DOQCS database

NCBS Home page

Accession List

Pathway List

Authorized Users

Help

News archives

Enter a Search String

Special character and space not allowed in the query term. Search string should be at least 2 characters long.

Molecule Parameter List for inact-GEF

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by

color.

Statistics

*inact-GEF* participated as	Molecule	Sum total of	Enzyme	Substrate of an enzyme	Product of an enzyme	Substrate in Reaction	Product in Reaction
No. of occurrences	25	0	25	25	0	49	49

Accession and Pathway Details

Accession Name	Accession No.	Accession Type	Pathway Link
Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13	82	Network	Shared_Object_Ajay_Bhalla_2007_ReacDiff1_1e-13, PKC, MAPK, Ras, CaM, PKM, chain, kinetics, PKC, MAPK, Ras, CaM, PKM, kinetics[1], PKC, MAPK, Ras, CaM, PKM, kinetics[2], PKC, MAPK, Ras, CaM, PKM, kinetics[3], PKC, MAPK, Ras, CaM, PKM, kinetics[4], PKC, MAPK, Ras, CaM, PKM, kinetics[5], PKC, MAPK, Ras, kinetics[6], CaM, PKM, PKC, MAPK, Ras, CaM, PKM, kinetics[7], PKC, MAPK, Ras, CaM, PKM, kinetics[8], PKC, MAPK, Ras, CaM, PKM, kinetics[9], PKC, MAPK, Ras, CaM, PKM, kinetics[10], PKC, MAPK, Ras, CaM, PKM, kinetics[11], PKC, MAPK, Ras, CaM, PKM, kinetics[12], PKC, MAPK, Ras, CaM, PKM, kinetics[13], PKC, MAPK, Ras, CaM, PKM, kinetics[14], PKC, MAPK, Ras, CaM, PKM, kinetics[15], PKC, MAPK, Ras, CaM, PKM, kinetics[16], PKC, MAPK, Ras, CaM, PKM, kinetics[17], PKC, MAPK, Ras, CaM, PKM, kinetics[18], PKC, MAPK, Ras, CaM, PKM, kinetics[19], PKC, MAPK, Ras, CaM, PKM, kinetics[20], PKC, MAPK, Ras, CaM, PKM, kinetics[21], PKC, MAPK, Ras, CaM, PKM, kinetics[22], PKC, MAPK, Ras, CaM, PKM, kinetics[23], PKC, MAPK, Ras, CaM, PKM
This is a 25-compartment reaction-diffusion version of the Ajay_Bhalla_2007_PKM model. The original single-compartment model is repeated 25 times. In addition, a subset (27 out of 42) molecules can diffuse between compartments. Diffusion is implemented as a reaction between corresponding molecules in neighboring compartments. For D = 1e-12 m^2/sec (i.e., 1 micron^2/sec ) the kf and kb of this reaction for these 10 micron compartments are both 0.01/sec. For D = 1e-13 m^2/sec (i.e., 0.1 micron^2/sec ) the kf and kb are 0.001/sec. The stimulus file pkm_mapk22_diff_1e-13_Fig4B which was used for the model to replicate Figure 4B from the paper. pkm_mapk22_diff_1e-13_Fig4H replicate Figure 4H. pkm_mapk22_diff_1e-13_Fig4I replicate Figure 4I.

inact-GEF acting as a Molecule in Ajay_Bhalla_2007_ReacDiff1_1e-13 Network

Name	Accession Name	Pathway Name	Initial Conc. (uM)	Volume (fL)	Buffered
inact-GEF	Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82	Ras Pathway No. : 529	0.1	1.5	No
Assume that SoS is present only at 50 nM. Revised to 100 nM to get equil to experimentally known levels.
inact-GEF	Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82	Ras Pathway No. : 536	0.1	1.5	No
Assume that SoS is present only at 50 nM. Revised to 100 nM to get equil to experimentally known levels.
inact-GEF	Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82	Ras Pathway No. : 542	0.1	1.5	No
Assume that SoS is present only at 50 nM. Revised to 100 nM to get equil to experimentally known levels.
inact-GEF	Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82	Ras Pathway No. : 548	0.1	1.5	No
Assume that SoS is present only at 50 nM. Revised to 100 nM to get equil to experimentally known levels.
inact-GEF	Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82	Ras Pathway No. : 554	0.1	1.5	No
Assume that SoS is present only at 50 nM. Revised to 100 nM to get equil to experimentally known levels.
inact-GEF	Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82	Ras Pathway No. : 560	0.1	1.5	No
Assume that SoS is present only at 50 nM. Revised to 100 nM to get equil to experimentally known levels.
inact-GEF	Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82	Ras Pathway No. : 566	0.1	1.5	No
Assume that SoS is present only at 50 nM. Revised to 100 nM to get equil to experimentally known levels.
inact-GEF	Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82	Ras Pathway No. : 572	0.1	1.5	No
Assume that SoS is present only at 50 nM. Revised to 100 nM to get equil to experimentally known levels.
inact-GEF	Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82	Ras Pathway No. : 578	0.1	1.5	No
Assume that SoS is present only at 50 nM. Revised to 100 nM to get equil to experimentally known levels.
inact-GEF	Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82	Ras Pathway No. : 584	0.1	1.5	No
Assume that SoS is present only at 50 nM. Revised to 100 nM to get equil to experimentally known levels.
inact-GEF	Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82	Ras Pathway No. : 590	0.1	1.5	No
Assume that SoS is present only at 50 nM. Revised to 100 nM to get equil to experimentally known levels.
inact-GEF	Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82	Ras Pathway No. : 596	0.1	1.5	No
Assume that SoS is present only at 50 nM. Revised to 100 nM to get equil to experimentally known levels.
inact-GEF	Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82	Ras Pathway No. : 602	0.1	1.5	No
Assume that SoS is present only at 50 nM. Revised to 100 nM to get equil to experimentally known levels.
inact-GEF	Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82	Ras Pathway No. : 608	0.1	1.5	No
Assume that SoS is present only at 50 nM. Revised to 100 nM to get equil to experimentally known levels.
inact-GEF	Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82	Ras Pathway No. : 614	0.1	1.5	No
Assume that SoS is present only at 50 nM. Revised to 100 nM to get equil to experimentally known levels.
inact-GEF	Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82	Ras Pathway No. : 620	0.1	1.5	No
Assume that SoS is present only at 50 nM. Revised to 100 nM to get equil to experimentally known levels.
inact-GEF	Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82	Ras Pathway No. : 626	0.1	1.5	No
Assume that SoS is present only at 50 nM. Revised to 100 nM to get equil to experimentally known levels.
inact-GEF	Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82	Ras Pathway No. : 632	0.1	1.5	No
Assume that SoS is present only at 50 nM. Revised to 100 nM to get equil to experimentally known levels.
inact-GEF	Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82	Ras Pathway No. : 638	0.1	1.5	No
Assume that SoS is present only at 50 nM. Revised to 100 nM to get equil to experimentally known levels.
inact-GEF	Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82	Ras Pathway No. : 644	0.1	1.5	No
Assume that SoS is present only at 50 nM. Revised to 100 nM to get equil to experimentally known levels.
inact-GEF	Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82	Ras Pathway No. : 650	0.1	1.5	No
Assume that SoS is present only at 50 nM. Revised to 100 nM to get equil to experimentally known levels.
inact-GEF	Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82	Ras Pathway No. : 656	0.1	1.5	No
Assume that SoS is present only at 50 nM. Revised to 100 nM to get equil to experimentally known levels.
inact-GEF	Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82	Ras Pathway No. : 662	0.1	1.5	No
Assume that SoS is present only at 50 nM. Revised to 100 nM to get equil to experimentally known levels.
inact-GEF	Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82	Ras Pathway No. : 668	0.1	1.5	No
Assume that SoS is present only at 50 nM. Revised to 100 nM to get equil to experimentally known levels.
inact-GEF	Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82	Ras Pathway No. : 674	0.1	1.5	No
Assume that SoS is present only at 50 nM. Revised to 100 nM to get equil to experimentally known levels.

