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Molecule Parameter List for DRG_2A | The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by  color. | | Statistics |
Accession and Pathway Details | |
| Accession Name | Accession No. | Accession Type | Pathway Link | Mammalian_cell_
cycle | 85 | Network |
Growth, CELLDIV, Rb_grp,
IE_GRP, CycB_Grp, Cdc20_Grp,
Cdh1_grp, E2F, CycA_Grp,
CycE_grp, Early_Response_Genes, Delayed_Response_Genes,
CycD_Grp | | This is a fairly complete mass-action reimplementation of the Novak and Tyson mammalian cell cycle model. It is inexact on two counts. First, it replaces many rather abstracted equations with mass action and Michaelis-Menten forms of enzymes. Second, it does not handle the halving of cellular volume at the division point. Within these limitations, the model does most of what the original paper shows including oscillation of the relevant molecules. |
DRG_2A acting as a Molecule in Mammalian_cell_cycle Network
DRG_2A acting as a Summed Molecule in Mammalian_cell_cycle Network
DRG_2A acting as a Substrate for an Enzyme in Mammalian_cell_cycle Network
Enzyme Molecule /
Enzyme Activity | Accession Name | Pathway Name | Km (uM) | kcat (s^-1) | Ratio | Enzyme Type | Reagents | DRG_synth /
DRG_synth | Mammalian_cell_
cycle
Accession No. : 85 | Delayed_
Response_Genes
Pathway No. : 1080 | 0.0899986 | 10 | 4 | explicit E-S complex | Substrate
DRG_2A
Product
DRG
| | k17 = 10 J17 = 0.3 This enz represents rate = k17([DRG]/J17)^2 / (1 + ([DRG]/J17)^2 ) Here we assume that the substrate conc = [DRG]^2. Then it expands into classical MM form: rate = k17.sub / (J17^2 + sub) provided [DRG_synth] = 1. |
| Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
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