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Molecule Parameter List for MAPK | The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by  color. | | Statistics |
Accession and Pathway Details | |
| Accession Name | Accession No. | Accession Type | Pathway Link | Ajay_Bhalla_
2007_ReacDiff1_
1e-13 | 82 | Network | Shared_Object_Ajay_Bhalla_2007_ReacDiff1_1e-13,
PKC, MAPK, Ras, CaM, PKM, chain, kinetics, PKC, MAPK, Ras, CaM, PKM, kinetics[1],
PKC, MAPK, Ras, CaM, PKM, kinetics[2], PKC, MAPK, Ras, CaM, PKM, kinetics[3],
PKC, MAPK, Ras, CaM, PKM, kinetics[4], PKC, MAPK, Ras, CaM, PKM, kinetics[5],
PKC, MAPK, Ras, kinetics[6], CaM, PKM, PKC, MAPK, Ras, CaM, PKM, kinetics[7],
PKC, MAPK, Ras, CaM, PKM, kinetics[8], PKC, MAPK, Ras, CaM, PKM, kinetics[9],
PKC, MAPK, Ras, CaM, PKM, kinetics[10], PKC, MAPK, Ras, CaM, PKM, kinetics[11],
PKC, MAPK, Ras, CaM, PKM, kinetics[12], PKC, MAPK, Ras, CaM, PKM, kinetics[13],
PKC, MAPK, Ras, CaM, PKM, kinetics[14], PKC, MAPK, Ras, CaM, PKM, kinetics[15],
PKC, MAPK, Ras, CaM, PKM, kinetics[16], PKC, MAPK, Ras, CaM, PKM, kinetics[17],
PKC, MAPK, Ras, CaM, PKM, kinetics[18], PKC, MAPK, Ras, CaM, PKM, kinetics[19],
PKC, MAPK, Ras, CaM, PKM, kinetics[20], PKC, MAPK, Ras, CaM, PKM, kinetics[21],
PKC, MAPK, Ras, CaM, PKM, kinetics[22], PKC, MAPK, Ras, CaM, PKM, kinetics[23],
PKC, MAPK, Ras, CaM, PKM | This is a 25-compartment reaction-diffusion version of the Ajay_Bhalla_2007_PKM model. The original single-compartment model is repeated 25 times. In addition, a subset (27 out of 42) molecules can diffuse between compartments. Diffusion is implemented as a reaction between corresponding molecules in neighboring compartments. For D = 1e-12 m^2/sec (i.e., 1 micron^2/sec ) the kf and kb of this reaction for these 10 micron compartments are both 0.01/sec. For D = 1e-13 m^2/sec (i.e., 0.1 micron^2/sec ) the kf and kb are 0.001/sec.
The stimulus file pkm_mapk22_diff_1e-13_Fig4B which was used for the model to replicate Figure 4B from the paper.
pkm_mapk22_diff_1e-13_Fig4H replicate Figure 4H.
pkm_mapk22_diff_1e-13_Fig4I replicate Figure 4I.
|
MAPK acting as a Molecule in Ajay_Bhalla_2007_ReacDiff1_1e-13 Network
| Name | Accession Name | Pathway Name | Initial Conc.
(uM) | Volume
(fL) | Buffered | | MAPK | Ajay_Bhalla_
2007_ReacDiff1_
1e-13
Accession No. : 82 | MAPK
Pathway No. : 528 | 3.5999 | 1.5 | No | | conc is from Sanghera et al JBC 265 pp 52 (1990) A second calculation gives 3.1 uM, from same paper. They est MAPK is 1e-4x total protein, and protein is 15% of cell wt, so MAPK is 1.5e-5g/ml = 0.36uM. which is closer to our first estimate. Lets use this. Updated 16 May 2003. Ortiz et al 1995 J Neurosci 15(2):1285-1297 provide estimates of ERK2 levels in hippocampus: 1009 ng/mg. This comes to about 3.6uM, which may still be an underestimate of synaptic levels. | | MAPK | Ajay_Bhalla_
2007_ReacDiff1_
1e-13
Accession No. : 82 | MAPK
Pathway No. : 535 | 3.5999 | 1.5 | No | | conc is from Sanghera et al JBC 265 pp 52 (1990) A second calculation gives 3.1 uM, from same paper. They est MAPK is 1e-4x total protein, and protein is 15% of cell wt, so MAPK is 1.5e-5g/ml = 0.36uM. which is closer to our first estimate. Lets use this. Updated 16 May 2003. Ortiz et al 1995 J Neurosci 15(2):1285-1297 provide estimates of ERK2 levels in hippocampus: 1009 ng/mg. This comes to about 3.6uM, which may still be an underestimate of synaptic levels. | | MAPK | Ajay_Bhalla_
2007_ReacDiff1_
1e-13
Accession No. : 82 | MAPK
Pathway No. : 541 | 3.5999 | 1.5 | No | | conc is from Sanghera et al JBC 265 pp 52 (1990) A second calculation gives 3.1 uM, from same paper. They est MAPK is 1e-4x total protein, and protein is 15% of cell wt, so MAPK is 1.5e-5g/ml = 0.36uM. which is closer to our first estimate. Lets use this. Updated 16 May 2003. Ortiz et al 1995 J Neurosci 15(2):1285-1297 provide estimates of ERK2 levels in hippocampus: 1009 ng/mg. This comes to about 3.6uM, which may still be an underestimate of synaptic levels. | | MAPK | Ajay_Bhalla_
2007_ReacDiff1_
1e-13
Accession No. : 82 | MAPK
Pathway No. : 547 | 3.5999 | 1.5 | No | | conc is from Sanghera et al JBC 265 pp 52 (1990) A second calculation gives 3.1 uM, from same paper. They est MAPK is 1e-4x total protein, and protein is 15% of cell wt, so MAPK is 1.5e-5g/ml = 0.36uM. which is closer to our first estimate. Lets use this. Updated 16 May 2003. Ortiz et al 1995 J Neurosci 15(2):1285-1297 provide estimates of ERK2 levels in hippocampus: 1009 ng/mg. This comes to about 3.6uM, which may still be an underestimate of synaptic levels. | | MAPK | Ajay_Bhalla_
2007_ReacDiff1_
1e-13
Accession No. : 82 | MAPK
Pathway No. : 553 | 3.5999 | 1.5 | No | | conc is from Sanghera et al JBC 265 pp 52 (1990) A second calculation gives 3.1 uM, from same paper. They est MAPK is 1e-4x total protein, and protein is 15% of cell wt, so MAPK is 1.5e-5g/ml = 0.36uM. which is closer to our first estimate. Lets use this. Updated 16 May 2003. Ortiz et al 1995 J Neurosci 15(2):1285-1297 provide estimates of ERK2 levels in hippocampus: 1009 ng/mg. This comes to about 3.6uM, which may still be an underestimate of synaptic levels. | | MAPK | Ajay_Bhalla_
2007_ReacDiff1_
1e-13
Accession No. : 82 | MAPK