inact-GEF acting as an Enzyme in Ajay_Bhalla_2007_ReacDiff1_1e-13 Network

	Enzyme Molecule / Enzyme Activity	Accession Name	Pathway Name	Km (uM)	kcat (s^-1)	Ratio	Enzyme Type	Reagents
1	inact-GEF / basal_GEF_ activity	Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82	Ras Pathway No. : 529	10.1015	0.02	4	explicit E-S complex	Substrate GDP-Ras Product GTP-Ras

2	inact-GEF / basal_GEF_ activity	Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82	Ras Pathway No. : 536	10.1015	0.02	4	explicit E-S complex	Substrate GDP-Ras Product GTP-Ras

3	inact-GEF / basal_GEF_ activity	Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82	Ras Pathway No. : 542	10.1015	0.02	4	explicit E-S complex	Substrate GDP-Ras Product GTP-Ras

4	inact-GEF / basal_GEF_ activity	Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82	Ras Pathway No. : 548	10.1015	0.02	4	explicit E-S complex	Substrate GDP-Ras Product GTP-Ras

5	inact-GEF / basal_GEF_ activity	Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82	Ras Pathway No. : 554	10.1015	0.02	4	explicit E-S complex	Substrate GDP-Ras Product GTP-Ras

6	inact-GEF / basal_GEF_ activity	Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82	Ras Pathway No. : 560	10.1015	0.02	4	explicit E-S complex	Substrate GDP-Ras Product GTP-Ras

7	inact-GEF / basal_GEF_ activity	Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82	Ras Pathway No. : 566	10.1015	0.02	4	explicit E-S complex	Substrate GDP-Ras Product GTP-Ras

8	inact-GEF / basal_GEF_ activity	Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82	Ras Pathway No. : 572	10.1015	0.02	4	explicit E-S complex	Substrate GDP-Ras Product GTP-Ras

9	inact-GEF / basal_GEF_ activity	Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82	Ras Pathway No. : 578	10.1015	0.02	4	explicit E-S complex	Substrate GDP-Ras Product GTP-Ras

10	inact-GEF / basal_GEF_ activity	Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82	Ras Pathway No. : 584	10.1015	0.02	4	explicit E-S complex	Substrate GDP-Ras Product GTP-Ras

11	inact-GEF / basal_GEF_ activity	Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82	Ras Pathway No. : 590	10.1015	0.02	4	explicit E-S complex	Substrate GDP-Ras Product GTP-Ras

12	inact-GEF / basal_GEF_ activity	Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82	Ras Pathway No. : 596	10.1015	0.02	4	explicit E-S complex	Substrate GDP-Ras Product GTP-Ras

13	inact-GEF / basal_GEF_ activity	Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82	Ras Pathway No. : 602	10.1015	0.02	4	explicit E-S complex	Substrate GDP-Ras Product GTP-Ras

14	inact-GEF / basal_GEF_ activity	Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82	Ras Pathway No. : 608	10.1015	0.02	4	explicit E-S complex	Substrate GDP-Ras Product GTP-Ras

15	inact-GEF / basal_GEF_ activity	Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82	Ras Pathway No. : 614	10.1015	0.02	4	explicit E-S complex	Substrate GDP-Ras Product GTP-Ras

16	inact-GEF / basal_GEF_ activity	Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82	Ras Pathway No. : 620	10.1015	0.02	4	explicit E-S complex	Substrate GDP-Ras Product GTP-Ras

17	inact-GEF / basal_GEF_ activity	Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82	Ras Pathway No. : 626	10.1015	0.02	4	explicit E-S complex	Substrate GDP-Ras Product GTP-Ras

18	inact-GEF / basal_GEF_ activity	Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82	Ras Pathway No. : 632	10.1015	0.02	4	explicit E-S complex	Substrate GDP-Ras Product GTP-Ras

19	inact-GEF / basal_GEF_ activity	Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82	Ras Pathway No. : 638	10.1015	0.02	4	explicit E-S complex	Substrate GDP-Ras Product GTP-Ras

20	inact-GEF / basal_GEF_ activity	Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82	Ras Pathway No. : 644	10.1015	0.02	4	explicit E-S complex	Substrate GDP-Ras Product GTP-Ras

21	inact-GEF / basal_GEF_ activity	Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82	Ras Pathway No. : 650	10.1015	0.02	4	explicit E-S complex	Substrate GDP-Ras Product GTP-Ras

22	inact-GEF / basal_GEF_ activity	Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82	Ras Pathway No. : 656	10.1015	0.02	4	explicit E-S complex	Substrate GDP-Ras Product GTP-Ras

23	inact-GEF / basal_GEF_ activity	Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82	Ras Pathway No. : 662	10.1015	0.02	4	explicit E-S complex	Substrate GDP-Ras Product GTP-Ras

24	inact-GEF / basal_GEF_ activity	Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82	Ras Pathway No. : 668	10.1015	0.02	4	explicit E-S complex	Substrate GDP-Ras Product GTP-Ras

25	inact-GEF / basal_GEF_ activity	Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82	Ras Pathway No. : 674	10.1015	0.02	4	explicit E-S complex	Substrate GDP-Ras Product GTP-Ras

inact-GEF acting as a Substrate for an Enzyme in Ajay_Bhalla_2007_ReacDiff1_1e-13 Network

