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Molecule Parameter List for CaM-Ca3 | The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network. The text color of a molecule is highlighted by color. | Statistics | Accession and Pathway Details | |
Accession Name | Accession No. | Accession Type | Pathway Link | Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 | 82 | Network | Shared_Object_Ajay_Bhalla_2007_ReacDiff1_1e-13, PKC, MAPK, Ras, CaM, PKM, chain, kinetics, PKC, MAPK, Ras, CaM, PKM, kinetics[1], PKC, MAPK, Ras, CaM, PKM, kinetics[2], PKC, MAPK, Ras, CaM, PKM, kinetics[3], PKC, MAPK, Ras, CaM, PKM, kinetics[4], PKC, MAPK, Ras, CaM, PKM, kinetics[5], PKC, MAPK, Ras, kinetics[6], CaM, PKM, PKC, MAPK, Ras, CaM, PKM, kinetics[7], PKC, MAPK, Ras, CaM, PKM, kinetics[8], PKC, MAPK, Ras, CaM, PKM, kinetics[9], PKC, MAPK, Ras, CaM, PKM, kinetics[10], PKC, MAPK, Ras, CaM, PKM, kinetics[11], PKC, MAPK, Ras, CaM, PKM, kinetics[12], PKC, MAPK, Ras, CaM, PKM, kinetics[13], PKC, MAPK, Ras, CaM, PKM, kinetics[14], PKC, MAPK, Ras, CaM, PKM, kinetics[15], PKC, MAPK, Ras, CaM, PKM, kinetics[16], PKC, MAPK, Ras, CaM, PKM, kinetics[17], PKC, MAPK, Ras, CaM, PKM, kinetics[18], PKC, MAPK, Ras, CaM, PKM, kinetics[19], PKC, MAPK, Ras, CaM, PKM, kinetics[20], PKC, MAPK, Ras, CaM, PKM, kinetics[21], PKC, MAPK, Ras, CaM, PKM, kinetics[22], PKC, MAPK, Ras, CaM, PKM, kinetics[23], PKC, MAPK, Ras, CaM, PKM | This is a 25-compartment reaction-diffusion version of the Ajay_Bhalla_2007_PKM model. The original single-compartment model is repeated 25 times. In addition, a subset (27 out of 42) molecules can diffuse between compartments. Diffusion is implemented as a reaction between corresponding molecules in neighboring compartments. For D = 1e-12 m^2/sec (i.e., 1 micron^2/sec ) the kf and kb of this reaction for these 10 micron compartments are both 0.01/sec. For D = 1e-13 m^2/sec (i.e., 0.1 micron^2/sec ) the kf and kb are 0.001/sec.
The stimulus file pkm_mapk22_diff_1e-13_Fig4B which was used for the model to replicate Figure 4B from the paper.
pkm_mapk22_diff_1e-13_Fig4H replicate Figure 4H.
pkm_mapk22_diff_1e-13_Fig4I replicate Figure 4I.
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CaM-Ca3 acting as a Molecule in Ajay_Bhalla_2007_ReacDiff1_1e-13 Network
CaM-Ca3 acting as a Substrate in a reaction in Ajay_Bhalla_2007_ReacDiff1_1e-13 Network
Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated.
Kd for higher order reaction are not consider. |
| Name | Accession Name | Pathway Name | Kf | Kb | Kd | tau | Reagents | 1 | CaM-Ca3-bind-Ca | Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82 | CaM Pathway No. : 530 | 0.465 (uM^-1 s^-1) | 10 (s^-1) | Kd(bf) = 21.5051(uM) | - | Substrate Ca CaM-Ca3
Product CaM-Ca4
| | Use K3 = 21.5 uM here from Stemmer and Klee table 3. kb/kf =21.5 * 6e5 so kf = 7.75e-7, kb = 10 | 2 | diff | Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82 | Shared_Object_ Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Pathway No. : 526 | 0.001 (s^-1) | 0.001 (s^-1) | Keq = 1(uM) | 500sec | Substrate CaM-Ca3
Product CaM-Ca3
| 3 | CaM-Ca3-bind-Ca | Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82 | CaM Pathway No. : 537 | 0.465 (uM^-1 s^-1) | 10 (s^-1) | Kd(bf) = 21.5051(uM) | - | Substrate Ca CaM-Ca3
Product CaM-Ca4
| | Use K3 = 21.5 uM here from Stemmer and Klee table 3. kb/kf =21.5 * 6e5 so kf = 7.75e-7, kb = 10 | 4 | diff | Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82 | Shared_Object_ Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Pathway No. : 526 | 0.001 (s^-1) | 0.001 (s^-1) | Keq = 1(uM) | 500sec | Substrate CaM-Ca3
Product CaM-Ca3
| 5 | CaM-Ca3-bind-Ca | Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82 | CaM Pathway No. : 543 | 0.465 (uM^-1 s^-1) | 10 (s^-1) | Kd(bf) = 21.5051(uM) | - | Substrate Ca CaM-Ca3
Product CaM-Ca4
| | Use K3 = 21.5 uM here from Stemmer and Klee table 3. kb/kf =21.5 * 6e5 so kf = 7.75e-7, kb = 10 | 6 | diff | Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82 | Shared_Object_ Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Pathway No. : 526 | 0.001 (s^-1) | 0.001 (s^-1) | Keq = 1(uM) | 500sec | Substrate CaM-Ca3