Pathway No. : 559 | 3.5999 | 1.5 | No | | conc is from Sanghera et al JBC 265 pp 52 (1990) A second calculation gives 3.1 uM, from same paper. They est MAPK is 1e-4x total protein, and protein is 15% of cell wt, so MAPK is 1.5e-5g/ml = 0.36uM. which is closer to our first estimate. Lets use this. Updated 16 May 2003. Ortiz et al 1995 J Neurosci 15(2):1285-1297 provide estimates of ERK2 levels in hippocampus: 1009 ng/mg. This comes to about 3.6uM, which may still be an underestimate of synaptic levels. | | MAPK | Ajay_Bhalla_
2007_ReacDiff1_
1e-13
Accession No. : 82 | MAPK
Pathway No. : 565 | 3.5999 | 1.5 | No | | conc is from Sanghera et al JBC 265 pp 52 (1990) A second calculation gives 3.1 uM, from same paper. They est MAPK is 1e-4x total protein, and protein is 15% of cell wt, so MAPK is 1.5e-5g/ml = 0.36uM. which is closer to our first estimate. Lets use this. Updated 16 May 2003. Ortiz et al 1995 J Neurosci 15(2):1285-1297 provide estimates of ERK2 levels in hippocampus: 1009 ng/mg. This comes to about 3.6uM, which may still be an underestimate of synaptic levels. | | MAPK | Ajay_Bhalla_
2007_ReacDiff1_
1e-13
Accession No. : 82 | MAPK
Pathway No. : 571 | 3.5999 | 1.5 | No | | conc is from Sanghera et al JBC 265 pp 52 (1990) A second calculation gives 3.1 uM, from same paper. They est MAPK is 1e-4x total protein, and protein is 15% of cell wt, so MAPK is 1.5e-5g/ml = 0.36uM. which is closer to our first estimate. Lets use this. Updated 16 May 2003. Ortiz et al 1995 J Neurosci 15(2):1285-1297 provide estimates of ERK2 levels in hippocampus: 1009 ng/mg. This comes to about 3.6uM, which may still be an underestimate of synaptic levels. | | MAPK | Ajay_Bhalla_
2007_ReacDiff1_
1e-13
Accession No. : 82 | MAPK
Pathway No. : 577 | 3.5999 | 1.5 | No | | conc is from Sanghera et al JBC 265 pp 52 (1990) A second calculation gives 3.1 uM, from same paper. They est MAPK is 1e-4x total protein, and protein is 15% of cell wt, so MAPK is 1.5e-5g/ml = 0.36uM. which is closer to our first estimate. Lets use this. Updated 16 May 2003. Ortiz et al 1995 J Neurosci 15(2):1285-1297 provide estimates of ERK2 levels in hippocampus: 1009 ng/mg. This comes to about 3.6uM, which may still be an underestimate of synaptic levels. | | MAPK | Ajay_Bhalla_
2007_ReacDiff1_
1e-13
Accession No. : 82 | MAPK
Pathway No. : 583 | 3.5999 | 1.5 | No | | conc is from Sanghera et al JBC 265 pp 52 (1990) A second calculation gives 3.1 uM, from same paper. They est MAPK is 1e-4x total protein, and protein is 15% of cell wt, so MAPK is 1.5e-5g/ml = 0.36uM. which is closer to our first estimate. Lets use this. Updated 16 May 2003. Ortiz et al 1995 J Neurosci 15(2):1285-1297 provide estimates of ERK2 levels in hippocampus: 1009 ng/mg. This comes to about 3.6uM, which may still be an underestimate of synaptic levels. | | MAPK | Ajay_Bhalla_
2007_ReacDiff1_
1e-13
Accession No. : 82 | MAPK
Pathway No. : 589 | 3.5999 | 1.5 | No | | conc is from Sanghera et al JBC 265 pp 52 (1990) A second calculation gives 3.1 uM, from same paper. They est MAPK is 1e-4x total protein, and protein is 15% of cell wt, so MAPK is 1.5e-5g/ml = 0.36uM. which is closer to our first estimate. Lets use this. Updated 16 May 2003. Ortiz et al 1995 J Neurosci 15(2):1285-1297 provide estimates of ERK2 levels in hippocampus: 1009 ng/mg. This comes to about 3.6uM, which may still be an underestimate of synaptic levels. | | MAPK | Ajay_Bhalla_
2007_ReacDiff1_
1e-13
Accession No. : 82 | MAPK
Pathway No. : 595 | 3.5999 | 1.5 | No | | conc is from Sanghera et al JBC 265 pp 52 (1990) A second calculation gives 3.1 uM, from same paper. They est MAPK is 1e-4x total protein, and protein is 15% of cell wt, so MAPK is 1.5e-5g/ml = 0.36uM. which is closer to our first estimate. Lets use this. Updated 16 May 2003. Ortiz et al 1995 J Neurosci 15(2):1285-1297 provide estimates of ERK2 levels in hippocampus: 1009 ng/mg. This comes to about 3.6uM, which may still be an underestimate of synaptic levels. | | MAPK | Ajay_Bhalla_
2007_ReacDiff1_
1e-13
Accession No. : 82 | MAPK
Pathway No. : 601 | 3.5999 | 1.5 | No | | conc is from Sanghera et al JBC 265 pp 52 (1990) A second calculation gives 3.1 uM, from same paper. They est MAPK is 1e-4x total protein, and protein is 15% of cell wt, so MAPK is 1.5e-5g/ml = 0.36uM. which is closer to our first estimate. Lets use this. Updated 16 May 2003. Ortiz et al 1995 J Neurosci 15(2):1285-1297 provide estimates of ERK2 levels in hippocampus: 1009 ng/mg. This comes to about 3.6uM, which may still be an underestimate of synaptic levels. | | MAPK | Ajay_Bhalla_
2007_ReacDiff1_
1e-13
Accession No. : 82 | MAPK
Pathway No. : 607 | 3.5999 | 1.5 | No | | conc is from Sanghera et al JBC 265 pp 52 (1990) A second calculation gives 3.1 uM, from same paper. They est MAPK is 1e-4x total protein, and protein is 15% of cell wt, so MAPK is 1.5e-5g/ml = 0.36uM. which is closer to our first estimate. Lets use this. Updated 16 May 2003. Ortiz et al 1995 J Neurosci 15(2):1285-1297 provide estimates of ERK2 levels in hippocampus: 1009 ng/mg. This comes to about 3.6uM, which may still be an underestimate of synaptic levels. | | MAPK | Ajay_Bhalla_
2007_ReacDiff1_
1e-13
Accession No. : 82 | MAPK
Pathway No. : 613 | 3.5999 | 1.5 | No | | conc is from Sanghera et al JBC 265 pp 52 (1990) A second calculation gives 3.1 uM, from same paper. They est MAPK is 1e-4x total protein, and protein is 15% of cell wt, so MAPK is 1.5e-5g/ml = 0.36uM. which is closer to our first estimate. Lets use this. Updated 16 May 2003. Ortiz et al 1995 J Neurosci 15(2):1285-1297 provide estimates of ERK2 levels in hippocampus: 1009 ng/mg. This comes to about 3.6uM, which may still be an underestimate of synaptic levels. | | MAPK | Ajay_Bhalla_
