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Molecule Parameter List for Raf-GTP-Ras

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by

color.

Statistics

*Raf-GTP-Ras* participated as	Molecule	Sum total of	Enzyme	Substrate of an enzyme	Product of an enzyme	Substrate in Reaction	Product in Reaction
No. of occurrences	25	0	50	0	0	0	25

Accession and Pathway Details

Accession Name	Accession No.	Accession Type	Pathway Link
Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13	82	Network	Shared_Object_Ajay_Bhalla_2007_ReacDiff1_1e-13, PKC, MAPK, Ras, CaM, PKM, chain, kinetics, PKC, MAPK, Ras, CaM, PKM, kinetics[1], PKC, MAPK, Ras, CaM, PKM, kinetics[2], PKC, MAPK, Ras, CaM, PKM, kinetics[3], PKC, MAPK, Ras, CaM, PKM, kinetics[4], PKC, MAPK, Ras, CaM, PKM, kinetics[5], PKC, MAPK, Ras, kinetics[6], CaM, PKM, PKC, MAPK, Ras, CaM, PKM, kinetics[7], PKC, MAPK, Ras, CaM, PKM, kinetics[8], PKC, MAPK, Ras, CaM, PKM, kinetics[9], PKC, MAPK, Ras, CaM, PKM, kinetics[10], PKC, MAPK, Ras, CaM, PKM, kinetics[11], PKC, MAPK, Ras, CaM, PKM, kinetics[12], PKC, MAPK, Ras, CaM, PKM, kinetics[13], PKC, MAPK, Ras, CaM, PKM, kinetics[14], PKC, MAPK, Ras, CaM, PKM, kinetics[15], PKC, MAPK, Ras, CaM, PKM, kinetics[16], PKC, MAPK, Ras, CaM, PKM, kinetics[17], PKC, MAPK, Ras, CaM, PKM, kinetics[18], PKC, MAPK, Ras, CaM, PKM, kinetics[19], PKC, MAPK, Ras, CaM, PKM, kinetics[20], PKC, MAPK, Ras, CaM, PKM, kinetics[21], PKC, MAPK, Ras, CaM, PKM, kinetics[22], PKC, MAPK, Ras, CaM, PKM, kinetics[23], PKC, MAPK, Ras, CaM, PKM
This is a 25-compartment reaction-diffusion version of the Ajay_Bhalla_2007_PKM model. The original single-compartment model is repeated 25 times. In addition, a subset (27 out of 42) molecules can diffuse between compartments. Diffusion is implemented as a reaction between corresponding molecules in neighboring compartments. For D = 1e-12 m^2/sec (i.e., 1 micron^2/sec ) the kf and kb of this reaction for these 10 micron compartments are both 0.01/sec. For D = 1e-13 m^2/sec (i.e., 0.1 micron^2/sec ) the kf and kb are 0.001/sec. The stimulus file pkm_mapk22_diff_1e-13_Fig4B which was used for the model to replicate Figure 4B from the paper. pkm_mapk22_diff_1e-13_Fig4H replicate Figure 4H. pkm_mapk22_diff_1e-13_Fig4I replicate Figure 4I.

Raf-GTP-Ras acting as a Molecule in Ajay_Bhalla_2007_ReacDiff1_1e-13 Network

Name	Accession Name	Pathway Name	Initial Conc. (uM)	Volume (fL)	Buffered
Raf-GTP-Ras	Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82	MAPK Pathway No. : 528	0	1.5	No
Raf-GTP-Ras	Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82	MAPK Pathway No. : 535	0	1.5	No
Raf-GTP-Ras	Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82	MAPK Pathway No. : 541	0	1.5	No
Raf-GTP-Ras	Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82	MAPK Pathway No. : 547	0	1.5	No
Raf-GTP-Ras	Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82	MAPK Pathway No. : 553	0	1.5	No
Raf-GTP-Ras	Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82	MAPK Pathway No. : 559	0	1.5	No
Raf-GTP-Ras	Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82	MAPK Pathway No. : 565	0	1.5	No
Raf-GTP-Ras	Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82	MAPK Pathway No. : 571	0	1.5	No
Raf-GTP-Ras	Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82	MAPK Pathway No. : 577	0	1.5	No
Raf-GTP-Ras	Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82	MAPK Pathway No. : 583	0	1.5	No
Raf-GTP-Ras	Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82	MAPK Pathway No. : 589	0	1.5	No
Raf-GTP-Ras	Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82	MAPK Pathway No. : 595	0	1.5	No
Raf-GTP-Ras	Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82	MAPK Pathway No. : 601	0	1.5	No
Raf-GTP-Ras	Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82	MAPK Pathway No. : 607	0	1.5	No
Raf-GTP-Ras	Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82	MAPK Pathway No. : 613	0	1.5	No
Raf-GTP-Ras	Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82	MAPK Pathway No. : 619	0	1.5	No
Raf-GTP-Ras	Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82	MAPK Pathway No. : 625	0	1.5	No
Raf-GTP-Ras	Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82	MAPK Pathway No. : 631	0	1.5	No
Raf-GTP-Ras	Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82	MAPK Pathway No. : 637	0	1.5	No
Raf-GTP-Ras	Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82	MAPK Pathway No. : 643	0	1.5	No
Raf-GTP-Ras	Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82	MAPK Pathway No. : 649	0	1.5	No
Raf-GTP-Ras	Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82	MAPK Pathway No. : 655	0	1.5	No
Raf-GTP-Ras	Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82	MAPK Pathway No. : 661	0	1.5	No
Raf-GTP-Ras	Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82	MAPK Pathway No. : 667	0	1.5	No
Raf-GTP-Ras	Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82	MAPK Pathway No. : 673	0	1.5	No

Raf-GTP-Ras acting as an Enzyme in Ajay_Bhalla_2007_ReacDiff1_1e-13 Network

	Enzyme Molecule / Enzyme Activity	Accession Name	Pathway Name	Km (uM)	kcat (s^-1)	Ratio	Enzyme Type	Reagents
1	Raf-GTP-Ras / Raf-GTP-Ras.1	Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82	MAPK Pathway No. : 528	0.159096	0.3	4	explicit E-S complex	Substrate MAPKK Product MAPKK-ser
	Kinetics are the same as for the craf_1* activity, ie., k1=5.5e-6, k2=0.42, k3 = 0.105 These are basedo n Force et al PNAS USA 91 1270-1274, 1994., but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here and for craf_1* activity: Km = 0.1591).