	Enzyme Molecule / Enzyme Activity	Accession Name	Pathway Name	Km (uM)	kcat (s^-1)	Ratio	Enzyme Type	Reagents
1	PKC-active / PKC-act-GEF	Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82	Shared_Object_ Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Pathway No. : 526	3.33333	4	4	explicit E-S complex	Substrate inact-GEF Product GEF*
	Rate consts from PKC-act-raf. This reaction activates GEF. It can lead to at least 2X stim of ras, and a 2X stim of MAPK over and above that obtained via direct phosph of c-raf. Note that it is a push-pull reaction, and there is also a contribution through the phosphorylation and inactivation of GAPs. The original PKC-act-raf rate consts are too fast. We lower K1 by 10 X
2	PKC-active / PKC-act-GEF	Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82	kinetics Pathway No. : 533	3.33333	4	4	explicit E-S complex	Substrate inact-GEF Product GEF*
	Rate consts from PKC-act-raf. This reaction activates GEF. It can lead to at least 2X stim of ras, and a 2X stim of MAPK over and above that obtained via direct phosph of c-raf. Note that it is a push-pull reaction, and there is also a contribution through the phosphorylation and inactivation of GAPs. The original PKC-act-raf rate consts are too fast. We lower K1 by 10 X
3	PKC-active / PKC-act-GEF	Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82	kinetics[1] Pathway No. : 539	3.33333	4	4	explicit E-S complex	Substrate inact-GEF Product GEF*
	Rate consts from PKC-act-raf. This reaction activates GEF. It can lead to at least 2X stim of ras, and a 2X stim of MAPK over and above that obtained via direct phosph of c-raf. Note that it is a push-pull reaction, and there is also a contribution through the phosphorylation and inactivation of GAPs. The original PKC-act-raf rate consts are too fast. We lower K1 by 10 X
4	PKC-active / PKC-act-GEF	Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82	kinetics[2] Pathway No. : 545	3.33333	4	4	explicit E-S complex	Substrate inact-GEF Product GEF*
	Rate consts from PKC-act-raf. This reaction activates GEF. It can lead to at least 2X stim of ras, and a 2X stim of MAPK over and above that obtained via direct phosph of c-raf. Note that it is a push-pull reaction, and there is also a contribution through the phosphorylation and inactivation of GAPs. The original PKC-act-raf rate consts are too fast. We lower K1 by 10 X
5	PKC-active / PKC-act-GEF	Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82	kinetics[3] Pathway No. : 551	3.33333	4	4	explicit E-S complex	Substrate inact-GEF Product GEF*
	Rate consts from PKC-act-raf. This reaction activates GEF. It can lead to at least 2X stim of ras, and a 2X stim of MAPK over and above that obtained via direct phosph of c-raf. Note that it is a push-pull reaction, and there is also a contribution through the phosphorylation and inactivation of GAPs. The original PKC-act-raf rate consts are too fast. We lower K1 by 10 X
6	PKC-active / PKC-act-GEF	Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82	kinetics[4] Pathway No. : 557	3.33333	4	4	explicit E-S complex	Substrate inact-GEF Product GEF*
	Rate consts from PKC-act-raf. This reaction activates GEF. It can lead to at least 2X stim of ras, and a 2X stim of MAPK over and above that obtained via direct phosph of c-raf. Note that it is a push-pull reaction, and there is also a contribution through the phosphorylation and inactivation of GAPs. The original PKC-act-raf rate consts are too fast. We lower K1 by 10 X
7	PKC-active / PKC-act-GEF	Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82	kinetics[5] Pathway No. : 563	3.33333	4	4	explicit E-S complex	Substrate inact-GEF Product GEF*
	Rate consts from PKC-act-raf. This reaction activates GEF. It can lead to at least 2X stim of ras, and a 2X stim of MAPK over and above that obtained via direct phosph of c-raf. Note that it is a push-pull reaction, and there is also a contribution through the phosphorylation and inactivation of GAPs. The original PKC-act-raf rate consts are too fast. We lower K1 by 10 X
8	PKC-active / PKC-act-GEF	Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82	kinetics[6] Pathway No. : 567	3.33333	4	4	explicit E-S complex	Substrate inact-GEF Product GEF*
	Rate consts from PKC-act-raf. This reaction activates GEF. It can lead to at least 2X stim of ras, and a 2X stim of MAPK over and above that obtained via direct phosph of c-raf. Note that it is a push-pull reaction, and there is also a contribution through the phosphorylation and inactivation of GAPs. The original PKC-act-raf rate consts are too fast. We lower K1 by 10 X
9	PKC-active / PKC-act-GEF	Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82	kinetics[7] Pathway No. : 575	3.33333	4	4	explicit E-S complex	Substrate inact-GEF Product GEF*
	Rate consts from PKC-act-raf. This reaction activates GEF. It can lead to at least 2X stim of ras, and a 2X stim of MAPK over and above that obtained via direct phosph of c-raf. Note that it is a push-pull reaction, and there is also a contribution through the phosphorylation and inactivation of GAPs. The original PKC-act-raf rate consts are too fast. We lower K1 by 10 X
10	PKC-active / PKC-act-GEF	Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82	kinetics[8] Pathway No. : 581	3.33333	4	4	explicit E-S complex	Substrate inact-GEF Product GEF*
	Rate consts from PKC-act-raf. This reaction activates GEF. It can lead to at least 2X stim of ras, and a 2X stim of MAPK over and above that obtained via direct phosph of c-raf. Note that it is a push-pull reaction, and there is also a contribution through the phosphorylation and inactivation of GAPs. The original PKC-act-raf rate consts are too fast. We lower K1 by 10 X
11	PKC-active / PKC-act-GEF	Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82	kinetics[9] Pathway No. : 587	3.33333	4	4	explicit E-S complex	Substrate inact-GEF Product GEF*
	Rate consts from PKC-act-raf. This reaction activates GEF. It can lead to at least 2X stim of ras, and a 2X stim of MAPK over and above that obtained via direct phosph of c-raf. Note that it is a push-pull reaction, and there is also a contribution through the phosphorylation and inactivation of GAPs. The original PKC-act-raf rate consts are too fast. We lower K1 by 10 X
12	PKC-active / PKC-act-GEF	Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82	kinetics[10] Pathway No. : 593	3.33333	4	4	explicit E-S complex	Substrate inact-GEF Product GEF*
	Rate consts from PKC-act-raf. This reaction activates GEF. It can lead to at least 2X stim of ras, and a 2X stim of MAPK over and above that obtained via direct phosph of c-raf. Note that it is a push-pull reaction, and there is also a contribution through the phosphorylation and inactivation of GAPs. The original PKC-act-raf rate consts are too fast. We lower K1 by 10 X
13	PKC-active / PKC-act-GEF	Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82	kinetics[11] Pathway No. : 599	3.33333	4	4	explicit E-S complex	Substrate inact-GEF Product GEF*