2007_ReacDiff1_
1e-13
Accession No. : 82 | MAPK
Pathway No. : 619 | 3.5999 | 1.5 | No | | conc is from Sanghera et al JBC 265 pp 52 (1990) A second calculation gives 3.1 uM, from same paper. They est MAPK is 1e-4x total protein, and protein is 15% of cell wt, so MAPK is 1.5e-5g/ml = 0.36uM. which is closer to our first estimate. Lets use this. Updated 16 May 2003. Ortiz et al 1995 J Neurosci 15(2):1285-1297 provide estimates of ERK2 levels in hippocampus: 1009 ng/mg. This comes to about 3.6uM, which may still be an underestimate of synaptic levels. | | MAPK | Ajay_Bhalla_
2007_ReacDiff1_
1e-13
Accession No. : 82 | MAPK
Pathway No. : 625 | 3.5999 | 1.5 | No | | conc is from Sanghera et al JBC 265 pp 52 (1990) A second calculation gives 3.1 uM, from same paper. They est MAPK is 1e-4x total protein, and protein is 15% of cell wt, so MAPK is 1.5e-5g/ml = 0.36uM. which is closer to our first estimate. Lets use this. Updated 16 May 2003. Ortiz et al 1995 J Neurosci 15(2):1285-1297 provide estimates of ERK2 levels in hippocampus: 1009 ng/mg. This comes to about 3.6uM, which may still be an underestimate of synaptic levels. | | MAPK | Ajay_Bhalla_
2007_ReacDiff1_
1e-13
Accession No. : 82 | MAPK
Pathway No. : 631 | 3.5999 | 1.5 | No | | conc is from Sanghera et al JBC 265 pp 52 (1990) A second calculation gives 3.1 uM, from same paper. They est MAPK is 1e-4x total protein, and protein is 15% of cell wt, so MAPK is 1.5e-5g/ml = 0.36uM. which is closer to our first estimate. Lets use this. Updated 16 May 2003. Ortiz et al 1995 J Neurosci 15(2):1285-1297 provide estimates of ERK2 levels in hippocampus: 1009 ng/mg. This comes to about 3.6uM, which may still be an underestimate of synaptic levels. | | MAPK | Ajay_Bhalla_
2007_ReacDiff1_
1e-13
Accession No. : 82 | MAPK
Pathway No. : 637 | 3.5999 | 1.5 | No | | conc is from Sanghera et al JBC 265 pp 52 (1990) A second calculation gives 3.1 uM, from same paper. They est MAPK is 1e-4x total protein, and protein is 15% of cell wt, so MAPK is 1.5e-5g/ml = 0.36uM. which is closer to our first estimate. Lets use this. Updated 16 May 2003. Ortiz et al 1995 J Neurosci 15(2):1285-1297 provide estimates of ERK2 levels in hippocampus: 1009 ng/mg. This comes to about 3.6uM, which may still be an underestimate of synaptic levels. | | MAPK | Ajay_Bhalla_
2007_ReacDiff1_
1e-13
Accession No. : 82 | MAPK
Pathway No. : 643 | 3.5999 | 1.5 | No | | conc is from Sanghera et al JBC 265 pp 52 (1990) A second calculation gives 3.1 uM, from same paper. They est MAPK is 1e-4x total protein, and protein is 15% of cell wt, so MAPK is 1.5e-5g/ml = 0.36uM. which is closer to our first estimate. Lets use this. Updated 16 May 2003. Ortiz et al 1995 J Neurosci 15(2):1285-1297 provide estimates of ERK2 levels in hippocampus: 1009 ng/mg. This comes to about 3.6uM, which may still be an underestimate of synaptic levels. | | MAPK | Ajay_Bhalla_
2007_ReacDiff1_
1e-13
Accession No. : 82 | MAPK
Pathway No. : 649 | 3.5999 | 1.5 | No | | conc is from Sanghera et al JBC 265 pp 52 (1990) A second calculation gives 3.1 uM, from same paper. They est MAPK is 1e-4x total protein, and protein is 15% of cell wt, so MAPK is 1.5e-5g/ml = 0.36uM. which is closer to our first estimate. Lets use this. Updated 16 May 2003. Ortiz et al 1995 J Neurosci 15(2):1285-1297 provide estimates of ERK2 levels in hippocampus: 1009 ng/mg. This comes to about 3.6uM, which may still be an underestimate of synaptic levels. | | MAPK | Ajay_Bhalla_
2007_ReacDiff1_
1e-13
Accession No. : 82 | MAPK
Pathway No. : 655 | 3.5999 | 1.5 | No | | conc is from Sanghera et al JBC 265 pp 52 (1990) A second calculation gives 3.1 uM, from same paper. They est MAPK is 1e-4x total protein, and protein is 15% of cell wt, so MAPK is 1.5e-5g/ml = 0.36uM. which is closer to our first estimate. Lets use this. Updated 16 May 2003. Ortiz et al 1995 J Neurosci 15(2):1285-1297 provide estimates of ERK2 levels in hippocampus: 1009 ng/mg. This comes to about 3.6uM, which may still be an underestimate of synaptic levels. | | MAPK | Ajay_Bhalla_
2007_ReacDiff1_
1e-13
Accession No. : 82 | MAPK
Pathway No. : 661 | 3.5999 | 1.5 | No | | conc is from Sanghera et al JBC 265 pp 52 (1990) A second calculation gives 3.1 uM, from same paper. They est MAPK is 1e-4x total protein, and protein is 15% of cell wt, so MAPK is 1.5e-5g/ml = 0.36uM. which is closer to our first estimate. Lets use this. Updated 16 May 2003. Ortiz et al 1995 J Neurosci 15(2):1285-1297 provide estimates of ERK2 levels in hippocampus: 1009 ng/mg. This comes to about 3.6uM, which may still be an underestimate of synaptic levels. | | MAPK | Ajay_Bhalla_
2007_ReacDiff1_
1e-13
Accession No. : 82 | MAPK
Pathway No. : 667 | 3.5999 | 1.5 | No | | conc is from Sanghera et al JBC 265 pp 52 (1990) A second calculation gives 3.1 uM, from same paper. They est MAPK is 1e-4x total protein, and protein is 15% of cell wt, so MAPK is 1.5e-5g/ml = 0.36uM. which is closer to our first estimate. Lets use this. Updated 16 May 2003. Ortiz et al 1995 J Neurosci 15(2):1285-1297 provide estimates of ERK2 levels in hippocampus: 1009 ng/mg. This comes to about 3.6uM, which may still be an underestimate of synaptic levels. | | MAPK | Ajay_Bhalla_
2007_ReacDiff1_
1e-13
Accession No. : 82 | MAPK