2	Raf-GTP-Ras / Raf-GTP-Ras.2	Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82	MAPK Pathway No. : 528	0.159096	0.3	4	explicit E-S complex	Substrate MAPKK-ser Product MAPKK*
	Kinetics are the same as for the craf_1* activity, ie., k1=5.5e-6, k2=0.42, k3 = 0.105 These are basedo n Force et al PNAS USA 91 1270-1274, 1994., but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here and for craf_1* activity: Km = 0.1591).
3	Raf-GTP-Ras / Raf-GTP-Ras.1	Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82	MAPK Pathway No. : 535	0.159096	0.3	4	explicit E-S complex	Substrate MAPKK Product MAPKK-ser
	Kinetics are the same as for the craf_1* activity, ie., k1=5.5e-6, k2=0.42, k3 = 0.105 These are basedo n Force et al PNAS USA 91 1270-1274, 1994., but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here and for craf_1* activity: Km = 0.1591).
4	Raf-GTP-Ras / Raf-GTP-Ras.2	Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82	MAPK Pathway No. : 535	0.159096	0.3	4	explicit E-S complex	Substrate MAPKK-ser Product MAPKK*
	Kinetics are the same as for the craf_1* activity, ie., k1=5.5e-6, k2=0.42, k3 = 0.105 These are basedo n Force et al PNAS USA 91 1270-1274, 1994., but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here and for craf_1* activity: Km = 0.1591).
5	Raf-GTP-Ras / Raf-GTP-Ras.1	Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82	MAPK Pathway No. : 541	0.159096	0.3	4	explicit E-S complex	Substrate MAPKK Product MAPKK-ser
	Kinetics are the same as for the craf_1* activity, ie., k1=5.5e-6, k2=0.42, k3 = 0.105 These are basedo n Force et al PNAS USA 91 1270-1274, 1994., but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here and for craf_1* activity: Km = 0.1591).
6	Raf-GTP-Ras / Raf-GTP-Ras.2	Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82	MAPK Pathway No. : 541	0.159096	0.3	4	explicit E-S complex	Substrate MAPKK-ser Product MAPKK*
	Kinetics are the same as for the craf_1* activity, ie., k1=5.5e-6, k2=0.42, k3 = 0.105 These are basedo n Force et al PNAS USA 91 1270-1274, 1994., but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here and for craf_1* activity: Km = 0.1591).
7	Raf-GTP-Ras / Raf-GTP-Ras.1	Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82	MAPK Pathway No. : 547	0.159096	0.3	4	explicit E-S complex	Substrate MAPKK Product MAPKK-ser
	Kinetics are the same as for the craf_1* activity, ie., k1=5.5e-6, k2=0.42, k3 = 0.105 These are basedo n Force et al PNAS USA 91 1270-1274, 1994., but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here and for craf_1* activity: Km = 0.1591).
8	Raf-GTP-Ras / Raf-GTP-Ras.2	Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82	MAPK Pathway No. : 547	0.159096	0.3	4	explicit E-S complex	Substrate MAPKK-ser Product MAPKK*
	Kinetics are the same as for the craf_1* activity, ie., k1=5.5e-6, k2=0.42, k3 = 0.105 These are basedo n Force et al PNAS USA 91 1270-1274, 1994., but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here and for craf_1* activity: Km = 0.1591).
9	Raf-GTP-Ras / Raf-GTP-Ras.1	Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82	MAPK Pathway No. : 553	0.159096	0.3	4	explicit E-S complex	Substrate MAPKK Product MAPKK-ser
	Kinetics are the same as for the craf_1* activity, ie., k1=5.5e-6, k2=0.42, k3 = 0.105 These are basedo n Force et al PNAS USA 91 1270-1274, 1994., but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here and for craf_1* activity: Km = 0.1591).