	Rate consts from PKC-act-raf. This reaction activates GEF. It can lead to at least 2X stim of ras, and a 2X stim of MAPK over and above that obtained via direct phosph of c-raf. Note that it is a push-pull reaction, and there is also a contribution through the phosphorylation and inactivation of GAPs. The original PKC-act-raf rate consts are too fast. We lower K1 by 10 X
14	PKC-active / PKC-act-GEF	Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82	kinetics[12] Pathway No. : 605	3.33333	4	4	explicit E-S complex	Substrate inact-GEF Product GEF*
	Rate consts from PKC-act-raf. This reaction activates GEF. It can lead to at least 2X stim of ras, and a 2X stim of MAPK over and above that obtained via direct phosph of c-raf. Note that it is a push-pull reaction, and there is also a contribution through the phosphorylation and inactivation of GAPs. The original PKC-act-raf rate consts are too fast. We lower K1 by 10 X
15	PKC-active / PKC-act-GEF	Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82	kinetics[13] Pathway No. : 611	3.33333	4	4	explicit E-S complex	Substrate inact-GEF Product GEF*
	Rate consts from PKC-act-raf. This reaction activates GEF. It can lead to at least 2X stim of ras, and a 2X stim of MAPK over and above that obtained via direct phosph of c-raf. Note that it is a push-pull reaction, and there is also a contribution through the phosphorylation and inactivation of GAPs. The original PKC-act-raf rate consts are too fast. We lower K1 by 10 X
16	PKC-active / PKC-act-GEF	Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82	kinetics[14] Pathway No. : 617	3.33333	4	4	explicit E-S complex	Substrate inact-GEF Product GEF*
	Rate consts from PKC-act-raf. This reaction activates GEF. It can lead to at least 2X stim of ras, and a 2X stim of MAPK over and above that obtained via direct phosph of c-raf. Note that it is a push-pull reaction, and there is also a contribution through the phosphorylation and inactivation of GAPs. The original PKC-act-raf rate consts are too fast. We lower K1 by 10 X
17	PKC-active / PKC-act-GEF	Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82	kinetics[15] Pathway No. : 623	3.33333	4	4	explicit E-S complex	Substrate inact-GEF Product GEF*
	Rate consts from PKC-act-raf. This reaction activates GEF. It can lead to at least 2X stim of ras, and a 2X stim of MAPK over and above that obtained via direct phosph of c-raf. Note that it is a push-pull reaction, and there is also a contribution through the phosphorylation and inactivation of GAPs. The original PKC-act-raf rate consts are too fast. We lower K1 by 10 X
18	PKC-active / PKC-act-GEF	Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82	kinetics[16] Pathway No. : 629	3.33333	4	4	explicit E-S complex	Substrate inact-GEF Product GEF*
	Rate consts from PKC-act-raf. This reaction activates GEF. It can lead to at least 2X stim of ras, and a 2X stim of MAPK over and above that obtained via direct phosph of c-raf. Note that it is a push-pull reaction, and there is also a contribution through the phosphorylation and inactivation of GAPs. The original PKC-act-raf rate consts are too fast. We lower K1 by 10 X
19	PKC-active / PKC-act-GEF	Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82	kinetics[17] Pathway No. : 635	3.33333	4	4	explicit E-S complex	Substrate inact-GEF Product GEF*
	Rate consts from PKC-act-raf. This reaction activates GEF. It can lead to at least 2X stim of ras, and a 2X stim of MAPK over and above that obtained via direct phosph of c-raf. Note that it is a push-pull reaction, and there is also a contribution through the phosphorylation and inactivation of GAPs. The original PKC-act-raf rate consts are too fast. We lower K1 by 10 X
20	PKC-active / PKC-act-GEF	Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82	kinetics[18] Pathway No. : 641	3.33333	4	4	explicit E-S complex	Substrate inact-GEF Product GEF*
	Rate consts from PKC-act-raf. This reaction activates GEF. It can lead to at least 2X stim of ras, and a 2X stim of MAPK over and above that obtained via direct phosph of c-raf. Note that it is a push-pull reaction, and there is also a contribution through the phosphorylation and inactivation of GAPs. The original PKC-act-raf rate consts are too fast. We lower K1 by 10 X
21	PKC-active / PKC-act-GEF	Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82	kinetics[19] Pathway No. : 647	3.33333	4	4	explicit E-S complex	Substrate inact-GEF Product GEF*
	Rate consts from PKC-act-raf. This reaction activates GEF. It can lead to at least 2X stim of ras, and a 2X stim of MAPK over and above that obtained via direct phosph of c-raf. Note that it is a push-pull reaction, and there is also a contribution through the phosphorylation and inactivation of GAPs. The original PKC-act-raf rate consts are too fast. We lower K1 by 10 X
22	PKC-active / PKC-act-GEF	Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82	kinetics[20] Pathway No. : 653	3.33333	4	4	explicit E-S complex	Substrate inact-GEF Product GEF*
	Rate consts from PKC-act-raf. This reaction activates GEF. It can lead to at least 2X stim of ras, and a 2X stim of MAPK over and above that obtained via direct phosph of c-raf. Note that it is a push-pull reaction, and there is also a contribution through the phosphorylation and inactivation of GAPs. The original PKC-act-raf rate consts are too fast. We lower K1 by 10 X
23	PKC-active / PKC-act-GEF	Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82	kinetics[21] Pathway No. : 659	3.33333	4	4	explicit E-S complex	Substrate inact-GEF Product GEF*
	Rate consts from PKC-act-raf. This reaction activates GEF. It can lead to at least 2X stim of ras, and a 2X stim of MAPK over and above that obtained via direct phosph of c-raf. Note that it is a push-pull reaction, and there is also a contribution through the phosphorylation and inactivation of GAPs. The original PKC-act-raf rate consts are too fast. We lower K1 by 10 X
24	PKC-active / PKC-act-GEF	Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82	kinetics[22] Pathway No. : 665	3.33333	4	4	explicit E-S complex	Substrate inact-GEF Product GEF*
	Rate consts from PKC-act-raf. This reaction activates GEF. It can lead to at least 2X stim of ras, and a 2X stim of MAPK over and above that obtained via direct phosph of c-raf. Note that it is a push-pull reaction, and there is also a contribution through the phosphorylation and inactivation of GAPs. The original PKC-act-raf rate consts are too fast. We lower K1 by 10 X
25	PKC-active / PKC-act-GEF	Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82	kinetics[23] Pathway No. : 671	3.33333	4	4	explicit E-S complex	Substrate inact-GEF Product GEF*
	Rate consts from PKC-act-raf. This reaction activates GEF. It can lead to at least 2X stim of ras, and a 2X stim of MAPK over and above that obtained via direct phosph of c-raf. Note that it is a push-pull reaction, and there is also a contribution through the phosphorylation and inactivation of GAPs. The original PKC-act-raf rate consts are too fast. We lower K1 by 10 X

