphosph
-raf | Ajay_Bhalla_
2007_ReacDiff1_
1e-13
Accession No. : 82 | kinetics[11]
Pathway No. : 599 | 0
(uM^-1 s^-1) | 0
(s^-1) | - | - | Substrate
GTP-Ras
craf-1
Product
Raf-GTP-Ras
| | | 18 May 2003. This reaction is here to provide basal activity for MAPK as well as the potential for direct EGF stimulus without PKC activation. Based on model from FB/fb28c.g: the model used for MKP-1 turnover. The rates there were constrained by basal activity values. | | 14 | Ras-act-unphosph
-raf | Ajay_Bhalla_
2007_ReacDiff1_
1e-13
Accession No. : 82 | kinetics[12]
Pathway No. : 605 | 0
(uM^-1 s^-1) | 0
(s^-1) | - | - | Substrate
GTP-Ras
craf-1
Product
Raf-GTP-Ras
| | | 18 May 2003. This reaction is here to provide basal activity for MAPK as well as the potential for direct EGF stimulus without PKC activation. Based on model from FB/fb28c.g: the model used for MKP-1 turnover. The rates there were constrained by basal activity values. | | 15 | Ras-act-unphosph
-raf | Ajay_Bhalla_
2007_ReacDiff1_
1e-13
Accession No. : 82 | kinetics[13]
Pathway No. : 611 | 0
(uM^-1 s^-1) | 0
(s^-1) | - | - | Substrate
GTP-Ras
craf-1
Product
Raf-GTP-Ras
| | | 18 May 2003. This reaction is here to provide basal activity for MAPK as well as the potential for direct EGF stimulus without PKC activation. Based on model from FB/fb28c.g: the model used for MKP-1 turnover. The rates there were constrained by basal activity values. | | 16 | Ras-act-unphosph
-raf | Ajay_Bhalla_
2007_ReacDiff1_
1e-13
Accession No. : 82 | kinetics[14]
Pathway No. : 617 | 0
(uM^-1 s^-1) | 0
(s^-1) | - | - | Substrate
GTP-Ras
craf-1
Product
Raf-GTP-Ras
| | | 18 May 2003. This reaction is here to provide basal activity for MAPK as well as the potential for direct EGF stimulus without PKC activation. Based on model from FB/fb28c.g: the model used for MKP-1 turnover. The rates there were constrained by basal activity values. | | 17 | Ras-act-unphosph
-raf | Ajay_Bhalla_
2007_ReacDiff1_
1e-13
Accession No. : 82 | kinetics[15]
Pathway No. : 623 | 0
(uM^-1 s^-1) | 0
(s^-1) | - | - | Substrate
GTP-Ras
craf-1
Product
Raf-GTP-Ras
| | | 18 May 2003. This reaction is here to provide basal activity for MAPK as well as the potential for direct EGF stimulus without PKC activation. Based on model from FB/fb28c.g: the model used for MKP-1 turnover. The rates there were constrained by basal activity values. | | 18 | Ras-act-unphosph
-raf | Ajay_Bhalla_
2007_ReacDiff1_
1e-13
Accession No. : 82 | kinetics[16]
Pathway No. : 629 | 0
(uM^-1 s^-1) | 0
(s^-1) | - | - | Substrate
GTP-Ras
craf-1
Product
Raf-GTP-Ras
| | | 18 May 2003. This reaction is here to provide basal activity for MAPK as well as the potential for direct EGF stimulus without PKC activation. Based on model from FB/fb28c.g: the model used for MKP-1 turnover. The rates there were constrained by basal activity values. | | 19 | Ras-act-unphosph
-raf | Ajay_Bhalla_
2007_ReacDiff1_
1e-13
Accession No. : 82 | kinetics[17]
Pathway No. : 635 | 0
(uM^-1 s^-1) | 0
(s^-1) | - | - | Substrate
GTP-Ras
craf-1
Product
Raf-GTP-Ras
| | | 18 May 2003. This reaction is here to provide basal activity for MAPK as well as the potential for direct EGF stimulus without PKC activation. Based on model from FB/fb28c.g: the model used for MKP-1 turnover. The rates there were constrained by basal activity values. | | 20 | Ras-act-unphosph