Product CaM-Ca3
| 7 | CaM-Ca3-bind-Ca | Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82 | CaM Pathway No. : 549 | 0.465 (uM^-1 s^-1) | 10 (s^-1) | Kd(bf) = 21.5051(uM) | - | Substrate Ca CaM-Ca3
Product CaM-Ca4
| | Use K3 = 21.5 uM here from Stemmer and Klee table 3. kb/kf =21.5 * 6e5 so kf = 7.75e-7, kb = 10 | 8 | diff | Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82 | Shared_Object_ Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Pathway No. : 526 | 0.001 (s^-1) | 0.001 (s^-1) | Keq = 1(uM) | 500sec | Substrate CaM-Ca3
Product CaM-Ca3
| 9 | CaM-Ca3-bind-Ca | Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82 | CaM Pathway No. : 555 | 0.465 (uM^-1 s^-1) | 10 (s^-1) | Kd(bf) = 21.5051(uM) | - | Substrate Ca CaM-Ca3
Product CaM-Ca4
| | Use K3 = 21.5 uM here from Stemmer and Klee table 3. kb/kf =21.5 * 6e5 so kf = 7.75e-7, kb = 10 | 10 | diff | Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82 | Shared_Object_ Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Pathway No. : 526 | 0.001 (s^-1) | 0.001 (s^-1) | Keq = 1(uM) | 500sec | Substrate CaM-Ca3
Product CaM-Ca3
| 11 | CaM-Ca3-bind-Ca | Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82 | CaM Pathway No. : 561 | 0.465 (uM^-1 s^-1) | 10 (s^-1) | Kd(bf) = 21.5051(uM) | - | Substrate Ca CaM-Ca3
Product CaM-Ca4
| | Use K3 = 21.5 uM here from Stemmer and Klee table 3. kb/kf =21.5 * 6e5 so kf = 7.75e-7, kb = 10 | 12 | diff | Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82 | Shared_Object_ Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Pathway No. : 526 | 0.001 (s^-1) | 0.001 (s^-1) | Keq = 1(uM) | 500sec | Substrate CaM-Ca3
Product CaM-Ca3
| 13 | CaM-Ca3-bind-Ca | Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82 | CaM Pathway No. : 568 | 0.465 (uM^-1 s^-1) | 10 (s^-1) | Kd(bf) = 21.5051(uM) | - | Substrate Ca CaM-Ca3
Product CaM-Ca4
| | Use K3 = 21.5 uM here from Stemmer and Klee table 3. kb/kf =21.5 * 6e5 so kf = 7.75e-7, kb = 10 | 14 | diff | Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82 | Shared_Object_ Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Pathway No. : 526 | 0.001 (s^-1) | 0.001 (s^-1) | Keq = 1(uM) | 500sec | Substrate CaM-Ca3
Product CaM-Ca3
| 15 | CaM-Ca3-bind-Ca | Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82 | CaM Pathway No. : 573 | 0.465 (uM^-1 s^-1) | 10 (s^-1) | Kd(bf) = 21.5051(uM) | - | Substrate Ca CaM-Ca3
Product CaM-Ca4
| | Use K3 = 21.5 uM here from Stemmer and Klee table 3. kb/kf =21.5 * 6e5 so kf = 7.75e-7, kb = 10 | 16 | diff | Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82 | Shared_Object_ Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Pathway No. : 526 | 0.001 (s^-1) | 0.001 (s^-1) | Keq = 1(uM) | 500sec | Substrate CaM-Ca3
Product CaM-Ca3
| 17 | CaM-Ca3-bind-Ca | Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82 | CaM Pathway No. : 579 | 0.465 (uM^-1 s^-1) | 10 (s^-1) | Kd(bf) = 21.5051(uM) | - | Substrate Ca CaM-Ca3
Product CaM-Ca4
| | Use K3 = 21.5 uM here from Stemmer and Klee table 3. kb/kf =21.5 * 6e5 so kf = 7.75e-7, kb = 10 | 18 | diff | Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82 | Shared_Object_ Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Pathway No. : 526 | 0.001 (s^-1) | 0.001 (s^-1) | Keq = 1(uM) | 500sec | Substrate CaM-Ca3
Product CaM-Ca3
| 19 | CaM-Ca3-bind-Ca | Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82 | CaM Pathway No. : 585 | 0.465 (uM^-1 s^-1) | 10 (s^-1) | Kd(bf) = 21.5051(uM) | - | Substrate Ca CaM-Ca3
Product CaM-Ca4
| | Use K3 = 21.5 uM here from Stemmer and Klee table 3. kb/kf =21.5 * 6e5 so kf = 7.75e-7, kb = 10 | 20 | diff | Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82 | Shared_Object_ Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Pathway No. : 526 | 0.001 (s^-1) | 0.001 (s^-1) | Keq = 1(uM) | 500sec | Substrate CaM-Ca3
Product CaM-Ca3