inact-GEF acting as a Substrate in a reaction in Ajay_Bhalla_2007_ReacDiff1_1e-13 Network

Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.

	Name	Accession Name	Pathway Name	Kf	Kb	Kd	tau	Reagents
1	diff	Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82	Shared_Object_ Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Pathway No. : 526	0.001 (s^-1)	0.001 (s^-1)	Keq = 1(uM)	500sec	Substrate inact-GEF Product inact-GEF
2	CaM-bind-GEF	Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82	Ras Pathway No. : 529	199.995 (uM^-1 s^-1)	1 (s^-1)	Kd(bf) = 0.005(uM)	-	Substrate CaM-Ca4 inact-GEF Product CaM-GEF
	We have no numbers for this. It is probably between the two extremes represented by the CaMKII phosph states, and I have used guesses based on this. kf=1e-4 kb=1 The reaction is based on Farnsworth et al Nature 376 524-527 1995
3	diff	Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82	Shared_Object_ Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Pathway No. : 526	0.001 (s^-1)	0.001 (s^-1)	Keq = 1(uM)	500sec	Substrate inact-GEF Product inact-GEF
4	CaM-bind-GEF	Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82	Ras Pathway No. : 536	199.995 (uM^-1 s^-1)	1 (s^-1)	Kd(bf) = 0.005(uM)	-	Substrate CaM-Ca4 inact-GEF Product CaM-GEF
	We have no numbers for this. It is probably between the two extremes represented by the CaMKII phosph states, and I have used guesses based on this. kf=1e-4 kb=1 The reaction is based on Farnsworth et al Nature 376 524-527 1995
5	diff	Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82	Shared_Object_ Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Pathway No. : 526	0.001 (s^-1)	0.001 (s^-1)	Keq = 1(uM)	500sec	Substrate inact-GEF Product inact-GEF
6	CaM-bind-GEF	Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82	Ras Pathway No. : 542	199.995 (uM^-1 s^-1)	1 (s^-1)	Kd(bf) = 0.005(uM)	-	Substrate CaM-Ca4 inact-GEF Product CaM-GEF
	We have no numbers for this. It is probably between the two extremes represented by the CaMKII phosph states, and I have used guesses based on this. kf=1e-4 kb=1 The reaction is based on Farnsworth et al Nature 376 524-527 1995
7	diff	Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82	Shared_Object_ Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Pathway No. : 526	0.001 (s^-1)	0.001 (s^-1)	Keq = 1(uM)	500sec	Substrate inact-GEF Product inact-GEF
8	CaM-bind-GEF	Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82	Ras Pathway No. : 548	199.995 (uM^-1 s^-1)	1 (s^-1)	Kd(bf) = 0.005(uM)	-	Substrate CaM-Ca4 inact-GEF Product CaM-GEF
	We have no numbers for this. It is probably between the two extremes represented by the CaMKII phosph states, and I have used guesses based on this. kf=1e-4 kb=1 The reaction is based on Farnsworth et al Nature 376 524-527 1995
9	diff	Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82	Shared_Object_ Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Pathway No. : 526	0.001 (s^-1)	0.001 (s^-1)	Keq = 1(uM)	500sec	Substrate inact-GEF Product inact-GEF
10	CaM-bind-GEF	Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82	Ras Pathway No. : 554	199.995 (uM^-1 s^-1)	1 (s^-1)	Kd(bf) = 0.005(uM)	-	Substrate CaM-Ca4 inact-GEF Product CaM-GEF
	We have no numbers for this. It is probably between the two extremes represented by the CaMKII phosph states, and I have used guesses based on this. kf=1e-4 kb=1 The reaction is based on Farnsworth et al Nature 376 524-527 1995
11	diff	Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82	Shared_Object_ Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Pathway No. : 526	0.001 (s^-1)	0.001 (s^-1)	Keq = 1(uM)	500sec	Substrate inact-GEF Product inact-GEF
12	CaM-bind-GEF	Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82	Ras Pathway No. : 560	199.995 (uM^-1 s^-1)	1 (s^-1)	Kd(bf) = 0.005(uM)	-	Substrate CaM-Ca4 inact-GEF Product CaM-GEF
	We have no numbers for this. It is probably between the two extremes represented by the CaMKII phosph states, and I have used guesses based on this. kf=1e-4 kb=1 The reaction is based on Farnsworth et al Nature 376 524-527 1995
13	diff	Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82	Shared_Object_ Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Pathway No. : 526	0.001 (s^-1)	0.001 (s^-1)	Keq = 1(uM)	500sec	Substrate inact-GEF Product inact-GEF
14	CaM-bind-GEF	Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82	Ras Pathway No. : 566	199.995 (uM^-1 s^-1)	1 (s^-1)	Kd(bf) = 0.005(uM)	-	Substrate CaM-Ca4 inact-GEF Product CaM-GEF
	We have no numbers for this. It is probably between the two extremes represented by the CaMKII phosph states, and I have used guesses based on this. kf=1e-4 kb=1 The reaction is based on Farnsworth et al Nature 376 524-527 1995
15	diff	Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82	Shared_Object_ Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Pathway No. : 526	0.001 (s^-1)	0.001 (s^-1)	Keq = 1(uM)	500sec	Substrate inact-GEF Product inact-GEF
16	CaM-bind-GEF	Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82	Ras Pathway No. : 572	199.995 (uM^-1 s^-1)	1 (s^-1)	Kd(bf) = 0.005(uM)	-	Substrate CaM-Ca4 inact-GEF Product CaM-GEF
	We have no numbers for this. It is probably between the two extremes represented by the CaMKII phosph states, and I have used guesses based on this. kf=1e-4 kb=1 The reaction is based on Farnsworth et al Nature 376 524-527 1995