-raf | Ajay_Bhalla_
2007_ReacDiff1_
1e-13
Accession No. : 82 | kinetics[18]
Pathway No. : 641 | 0
(uM^-1 s^-1) | 0
(s^-1) | - | - | Substrate
GTP-Ras
craf-1
Product
Raf-GTP-Ras
| | | 18 May 2003. This reaction is here to provide basal activity for MAPK as well as the potential for direct EGF stimulus without PKC activation. Based on model from FB/fb28c.g: the model used for MKP-1 turnover. The rates there were constrained by basal activity values. | | 21 | Ras-act-unphosph
-raf | Ajay_Bhalla_
2007_ReacDiff1_
1e-13
Accession No. : 82 | kinetics[19]
Pathway No. : 647 | 0
(uM^-1 s^-1) | 0
(s^-1) | - | - | Substrate
GTP-Ras
craf-1
Product
Raf-GTP-Ras
| | | 18 May 2003. This reaction is here to provide basal activity for MAPK as well as the potential for direct EGF stimulus without PKC activation. Based on model from FB/fb28c.g: the model used for MKP-1 turnover. The rates there were constrained by basal activity values. | | 22 | Ras-act-unphosph
-raf | Ajay_Bhalla_
2007_ReacDiff1_
1e-13
Accession No. : 82 | kinetics[20]
Pathway No. : 653 | 0
(uM^-1 s^-1) | 0
(s^-1) | - | - | Substrate
GTP-Ras
craf-1
Product
Raf-GTP-Ras
| | | 18 May 2003. This reaction is here to provide basal activity for MAPK as well as the potential for direct EGF stimulus without PKC activation. Based on model from FB/fb28c.g: the model used for MKP-1 turnover. The rates there were constrained by basal activity values. | | 23 | Ras-act-unphosph
-raf | Ajay_Bhalla_
2007_ReacDiff1_
1e-13
Accession No. : 82 | kinetics[21]
Pathway No. : 659 | 0
(uM^-1 s^-1) | 0
(s^-1) | - | - | Substrate
GTP-Ras
craf-1
Product
Raf-GTP-Ras
| | | 18 May 2003. This reaction is here to provide basal activity for MAPK as well as the potential for direct EGF stimulus without PKC activation. Based on model from FB/fb28c.g: the model used for MKP-1 turnover. The rates there were constrained by basal activity values. | | 24 | Ras-act-unphosph
-raf | Ajay_Bhalla_
2007_ReacDiff1_
1e-13
Accession No. : 82 | kinetics[22]
Pathway No. : 665 | 0
(uM^-1 s^-1) | 0
(s^-1) | - | - | Substrate
GTP-Ras
craf-1
Product
Raf-GTP-Ras
| | | 18 May 2003. This reaction is here to provide basal activity for MAPK as well as the potential for direct EGF stimulus without PKC activation. Based on model from FB/fb28c.g: the model used for MKP-1 turnover. The rates there were constrained by basal activity values. | | 25 | Ras-act-unphosph
-raf | Ajay_Bhalla_
2007_ReacDiff1_
1e-13
Accession No. : 82 | kinetics[23]
Pathway No. : 671 | 0
(uM^-1 s^-1) | 0
(s^-1) | - | - | Substrate
GTP-Ras
craf-1
Product
Raf-GTP-Ras
| | | 18 May 2003. This reaction is here to provide basal activity for MAPK as well as the potential for direct EGF stimulus without PKC activation. Based on model from FB/fb28c.g: the model used for MKP-1 turnover. The rates there were constrained by basal activity values. |
| Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
This Copyright is applied to ensure that the contents of this database remain freely available. Please see FAQ for details. |
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