Pathway No. : 673 | 3.5999 | 1.5 | No | | conc is from Sanghera et al JBC 265 pp 52 (1990) A second calculation gives 3.1 uM, from same paper. They est MAPK is 1e-4x total protein, and protein is 15% of cell wt, so MAPK is 1.5e-5g/ml = 0.36uM. which is closer to our first estimate. Lets use this. Updated 16 May 2003. Ortiz et al 1995 J Neurosci 15(2):1285-1297 provide estimates of ERK2 levels in hippocampus: 1009 ng/mg. This comes to about 3.6uM, which may still be an underestimate of synaptic levels. |
MAPK acting as a Substrate for an Enzyme in Ajay_Bhalla_2007_ReacDiff1_1e-13 Network
| | Enzyme Molecule /
Enzyme Activity | Accession Name | Pathway Name | Km (uM) | kcat (s^-1) | Ratio | Enzyme Type | Reagents | | 1 | MAPKK* /
MAPKKtyr | Ajay_Bhalla_
2007_ReacDiff1_
1e-13
Accession No. : 82 | MAPK
Pathway No. : 528 | 0.0462964 | 0.3 | 4 | explicit E-S complex | Substrate
MAPK
Product
MAPK-tyr
| | | The actual MAPKK is 2 forms from Seger et al JBC 267:20 14373(1992) Vmax = 150nmol/min/mg From Haystead et al FEBS 306(1):17-22 we get Km=46.6nM for at least one of the phosphs. Putting these together: k3=0.15/sec, scale to get k2=0.6. k1=0.75/46.6nM=2.7e-5 | | 2 | MAPKK* /
MAPKKtyr | Ajay_Bhalla_
2007_ReacDiff1_
1e-13
Accession No. : 82 | MAPK
Pathway No. : 535 | 0.0462964 | 0.3 | 4 | explicit E-S complex | Substrate
MAPK
Product
MAPK-tyr
| | | The actual MAPKK is 2 forms from Seger et al JBC 267:20 14373(1992) Vmax = 150nmol/min/mg From Haystead et al FEBS 306(1):17-22 we get Km=46.6nM for at least one of the phosphs. Putting these together: k3=0.15/sec, scale to get k2=0.6. k1=0.75/46.6nM=2.7e-5 | | 3 | MAPKK* /
MAPKKtyr | Ajay_Bhalla_
2007_ReacDiff1_
1e-13
Accession No. : 82 | MAPK
Pathway No. : 541 | 0.0462964 | 0.3 | 4 | explicit E-S complex | Substrate
MAPK
Product
MAPK-tyr
| | | The actual MAPKK is 2 forms from Seger et al JBC 267:20 14373(1992) Vmax = 150nmol/min/mg From Haystead et al FEBS 306(1):17-22 we get Km=46.6nM for at least one of the phosphs. Putting these together: k3=0.15/sec, scale to get k2=0.6. k1=0.75/46.6nM=2.7e-5 | | 4 | MAPKK* /
MAPKKtyr | Ajay_Bhalla_
2007_ReacDiff1_
1e-13
Accession No. : 82 | MAPK
Pathway No. : 547 | 0.0462964 | 0.3 | 4 | explicit E-S complex | Substrate
MAPK
Product
MAPK-tyr
| | | The actual MAPKK is 2 forms from Seger et al JBC 267:20 14373(1992) Vmax = 150nmol/min/mg From Haystead et al FEBS 306(1):17-22 we get Km=46.6nM for at least one of the phosphs. Putting these together: k3=0.15/sec, scale to get k2=0.6. k1=0.75/46.6nM=2.7e-5 | | 5 | MAPKK* /
MAPKKtyr | Ajay_Bhalla_
2007_ReacDiff1_
1e-13
Accession No. : 82 | MAPK
Pathway No. : 553 | 0.0462964 | 0.3 | 4 | explicit E-S complex | Substrate
MAPK
Product
MAPK-tyr
| | | The actual MAPKK is 2 forms from Seger et al JBC 267:20 14373(1992) Vmax = 150nmol/min/mg From Haystead et al FEBS 306(1):17-22 we get Km=46.6nM for at least one of the phosphs. Putting these together: k3=0.15/sec, scale to get k2=0.6. k1=0.75/46.6nM=2.7e-5 | | 6 | MAPKK* /
MAPKKtyr | Ajay_Bhalla_
2007_ReacDiff1_
1e-13
Accession No. : 82 | MAPK
Pathway No. : 559 | 0.0462964 | 0.3 | 4 | explicit E-S complex | Substrate
MAPK
Product
MAPK-tyr
| | | The actual MAPKK is 2 forms from Seger et al JBC 267:20 14373(1992) Vmax = 150nmol/min/mg From Haystead et al FEBS 306(1):17-22 we get Km=46.6nM for at least one of the phosphs. Putting these together: k3=0.15/sec, scale to get k2=0.6. k1=0.75/46.6nM=2.7e-5 | | 7 | MAPKK* /
MAPKKtyr | Ajay_Bhalla_
2007_ReacDiff1_
1e-13
Accession No. : 82 | MAPK
Pathway No. : 565 | 0.0462964 | 0.3 | 4 | explicit E-S complex | Substrate
MAPK
Product
MAPK-tyr
| | | The actual MAPKK is 2 forms from Seger et al JBC 267:20 14373(1992) Vmax = 150nmol/min/mg From Haystead et al FEBS 306(1):17-22 we get Km=46.6nM for at least one of the phosphs. Putting these together: k3=0.15/sec, scale to get k2=0.6. k1=0.75/46.6nM=2.7e-5 | | 8 | MAPKK* /
MAPKKtyr | Ajay_Bhalla_
2007_ReacDiff1_
1e-13
Accession No. : 82 | MAPK
Pathway No. : 571 | 0.0462964 | 0.3 | 4 | explicit E-S complex | Substrate
MAPK
Product
MAPK-tyr
| | | The actual MAPKK is 2 forms from Seger et al JBC 267:20 14373(1992) Vmax = 150nmol/min/mg From Haystead et al FEBS 306(1):17-22 we get Km=46.6nM for at least one of the phosphs. Putting these together: k3=0.15/sec, scale to get k2=0.6. k1=0.75/46.6nM=2.7e-5 | | 9 | MAPKK* /
MAPKKtyr | Ajay_Bhalla_
2007_ReacDiff1_
1e-13
Accession No. : 82 | MAPK
Pathway No. : 577 | 0.0462964 | 0.3 | 4 | explicit E-S complex | Substrate
MAPK
Product
MAPK-tyr
| | | The actual MAPKK is 2 forms from Seger et al JBC 267:20 14373(1992) Vmax = 150nmol/min/mg From Haystead et al FEBS 306(1):17-22 we get Km=46.6nM for at least one of the phosphs. Putting these together: k3=0.15/sec, scale to get k2=0.6. k1=0.75/46.6nM=2.7e-5 | | 10 | MAPKK* /
MAPKKtyr | Ajay_Bhalla_
2007_ReacDiff1_
1e-13
Accession No. : 82 | MAPK
Pathway No. : 583 | 0.0462964 | 0.3 | 4 | explicit E-S complex | Substrate
MAPK
Product
MAPK-tyr
| | | The actual MAPKK is 2 forms from Seger et al JBC 267:20 14373(1992) Vmax = 150nmol/min/mg From Haystead et al FEBS 306(1):17-22 we get Km=46.6nM for at least one of the phosphs. Putting these together: k3=0.15/sec, scale to get k2=0.6. k1=0.75/46.6nM=2.7e-5 | | 11 | MAPKK* /
MAPKKtyr | Ajay_Bhalla_
2007_ReacDiff1_
1e-13
Accession No. : 82 | MAPK
Pathway No. : 589 | 0.0462964 | 0.3 | 4 | explicit E-S complex | Substrate
MAPK
Product
MAPK-tyr
| | | The actual MAPKK is 2 forms from Seger et al JBC 267:20 14373(1992) Vmax = 150nmol/min/mg From Haystead et al FEBS 306(1):17-22 we get Km=46.6nM for at least one of the phosphs. Putting these together: k3=0.15/sec, scale to get k2=0.6. k1=0.75/46.6nM=2.7e-5 | | 12 | MAPKK* /