10	Raf-GTP-Ras / Raf-GTP-Ras.2	Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82	MAPK Pathway No. : 553	0.159096	0.3	4	explicit E-S complex	Substrate MAPKK-ser Product MAPKK*
	Kinetics are the same as for the craf_1* activity, ie., k1=5.5e-6, k2=0.42, k3 = 0.105 These are basedo n Force et al PNAS USA 91 1270-1274, 1994., but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here and for craf_1* activity: Km = 0.1591).
11	Raf-GTP-Ras / Raf-GTP-Ras.1	Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82	MAPK Pathway No. : 559	0.159096	0.3	4	explicit E-S complex	Substrate MAPKK Product MAPKK-ser
	Kinetics are the same as for the craf_1* activity, ie., k1=5.5e-6, k2=0.42, k3 = 0.105 These are basedo n Force et al PNAS USA 91 1270-1274, 1994., but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here and for craf_1* activity: Km = 0.1591).
12	Raf-GTP-Ras / Raf-GTP-Ras.2	Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82	MAPK Pathway No. : 559	0.159096	0.3	4	explicit E-S complex	Substrate MAPKK-ser Product MAPKK*
	Kinetics are the same as for the craf_1* activity, ie., k1=5.5e-6, k2=0.42, k3 = 0.105 These are basedo n Force et al PNAS USA 91 1270-1274, 1994., but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here and for craf_1* activity: Km = 0.1591).
13	Raf-GTP-Ras / Raf-GTP-Ras.1	Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82	MAPK Pathway No. : 565	0.159096	0.3	4	explicit E-S complex	Substrate MAPKK Product MAPKK-ser
	Kinetics are the same as for the craf_1* activity, ie., k1=5.5e-6, k2=0.42, k3 = 0.105 These are basedo n Force et al PNAS USA 91 1270-1274, 1994., but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here and for craf_1* activity: Km = 0.1591).
14	Raf-GTP-Ras / Raf-GTP-Ras.2	Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82	MAPK Pathway No. : 565	0.159096	0.3	4	explicit E-S complex	Substrate MAPKK-ser Product MAPKK*
	Kinetics are the same as for the craf_1* activity, ie., k1=5.5e-6, k2=0.42, k3 = 0.105 These are basedo n Force et al PNAS USA 91 1270-1274, 1994., but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here and for craf_1* activity: Km = 0.1591).
15	Raf-GTP-Ras / Raf-GTP-Ras.1	Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82	MAPK Pathway No. : 571	0.159096	0.3	4	explicit E-S complex	Substrate MAPKK Product MAPKK-ser
	Kinetics are the same as for the craf_1* activity, ie., k1=5.5e-6, k2=0.42, k3 = 0.105 These are basedo n Force et al PNAS USA 91 1270-1274, 1994., but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here and for craf_1* activity: Km = 0.1591).
16	Raf-GTP-Ras / Raf-GTP-Ras.2	Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82	MAPK Pathway No. : 571	0.159096	0.3	4	explicit E-S complex	Substrate MAPKK-ser Product MAPKK*
	Kinetics are the same as for the craf_1* activity, ie., k1=5.5e-6, k2=0.42, k3 = 0.105 These are basedo n Force et al PNAS USA 91 1270-1274, 1994., but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here and for craf_1* activity: Km = 0.1591).
17	Raf-GTP-Ras / Raf-GTP-Ras.1	Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82	MAPK Pathway No. : 577	0.159096	0.3	4	explicit E-S complex	Substrate MAPKK Product MAPKK-ser
	Kinetics are the same as for the craf_1* activity, ie., k1=5.5e-6, k2=0.42, k3 = 0.105 These are basedo n Force et al PNAS USA 91 1270-1274, 1994., but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here and for craf_1* activity: Km = 0.1591).
18	Raf-GTP-Ras / Raf-GTP-Ras.2	Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82	MAPK Pathway No. : 577	0.159096	0.3	4	explicit E-S complex	Substrate MAPKK-ser Product MAPKK*
	Kinetics are the same as for the craf_1* activity, ie., k1=5.5e-6, k2=0.42, k3 = 0.105 These are basedo n Force et al PNAS USA 91 1270-1274, 1994., but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here and for craf_1* activity: Km = 0.1591).
19	Raf-GTP-Ras / Raf-GTP-Ras.1	Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82	MAPK Pathway No. : 583	0.159096	0.3	4	explicit E-S complex	Substrate MAPKK Product MAPKK-ser
	Kinetics are the same as for the craf_1* activity, ie., k1=5.5e-6, k2=0.42, k3 = 0.105 These are basedo n Force et al PNAS USA 91 1270-1274, 1994., but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here and for craf_1* activity: Km = 0.1591).
20	Raf-GTP-Ras / Raf-GTP-Ras.2	Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82	MAPK Pathway No. : 583	0.159096	0.3	4	explicit E-S complex	Substrate MAPKK-ser Product MAPKK*
	Kinetics are the same as for the craf_1* activity, ie., k1=5.5e-6, k2=0.42, k3 = 0.105 These are basedo n Force et al PNAS USA 91 1270-1274, 1994., but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here and for craf_1* activity: Km = 0.1591).