| 21 | CaM-Ca3-bind-Ca | Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82 | CaM Pathway No. : 591 | 0.465 (uM^-1 s^-1) | 10 (s^-1) | Kd(bf) = 21.5051(uM) | - | Substrate Ca CaM-Ca3
Product CaM-Ca4
| | Use K3 = 21.5 uM here from Stemmer and Klee table 3. kb/kf =21.5 * 6e5 so kf = 7.75e-7, kb = 10 | 22 | diff | Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82 | Shared_Object_ Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Pathway No. : 526 | 0.001 (s^-1) | 0.001 (s^-1) | Keq = 1(uM) | 500sec | Substrate CaM-Ca3
Product CaM-Ca3
| 23 | CaM-Ca3-bind-Ca | Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82 | CaM Pathway No. : 597 | 0.465 (uM^-1 s^-1) | 10 (s^-1) | Kd(bf) = 21.5051(uM) | - | Substrate Ca CaM-Ca3
Product CaM-Ca4
| | Use K3 = 21.5 uM here from Stemmer and Klee table 3. kb/kf =21.5 * 6e5 so kf = 7.75e-7, kb = 10 | 24 | diff | Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82 | Shared_Object_ Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Pathway No. : 526 | 0.001 (s^-1) | 0.001 (s^-1) | Keq = 1(uM) | 500sec | Substrate CaM-Ca3
Product CaM-Ca3
| 25 | CaM-Ca3-bind-Ca | Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82 | CaM Pathway No. : 603 | 0.465 (uM^-1 s^-1) | 10 (s^-1) | Kd(bf) = 21.5051(uM) | - | Substrate Ca CaM-Ca3
Product CaM-Ca4
| | Use K3 = 21.5 uM here from Stemmer and Klee table 3. kb/kf =21.5 * 6e5 so kf = 7.75e-7, kb = 10 | 26 | diff | Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82 | Shared_Object_ Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Pathway No. : 526 | 0.001 (s^-1) | 0.001 (s^-1) | Keq = 1(uM) | 500sec | Substrate CaM-Ca3
Product CaM-Ca3
| 27 | CaM-Ca3-bind-Ca | Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82 | CaM Pathway No. : 609 | 0.465 (uM^-1 s^-1) | 10 (s^-1) | Kd(bf) = 21.5051(uM) | - | Substrate Ca CaM-Ca3
Product CaM-Ca4
| | Use K3 = 21.5 uM here from Stemmer and Klee table 3. kb/kf =21.5 * 6e5 so kf = 7.75e-7, kb = 10 | 28 | diff | Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82 | Shared_Object_ Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Pathway No. : 526 | 0.001 (s^-1) | 0.001 (s^-1) | Keq = 1(uM) | 500sec | Substrate CaM-Ca3
Product CaM-Ca3
| 29 | CaM-Ca3-bind-Ca | Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82 | CaM Pathway No. : 615 | 0.465 (uM^-1 s^-1) | 10 (s^-1) | Kd(bf) = 21.5051(uM) | - | Substrate Ca CaM-Ca3
Product CaM-Ca4
| | Use K3 = 21.5 uM here from Stemmer and Klee table 3. kb/kf =21.5 * 6e5 so kf = 7.75e-7, kb = 10 | 30 | diff | Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82 | Shared_Object_ Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Pathway No. : 526 | 0.001 (s^-1) | 0.001 (s^-1) | Keq = 1(uM) | 500sec | Substrate CaM-Ca3
Product CaM-Ca3
| 31 | CaM-Ca3-bind-Ca | Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82 | CaM Pathway No. : 621 | 0.465 (uM^-1 s^-1) | 10 (s^-1) | Kd(bf) = 21.5051(uM) | - | Substrate Ca CaM-Ca3
Product CaM-Ca4
| | Use K3 = 21.5 uM here from Stemmer and Klee table 3. kb/kf =21.5 * 6e5 so kf = 7.75e-7, kb = 10 | 32 | diff | Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82 | Shared_Object_ Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Pathway No. : 526 | 0.001 (s^-1) | 0.001 (s^-1) | Keq = 1(uM) | 500sec | Substrate CaM-Ca3
Product CaM-Ca3
| 33 | CaM-Ca3-bind-Ca | Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82 | CaM Pathway No. : 627 | 0.465 (uM^-1 s^-1) | 10 (s^-1) | Kd(bf) = 21.5051(uM) | - | Substrate Ca CaM-Ca3
Product CaM-Ca4
| | Use K3 = 21.5 uM here from Stemmer and Klee table 3. kb/kf =21.5 * 6e5 so kf = 7.75e-7, kb = 10 | 34 | diff | Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82 | Shared_Object_ Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Pathway No. : 526 | 0.001 (s^-1) | 0.001 (s^-1) | Keq = 1(uM) | 500sec | Substrate CaM-Ca3
Product CaM-Ca3
| 35 | CaM-Ca3-bind-Ca | Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82 | CaM Pathway No. : 633 | 0.465 (uM^-1 s^-1) | 10 (s^-1) | Kd(bf) = 21.5051(uM) | - | Substrate Ca CaM-Ca3
Product CaM-Ca4