MAPKKtyr | Ajay_Bhalla_
2007_ReacDiff1_
1e-13
Accession No. : 82 | MAPK
Pathway No. : 595 | 0.0462964 | 0.3 | 4 | explicit E-S complex | Substrate
MAPK
Product
MAPK-tyr
| | | The actual MAPKK is 2 forms from Seger et al JBC 267:20 14373(1992) Vmax = 150nmol/min/mg From Haystead et al FEBS 306(1):17-22 we get Km=46.6nM for at least one of the phosphs. Putting these together: k3=0.15/sec, scale to get k2=0.6. k1=0.75/46.6nM=2.7e-5 | | 13 | MAPKK* /
MAPKKtyr | Ajay_Bhalla_
2007_ReacDiff1_
1e-13
Accession No. : 82 | MAPK
Pathway No. : 601 | 0.0462964 | 0.3 | 4 | explicit E-S complex | Substrate
MAPK
Product
MAPK-tyr
| | | The actual MAPKK is 2 forms from Seger et al JBC 267:20 14373(1992) Vmax = 150nmol/min/mg From Haystead et al FEBS 306(1):17-22 we get Km=46.6nM for at least one of the phosphs. Putting these together: k3=0.15/sec, scale to get k2=0.6. k1=0.75/46.6nM=2.7e-5 | | 14 | MAPKK* /
MAPKKtyr | Ajay_Bhalla_
2007_ReacDiff1_
1e-13
Accession No. : 82 | MAPK
Pathway No. : 607 | 0.0462964 | 0.3 | 4 | explicit E-S complex | Substrate
MAPK
Product
MAPK-tyr
| | | The actual MAPKK is 2 forms from Seger et al JBC 267:20 14373(1992) Vmax = 150nmol/min/mg From Haystead et al FEBS 306(1):17-22 we get Km=46.6nM for at least one of the phosphs. Putting these together: k3=0.15/sec, scale to get k2=0.6. k1=0.75/46.6nM=2.7e-5 | | 15 | MAPKK* /
MAPKKtyr | Ajay_Bhalla_
2007_ReacDiff1_
1e-13
Accession No. : 82 | MAPK
Pathway No. : 613 | 0.0462964 | 0.3 | 4 | explicit E-S complex | Substrate
MAPK
Product
MAPK-tyr
| | | The actual MAPKK is 2 forms from Seger et al JBC 267:20 14373(1992) Vmax = 150nmol/min/mg From Haystead et al FEBS 306(1):17-22 we get Km=46.6nM for at least one of the phosphs. Putting these together: k3=0.15/sec, scale to get k2=0.6. k1=0.75/46.6nM=2.7e-5 | | 16 | MAPKK* /
MAPKKtyr | Ajay_Bhalla_
2007_ReacDiff1_
1e-13
Accession No. : 82 | MAPK
Pathway No. : 619 | 0.0462964 | 0.3 | 4 | explicit E-S complex | Substrate
MAPK
Product
MAPK-tyr
| | | The actual MAPKK is 2 forms from Seger et al JBC 267:20 14373(1992) Vmax = 150nmol/min/mg From Haystead et al FEBS 306(1):17-22 we get Km=46.6nM for at least one of the phosphs. Putting these together: k3=0.15/sec, scale to get k2=0.6. k1=0.75/46.6nM=2.7e-5 | | 17 | MAPKK* /
MAPKKtyr | Ajay_Bhalla_
2007_ReacDiff1_
1e-13
Accession No. : 82 | MAPK
Pathway No. : 625 | 0.0462964 | 0.3 | 4 | explicit E-S complex | Substrate
MAPK
Product
MAPK-tyr
| | | The actual MAPKK is 2 forms from Seger et al JBC 267:20 14373(1992) Vmax = 150nmol/min/mg From Haystead et al FEBS 306(1):17-22 we get Km=46.6nM for at least one of the phosphs. Putting these together: k3=0.15/sec, scale to get k2=0.6. k1=0.75/46.6nM=2.7e-5 | | 18 | MAPKK* /
MAPKKtyr | Ajay_Bhalla_
2007_ReacDiff1_
1e-13
Accession No. : 82 | MAPK
Pathway No. : 631 | 0.0462964 | 0.3 | 4 | explicit E-S complex | Substrate
MAPK
Product
MAPK-tyr
| | | The actual MAPKK is 2 forms from Seger et al JBC 267:20 14373(1992) Vmax = 150nmol/min/mg From Haystead et al FEBS 306(1):17-22 we get Km=46.6nM for at least one of the phosphs. Putting these together: k3=0.15/sec, scale to get k2=0.6. k1=0.75/46.6nM=2.7e-5 | | 19 | MAPKK* /
MAPKKtyr | Ajay_Bhalla_
2007_ReacDiff1_
1e-13
Accession No. : 82 | MAPK
Pathway No. : 637 | 0.0462964 | 0.3 | 4 | explicit E-S complex | Substrate
MAPK
Product
MAPK-tyr
| | | The actual MAPKK is 2 forms from Seger et al JBC 267:20 14373(1992) Vmax = 150nmol/min/mg From Haystead et al FEBS 306(1):17-22 we get Km=46.6nM for at least one of the phosphs. Putting these together: k3=0.15/sec, scale to get k2=0.6. k1=0.75/46.6nM=2.7e-5 | | 20 | MAPKK* /
MAPKKtyr | Ajay_Bhalla_
2007_ReacDiff1_
1e-13
Accession No. : 82 | MAPK
Pathway No. : 643 | 0.0462964 | 0.3 | 4 | explicit E-S complex | Substrate
MAPK
Product
MAPK-tyr
| | | The actual MAPKK is 2 forms from Seger et al JBC 267:20 14373(1992) Vmax = 150nmol/min/mg From Haystead et al FEBS 306(1):17-22 we get Km=46.6nM for at least one of the phosphs. Putting these together: k3=0.15/sec, scale to get k2=0.6. k1=0.75/46.6nM=2.7e-5 | | 21 | MAPKK* /
MAPKKtyr | Ajay_Bhalla_
2007_ReacDiff1_
1e-13
Accession No. : 82 | MAPK
Pathway No. : 649 | 0.0462964 | 0.3 | 4 | explicit E-S complex | Substrate
MAPK
Product
MAPK-tyr
| | | The actual MAPKK is 2 forms from Seger et al JBC 267:20 14373(1992) Vmax = 150nmol/min/mg From Haystead et al FEBS 306(1):17-22 we get Km=46.6nM for at least one of the phosphs. Putting these together: k3=0.15/sec, scale to get k2=0.6. k1=0.75/46.6nM=2.7e-5 | | 22 | MAPKK* /
MAPKKtyr | Ajay_Bhalla_
2007_ReacDiff1_
1e-13
Accession No. : 82 | MAPK
Pathway No. : 655 | 0.0462964 | 0.3 | 4 | explicit E-S complex | Substrate
MAPK
Product
MAPK-tyr
| | | The actual MAPKK is 2 forms from Seger et al JBC 267:20 14373(1992) Vmax = 150nmol/min/mg From Haystead et al FEBS 306(1):17-22 we get Km=46.6nM for at least one of the phosphs. Putting these together: k3=0.15/sec, scale to get k2=0.6. k1=0.75/46.6nM=2.7e-5 | | 23 | MAPKK* /
MAPKKtyr | Ajay_Bhalla_
2007_ReacDiff1_
1e-13
Accession No. : 82 | MAPK
Pathway No. : 661 | 0.0462964 | 0.3 | 4 | explicit E-S complex | Substrate
MAPK
Product
MAPK-tyr
| | | The actual MAPKK is 2 forms from Seger et al JBC 267:20 14373(1992) Vmax = 150nmol/min/mg From Haystead et al FEBS 306(1):17-22 we get Km=46.6nM for at least one of the phosphs. Putting these together: k3=0.15/sec, scale to get k2=0.6. k1=0.75/46.6nM=2.7e-5 | | 24 | MAPKK* /