21	Raf-GTP-Ras / Raf-GTP-Ras.1	Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82	MAPK Pathway No. : 589	0.159096	0.3	4	explicit E-S complex	Substrate MAPKK Product MAPKK-ser
	Kinetics are the same as for the craf_1* activity, ie., k1=5.5e-6, k2=0.42, k3 = 0.105 These are basedo n Force et al PNAS USA 91 1270-1274, 1994., but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here and for craf_1* activity: Km = 0.1591).
22	Raf-GTP-Ras / Raf-GTP-Ras.2	Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82	MAPK Pathway No. : 589	0.159096	0.3	4	explicit E-S complex	Substrate MAPKK-ser Product MAPKK*
	Kinetics are the same as for the craf_1* activity, ie., k1=5.5e-6, k2=0.42, k3 = 0.105 These are basedo n Force et al PNAS USA 91 1270-1274, 1994., but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here and for craf_1* activity: Km = 0.1591).
23	Raf-GTP-Ras / Raf-GTP-Ras.1	Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82	MAPK Pathway No. : 595	0.159096	0.3	4	explicit E-S complex	Substrate MAPKK Product MAPKK-ser
	Kinetics are the same as for the craf_1* activity, ie., k1=5.5e-6, k2=0.42, k3 = 0.105 These are basedo n Force et al PNAS USA 91 1270-1274, 1994., but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here and for craf_1* activity: Km = 0.1591).
24	Raf-GTP-Ras / Raf-GTP-Ras.2	Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82	MAPK Pathway No. : 595	0.159096	0.3	4	explicit E-S complex	Substrate MAPKK-ser Product MAPKK*
	Kinetics are the same as for the craf_1* activity, ie., k1=5.5e-6, k2=0.42, k3 = 0.105 These are basedo n Force et al PNAS USA 91 1270-1274, 1994., but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here and for craf_1* activity: Km = 0.1591).
25	Raf-GTP-Ras / Raf-GTP-Ras.1	Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82	MAPK Pathway No. : 601	0.159096	0.3	4	explicit E-S complex	Substrate MAPKK Product MAPKK-ser
	Kinetics are the same as for the craf_1* activity, ie., k1=5.5e-6, k2=0.42, k3 = 0.105 These are basedo n Force et al PNAS USA 91 1270-1274, 1994., but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here and for craf_1* activity: Km = 0.1591).
26	Raf-GTP-Ras / Raf-GTP-Ras.2	Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82	MAPK Pathway No. : 601	0.159096	0.3	4	explicit E-S complex	Substrate MAPKK-ser Product MAPKK*
	Kinetics are the same as for the craf_1* activity, ie., k1=5.5e-6, k2=0.42, k3 = 0.105 These are basedo n Force et al PNAS USA 91 1270-1274, 1994., but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here and for craf_1* activity: Km = 0.1591).
27	Raf-GTP-Ras / Raf-GTP-Ras.1	Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82	MAPK Pathway No. : 607	0.159096	0.3	4	explicit E-S complex	Substrate MAPKK Product MAPKK-ser
	Kinetics are the same as for the craf_1* activity, ie., k1=5.5e-6, k2=0.42, k3 = 0.105 These are basedo n Force et al PNAS USA 91 1270-1274, 1994., but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here and for craf_1* activity: Km = 0.1591).
28	Raf-GTP-Ras / Raf-GTP-Ras.2	Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82	MAPK Pathway No. : 607	0.159096	0.3	4	explicit E-S complex	Substrate MAPKK-ser Product MAPKK*
	Kinetics are the same as for the craf_1* activity, ie., k1=5.5e-6, k2=0.42, k3 = 0.105 These are basedo n Force et al PNAS USA 91 1270-1274, 1994., but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here and for craf_1* activity: Km = 0.1591).
29	Raf-GTP-Ras / Raf-GTP-Ras.1	Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82	MAPK Pathway No. : 613	0.159096	0.3	4	explicit E-S complex	Substrate MAPKK Product MAPKK-ser
	Kinetics are the same as for the craf_1* activity, ie., k1=5.5e-6, k2=0.42, k3 = 0.105 These are basedo n Force et al PNAS USA 91 1270-1274, 1994., but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here and for craf_1* activity: Km = 0.1591).
30	Raf-GTP-Ras / Raf-GTP-Ras.2	Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82	MAPK Pathway No. : 613	0.159096	0.3	4	explicit E-S complex	Substrate MAPKK-ser Product MAPKK*
	Kinetics are the same as for the craf_1* activity, ie., k1=5.5e-6, k2=0.42, k3 = 0.105 These are basedo n Force et al PNAS USA 91 1270-1274, 1994., but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here and for craf_1* activity: Km = 0.1591).
31	Raf-GTP-Ras / Raf-GTP-Ras.1	Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82	MAPK Pathway No. : 619	0.159096	0.3	4	explicit E-S complex	Substrate MAPKK Product MAPKK-ser
	Kinetics are the same as for the craf_1* activity, ie., k1=5.5e-6, k2=0.42, k3 = 0.105 These are basedo n Force et al PNAS USA 91 1270-1274, 1994., but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here and for craf_1* activity: Km = 0.1591).