| | Use K3 = 21.5 uM here from Stemmer and Klee table 3. kb/kf =21.5 * 6e5 so kf = 7.75e-7, kb = 10 | 36 | diff | Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82 | Shared_Object_ Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Pathway No. : 526 | 0.001 (s^-1) | 0.001 (s^-1) | Keq = 1(uM) | 500sec | Substrate CaM-Ca3
Product CaM-Ca3
| 37 | CaM-Ca3-bind-Ca | Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82 | CaM Pathway No. : 639 | 0.465 (uM^-1 s^-1) | 10 (s^-1) | Kd(bf) = 21.5051(uM) | - | Substrate Ca CaM-Ca3
Product CaM-Ca4
| | Use K3 = 21.5 uM here from Stemmer and Klee table 3. kb/kf =21.5 * 6e5 so kf = 7.75e-7, kb = 10 | 38 | diff | Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82 | Shared_Object_ Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Pathway No. : 526 | 0.001 (s^-1) | 0.001 (s^-1) | Keq = 1(uM) | 500sec | Substrate CaM-Ca3
Product CaM-Ca3
| 39 | CaM-Ca3-bind-Ca | Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82 | CaM Pathway No. : 645 | 0.465 (uM^-1 s^-1) | 10 (s^-1) | Kd(bf) = 21.5051(uM) | - | Substrate Ca CaM-Ca3
Product CaM-Ca4
| | Use K3 = 21.5 uM here from Stemmer and Klee table 3. kb/kf =21.5 * 6e5 so kf = 7.75e-7, kb = 10 | 40 | diff | Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82 | Shared_Object_ Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Pathway No. : 526 | 0.001 (s^-1) | 0.001 (s^-1) | Keq = 1(uM) | 500sec | Substrate CaM-Ca3
Product CaM-Ca3
| 41 | CaM-Ca3-bind-Ca | Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82 | CaM Pathway No. : 651 | 0.465 (uM^-1 s^-1) | 10 (s^-1) | Kd(bf) = 21.5051(uM) | - | Substrate Ca CaM-Ca3
Product CaM-Ca4
| | Use K3 = 21.5 uM here from Stemmer and Klee table 3. kb/kf =21.5 * 6e5 so kf = 7.75e-7, kb = 10 | 42 | diff | Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82 | Shared_Object_ Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Pathway No. : 526 | 0.001 (s^-1) | 0.001 (s^-1) | Keq = 1(uM) | 500sec | Substrate CaM-Ca3
Product CaM-Ca3
| 43 | CaM-Ca3-bind-Ca | Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82 | CaM Pathway No. : 657 | 0.465 (uM^-1 s^-1) | 10 (s^-1) | Kd(bf) = 21.5051(uM) | - | Substrate Ca CaM-Ca3
Product CaM-Ca4
| | Use K3 = 21.5 uM here from Stemmer and Klee table 3. kb/kf =21.5 * 6e5 so kf = 7.75e-7, kb = 10 | 44 | diff | Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82 | Shared_Object_ Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Pathway No. : 526 | 0.001 (s^-1) | 0.001 (s^-1) | Keq = 1(uM) | 500sec | Substrate CaM-Ca3
Product CaM-Ca3
| 45 | CaM-Ca3-bind-Ca | Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82 | CaM Pathway No. : 663 | 0.465 (uM^-1 s^-1) | 10 (s^-1) | Kd(bf) = 21.5051(uM) | - | Substrate Ca CaM-Ca3
Product CaM-Ca4
| | Use K3 = 21.5 uM here from Stemmer and Klee table 3. kb/kf =21.5 * 6e5 so kf = 7.75e-7, kb = 10 | 46 | diff | Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82 | Shared_Object_ Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Pathway No. : 526 | 0.001 (s^-1) | 0.001 (s^-1) | Keq = 1(uM) | 500sec | Substrate CaM-Ca3
Product CaM-Ca3
| 47 | CaM-Ca3-bind-Ca | Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82 | CaM Pathway No. : 669 | 0.465 (uM^-1 s^-1) | 10 (s^-1) | Kd(bf) = 21.5051(uM) | - | Substrate Ca CaM-Ca3
Product CaM-Ca4
| | Use K3 = 21.5 uM here from Stemmer and Klee table 3. kb/kf =21.5 * 6e5 so kf = 7.75e-7, kb = 10 | 48 | diff | Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82 | Shared_Object_ Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Pathway No. : 526 | 0.001 (s^-1) | 0.001 (s^-1) | Keq = 1(uM) | 500sec | Substrate CaM-Ca3
Product CaM-Ca3
| 49 | CaM-Ca3-bind-Ca | Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82 | CaM Pathway No. : 675 | 0.465 (uM^-1 s^-1) | 10 (s^-1) | Kd(bf) = 21.5051(uM) | - | Substrate Ca CaM-Ca3
Product CaM-Ca4
| | Use K3 = 21.5 uM here from Stemmer and Klee table 3. kb/kf =21.5 * 6e5 so kf = 7.75e-7, kb = 10 |
CaM-Ca3 acting as a Product in a reaction in Ajay_Bhalla_2007_ReacDiff1_1e-13 Network
Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated.