MAPKKtyr | Ajay_Bhalla_
2007_ReacDiff1_
1e-13
Accession No. : 82 | MAPK
Pathway No. : 667 | 0.0462964 | 0.3 | 4 | explicit E-S complex | Substrate
MAPK
Product
MAPK-tyr
| | | The actual MAPKK is 2 forms from Seger et al JBC 267:20 14373(1992) Vmax = 150nmol/min/mg From Haystead et al FEBS 306(1):17-22 we get Km=46.6nM for at least one of the phosphs. Putting these together: k3=0.15/sec, scale to get k2=0.6. k1=0.75/46.6nM=2.7e-5 | | 25 | MAPKK* /
MAPKKtyr | Ajay_Bhalla_
2007_ReacDiff1_
1e-13
Accession No. : 82 | MAPK
Pathway No. : 673 | 0.0462964 | 0.3 | 4 | explicit E-S complex | Substrate
MAPK
Product
MAPK-tyr
| | | The actual MAPKK is 2 forms from Seger et al JBC 267:20 14373(1992) Vmax = 150nmol/min/mg From Haystead et al FEBS 306(1):17-22 we get Km=46.6nM for at least one of the phosphs. Putting these together: k3=0.15/sec, scale to get k2=0.6. k1=0.75/46.6nM=2.7e-5 |
MAPK acting as a Product of an Enzyme in Ajay_Bhalla_2007_ReacDiff1_1e-13 Network
| | Enzyme Molecule /
Enzyme Activity | Accession Name | Pathway Name | Km (uM) | kcat (s^-1) | Ratio | Enzyme Type | Reagents | | 1 | MKP-1 /
MKP1-tyr-deph | Ajay_Bhalla_
2007_ReacDiff1_
1e-13
Accession No. : 82 | Shared_Object_
Ajay_Bhalla_
2007_ReacDiff1_
1e-13
Pathway No. : 526 | 7.00003 | 4 | 4 | explicit E-S complex | Substrate
MAPK-tyr
Product
MAPK
| | | The original kinetics have been modified to obey the k2 = 4 * k3 rule, while keeping kcat and Km fixed. As noted in the NOTES, the only constraining data point is the time course of MAPK dephosphorylation, which this model satisfies. It would be nice to have more accurate estimates of rate consts and MKP-1 levels from the literature. Effective Km : 67 nM kcat = 1.43 umol/min/mg | | 2 | MKP-1 /
MKP1-tyr-deph | Ajay_Bhalla_
2007_ReacDiff1_
1e-13
Accession No. : 82 | kinetics
Pathway No. : 533 | 7.00003 | 4 | 4 | explicit E-S complex | Substrate
MAPK-tyr
Product
MAPK
| | | The original kinetics have been modified to obey the k2 = 4 * k3 rule, while keeping kcat and Km fixed. As noted in the NOTES, the only constraining data point is the time course of MAPK dephosphorylation, which this model satisfies. It would be nice to have more accurate estimates of rate consts and MKP-1 levels from the literature. Effective Km : 67 nM kcat = 1.43 umol/min/mg | | 3 | MKP-1 /
MKP1-tyr-deph | Ajay_Bhalla_
2007_ReacDiff1_
1e-13
Accession No. : 82 | kinetics[1]
Pathway No. : 539 | 7.00003 | 4 | 4 | explicit E-S complex | Substrate
MAPK-tyr
Product
MAPK
| | | The original kinetics have been modified to obey the k2 = 4 * k3 rule, while keeping kcat and Km fixed. As noted in the NOTES, the only constraining data point is the time course of MAPK dephosphorylation, which this model satisfies. It would be nice to have more accurate estimates of rate consts and MKP-1 levels from the literature. Effective Km : 67 nM kcat = 1.43 umol/min/mg | | 4 | MKP-1 /
MKP1-tyr-deph | Ajay_Bhalla_
2007_ReacDiff1_
1e-13
Accession No. : 82 | kinetics[2]
Pathway No. : 545 | 7.00003 | 4 | 4 | explicit E-S complex | Substrate
MAPK-tyr
Product
MAPK
| | | The original kinetics have been modified to obey the k2 = 4 * k3 rule, while keeping kcat and Km fixed. As noted in the NOTES, the only constraining data point is the time course of MAPK dephosphorylation, which this model satisfies. It would be nice to have more accurate estimates of rate consts and MKP-1 levels from the literature. Effective Km : 67 nM kcat = 1.43 umol/min/mg | | 5 | MKP-1 /
MKP1-tyr-deph | Ajay_Bhalla_
2007_ReacDiff1_
1e-13
Accession No. : 82 | kinetics[3]
Pathway No. : 551 | 7.00003 | 4 | 4 | explicit E-S complex | Substrate
MAPK-tyr
Product
MAPK
| | | The original kinetics have been modified to obey the k2 = 4 * k3 rule, while keeping kcat and Km fixed. As noted in the NOTES, the only constraining data point is the time course of MAPK dephosphorylation, which this model satisfies. It would be nice to have more accurate estimates of rate consts and MKP-1 levels from the literature. Effective Km : 67 nM kcat = 1.43 umol/min/mg | | 6 | MKP-1 /
MKP1-tyr-deph | Ajay_Bhalla_
2007_ReacDiff1_
1e-13
Accession No. : 82 | kinetics[4]
Pathway No. : 557 | 7.00003 | 4 | 4 | explicit E-S complex | Substrate
MAPK-tyr
Product
MAPK
| | | The original kinetics have been modified to obey the k2 = 4 * k3 rule, while keeping kcat and Km fixed. As noted in the NOTES, the only constraining data point is the time course of MAPK dephosphorylation, which this model satisfies. It would be nice to have more accurate estimates of rate consts and MKP-1 levels from the literature. Effective Km : 67 nM kcat = 1.43 umol/min/mg | | 7 | MKP-1 /
MKP1-tyr-deph | Ajay_Bhalla_
2007_ReacDiff1_
1e-13
Accession No. : 82 | kinetics[5]
Pathway No. : 563 | 7.00003 | 4 | 4 | explicit E-S complex | Substrate
MAPK-tyr
Product
MAPK
| | | The original kinetics have been modified to obey the k2 = 4 * k3 rule, while keeping kcat and Km fixed. As noted in the NOTES, the only constraining data point is the time course of MAPK dephosphorylation, which this model satisfies. It would be nice to have more accurate estimates of rate consts and MKP-1 levels from the literature. Effective Km : 67 nM kcat = 1.43 umol/min/mg | | 8 | MKP-1 /
MKP1-tyr-deph | Ajay_Bhalla_
2007_ReacDiff1_
1e-13
Accession No. : 82 | kinetics[6]
Pathway No. : 567 | 7.00003 | 4 | 4 | explicit E-S complex | Substrate