32	Raf-GTP-Ras / Raf-GTP-Ras.2	Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82	MAPK Pathway No. : 619	0.159096	0.3	4	explicit E-S complex	Substrate MAPKK-ser Product MAPKK*
	Kinetics are the same as for the craf_1* activity, ie., k1=5.5e-6, k2=0.42, k3 = 0.105 These are basedo n Force et al PNAS USA 91 1270-1274, 1994., but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here and for craf_1* activity: Km = 0.1591).
33	Raf-GTP-Ras / Raf-GTP-Ras.1	Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82	MAPK Pathway No. : 625	0.159096	0.3	4	explicit E-S complex	Substrate MAPKK Product MAPKK-ser
	Kinetics are the same as for the craf_1* activity, ie., k1=5.5e-6, k2=0.42, k3 = 0.105 These are basedo n Force et al PNAS USA 91 1270-1274, 1994., but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here and for craf_1* activity: Km = 0.1591).
34	Raf-GTP-Ras / Raf-GTP-Ras.2	Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82	MAPK Pathway No. : 625	0.159096	0.3	4	explicit E-S complex	Substrate MAPKK-ser Product MAPKK*
	Kinetics are the same as for the craf_1* activity, ie., k1=5.5e-6, k2=0.42, k3 = 0.105 These are basedo n Force et al PNAS USA 91 1270-1274, 1994., but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here and for craf_1* activity: Km = 0.1591).
35	Raf-GTP-Ras / Raf-GTP-Ras.1	Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82	MAPK Pathway No. : 631	0.159096	0.3	4	explicit E-S complex	Substrate MAPKK Product MAPKK-ser
	Kinetics are the same as for the craf_1* activity, ie., k1=5.5e-6, k2=0.42, k3 = 0.105 These are basedo n Force et al PNAS USA 91 1270-1274, 1994., but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here and for craf_1* activity: Km = 0.1591).
36	Raf-GTP-Ras / Raf-GTP-Ras.2	Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82	MAPK Pathway No. : 631	0.159096	0.3	4	explicit E-S complex	Substrate MAPKK-ser Product MAPKK*
	Kinetics are the same as for the craf_1* activity, ie., k1=5.5e-6, k2=0.42, k3 = 0.105 These are basedo n Force et al PNAS USA 91 1270-1274, 1994., but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here and for craf_1* activity: Km = 0.1591).
37	Raf-GTP-Ras / Raf-GTP-Ras.1	Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82	MAPK Pathway No. : 637	0.159096	0.3	4	explicit E-S complex	Substrate MAPKK Product MAPKK-ser
	Kinetics are the same as for the craf_1* activity, ie., k1=5.5e-6, k2=0.42, k3 = 0.105 These are basedo n Force et al PNAS USA 91 1270-1274, 1994., but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here and for craf_1* activity: Km = 0.1591).
38	Raf-GTP-Ras / Raf-GTP-Ras.2	Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82	MAPK Pathway No. : 637	0.159096	0.3	4	explicit E-S complex	Substrate MAPKK-ser Product MAPKK*
	Kinetics are the same as for the craf_1* activity, ie., k1=5.5e-6, k2=0.42, k3 = 0.105 These are basedo n Force et al PNAS USA 91 1270-1274, 1994., but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here and for craf_1* activity: Km = 0.1591).
39	Raf-GTP-Ras / Raf-GTP-Ras.1	Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82	MAPK Pathway No. : 643	0.159096	0.3	4	explicit E-S complex	Substrate MAPKK Product MAPKK-ser
	Kinetics are the same as for the craf_1* activity, ie., k1=5.5e-6, k2=0.42, k3 = 0.105 These are basedo n Force et al PNAS USA 91 1270-1274, 1994., but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here and for craf_1* activity: Km = 0.1591).
40	Raf-GTP-Ras / Raf-GTP-Ras.2	Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82	MAPK Pathway No. : 643	0.159096	0.3	4	explicit E-S complex	Substrate MAPKK-ser Product MAPKK*
	Kinetics are the same as for the craf_1* activity, ie., k1=5.5e-6, k2=0.42, k3 = 0.105 These are basedo n Force et al PNAS USA 91 1270-1274, 1994., but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here and for craf_1* activity: Km = 0.1591).
41	Raf-GTP-Ras / Raf-GTP-Ras.1	Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82	MAPK Pathway No. : 649	0.159096	0.3	4	explicit E-S complex	Substrate MAPKK Product MAPKK-ser
	Kinetics are the same as for the craf_1* activity, ie., k1=5.5e-6, k2=0.42, k3 = 0.105 These are basedo n Force et al PNAS USA 91 1270-1274, 1994., but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here and for craf_1* activity: Km = 0.1591).
42	Raf-GTP-Ras / Raf-GTP-Ras.2	Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82	MAPK Pathway No. : 649	0.159096	0.3	4	explicit E-S complex	Substrate MAPKK-ser Product MAPKK*
	Kinetics are the same as for the craf_1* activity, ie., k1=5.5e-6, k2=0.42, k3 = 0.105 These are basedo n Force et al PNAS USA 91 1270-1274, 1994., but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here and for craf_1* activity: Km = 0.1591).
43	Raf-GTP-Ras / Raf-GTP-Ras.1	Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82	MAPK Pathway No. : 655	0.159096	0.3	4	explicit E-S complex	Substrate MAPKK Product MAPKK-ser
	Kinetics are the same as for the craf_1* activity, ie., k1=5.5e-6, k2=0.42, k3 = 0.105 These are basedo n Force et al PNAS USA 91 1270-1274, 1994., but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here and for craf_1* activity: Km = 0.1591).
