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Molecule Parameter List for Ca_input

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network. The text color of a molecule is highlighted by color.

Statistics

Ca_input participated as	Molecule	Sum total of	Enzyme	Substrate of an enzyme	Product of an enzyme	Substrate in Reaction	Product in Reaction
No. of occurrences	25	0	0	0	0	25	0

Accession and Pathway Details

Accession Name	Accession No.	Accession Type	Pathway Link
Ajay_Bhalla_ 2007_ReacDiff3	84	Network	Shared_Object_Ajay_Bhalla_2007_ReacDiff3,  PKC,  PLA2,   MAPK,  PLA2,  Ras,  CaM,  chain,  kinetics,  PKC,  MAPK,  Ras,  CaM,  kinetics[1],   PKC,  PLA2,  MAPK,  Ras,  CaM,  kinetics[2],  PKC,  PLA2,  MAPK,  Ras,  CaM,  kinetics[3],   PKC,  PLA2,  MAPK,  Ras,  CaM,  kinetics[4],  PKC,  PLA2,  MAPK,  Ras,  CaM,  kinetics[5],   PKC,  PLA2,  MAPK,  Ras,  MAPK,  CaM,  kinetics[6],  PKC,  PLA2,  MAPK,  Ras,   CaM,  kinetics[7],  PKC,  PLA2,  MAPK,  Ras,  CaM,  PKC,  kinetics[8],  PLA2,   MAPK,  Ras,  CaM,  kinetics[9],  PKC,  PLA2,  MAPK,  Ras,  CaM,  kinetics[10],   PKC,  PLA2,  MAPK,  Ras,  CaM,  kinetics[11],  PKC,  PLA2,  MAPK,  Ras,  CaM,   kinetics[12],  PKC,  PLA2,  Ras,  CaM,  kinetics[13],  PKC,  PLA2,  MAPK,   Ras,  CaM,  kinetics[14],  PKC,  PLA2,  MAPK,  Ras,  CaM,  kinetics[15],   PKC,  PLA2,  MAPK,  Ras,  kinetics[16],  CaM,  PKC,  PLA2,  MAPK,  Ras,  CaM,   kinetics[17],  PKC,  PLA2,  MAPK,  Ras,  CaM,  kinetics[18],  PKC,  PLA2,   MAPK,  Ras,  CaM,  kinetics[19],  PKC,  PLA2,  MAPK,  Ras,  CaM,  kinetics[20],   PKC,  PLA2,  MAPK,  Ras,  CaM,  kinetics[21],  PKC,  PLA2,  MAPK,  Ras,  CaM,   kinetics[22],  PKC,  PLA2,  MAPK,  Ras,  CaM,  kinetics[23],  PKC,  PLA2,   MAPK,  Ras,  CaM
This is a 25-compartment reaction-diffusion version of the Ajay_Bhalla_2007_bistable model. The original single-compartment model is repeated 25 times. In addition, a subset (33 out of 50) molecules can diffuse between compartments. Diffusion is implemented as a reaction between corresponding molecules in neighboring compartments. Here D = 1e-13 m^2/sec (i.e., 0.1 micron^2/sec ) so the kf and kb of this reaction for these 10 micron compartments are both 0.001/sec. The basal calcium level in this model is held at 95 nM which is rather close to threshold for the flip to the active state. This is necessary to sustain active propagation of activation. The stimulus file bis6-propgn_D1e-13_FigEF which was used for the model to replicate Figure 4E and 4F from the paper.