Kd for higher order reaction are not consider. |
| Name | Accession Name | Pathway Name | Kf | Kb | Kd | tau | Reagents | 1 | diff | Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82 | Shared_Object_ Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Pathway No. : 526 | 0.001 (s^-1) | 0.001 (s^-1) | Keq = 1(uM) | 500sec | Substrate CaM-Ca3
Product CaM-Ca3
| 2 | CaM-Ca2-bind-Ca | Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82 | CaM Pathway No. : 530 | 3.6 (uM^-1 s^-1) | 10 (s^-1) | Kd(bf) = 2.7778(uM) | - | Substrate Ca CaM-Ca2
Product CaM-Ca3
| | K3 = 21.5, K4 = 2.8. Assuming that the K4 step happens first, we get kb/kf = 2.8 uM = 1.68e6 so kf =6e-6 assuming kb = 10 | 3 | diff | Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82 | Shared_Object_ Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Pathway No. : 526 | 0.001 (s^-1) | 0.001 (s^-1) | Keq = 1(uM) | 500sec | Substrate CaM-Ca3
Product CaM-Ca3
| 4 | CaM-Ca2-bind-Ca | Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82 | CaM Pathway No. : 537 | 3.6 (uM^-1 s^-1) | 10 (s^-1) | Kd(bf) = 2.7778(uM) | - | Substrate Ca CaM-Ca2
Product CaM-Ca3
| | K3 = 21.5, K4 = 2.8. Assuming that the K4 step happens first, we get kb/kf = 2.8 uM = 1.68e6 so kf =6e-6 assuming kb = 10 | 5 | diff | Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82 | Shared_Object_ Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Pathway No. : 526 | 0.001 (s^-1) | 0.001 (s^-1) | Keq = 1(uM) | 500sec | Substrate CaM-Ca3
Product CaM-Ca3
| 6 | CaM-Ca2-bind-Ca | Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82 | CaM Pathway No. : 543 | 3.6 (uM^-1 s^-1) | 10 (s^-1) | Kd(bf) = 2.7778(uM) | - | Substrate Ca CaM-Ca2
Product CaM-Ca3
| | K3 = 21.5, K4 = 2.8. Assuming that the K4 step happens first, we get kb/kf = 2.8 uM = 1.68e6 so kf =6e-6 assuming kb = 10 | 7 | diff | Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82 | Shared_Object_ Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Pathway No. : 526 | 0.001 (s^-1) | 0.001 (s^-1) | Keq = 1(uM) | 500sec | Substrate CaM-Ca3
Product CaM-Ca3
| 8 | CaM-Ca2-bind-Ca | Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82 | CaM Pathway No. : 549 | 3.6 (uM^-1 s^-1) | 10 (s^-1) | Kd(bf) = 2.7778(uM) | - | Substrate Ca CaM-Ca2
Product CaM-Ca3
| | K3 = 21.5, K4 = 2.8. Assuming that the K4 step happens first, we get kb/kf = 2.8 uM = 1.68e6 so kf =6e-6 assuming kb = 10 | 9 | diff | Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82 | Shared_Object_ Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Pathway No. : 526 | 0.001 (s^-1) | 0.001 (s^-1) | Keq = 1(uM) | 500sec | Substrate CaM-Ca3
Product CaM-Ca3
| 10 | CaM-Ca2-bind-Ca | Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82 | CaM Pathway No. : 555 | 3.6 (uM^-1 s^-1) | 10 (s^-1) | Kd(bf) = 2.7778(uM) | - | Substrate Ca CaM-Ca2
Product CaM-Ca3
| | K3 = 21.5, K4 = 2.8. Assuming that the K4 step happens first, we get kb/kf = 2.8 uM = 1.68e6 so kf =6e-6 assuming kb = 10 | 11 | diff | Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82 | Shared_Object_ Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Pathway No. : 526 | 0.001 (s^-1) | 0.001 (s^-1) | Keq = 1(uM) | 500sec | Substrate CaM-Ca3
Product CaM-Ca3
| 12 | CaM-Ca2-bind-Ca | Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82 | CaM Pathway No. : 561 | 3.6 (uM^-1 s^-1) | 10 (s^-1) | Kd(bf) = 2.7778(uM) | - | Substrate Ca CaM-Ca2
Product CaM-Ca3