44	Raf-GTP-Ras / Raf-GTP-Ras.2	Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82	MAPK Pathway No. : 655	0.159096	0.3	4	explicit E-S complex	Substrate MAPKK-ser Product MAPKK*
	Kinetics are the same as for the craf_1* activity, ie., k1=5.5e-6, k2=0.42, k3 = 0.105 These are basedo n Force et al PNAS USA 91 1270-1274, 1994., but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here and for craf_1* activity: Km = 0.1591).
45	Raf-GTP-Ras / Raf-GTP-Ras.1	Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82	MAPK Pathway No. : 661	0.159096	0.3	4	explicit E-S complex	Substrate MAPKK Product MAPKK-ser
	Kinetics are the same as for the craf_1* activity, ie., k1=5.5e-6, k2=0.42, k3 = 0.105 These are basedo n Force et al PNAS USA 91 1270-1274, 1994., but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here and for craf_1* activity: Km = 0.1591).
46	Raf-GTP-Ras / Raf-GTP-Ras.2	Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82	MAPK Pathway No. : 661	0.159096	0.3	4	explicit E-S complex	Substrate MAPKK-ser Product MAPKK*
	Kinetics are the same as for the craf_1* activity, ie., k1=5.5e-6, k2=0.42, k3 = 0.105 These are basedo n Force et al PNAS USA 91 1270-1274, 1994., but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here and for craf_1* activity: Km = 0.1591).
47	Raf-GTP-Ras / Raf-GTP-Ras.1	Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82	MAPK Pathway No. : 667	0.159096	0.3	4	explicit E-S complex	Substrate MAPKK Product MAPKK-ser
	Kinetics are the same as for the craf_1* activity, ie., k1=5.5e-6, k2=0.42, k3 = 0.105 These are basedo n Force et al PNAS USA 91 1270-1274, 1994., but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here and for craf_1* activity: Km = 0.1591).
48	Raf-GTP-Ras / Raf-GTP-Ras.2	Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82	MAPK Pathway No. : 667	0.159096	0.3	4	explicit E-S complex	Substrate MAPKK-ser Product MAPKK*
	Kinetics are the same as for the craf_1* activity, ie., k1=5.5e-6, k2=0.42, k3 = 0.105 These are basedo n Force et al PNAS USA 91 1270-1274, 1994., but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here and for craf_1* activity: Km = 0.1591).
49	Raf-GTP-Ras / Raf-GTP-Ras.1	Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82	MAPK Pathway No. : 673	0.159096	0.3	4	explicit E-S complex	Substrate MAPKK Product MAPKK-ser
	Kinetics are the same as for the craf_1* activity, ie., k1=5.5e-6, k2=0.42, k3 = 0.105 These are basedo n Force et al PNAS USA 91 1270-1274, 1994., but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here and for craf_1* activity: Km = 0.1591).
50	Raf-GTP-Ras / Raf-GTP-Ras.2	Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82	MAPK Pathway No. : 673	0.159096	0.3	4	explicit E-S complex	Substrate MAPKK-ser Product MAPKK*
	Kinetics are the same as for the craf_1* activity, ie., k1=5.5e-6, k2=0.42, k3 = 0.105 These are basedo n Force et al PNAS USA 91 1270-1274, 1994., but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here and for craf_1* activity: Km = 0.1591).

Raf-GTP-Ras acting as a Product in a reaction in Ajay_Bhalla_2007_ReacDiff1_1e-13 Network

Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.

	Name	Accession Name	Pathway Name	Kf	Kb	Kd	tau	Reagents
1	Ras-act-unphosph -raf	Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82	Shared_Object_ Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Pathway No. : 526	0 (uM^-1 s^-1)	0 (s^-1)	-	-	Substrate GTP-Ras craf-1 Product Raf-GTP-Ras
	18 May 2003. This reaction is here to provide basal activity for MAPK as well as the potential for direct EGF stimulus without PKC activation. Based on model from FB/fb28c.g: the model used for MKP-1 turnover. The rates there were constrained by basal activity values.
2	Ras-act-unphosph -raf	Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82	kinetics Pathway No. : 533	0 (uM^-1 s^-1)	0 (s^-1)	-	-	Substrate GTP-Ras craf-1 Product Raf-GTP-Ras
	18 May 2003. This reaction is here to provide basal activity for MAPK as well as the potential for direct EGF stimulus without PKC activation. Based on model from FB/fb28c.g: the model used for MKP-1 turnover. The rates there were constrained by basal activity values.
3	Ras-act-unphosph -raf	Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82	kinetics[1] Pathway No. : 539	0 (uM^-1 s^-1)	0 (s^-1)	-	-	Substrate GTP-Ras craf-1 Product Raf-GTP-Ras
	18 May 2003. This reaction is here to provide basal activity for MAPK as well as the potential for direct EGF stimulus without PKC activation. Based on model from FB/fb28c.g: the model used for MKP-1 turnover. The rates there were constrained by basal activity values.
