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Reaction List for pathway Ras (Pathway Number 959) in Accession Ajay_Bhalla_2007_ReacDiff3 (Accession Number 84) | Entries are grouped according to Pathway Number and they are alternately color coded using and color.
Further ordering can be done to the table header. indicates that ordering is done according to ascending or descending order. Keq is calculated only for first order reactions.
Kd is calculated only for second order reactions. [nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules] |
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Reaction Name | Pathway Name / Pathway No. | Kf | Kb | Kd | tau | Reagents | 1 | CaM-bind-GEF | Ras
Pathway No. 959 | 199.995 (uM^-1 s^-1) | 1 (s^-1) | Kd(bf) = 0.005(uM) | - | Substrate: inact-GEF CaM-Ca4
Products: CaM-GEF
| | We have no numbers for this. It is probably between the two extremes represented by the CaMKII phosph states, and I have used guesses based on this. kf=1e-4 kb=1 The reaction is based on Farnsworth et al Nature 376 524-527 1995 28 Feb 2006: Increased affinity 36-fold to account for Ca input to MAPK cascade, possibly folding in other pathway inputs. 21 April 2006: Altered affinity to same level as pkm_mapk21.g model to prevent spontaneous turnon. Kf = 200, Kb = 1. | 2 | dephosph-GEF | Ras
Pathway No. 959 | 1 (s^-1) | 0 (s^-1) | - | - | Substrate: GEF*
Products: inact-GEF
| 3 | Ras-intrinsic-GT Pase | Ras
Pathway No. 959 | 0.0001 (s^-1) | 0 (s^-1) | - | - | Substrate: GTP-Ras
Products: GDP-Ras
| | This is extremely slow (1e-4), but it is significant as so little GAP actually gets complexed with it that the total GTP turnover rises only by 2-3 X (see Gibbs et al, JBC 265(33) 20437-20422) and Eccleston et al JBC 268(36) 27012-27019 kf = 1e-4 | 4 | dephosph-GAP | Ras
Pathway No. 959 | 0.1 (s^-1) | 0 (s^-1) | - | - | Substrate: GAP*
Products: GAP
| | Assume a reasonably good rate for dephosphorylating it, 1/sec |
| Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR This Copyright is applied to ensure that the contents of this database remain freely available. Please see FAQ for details. |
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