| | K3 = 21.5, K4 = 2.8. Assuming that the K4 step happens first, we get kb/kf = 2.8 uM = 1.68e6 so kf =6e-6 assuming kb = 10 | 13 | diff | Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82 | Shared_Object_ Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Pathway No. : 526 | 0.001 (s^-1) | 0.001 (s^-1) | Keq = 1(uM) | 500sec | Substrate CaM-Ca3
Product CaM-Ca3
| 14 | CaM-Ca2-bind-Ca | Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82 | CaM Pathway No. : 568 | 3.6 (uM^-1 s^-1) | 10 (s^-1) | Kd(bf) = 2.7778(uM) | - | Substrate Ca CaM-Ca2
Product CaM-Ca3
| | K3 = 21.5, K4 = 2.8. Assuming that the K4 step happens first, we get kb/kf = 2.8 uM = 1.68e6 so kf =6e-6 assuming kb = 10 | 15 | diff | Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82 | Shared_Object_ Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Pathway No. : 526 | 0.001 (s^-1) | 0.001 (s^-1) | Keq = 1(uM) | 500sec | Substrate CaM-Ca3
Product CaM-Ca3
| 16 | CaM-Ca2-bind-Ca | Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82 | CaM Pathway No. : 573 | 3.6 (uM^-1 s^-1) | 10 (s^-1) | Kd(bf) = 2.7778(uM) | - | Substrate Ca CaM-Ca2
Product CaM-Ca3
| | K3 = 21.5, K4 = 2.8. Assuming that the K4 step happens first, we get kb/kf = 2.8 uM = 1.68e6 so kf =6e-6 assuming kb = 10 | 17 | diff | Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82 | Shared_Object_ Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Pathway No. : 526 | 0.001 (s^-1) | 0.001 (s^-1) | Keq = 1(uM) | 500sec | Substrate CaM-Ca3
Product CaM-Ca3
| 18 | CaM-Ca2-bind-Ca | Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82 | CaM Pathway No. : 579 | 3.6 (uM^-1 s^-1) | 10 (s^-1) | Kd(bf) = 2.7778(uM) | - | Substrate Ca CaM-Ca2
Product CaM-Ca3
| | K3 = 21.5, K4 = 2.8. Assuming that the K4 step happens first, we get kb/kf = 2.8 uM = 1.68e6 so kf =6e-6 assuming kb = 10 | 19 | diff | Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82 | Shared_Object_ Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Pathway No. : 526 | 0.001 (s^-1) | 0.001 (s^-1) | Keq = 1(uM) | 500sec | Substrate CaM-Ca3
Product CaM-Ca3
| 20 | CaM-Ca2-bind-Ca | Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82 | CaM Pathway No. : 585 | 3.6 (uM^-1 s^-1) | 10 (s^-1) | Kd(bf) = 2.7778(uM) | - | Substrate Ca CaM-Ca2
Product CaM-Ca3
| | K3 = 21.5, K4 = 2.8. Assuming that the K4 step happens first, we get kb/kf = 2.8 uM = 1.68e6 so kf =6e-6 assuming kb = 10 | 21 | diff | Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82 | Shared_Object_ Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Pathway No. : 526 | 0.001 (s^-1) | 0.001 (s^-1) | Keq = 1(uM) | 500sec | Substrate CaM-Ca3
Product CaM-Ca3
| 22 | CaM-Ca2-bind-Ca | Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82 | CaM Pathway No. : 591 | 3.6 (uM^-1 s^-1) | 10 (s^-1) | Kd(bf) = 2.7778(uM) | - | Substrate Ca CaM-Ca2
Product CaM-Ca3
| | K3 = 21.5, K4 = 2.8. Assuming that the K4 step happens first, we get kb/kf = 2.8 uM = 1.68e6 so kf =6e-6 assuming kb = 10 | 23 | diff | Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82 | Shared_Object_ Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Pathway No. : 526 | 0.001 (s^-1) | 0.001 (s^-1) | Keq = 1(uM) | 500sec | Substrate CaM-Ca3
Product CaM-Ca3
| 24 | CaM-Ca2-bind-Ca | Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82 | CaM Pathway No. : 597 | 3.6 (uM^-1 s^-1) | 10 (s^-1) | Kd(bf) = 2.7778(uM) | - | Substrate Ca CaM-Ca2
Product CaM-Ca3
| | K3 = 21.5, K4 = 2.8. Assuming that the K4 step happens first, we get kb/kf = 2.8 uM = 1.68e6 so kf =6e-6 assuming kb = 10 | 25 | diff | Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82 | Shared_Object_ Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Pathway No. : 526 | 0.001 (s^-1) | 0.001 (s^-1) | Keq = 1(uM) | 500sec | Substrate CaM-Ca3