Ca_input acting as a Molecule in  Ajay_Bhalla_2007_ReacDiff3 Network

Name	Accession Name	Pathway Name	Initial Conc. (uM)	Volume (fL)	Buffered
Ca_input	Ajay_Bhalla_ 2007_ReacDiff3 Accession No. : 84	Shared_Object_ Ajay_Bhalla_ 2007_ReacDiff3 Pathway No. : 918	0.08	125.7	Yes
Ca_input	Ajay_Bhalla_ 2007_ReacDiff3 Accession No. : 84	kinetics Pathway No. : 926	0.08	125.7	Yes
Ca_input	Ajay_Bhalla_ 2007_ReacDiff3 Accession No. : 84	kinetics[1] Pathway No. : 931	0.08	125.7	Yes
Ca_input	Ajay_Bhalla_ 2007_ReacDiff3 Accession No. : 84	kinetics[2] Pathway No. : 937	0.08	125.7	Yes
Ca_input	Ajay_Bhalla_ 2007_ReacDiff3 Accession No. : 84	kinetics[3] Pathway No. : 943	0.08	125.7	Yes
Ca_input	Ajay_Bhalla_ 2007_ReacDiff3 Accession No. : 84	kinetics[4] Pathway No. : 949	0.08	125.7	Yes
Ca_input	Ajay_Bhalla_ 2007_ReacDiff3 Accession No. : 84	kinetics[5] Pathway No. : 955	0.08	125.7	Yes
Ca_input	Ajay_Bhalla_ 2007_ReacDiff3 Accession No. : 84	kinetics[6] Pathway No. : 962	0.08	125.7	Yes
Ca_input	Ajay_Bhalla_ 2007_ReacDiff3 Accession No. : 84	kinetics[7] Pathway No. : 968	0.08	125.7	Yes
Ca_input	Ajay_Bhalla_ 2007_ReacDiff3 Accession No. : 84	kinetics[8] Pathway No. : 975	0.08	125.7	Yes
Ca_input	Ajay_Bhalla_ 2007_ReacDiff3 Accession No. : 84	kinetics[9] Pathway No. : 980	0.08	125.7	Yes
Ca_input	Ajay_Bhalla_ 2007_ReacDiff3 Accession No. : 84	kinetics[10] Pathway No. : 986	0.08	125.7	Yes
Ca_input	Ajay_Bhalla_ 2007_ReacDiff3 Accession No. : 84	kinetics[11] Pathway No. : 992	0.08	125.7	Yes
Ca_input	Ajay_Bhalla_ 2007_ReacDiff3 Accession No. : 84	kinetics[12] Pathway No. : 998	0.08	125.7	Yes
Ca_input	Ajay_Bhalla_ 2007_ReacDiff3 Accession No. : 84	kinetics[13] Pathway No. : 1003	0.08	125.7	Yes
Ca_input	Ajay_Bhalla_ 2007_ReacDiff3 Accession No. : 84	kinetics[14] Pathway No. : 1009	0.08	125.7	Yes
Ca_input	Ajay_Bhalla_ 2007_ReacDiff3 Accession No. : 84	kinetics[15] Pathway No. : 1015	0.08	125.7	Yes
Ca_input	Ajay_Bhalla_ 2007_ReacDiff3 Accession No. : 84	kinetics[16] Pathway No. : 1020	0.08	125.7	Yes
Ca_input	Ajay_Bhalla_ 2007_ReacDiff3 Accession No. : 84	kinetics[17] Pathway No. : 1027	0.08	125.7	Yes
Ca_input	Ajay_Bhalla_ 2007_ReacDiff3 Accession No. : 84	kinetics[18] Pathway No. : 1033	0.08	125.7	Yes
Ca_input	Ajay_Bhalla_ 2007_ReacDiff3 Accession No. : 84	kinetics[19] Pathway No. : 1039	0.08	125.7	Yes
Ca_input	Ajay_Bhalla_ 2007_ReacDiff3 Accession No. : 84	kinetics[20] Pathway No. : 1045	0.08	125.7	Yes
Ca_input	Ajay_Bhalla_ 2007_ReacDiff3 Accession No. : 84	kinetics[21] Pathway No. : 1051	0.08	125.7	Yes
Ca_input	Ajay_Bhalla_ 2007_ReacDiff3 Accession No. : 84	kinetics[22] Pathway No. : 1057	0.08	125.7	Yes
Ca_input	Ajay_Bhalla_ 2007_ReacDiff3 Accession No. : 84	kinetics[23] Pathway No. : 1063	0.08	125.7	Yes

Ca_input acting as a Substrate in a reaction in  Ajay_Bhalla_2007_ReacDiff3 Network

Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.