17	diff	Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82	Shared_Object_ Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Pathway No. : 526	0.001 (s^-1)	0.001 (s^-1)	Keq = 1(uM)	500sec	Substrate inact-GEF Product inact-GEF
18	CaM-bind-GEF	Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82	Ras Pathway No. : 578	199.995 (uM^-1 s^-1)	1 (s^-1)	Kd(bf) = 0.005(uM)	-	Substrate CaM-Ca4 inact-GEF Product CaM-GEF
	We have no numbers for this. It is probably between the two extremes represented by the CaMKII phosph states, and I have used guesses based on this. kf=1e-4 kb=1 The reaction is based on Farnsworth et al Nature 376 524-527 1995
19	diff	Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82	Shared_Object_ Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Pathway No. : 526	0.001 (s^-1)	0.001 (s^-1)	Keq = 1(uM)	500sec	Substrate inact-GEF Product inact-GEF
20	CaM-bind-GEF	Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82	Ras Pathway No. : 584	199.995 (uM^-1 s^-1)	1 (s^-1)	Kd(bf) = 0.005(uM)	-	Substrate CaM-Ca4 inact-GEF Product CaM-GEF
	We have no numbers for this. It is probably between the two extremes represented by the CaMKII phosph states, and I have used guesses based on this. kf=1e-4 kb=1 The reaction is based on Farnsworth et al Nature 376 524-527 1995
21	diff	Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82	Shared_Object_ Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Pathway No. : 526	0.001 (s^-1)	0.001 (s^-1)	Keq = 1(uM)	500sec	Substrate inact-GEF Product inact-GEF
22	CaM-bind-GEF	Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82	Ras Pathway No. : 590	199.995 (uM^-1 s^-1)	1 (s^-1)	Kd(bf) = 0.005(uM)	-	Substrate CaM-Ca4 inact-GEF Product CaM-GEF
	We have no numbers for this. It is probably between the two extremes represented by the CaMKII phosph states, and I have used guesses based on this. kf=1e-4 kb=1 The reaction is based on Farnsworth et al Nature 376 524-527 1995
23	diff	Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82	Shared_Object_ Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Pathway No. : 526	0.001 (s^-1)	0.001 (s^-1)	Keq = 1(uM)	500sec	Substrate inact-GEF Product inact-GEF
24	CaM-bind-GEF	Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82	Ras Pathway No. : 596	199.995 (uM^-1 s^-1)	1 (s^-1)	Kd(bf) = 0.005(uM)	-	Substrate CaM-Ca4 inact-GEF Product CaM-GEF
	We have no numbers for this. It is probably between the two extremes represented by the CaMKII phosph states, and I have used guesses based on this. kf=1e-4 kb=1 The reaction is based on Farnsworth et al Nature 376 524-527 1995
25	diff	Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82	Shared_Object_ Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Pathway No. : 526	0.001 (s^-1)	0.001 (s^-1)	Keq = 1(uM)	500sec	Substrate inact-GEF Product inact-GEF
26	CaM-bind-GEF	Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82	Ras Pathway No. : 602	199.995 (uM^-1 s^-1)	1 (s^-1)	Kd(bf) = 0.005(uM)	-	Substrate CaM-Ca4 inact-GEF Product CaM-GEF
	We have no numbers for this. It is probably between the two extremes represented by the CaMKII phosph states, and I have used guesses based on this. kf=1e-4 kb=1 The reaction is based on Farnsworth et al Nature 376 524-527 1995
27	diff	Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82	Shared_Object_ Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Pathway No. : 526	0.001 (s^-1)	0.001 (s^-1)	Keq = 1(uM)	500sec	Substrate inact-GEF Product inact-GEF
28	CaM-bind-GEF	Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82	Ras Pathway No. : 608	199.995 (uM^-1 s^-1)	1 (s^-1)	Kd(bf) = 0.005(uM)	-	Substrate CaM-Ca4 inact-GEF Product CaM-GEF
	We have no numbers for this. It is probably between the two extremes represented by the CaMKII phosph states, and I have used guesses based on this. kf=1e-4 kb=1 The reaction is based on Farnsworth et al Nature 376 524-527 1995
29	diff	Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82	Shared_Object_ Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Pathway No. : 526	0.001 (s^-1)	0.001 (s^-1)	Keq = 1(uM)	500sec	Substrate inact-GEF Product inact-GEF
30	CaM-bind-GEF	Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82	Ras Pathway No. : 614	199.995 (uM^-1 s^-1)	1 (s^-1)	Kd(bf) = 0.005(uM)	-	Substrate CaM-Ca4 inact-GEF Product CaM-GEF
	We have no numbers for this. It is probably between the two extremes represented by the CaMKII phosph states, and I have used guesses based on this. kf=1e-4 kb=1 The reaction is based on Farnsworth et al Nature 376 524-527 1995
31	diff	Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82	Shared_Object_ Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Pathway No. : 526	0.001 (s^-1)	0.001 (s^-1)	Keq = 1(uM)	500sec	Substrate inact-GEF Product inact-GEF
32	CaM-bind-GEF	Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82	Ras Pathway No. : 620	199.995 (uM^-1 s^-1)	1 (s^-1)	Kd(bf) = 0.005(uM)	-	Substrate CaM-Ca4 inact-GEF Product CaM-GEF
	We have no numbers for this. It is probably between the two extremes represented by the CaMKII phosph states, and I have used guesses based on this. kf=1e-4 kb=1 The reaction is based on Farnsworth et al Nature 376 524-527 1995
33	diff	Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82	Shared_Object_ Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Pathway No. : 526	0.001 (s^-1)	0.001 (s^-1)	Keq = 1(uM)	500sec	Substrate inact-GEF Product inact-GEF