4	Ras-act-unphosph -raf	Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82	kinetics[2] Pathway No. : 545	0 (uM^-1 s^-1)	0 (s^-1)	-	-	Substrate GTP-Ras craf-1 Product Raf-GTP-Ras
	18 May 2003. This reaction is here to provide basal activity for MAPK as well as the potential for direct EGF stimulus without PKC activation. Based on model from FB/fb28c.g: the model used for MKP-1 turnover. The rates there were constrained by basal activity values.
5	Ras-act-unphosph -raf	Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82	kinetics[3] Pathway No. : 551	0 (uM^-1 s^-1)	0 (s^-1)	-	-	Substrate GTP-Ras craf-1 Product Raf-GTP-Ras
	18 May 2003. This reaction is here to provide basal activity for MAPK as well as the potential for direct EGF stimulus without PKC activation. Based on model from FB/fb28c.g: the model used for MKP-1 turnover. The rates there were constrained by basal activity values.
6	Ras-act-unphosph -raf	Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82	kinetics[4] Pathway No. : 557	0 (uM^-1 s^-1)	0 (s^-1)	-	-	Substrate GTP-Ras craf-1 Product Raf-GTP-Ras
	18 May 2003. This reaction is here to provide basal activity for MAPK as well as the potential for direct EGF stimulus without PKC activation. Based on model from FB/fb28c.g: the model used for MKP-1 turnover. The rates there were constrained by basal activity values.
7	Ras-act-unphosph -raf	Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82	kinetics[5] Pathway No. : 563	0 (uM^-1 s^-1)	0 (s^-1)	-	-	Substrate GTP-Ras craf-1 Product Raf-GTP-Ras
	18 May 2003. This reaction is here to provide basal activity for MAPK as well as the potential for direct EGF stimulus without PKC activation. Based on model from FB/fb28c.g: the model used for MKP-1 turnover. The rates there were constrained by basal activity values.
8	Ras-act-unphosph -raf	Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82	kinetics[6] Pathway No. : 567	0 (uM^-1 s^-1)	0 (s^-1)	-	-	Substrate GTP-Ras craf-1 Product Raf-GTP-Ras
	18 May 2003. This reaction is here to provide basal activity for MAPK as well as the potential for direct EGF stimulus without PKC activation. Based on model from FB/fb28c.g: the model used for MKP-1 turnover. The rates there were constrained by basal activity values.
9	Ras-act-unphosph -raf	Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82	kinetics[7] Pathway No. : 575	0 (uM^-1 s^-1)	0 (s^-1)	-	-	Substrate GTP-Ras craf-1 Product Raf-GTP-Ras
	18 May 2003. This reaction is here to provide basal activity for MAPK as well as the potential for direct EGF stimulus without PKC activation. Based on model from FB/fb28c.g: the model used for MKP-1 turnover. The rates there were constrained by basal activity values.
10	Ras-act-unphosph -raf	Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82	kinetics[8] Pathway No. : 581	0 (uM^-1 s^-1)	0 (s^-1)	-	-	Substrate GTP-Ras craf-1 Product Raf-GTP-Ras
	18 May 2003. This reaction is here to provide basal activity for MAPK as well as the potential for direct EGF stimulus without PKC activation. Based on model from FB/fb28c.g: the model used for MKP-1 turnover. The rates there were constrained by basal activity values.
11	Ras-act-unphosph -raf	Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82	kinetics[9] Pathway No. : 587	0 (uM^-1 s^-1)	0 (s^-1)	-	-	Substrate GTP-Ras craf-1 Product Raf-GTP-Ras
	18 May 2003. This reaction is here to provide basal activity for MAPK as well as the potential for direct EGF stimulus without PKC activation. Based on model from FB/fb28c.g: the model used for MKP-1 turnover. The rates there were constrained by basal activity values.
12	Ras-act-unphosph -raf	Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82	kinetics[10] Pathway No. : 593	0 (uM^-1 s^-1)	0 (s^-1)	-	-	Substrate GTP-Ras craf-1 Product Raf-GTP-Ras
	18 May 2003. This reaction is here to provide basal activity for MAPK as well as the potential for direct EGF stimulus without PKC activation. Based on model from FB/fb28c.g: the model used for MKP-1 turnover. The rates there were constrained by basal activity values.
13	Ras-act-unphosph -raf	Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82	kinetics[11] Pathway No. : 599	0 (uM^-1 s^-1)	0 (s^-1)	-	-	Substrate GTP-Ras craf-1 Product Raf-GTP-Ras
	18 May 2003. This reaction is here to provide basal activity for MAPK as well as the potential for direct EGF stimulus without PKC activation. Based on model from FB/fb28c.g: the model used for MKP-1 turnover. The rates there were constrained by basal activity values.
14	Ras-act-unphosph -raf	Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82	kinetics[12] Pathway No. : 605	0 (uM^-1 s^-1)	0 (s^-1)	-	-	Substrate GTP-Ras craf-1 Product Raf-GTP-Ras
	18 May 2003. This reaction is here to provide basal activity for MAPK as well as the potential for direct EGF stimulus without PKC activation. Based on model from FB/fb28c.g: the model used for MKP-1 turnover. The rates there were constrained by basal activity values.