	Name	Accession Name	Pathway Name	Kf	Kb	Kd	tau	Reagents
1	Ca_diff	Ajay_Bhalla_ 2007_ReacDiff3 Accession No. : 84	Shared_Object_ Ajay_Bhalla_ 2007_ReacDiff3 Pathway No. : 918	2 (s^-1)	2 (s^-1)	Keq = 1(uM)	0.25sec	Substrate Ca_input Product Ca
2	Ca_diff	Ajay_Bhalla_ 2007_ReacDiff3 Accession No. : 84	kinetics Pathway No. : 926	2 (s^-1)	2 (s^-1)	Keq = 1(uM)	0.25sec	Substrate Ca_input Product Ca
3	Ca_diff	Ajay_Bhalla_ 2007_ReacDiff3 Accession No. : 84	kinetics[1] Pathway No. : 931	2 (s^-1)	2 (s^-1)	Keq = 1(uM)	0.25sec	Substrate Ca_input Product Ca
4	Ca_diff	Ajay_Bhalla_ 2007_ReacDiff3 Accession No. : 84	kinetics[2] Pathway No. : 937	2 (s^-1)	2 (s^-1)	Keq = 1(uM)	0.25sec	Substrate Ca_input Product Ca
5	Ca_diff	Ajay_Bhalla_ 2007_ReacDiff3 Accession No. : 84	kinetics[3] Pathway No. : 943	2 (s^-1)	2 (s^-1)	Keq = 1(uM)	0.25sec	Substrate Ca_input Product Ca
6	Ca_diff	Ajay_Bhalla_ 2007_ReacDiff3 Accession No. : 84	kinetics[4] Pathway No. : 949	2 (s^-1)	2 (s^-1)	Keq = 1(uM)	0.25sec	Substrate Ca_input Product Ca
7	Ca_diff	Ajay_Bhalla_ 2007_ReacDiff3 Accession No. : 84	kinetics[5] Pathway No. : 955	2 (s^-1)	2 (s^-1)	Keq = 1(uM)	0.25sec	Substrate Ca_input Product Ca
8	Ca_diff	Ajay_Bhalla_ 2007_ReacDiff3 Accession No. : 84	kinetics[6] Pathway No. : 962	2 (s^-1)	2 (s^-1)	Keq = 1(uM)	0.25sec	Substrate Ca_input Product Ca
9	Ca_diff	Ajay_Bhalla_ 2007_ReacDiff3 Accession No. : 84	kinetics[7] Pathway No. : 968	2 (s^-1)	2 (s^-1)	Keq = 1(uM)	0.25sec	Substrate Ca_input Product Ca
10	Ca_diff	Ajay_Bhalla_ 2007_ReacDiff3 Accession No. : 84	kinetics[8] Pathway No. : 975	2 (s^-1)	2 (s^-1)	Keq = 1(uM)	0.25sec	Substrate Ca_input Product Ca
11	Ca_diff	Ajay_Bhalla_ 2007_ReacDiff3 Accession No. : 84	kinetics[9] Pathway No. : 980	2 (s^-1)	2 (s^-1)	Keq = 1(uM)	0.25sec	Substrate Ca_input Product Ca
12	Ca_diff	Ajay_Bhalla_ 2007_ReacDiff3 Accession No. : 84	kinetics[10] Pathway No. : 986	2 (s^-1)	2 (s^-1)	Keq = 1(uM)	0.25sec	Substrate Ca_input Product Ca
13	Ca_diff	Ajay_Bhalla_ 2007_ReacDiff3 Accession No. : 84	kinetics[11] Pathway No. : 992	2 (s^-1)	2 (s^-1)	Keq = 1(uM)	0.25sec	Substrate Ca_input Product Ca
14	Ca_diff	Ajay_Bhalla_ 2007_ReacDiff3 Accession No. : 84	kinetics[12] Pathway No. : 998	2 (s^-1)	2 (s^-1)	Keq = 1(uM)	0.25sec	Substrate Ca_input Product Ca
15	Ca_diff	Ajay_Bhalla_ 2007_ReacDiff3 Accession No. : 84	kinetics[13] Pathway No. : 1003	2 (s^-1)	2 (s^-1)	Keq = 1(uM)	0.25sec	Substrate Ca_input Product Ca
16	Ca_diff	Ajay_Bhalla_ 2007_ReacDiff3 Accession No. : 84	kinetics[14] Pathway No. : 1009	2 (s^-1)	2 (s^-1)	Keq = 1(uM)	0.25sec	Substrate Ca_input Product Ca
17	Ca_diff	Ajay_Bhalla_ 2007_ReacDiff3 Accession No. : 84	kinetics[15] Pathway No. : 1015	2 (s^-1)	2 (s^-1)	Keq = 1(uM)	0.25sec	Substrate Ca_input Product Ca
18	Ca_diff	Ajay_Bhalla_ 2007_ReacDiff3 Accession No. : 84	kinetics[16] Pathway No. : 1020	2 (s^-1)	2 (s^-1)	Keq = 1(uM)	0.25sec	Substrate Ca_input Product Ca
19	Ca_diff	Ajay_Bhalla_ 2007_ReacDiff3 Accession No. : 84	kinetics[17] Pathway No. : 1027	2 (s^-1)	2 (s^-1)	Keq = 1(uM)	0.25sec	Substrate Ca_input Product Ca
20	Ca_diff	Ajay_Bhalla_ 2007_ReacDiff3 Accession No. : 84	kinetics[18] Pathway No. : 1033	2 (s^-1)	2 (s^-1)	Keq = 1(uM)	0.25sec	Substrate Ca_input Product Ca
21	Ca_diff	Ajay_Bhalla_ 2007_ReacDiff3 Accession No. : 84	kinetics[19] Pathway No. : 1039	2 (s^-1)	2 (s^-1)	Keq = 1(uM)	0.25sec	Substrate Ca_input Product Ca
22	Ca_diff	Ajay_Bhalla_ 2007_ReacDiff3 Accession No. : 84	kinetics[20] Pathway No. : 1045	2 (s^-1)	2 (s^-1)	Keq = 1(uM)	0.25sec	Substrate Ca_input Product Ca
23	Ca_diff	Ajay_Bhalla_ 2007_ReacDiff3 Accession No. : 84	kinetics[21] Pathway No. : 1051	2 (s^-1)	2 (s^-1)	Keq = 1(uM)	0.25sec	Substrate Ca_input Product Ca
24	Ca_diff	Ajay_Bhalla_ 2007_ReacDiff3 Accession No. : 84	kinetics[22] Pathway No. : 1057	2 (s^-1)	2 (s^-1)	Keq = 1(uM)	0.25sec	Substrate Ca_input Product Ca
25	Ca_diff	Ajay_Bhalla_ 2007_ReacDiff3 Accession No. : 84	kinetics[23] Pathway No. : 1063	2 (s^-1)	2 (s^-1)	Keq = 1(uM)	0.25sec	Substrate Ca_input Product Ca