MAPK-tyr
Product
MAPK
| | | The original kinetics have been modified to obey the k2 = 4 * k3 rule, while keeping kcat and Km fixed. As noted in the NOTES, the only constraining data point is the time course of MAPK dephosphorylation, which this model satisfies. It would be nice to have more accurate estimates of rate consts and MKP-1 levels from the literature. Effective Km : 67 nM kcat = 1.43 umol/min/mg | | 9 | MKP-1 /
MKP1-tyr-deph | Ajay_Bhalla_
2007_ReacDiff1_
1e-13
Accession No. : 82 | kinetics[7]
Pathway No. : 575 | 7.00003 | 4 | 4 | explicit E-S complex | Substrate
MAPK-tyr
Product
MAPK
| | | The original kinetics have been modified to obey the k2 = 4 * k3 rule, while keeping kcat and Km fixed. As noted in the NOTES, the only constraining data point is the time course of MAPK dephosphorylation, which this model satisfies. It would be nice to have more accurate estimates of rate consts and MKP-1 levels from the literature. Effective Km : 67 nM kcat = 1.43 umol/min/mg | | 10 | MKP-1 /
MKP1-tyr-deph | Ajay_Bhalla_
2007_ReacDiff1_
1e-13
Accession No. : 82 | kinetics[8]
Pathway No. : 581 | 7.00003 | 4 | 4 | explicit E-S complex | Substrate
MAPK-tyr
Product
MAPK
| | | The original kinetics have been modified to obey the k2 = 4 * k3 rule, while keeping kcat and Km fixed. As noted in the NOTES, the only constraining data point is the time course of MAPK dephosphorylation, which this model satisfies. It would be nice to have more accurate estimates of rate consts and MKP-1 levels from the literature. Effective Km : 67 nM kcat = 1.43 umol/min/mg | | 11 | MKP-1 /
MKP1-tyr-deph | Ajay_Bhalla_
2007_ReacDiff1_
1e-13
Accession No. : 82 | kinetics[9]
Pathway No. : 587 | 7.00003 | 4 | 4 | explicit E-S complex | Substrate
MAPK-tyr
Product
MAPK
| | | The original kinetics have been modified to obey the k2 = 4 * k3 rule, while keeping kcat and Km fixed. As noted in the NOTES, the only constraining data point is the time course of MAPK dephosphorylation, which this model satisfies. It would be nice to have more accurate estimates of rate consts and MKP-1 levels from the literature. Effective Km : 67 nM kcat = 1.43 umol/min/mg | | 12 | MKP-1 /
MKP1-tyr-deph | Ajay_Bhalla_
2007_ReacDiff1_
1e-13
Accession No. : 82 | kinetics[10]
Pathway No. : 593 | 7.00003 | 4 | 4 | explicit E-S complex | Substrate
MAPK-tyr
Product
MAPK
| | | The original kinetics have been modified to obey the k2 = 4 * k3 rule, while keeping kcat and Km fixed. As noted in the NOTES, the only constraining data point is the time course of MAPK dephosphorylation, which this model satisfies. It would be nice to have more accurate estimates of rate consts and MKP-1 levels from the literature. Effective Km : 67 nM kcat = 1.43 umol/min/mg | | 13 | MKP-1 /
MKP1-tyr-deph | Ajay_Bhalla_
2007_ReacDiff1_
1e-13
Accession No. : 82 | kinetics[11]
Pathway No. : 599 | 7.00003 | 4 | 4 | explicit E-S complex | Substrate
MAPK-tyr
Product
MAPK
| | | The original kinetics have been modified to obey the k2 = 4 * k3 rule, while keeping kcat and Km fixed. As noted in the NOTES, the only constraining data point is the time course of MAPK dephosphorylation, which this model satisfies. It would be nice to have more accurate estimates of rate consts and MKP-1 levels from the literature. Effective Km : 67 nM kcat = 1.43 umol/min/mg | | 14 | MKP-1 /
MKP1-tyr-deph | Ajay_Bhalla_
2007_ReacDiff1_
1e-13
Accession No. : 82 | kinetics[12]
Pathway No. : 605 | 7.00003 | 4 | 4 | explicit E-S complex | Substrate
MAPK-tyr
Product
MAPK
| | | The original kinetics have been modified to obey the k2 = 4 * k3 rule, while keeping kcat and Km fixed. As noted in the NOTES, the only constraining data point is the time course of MAPK dephosphorylation, which this model satisfies. It would be nice to have more accurate estimates of rate consts and MKP-1 levels from the literature. Effective Km : 67 nM kcat = 1.43 umol/min/mg | | 15 | MKP-1 /
MKP1-tyr-deph | Ajay_Bhalla_
2007_ReacDiff1_
1e-13
Accession No. : 82 | kinetics[13]
Pathway No. : 611 | 7.00003 | 4 | 4 | explicit E-S complex | Substrate
MAPK-tyr
Product
MAPK
| | | The original kinetics have been modified to obey the k2 = 4 * k3 rule, while keeping kcat and Km fixed. As noted in the NOTES, the only constraining data point is the time course of MAPK dephosphorylation, which this model satisfies. It would be nice to have more accurate estimates of rate consts and MKP-1 levels from the literature. Effective Km : 67 nM kcat = 1.43 umol/min/mg | | 16 | MKP-1 /
MKP1-tyr-deph | Ajay_Bhalla_
2007_ReacDiff1_
1e-13
Accession No. : 82 | kinetics[14]
Pathway No. : 617 | 7.00003 | 4 | 4 | explicit E-S complex | Substrate
MAPK-tyr
Product
MAPK
| | | The original kinetics have been modified to obey the k2 = 4 * k3 rule, while keeping kcat and Km fixed. As noted in the NOTES, the only constraining data point is the time course of MAPK dephosphorylation, which this model satisfies. It would be nice to have more accurate estimates of rate consts and MKP-1 levels from the literature. Effective Km : 67 nM kcat = 1.43 umol/min/mg | | 17 | MKP-1 /
MKP1-tyr-deph | Ajay_Bhalla_
2007_ReacDiff1_
1e-13
Accession No. : 82 | kinetics[15]
Pathway No. : 623 | 7.00003 | 4 | 4 | explicit E-S complex | Substrate
MAPK-tyr
Product
MAPK