Product CaM-Ca3
| 26 | CaM-Ca2-bind-Ca | Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82 | CaM Pathway No. : 603 | 3.6 (uM^-1 s^-1) | 10 (s^-1) | Kd(bf) = 2.7778(uM) | - | Substrate Ca CaM-Ca2
Product CaM-Ca3
| | K3 = 21.5, K4 = 2.8. Assuming that the K4 step happens first, we get kb/kf = 2.8 uM = 1.68e6 so kf =6e-6 assuming kb = 10 | 27 | diff | Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82 | Shared_Object_ Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Pathway No. : 526 | 0.001 (s^-1) | 0.001 (s^-1) | Keq = 1(uM) | 500sec | Substrate CaM-Ca3
Product CaM-Ca3
| 28 | CaM-Ca2-bind-Ca | Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82 | CaM Pathway No. : 609 | 3.6 (uM^-1 s^-1) | 10 (s^-1) | Kd(bf) = 2.7778(uM) | - | Substrate Ca CaM-Ca2
Product CaM-Ca3
| | K3 = 21.5, K4 = 2.8. Assuming that the K4 step happens first, we get kb/kf = 2.8 uM = 1.68e6 so kf =6e-6 assuming kb = 10 | 29 | diff | Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82 | Shared_Object_ Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Pathway No. : 526 | 0.001 (s^-1) | 0.001 (s^-1) | Keq = 1(uM) | 500sec | Substrate CaM-Ca3
Product CaM-Ca3
| 30 | CaM-Ca2-bind-Ca | Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82 | CaM Pathway No. : 615 | 3.6 (uM^-1 s^-1) | 10 (s^-1) | Kd(bf) = 2.7778(uM) | - | Substrate Ca CaM-Ca2
Product CaM-Ca3
| | K3 = 21.5, K4 = 2.8. Assuming that the K4 step happens first, we get kb/kf = 2.8 uM = 1.68e6 so kf =6e-6 assuming kb = 10 | 31 | diff | Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82 | Shared_Object_ Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Pathway No. : 526 | 0.001 (s^-1) | 0.001 (s^-1) | Keq = 1(uM) | 500sec | Substrate CaM-Ca3
Product CaM-Ca3
| 32 | CaM-Ca2-bind-Ca | Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82 | CaM Pathway No. : 621 | 3.6 (uM^-1 s^-1) | 10 (s^-1) | Kd(bf) = 2.7778(uM) | - | Substrate Ca CaM-Ca2
Product CaM-Ca3
| | K3 = 21.5, K4 = 2.8. Assuming that the K4 step happens first, we get kb/kf = 2.8 uM = 1.68e6 so kf =6e-6 assuming kb = 10 | 33 | diff | Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82 | Shared_Object_ Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Pathway No. : 526 | 0.001 (s^-1) | 0.001 (s^-1) | Keq = 1(uM) | 500sec | Substrate CaM-Ca3
Product CaM-Ca3
| 34 | CaM-Ca2-bind-Ca | Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82 | CaM Pathway No. : 627 | 3.6 (uM^-1 s^-1) | 10 (s^-1) | Kd(bf) = 2.7778(uM) | - | Substrate Ca CaM-Ca2
Product CaM-Ca3
| | K3 = 21.5, K4 = 2.8. Assuming that the K4 step happens first, we get kb/kf = 2.8 uM = 1.68e6 so kf =6e-6 assuming kb = 10 | 35 | diff | Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82 | Shared_Object_ Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Pathway No. : 526 | 0.001 (s^-1) | 0.001 (s^-1) | Keq = 1(uM) | 500sec | Substrate CaM-Ca3
Product CaM-Ca3
| 36 | CaM-Ca2-bind-Ca | Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82 | CaM Pathway No. : 633 | 3.6 (uM^-1 s^-1) | 10 (s^-1) | Kd(bf) = 2.7778(uM) | - | Substrate Ca CaM-Ca2
Product CaM-Ca3
| | K3 = 21.5, K4 = 2.8. Assuming that the K4 step happens first, we get kb/kf = 2.8 uM = 1.68e6 so kf =6e-6 assuming kb = 10 | 37 | diff | Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82 | Shared_Object_ Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Pathway No. : 526 | 0.001 (s^-1) | 0.001 (s^-1) | Keq = 1(uM) | 500sec | Substrate CaM-Ca3
Product CaM-Ca3