34	CaM-bind-GEF	Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82	Ras Pathway No. : 626	199.995 (uM^-1 s^-1)	1 (s^-1)	Kd(bf) = 0.005(uM)	-	Substrate CaM-Ca4 inact-GEF Product CaM-GEF
	We have no numbers for this. It is probably between the two extremes represented by the CaMKII phosph states, and I have used guesses based on this. kf=1e-4 kb=1 The reaction is based on Farnsworth et al Nature 376 524-527 1995
35	diff	Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82	Shared_Object_ Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Pathway No. : 526	0.001 (s^-1)	0.001 (s^-1)	Keq = 1(uM)	500sec	Substrate inact-GEF Product inact-GEF
36	CaM-bind-GEF	Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82	Ras Pathway No. : 632	199.995 (uM^-1 s^-1)	1 (s^-1)	Kd(bf) = 0.005(uM)	-	Substrate CaM-Ca4 inact-GEF Product CaM-GEF
	We have no numbers for this. It is probably between the two extremes represented by the CaMKII phosph states, and I have used guesses based on this. kf=1e-4 kb=1 The reaction is based on Farnsworth et al Nature 376 524-527 1995
37	diff	Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82	Shared_Object_ Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Pathway No. : 526	0.001 (s^-1)	0.001 (s^-1)	Keq = 1(uM)	500sec	Substrate inact-GEF Product inact-GEF
38	CaM-bind-GEF	Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82	Ras Pathway No. : 638	199.995 (uM^-1 s^-1)	1 (s^-1)	Kd(bf) = 0.005(uM)	-	Substrate CaM-Ca4 inact-GEF Product CaM-GEF
	We have no numbers for this. It is probably between the two extremes represented by the CaMKII phosph states, and I have used guesses based on this. kf=1e-4 kb=1 The reaction is based on Farnsworth et al Nature 376 524-527 1995
39	diff	Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82	Shared_Object_ Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Pathway No. : 526	0.001 (s^-1)	0.001 (s^-1)	Keq = 1(uM)	500sec	Substrate inact-GEF Product inact-GEF
40	CaM-bind-GEF	Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82	Ras Pathway No. : 644	199.995 (uM^-1 s^-1)	1 (s^-1)	Kd(bf) = 0.005(uM)	-	Substrate CaM-Ca4 inact-GEF Product CaM-GEF
	We have no numbers for this. It is probably between the two extremes represented by the CaMKII phosph states, and I have used guesses based on this. kf=1e-4 kb=1 The reaction is based on Farnsworth et al Nature 376 524-527 1995
41	diff	Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82	Shared_Object_ Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Pathway No. : 526	0.001 (s^-1)	0.001 (s^-1)	Keq = 1(uM)	500sec	Substrate inact-GEF Product inact-GEF
42	CaM-bind-GEF	Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82	Ras Pathway No. : 650	199.995 (uM^-1 s^-1)	1 (s^-1)	Kd(bf) = 0.005(uM)	-	Substrate CaM-Ca4 inact-GEF Product CaM-GEF
	We have no numbers for this. It is probably between the two extremes represented by the CaMKII phosph states, and I have used guesses based on this. kf=1e-4 kb=1 The reaction is based on Farnsworth et al Nature 376 524-527 1995
43	diff	Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82	Shared_Object_ Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Pathway No. : 526	0.001 (s^-1)	0.001 (s^-1)	Keq = 1(uM)	500sec	Substrate inact-GEF Product inact-GEF
44	CaM-bind-GEF	Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82	Ras Pathway No. : 656	199.995 (uM^-1 s^-1)	1 (s^-1)	Kd(bf) = 0.005(uM)	-	Substrate CaM-Ca4 inact-GEF Product CaM-GEF
	We have no numbers for this. It is probably between the two extremes represented by the CaMKII phosph states, and I have used guesses based on this. kf=1e-4 kb=1 The reaction is based on Farnsworth et al Nature 376 524-527 1995
45	diff	Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82	Shared_Object_ Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Pathway No. : 526	0.001 (s^-1)	0.001 (s^-1)	Keq = 1(uM)	500sec	Substrate inact-GEF Product inact-GEF
46	CaM-bind-GEF	Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82	Ras Pathway No. : 662	199.995 (uM^-1 s^-1)	1 (s^-1)	Kd(bf) = 0.005(uM)	-	Substrate CaM-Ca4 inact-GEF Product CaM-GEF
	We have no numbers for this. It is probably between the two extremes represented by the CaMKII phosph states, and I have used guesses based on this. kf=1e-4 kb=1 The reaction is based on Farnsworth et al Nature 376 524-527 1995
47	diff	Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82	Shared_Object_ Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Pathway No. : 526	0.001 (s^-1)	0.001 (s^-1)	Keq = 1(uM)	500sec	Substrate inact-GEF Product inact-GEF
48	CaM-bind-GEF	Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82	Ras Pathway No. : 668	199.995 (uM^-1 s^-1)	1 (s^-1)	Kd(bf) = 0.005(uM)	-	Substrate CaM-Ca4 inact-GEF Product CaM-GEF
	We have no numbers for this. It is probably between the two extremes represented by the CaMKII phosph states, and I have used guesses based on this. kf=1e-4 kb=1 The reaction is based on Farnsworth et al Nature 376 524-527 1995
49	CaM-bind-GEF	Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82	Ras Pathway No. : 674	199.995 (uM^-1 s^-1)	1 (s^-1)	Kd(bf) = 0.005(uM)	-	Substrate CaM-Ca4 inact-GEF Product CaM-GEF
	We have no numbers for this. It is probably between the two extremes represented by the CaMKII phosph states, and I have used guesses based on this. kf=1e-4 kb=1 The reaction is based on Farnsworth et al Nature 376 524-527 1995