| | | The original kinetics have been modified to obey the k2 = 4 * k3 rule, while keeping kcat and Km fixed. As noted in the NOTES, the only constraining data point is the time course of MAPK dephosphorylation, which this model satisfies. It would be nice to have more accurate estimates of rate consts and MKP-1 levels from the literature. Effective Km : 67 nM kcat = 1.43 umol/min/mg | | 18 | MKP-1 /
MKP1-tyr-deph | Ajay_Bhalla_
2007_ReacDiff1_
1e-13
Accession No. : 82 | kinetics[16]
Pathway No. : 629 | 7.00003 | 4 | 4 | explicit E-S complex | Substrate
MAPK-tyr
Product
MAPK
| | | The original kinetics have been modified to obey the k2 = 4 * k3 rule, while keeping kcat and Km fixed. As noted in the NOTES, the only constraining data point is the time course of MAPK dephosphorylation, which this model satisfies. It would be nice to have more accurate estimates of rate consts and MKP-1 levels from the literature. Effective Km : 67 nM kcat = 1.43 umol/min/mg | | 19 | MKP-1 /
MKP1-tyr-deph | Ajay_Bhalla_
2007_ReacDiff1_
1e-13
Accession No. : 82 | kinetics[17]
Pathway No. : 635 | 7.00003 | 4 | 4 | explicit E-S complex | Substrate
MAPK-tyr
Product
MAPK
| | | The original kinetics have been modified to obey the k2 = 4 * k3 rule, while keeping kcat and Km fixed. As noted in the NOTES, the only constraining data point is the time course of MAPK dephosphorylation, which this model satisfies. It would be nice to have more accurate estimates of rate consts and MKP-1 levels from the literature. Effective Km : 67 nM kcat = 1.43 umol/min/mg | | 20 | MKP-1 /
MKP1-tyr-deph | Ajay_Bhalla_
2007_ReacDiff1_
1e-13
Accession No. : 82 | kinetics[18]
Pathway No. : 641 | 7.00003 | 4 | 4 | explicit E-S complex | Substrate
MAPK-tyr
Product
MAPK
| | | The original kinetics have been modified to obey the k2 = 4 * k3 rule, while keeping kcat and Km fixed. As noted in the NOTES, the only constraining data point is the time course of MAPK dephosphorylation, which this model satisfies. It would be nice to have more accurate estimates of rate consts and MKP-1 levels from the literature. Effective Km : 67 nM kcat = 1.43 umol/min/mg | | 21 | MKP-1 /
MKP1-tyr-deph | Ajay_Bhalla_
2007_ReacDiff1_
1e-13
Accession No. : 82 | kinetics[19]
Pathway No. : 647 | 7.00003 | 4 | 4 | explicit E-S complex | Substrate
MAPK-tyr
Product
MAPK
| | | The original kinetics have been modified to obey the k2 = 4 * k3 rule, while keeping kcat and Km fixed. As noted in the NOTES, the only constraining data point is the time course of MAPK dephosphorylation, which this model satisfies. It would be nice to have more accurate estimates of rate consts and MKP-1 levels from the literature. Effective Km : 67 nM kcat = 1.43 umol/min/mg | | 22 | MKP-1 /
MKP1-tyr-deph | Ajay_Bhalla_
2007_ReacDiff1_
1e-13
Accession No. : 82 | kinetics[20]
Pathway No. : 653 | 7.00003 | 4 | 4 | explicit E-S complex | Substrate
MAPK-tyr
Product
MAPK
| | | The original kinetics have been modified to obey the k2 = 4 * k3 rule, while keeping kcat and Km fixed. As noted in the NOTES, the only constraining data point is the time course of MAPK dephosphorylation, which this model satisfies. It would be nice to have more accurate estimates of rate consts and MKP-1 levels from the literature. Effective Km : 67 nM kcat = 1.43 umol/min/mg | | 23 | MKP-1 /
MKP1-tyr-deph | Ajay_Bhalla_
2007_ReacDiff1_
1e-13
Accession No. : 82 | kinetics[21]
Pathway No. : 659 | 7.00003 | 4 | 4 | explicit E-S complex | Substrate
MAPK-tyr
Product
MAPK
| | | The original kinetics have been modified to obey the k2 = 4 * k3 rule, while keeping kcat and Km fixed. As noted in the NOTES, the only constraining data point is the time course of MAPK dephosphorylation, which this model satisfies. It would be nice to have more accurate estimates of rate consts and MKP-1 levels from the literature. Effective Km : 67 nM kcat = 1.43 umol/min/mg | | 24 | MKP-1 /
MKP1-tyr-deph | Ajay_Bhalla_
2007_ReacDiff1_
1e-13
Accession No. : 82 | kinetics[22]
Pathway No. : 665 | 7.00003 | 4 | 4 | explicit E-S complex | Substrate
MAPK-tyr
Product
MAPK
| | | The original kinetics have been modified to obey the k2 = 4 * k3 rule, while keeping kcat and Km fixed. As noted in the NOTES, the only constraining data point is the time course of MAPK dephosphorylation, which this model satisfies. It would be nice to have more accurate estimates of rate consts and MKP-1 levels from the literature. Effective Km : 67 nM kcat = 1.43 umol/min/mg | | 25 | MKP-1 /
MKP1-tyr-deph | Ajay_Bhalla_
2007_ReacDiff1_
1e-13
Accession No. : 82 | kinetics[23]
Pathway No. : 671 | 7.00003 | 4 | 4 | explicit E-S complex | Substrate
MAPK-tyr
Product
MAPK
| | | The original kinetics have been modified to obey the k2 = 4 * k3 rule, while keeping kcat and Km fixed. As noted in the NOTES, the only constraining data point is the time course of MAPK dephosphorylation, which this model satisfies. It would be nice to have more accurate estimates of rate consts and MKP-1 levels from the literature. Effective Km : 67 nM kcat = 1.43 umol/min/mg |
MAPK acting as a Substrate in a reaction in Ajay_Bhalla_2007_ReacDiff1_1e-13 Network
| Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated.
Kd for higher order reaction are not consider. |
MAPK acting as a Product in a reaction in Ajay_Bhalla_2007_ReacDiff1_1e-13 Network
| Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated.
Kd for higher order reaction are not consider. |
| Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
This Copyright is applied to ensure that the contents of this database remain freely available. Please see FAQ for details. |
|