| 38 | CaM-Ca2-bind-Ca | Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82 | CaM Pathway No. : 639 | 3.6 (uM^-1 s^-1) | 10 (s^-1) | Kd(bf) = 2.7778(uM) | - | Substrate Ca CaM-Ca2
Product CaM-Ca3
| | K3 = 21.5, K4 = 2.8. Assuming that the K4 step happens first, we get kb/kf = 2.8 uM = 1.68e6 so kf =6e-6 assuming kb = 10 | 39 | diff | Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82 | Shared_Object_ Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Pathway No. : 526 | 0.001 (s^-1) | 0.001 (s^-1) | Keq = 1(uM) | 500sec | Substrate CaM-Ca3
Product CaM-Ca3
| 40 | CaM-Ca2-bind-Ca | Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82 | CaM Pathway No. : 645 | 3.6 (uM^-1 s^-1) | 10 (s^-1) | Kd(bf) = 2.7778(uM) | - | Substrate Ca CaM-Ca2
Product CaM-Ca3
| | K3 = 21.5, K4 = 2.8. Assuming that the K4 step happens first, we get kb/kf = 2.8 uM = 1.68e6 so kf =6e-6 assuming kb = 10 | 41 | diff | Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82 | Shared_Object_ Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Pathway No. : 526 | 0.001 (s^-1) | 0.001 (s^-1) | Keq = 1(uM) | 500sec | Substrate CaM-Ca3
Product CaM-Ca3
| 42 | CaM-Ca2-bind-Ca | Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82 | CaM Pathway No. : 651 | 3.6 (uM^-1 s^-1) | 10 (s^-1) | Kd(bf) = 2.7778(uM) | - | Substrate Ca CaM-Ca2
Product CaM-Ca3
| | K3 = 21.5, K4 = 2.8. Assuming that the K4 step happens first, we get kb/kf = 2.8 uM = 1.68e6 so kf =6e-6 assuming kb = 10 | 43 | diff | Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82 | Shared_Object_ Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Pathway No. : 526 | 0.001 (s^-1) | 0.001 (s^-1) | Keq = 1(uM) | 500sec | Substrate CaM-Ca3
Product CaM-Ca3
| 44 | CaM-Ca2-bind-Ca | Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82 | CaM Pathway No. : 657 | 3.6 (uM^-1 s^-1) | 10 (s^-1) | Kd(bf) = 2.7778(uM) | - | Substrate Ca CaM-Ca2
Product CaM-Ca3
| | K3 = 21.5, K4 = 2.8. Assuming that the K4 step happens first, we get kb/kf = 2.8 uM = 1.68e6 so kf =6e-6 assuming kb = 10 | 45 | diff | Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82 | Shared_Object_ Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Pathway No. : 526 | 0.001 (s^-1) | 0.001 (s^-1) | Keq = 1(uM) | 500sec | Substrate CaM-Ca3
Product CaM-Ca3
| 46 | CaM-Ca2-bind-Ca | Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82 | CaM Pathway No. : 663 | 3.6 (uM^-1 s^-1) | 10 (s^-1) | Kd(bf) = 2.7778(uM) | - | Substrate Ca CaM-Ca2
Product CaM-Ca3
| | K3 = 21.5, K4 = 2.8. Assuming that the K4 step happens first, we get kb/kf = 2.8 uM = 1.68e6 so kf =6e-6 assuming kb = 10 | 47 | diff | Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82 | Shared_Object_ Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Pathway No. : 526 | 0.001 (s^-1) | 0.001 (s^-1) | Keq = 1(uM) | 500sec | Substrate CaM-Ca3
Product CaM-Ca3
| 48 | CaM-Ca2-bind-Ca | Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82 | CaM Pathway No. : 669 | 3.6 (uM^-1 s^-1) | 10 (s^-1) | Kd(bf) = 2.7778(uM) | - | Substrate Ca CaM-Ca2
Product CaM-Ca3
| | K3 = 21.5, K4 = 2.8. Assuming that the K4 step happens first, we get kb/kf = 2.8 uM = 1.68e6 so kf =6e-6 assuming kb = 10 | 49 | CaM-Ca2-bind-Ca | Ajay_Bhalla_ 2007_ReacDiff1_ 1e-13 Accession No. : 82 | CaM Pathway No. : 675 | 3.6 (uM^-1 s^-1) | 10 (s^-1) | Kd(bf) = 2.7778(uM) | - | Substrate Ca CaM-Ca2
Product CaM-Ca3
| | K3 = 21.5, K4 = 2.8. Assuming that the K4 step happens first, we get kb/kf = 2.8 uM = 1.68e6 so kf =6e-6 assuming kb = 10 |
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