inact-GEF acting as a Product in a reaction in Ajay_Bhalla_2007_ReacDiff1_1e-13 Network

	Name	Accession Name	Pathway Name	Kf	Kb	Kd	tau	Reagents
1	dephosph-GEF	Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82	Ras Pathway No. : 529	1 (s^-1)	0 (s^-1)	-	-	Substrate GEF* Product inact-GEF
2	diff	Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82	Shared_Object_ Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Pathway No. : 526	0.001 (s^-1)	0.001 (s^-1)	Keq = 1(uM)	500sec	Substrate inact-GEF Product inact-GEF
3	dephosph-GEF	Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82	Ras Pathway No. : 536	1 (s^-1)	0 (s^-1)	-	-	Substrate GEF* Product inact-GEF
4	diff	Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82	Shared_Object_ Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Pathway No. : 526	0.001 (s^-1)	0.001 (s^-1)	Keq = 1(uM)	500sec	Substrate inact-GEF Product inact-GEF
5	dephosph-GEF	Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82	Ras Pathway No. : 542	1 (s^-1)	0 (s^-1)	-	-	Substrate GEF* Product inact-GEF
6	diff	Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82	Shared_Object_ Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Pathway No. : 526	0.001 (s^-1)	0.001 (s^-1)	Keq = 1(uM)	500sec	Substrate inact-GEF Product inact-GEF
7	dephosph-GEF	Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82	Ras Pathway No. : 548	1 (s^-1)	0 (s^-1)	-	-	Substrate GEF* Product inact-GEF
8	diff	Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82	Shared_Object_ Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Pathway No. : 526	0.001 (s^-1)	0.001 (s^-1)	Keq = 1(uM)	500sec	Substrate inact-GEF Product inact-GEF
9	dephosph-GEF	Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82	Ras Pathway No. : 554	1 (s^-1)	0 (s^-1)	-	-	Substrate GEF* Product inact-GEF
10	diff	Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82	Shared_Object_ Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Pathway No. : 526	0.001 (s^-1)	0.001 (s^-1)	Keq = 1(uM)	500sec	Substrate inact-GEF Product inact-GEF
11	dephosph-GEF	Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82	Ras Pathway No. : 560	1 (s^-1)	0 (s^-1)	-	-	Substrate GEF* Product inact-GEF
12	diff	Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82	Shared_Object_ Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Pathway No. : 526	0.001 (s^-1)	0.001 (s^-1)	Keq = 1(uM)	500sec	Substrate inact-GEF Product inact-GEF
13	dephosph-GEF	Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82	Ras Pathway No. : 566	1 (s^-1)	0 (s^-1)	-	-	Substrate GEF* Product inact-GEF
14	diff	Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82	Shared_Object_ Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Pathway No. : 526	0.001 (s^-1)	0.001 (s^-1)	Keq = 1(uM)	500sec	Substrate inact-GEF Product inact-GEF
15	dephosph-GEF	Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82	Ras Pathway No. : 572	1 (s^-1)	0 (s^-1)	-	-	Substrate GEF* Product inact-GEF
16	diff	Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82	Shared_Object_ Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Pathway No. : 526	0.001 (s^-1)	0.001 (s^-1)	Keq = 1(uM)	500sec	Substrate inact-GEF Product inact-GEF
17	dephosph-GEF	Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82	Ras Pathway No. : 578	1 (s^-1)	0 (s^-1)	-	-	Substrate GEF* Product inact-GEF
18	diff	Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82	Shared_Object_ Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Pathway No. : 526	0.001 (s^-1)	0.001 (s^-1)	Keq = 1(uM)	500sec	Substrate inact-GEF Product inact-GEF
19	dephosph-GEF	Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82	Ras Pathway No. : 584	1 (s^-1)	0 (s^-1)	-	-	Substrate GEF* Product inact-GEF
20	diff	Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82	Shared_Object_ Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Pathway No. : 526	0.001 (s^-1)	0.001 (s^-1)	Keq = 1(uM)	500sec	Substrate inact-GEF Product inact-GEF
21	dephosph-GEF	Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82	Ras Pathway No. : 590	1 (s^-1)	0 (s^-1)	-	-	Substrate GEF* Product inact-GEF
22	diff	Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82	Shared_Object_ Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Pathway No. : 526	0.001 (s^-1)	0.001 (s^-1)	Keq = 1(uM)	500sec	Substrate inact-GEF Product inact-GEF
23	dephosph-GEF	Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82	Ras Pathway No. : 596	1 (s^-1)	0 (s^-1)	-	-	Substrate GEF* Product inact-GEF
24	diff	Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82	Shared_Object_ Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Pathway No. : 526	0.001 (s^-1)	0.001 (s^-1)	Keq = 1(uM)	500sec	Substrate inact-GEF Product inact-GEF
25	dephosph-GEF	Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82	Ras Pathway No. : 602	1 (s^-1)	0 (s^-1)	-	-	Substrate GEF* Product inact-GEF
26	diff	Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82	Shared_Object_ Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Pathway No. : 526	0.001 (s^-1)	0.001 (s^-1)	Keq = 1(uM)	500sec	Substrate inact-GEF Product inact-GEF
27	dephosph-GEF	Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82	Ras Pathway No. : 608	1 (s^-1)	0 (s^-1)	-	-	Substrate GEF* Product inact-GEF
28	diff	Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82	Shared_Object_ Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Pathway No. : 526	0.001 (s^-1)	0.001 (s^-1)	Keq = 1(uM)	500sec	Substrate inact-GEF Product inact-GEF
29	dephosph-GEF	Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82	Ras Pathway No. : 614	1 (s^-1)	0 (s^-1)	-	-	Substrate GEF* Product inact-GEF
30	diff	Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82	Shared_Object_ Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Pathway No. : 526	0.001 (s^-1)	0.001 (s^-1)	Keq = 1(uM)	500sec	Substrate inact-GEF Product inact-GEF
31	dephosph-GEF	Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82	Ras Pathway No. : 620	1 (s^-1)	0 (s^-1)	-	-	Substrate GEF* Product inact-GEF
32	diff	Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82	Shared_Object_ Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Pathway No. : 526	0.001 (s^-1)	0.001 (s^-1)	Keq = 1(uM)	500sec	Substrate inact-GEF Product inact-GEF
33	dephosph-GEF	Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82	Ras Pathway No. : 626	1 (s^-1)	0 (s^-1)	-	-	Substrate GEF* Product inact-GEF
34	diff	Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82	Shared_Object_ Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Pathway No. : 526	0.001 (s^-1)	0.001 (s^-1)	Keq = 1(uM)	500sec	Substrate inact-GEF Product inact-GEF
35	dephosph-GEF	Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82	Ras Pathway No. : 632	1 (s^-1)	0 (s^-1)	-	-	Substrate GEF* Product inact-GEF
36	diff	Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82	Shared_Object_ Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Pathway No. : 526	0.001 (s^-1)	0.001 (s^-1)	Keq = 1(uM)	500sec	Substrate inact-GEF Product inact-GEF
37	dephosph-GEF	Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82	Ras Pathway No. : 638	1 (s^-1)	0 (s^-1)	-	-	Substrate GEF* Product inact-GEF
38	diff	Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82	Shared_Object_ Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Pathway No. : 526	0.001 (s^-1)	0.001 (s^-1)	Keq = 1(uM)	500sec	Substrate inact-GEF Product inact-GEF
39	dephosph-GEF	Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82	Ras Pathway No. : 644	1 (s^-1)	0 (s^-1)	-	-	Substrate GEF* Product inact-GEF
40	diff	Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82	Shared_Object_ Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Pathway No. : 526	0.001 (s^-1)	0.001 (s^-1)	Keq = 1(uM)	500sec	Substrate inact-GEF Product inact-GEF
41	dephosph-GEF	Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82	Ras Pathway No. : 650	1 (s^-1)	0 (s^-1)	-	-	Substrate GEF* Product inact-GEF
42	diff	Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82	Shared_Object_ Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Pathway No. : 526	0.001 (s^-1)	0.001 (s^-1)	Keq = 1(uM)	500sec	Substrate inact-GEF Product inact-GEF
43	dephosph-GEF	Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82	Ras Pathway No. : 656	1 (s^-1)	0 (s^-1)	-	-	Substrate GEF* Product inact-GEF
44	diff	Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82	Shared_Object_ Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Pathway No. : 526	0.001 (s^-1)	0.001 (s^-1)	Keq = 1(uM)	500sec	Substrate inact-GEF Product inact-GEF
45	dephosph-GEF	Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82	Ras Pathway No. : 662	1 (s^-1)	0 (s^-1)	-	-	Substrate GEF* Product inact-GEF
46	diff	Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82	Shared_Object_ Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Pathway No. : 526	0.001 (s^-1)	0.001 (s^-1)	Keq = 1(uM)	500sec	Substrate inact-GEF Product inact-GEF
47	dephosph-GEF	Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82	Ras Pathway No. : 668	1 (s^-1)	0 (s^-1)	-	-	Substrate GEF* Product inact-GEF
48	diff	Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82	Shared_Object_ Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Pathway No. : 526	0.001 (s^-1)	0.001 (s^-1)	Keq = 1(uM)	500sec	Substrate inact-GEF Product inact-GEF
49	dephosph-GEF	Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82	Ras Pathway No. : 674	1 (s^-1)	0 (s^-1)	-	-	Substrate GEF* Product inact-GEF

Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
This Copyright is applied to ensure that the contents of this database remain freely available. Please see FAQ for details.