15	Ras-act-unphosph -raf	Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82	kinetics[13] Pathway No. : 611	0 (uM^-1 s^-1)	0 (s^-1)	-	-	Substrate GTP-Ras craf-1 Product Raf-GTP-Ras
	18 May 2003. This reaction is here to provide basal activity for MAPK as well as the potential for direct EGF stimulus without PKC activation. Based on model from FB/fb28c.g: the model used for MKP-1 turnover. The rates there were constrained by basal activity values.
16	Ras-act-unphosph -raf	Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82	kinetics[14] Pathway No. : 617	0 (uM^-1 s^-1)	0 (s^-1)	-	-	Substrate GTP-Ras craf-1 Product Raf-GTP-Ras
	18 May 2003. This reaction is here to provide basal activity for MAPK as well as the potential for direct EGF stimulus without PKC activation. Based on model from FB/fb28c.g: the model used for MKP-1 turnover. The rates there were constrained by basal activity values.
17	Ras-act-unphosph -raf	Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82	kinetics[15] Pathway No. : 623	0 (uM^-1 s^-1)	0 (s^-1)	-	-	Substrate GTP-Ras craf-1 Product Raf-GTP-Ras
	18 May 2003. This reaction is here to provide basal activity for MAPK as well as the potential for direct EGF stimulus without PKC activation. Based on model from FB/fb28c.g: the model used for MKP-1 turnover. The rates there were constrained by basal activity values.
18	Ras-act-unphosph -raf	Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82	kinetics[16] Pathway No. : 629	0 (uM^-1 s^-1)	0 (s^-1)	-	-	Substrate GTP-Ras craf-1 Product Raf-GTP-Ras
	18 May 2003. This reaction is here to provide basal activity for MAPK as well as the potential for direct EGF stimulus without PKC activation. Based on model from FB/fb28c.g: the model used for MKP-1 turnover. The rates there were constrained by basal activity values.
19	Ras-act-unphosph -raf	Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82	kinetics[17] Pathway No. : 635	0 (uM^-1 s^-1)	0 (s^-1)	-	-	Substrate GTP-Ras craf-1 Product Raf-GTP-Ras
	18 May 2003. This reaction is here to provide basal activity for MAPK as well as the potential for direct EGF stimulus without PKC activation. Based on model from FB/fb28c.g: the model used for MKP-1 turnover. The rates there were constrained by basal activity values.
20	Ras-act-unphosph -raf	Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82	kinetics[18] Pathway No. : 641	0 (uM^-1 s^-1)	0 (s^-1)	-	-	Substrate GTP-Ras craf-1 Product Raf-GTP-Ras
	18 May 2003. This reaction is here to provide basal activity for MAPK as well as the potential for direct EGF stimulus without PKC activation. Based on model from FB/fb28c.g: the model used for MKP-1 turnover. The rates there were constrained by basal activity values.
21	Ras-act-unphosph -raf	Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82	kinetics[19] Pathway No. : 647	0 (uM^-1 s^-1)	0 (s^-1)	-	-	Substrate GTP-Ras craf-1 Product Raf-GTP-Ras
	18 May 2003. This reaction is here to provide basal activity for MAPK as well as the potential for direct EGF stimulus without PKC activation. Based on model from FB/fb28c.g: the model used for MKP-1 turnover. The rates there were constrained by basal activity values.
22	Ras-act-unphosph -raf	Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82	kinetics[20] Pathway No. : 653	0 (uM^-1 s^-1)	0 (s^-1)	-	-	Substrate GTP-Ras craf-1 Product Raf-GTP-Ras
	18 May 2003. This reaction is here to provide basal activity for MAPK as well as the potential for direct EGF stimulus without PKC activation. Based on model from FB/fb28c.g: the model used for MKP-1 turnover. The rates there were constrained by basal activity values.
23	Ras-act-unphosph -raf	Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82	kinetics[21] Pathway No. : 659	0 (uM^-1 s^-1)	0 (s^-1)	-	-	Substrate GTP-Ras craf-1 Product Raf-GTP-Ras
	18 May 2003. This reaction is here to provide basal activity for MAPK as well as the potential for direct EGF stimulus without PKC activation. Based on model from FB/fb28c.g: the model used for MKP-1 turnover. The rates there were constrained by basal activity values.
24	Ras-act-unphosph -raf	Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82	kinetics[22] Pathway No. : 665	0 (uM^-1 s^-1)	0 (s^-1)	-	-	Substrate GTP-Ras craf-1 Product Raf-GTP-Ras
	18 May 2003. This reaction is here to provide basal activity for MAPK as well as the potential for direct EGF stimulus without PKC activation. Based on model from FB/fb28c.g: the model used for MKP-1 turnover. The rates there were constrained by basal activity values.
25	Ras-act-unphosph -raf	Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82	kinetics[23] Pathway No. : 671	0 (uM^-1 s^-1)	0 (s^-1)	-	-	Substrate GTP-Ras craf-1 Product Raf-GTP-Ras
	18 May 2003. This reaction is here to provide basal activity for MAPK as well as the potential for direct EGF stimulus without PKC activation. Based on model from FB/fb28c.g: the model used for MKP-1 turnover. The rates there were constrained by basal activity values.

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