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Molecule Parameter List for CaM-Ca4

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by color.
Statistics
CaM-Ca4 participated asMoleculeSum total ofEnzymeSubstrate of an enzymeProduct of an enzymeSubstrate in ReactionProduct in Reaction
No. of occurrences2500004949

Accession and Pathway Details
Accession NameAccession No.Accession TypePathway Link
  • Ajay_Bhalla_
    2007_ReacDiff3
    		• 84NetworkShared_Object_Ajay_Bhalla_2007_ReacDiff3,  PKC,  PLA2,  
    MAPK,  PLA2,  Ras,  CaM,  chain,  kinetics,  PKC,  MAPK,  Ras,  CaM,  kinetics[1],  
    PKC,  PLA2,  MAPK,  Ras,  CaM,  kinetics[2],  PKC,  PLA2,  MAPK,  Ras,  CaM,  kinetics[3],  
    PKC,  PLA2,  MAPK,  Ras,  CaM,  kinetics[4],  PKC,  PLA2,  MAPK,  Ras,  CaM,  kinetics[5],  
    PKC,  PLA2,  MAPK,  Ras,  MAPK,  CaM,  kinetics[6],  PKC,  PLA2,  MAPK,  Ras,  
    CaM,  kinetics[7],  PKC,  PLA2,  MAPK,  Ras,  CaM,  PKC,  kinetics[8],  PLA2,  
    MAPK,  Ras,  CaM,  kinetics[9],  PKC,  PLA2,  MAPK,  Ras,  CaM,  kinetics[10],  
    PKC,  PLA2,  MAPK,  Ras,  CaM,  kinetics[11],  PKC,  PLA2,  MAPK,  Ras,  CaM,  
    kinetics[12],  PKC,  PLA2,  Ras,  CaM,  kinetics[13],  PKC,  PLA2,  MAPK,  
    Ras,  CaM,  kinetics[14],  PKC,  PLA2,  MAPK,  Ras,  CaM,  kinetics[15],  
    PKC,  PLA2,  MAPK,  Ras,  kinetics[16],  CaM,  PKC,  PLA2,  MAPK,  Ras,  CaM,  
    kinetics[17],  PKC,  PLA2,  MAPK,  Ras,  CaM,  kinetics[18],  PKC,  PLA2,  
    MAPK,  Ras,  CaM,  kinetics[19],  PKC,  PLA2,  MAPK,  Ras,  CaM,  kinetics[20],  
    PKC,  PLA2,  MAPK,  Ras,  CaM,  kinetics[21],  PKC,  PLA2,  MAPK,  Ras,  CaM,  
    kinetics[22],  PKC,  PLA2,  MAPK,  Ras,  CaM,  kinetics[23],  PKC,  PLA2,  
    MAPK,  Ras,  CaM 
    This is a 25-compartment reaction-diffusion version of the Ajay_Bhalla_2007_bistable model. The original single-compartment model is repeated 25 times.
    In addition, a subset (33 out of 50) molecules can diffuse between compartments. Diffusion is implemented as a reaction between corresponding molecules in neighboring compartments. Here D = 1e-13 m^2/sec (i.e., 0.1 micron^2/sec ) so the kf and kb of this reaction for these 10 micron compartments are both 0.001/sec.
    The basal calcium level in this model is held at 95 nM which is rather close to threshold for the flip to the active state. This is necessary to sustain active propagation of activation.
    The stimulus file bis6-propgn_D1e-13_FigEF which was used for the model to replicate Figure 4E and 4F from the paper.

    CaM-Ca4 acting as a Molecule in      Ajay_Bhalla_2007_ReacDiff3 Network
    NameAccession NamePathway NameInitial Conc.
    (uM)    		Volume
    (fL)    		Buffered
    CaM-Ca4
  • Ajay_Bhalla_
    2007_ReacDiff3
    Accession No. : 84
    		• CaM
    Pathway No. : 924    		0125.7No
    CaM-Ca4
  • Ajay_Bhalla_
    2007_ReacDiff3
    Accession No. : 84
    		• CaM
    Pathway No. : 930    		0125.7No
    CaM-Ca4
  • Ajay_Bhalla_
    2007_ReacDiff3
    Accession No. : 84
    		• CaM
    Pathway No. : 936    		0125.7No
    CaM-Ca4
  • Ajay_Bhalla_
    2007_ReacDiff3
    Accession No. : 84
    		• CaM
    Pathway No. : 942    		0125.7No
    CaM-Ca4
  • Ajay_Bhalla_
    2007_ReacDiff3
    Accession No. : 84
    		• CaM
    Pathway No. : 948    		0125.7No
    CaM-Ca4
  • Ajay_Bhalla_
    2007_ReacDiff3
    Accession No. : 84
    		• CaM
    Pathway No. : 954    		0125.7No
    CaM-Ca4
  • Ajay_Bhalla_
    2007_ReacDiff3
    Accession No. : 84
    		• CaM
    Pathway No. : 961    		0125.7No
    CaM-Ca4
  • Ajay_Bhalla_
    2007_ReacDiff3
    Accession No. : 84
    		• CaM
    Pathway No. : 967    		0125.7No
    CaM-Ca4
  • Ajay_Bhalla_
    2007_ReacDiff3
    Accession No. : 84
    		• CaM
    Pathway No. : 973    		0125.7No
    CaM-Ca4
  • Ajay_Bhalla_
    2007_ReacDiff3
    Accession No. : 84
    		• CaM
    Pathway No. : 979    		0125.7No
    CaM-Ca4
  • Ajay_Bhalla_
    2007_ReacDiff3
    Accession No. : 84
    		• CaM
    Pathway No. : 985    		0125.7No
    CaM-Ca4
  • Ajay_Bhalla_
    2007_ReacDiff3
    Accession No. : 84
    		• CaM
    Pathway No. : 991    		0125.7No
    CaM-Ca4
  • Ajay_Bhalla_
    2007_ReacDiff3
    Accession No. : 84
    		• CaM
    Pathway No. : 997    		0125.7No
    CaM-Ca4
  • Ajay_Bhalla_
    2007_ReacDiff3
    Accession No. : 84
    		• CaM
    Pathway No. : 1002    		0125.7No
    CaM-Ca4
  • Ajay_Bhalla_
    2007_ReacDiff3
    Accession No. : 84
    		• CaM
    Pathway No. : 1008    		0125.7No
    CaM-Ca4
  • Ajay_Bhalla_
    2007_ReacDiff3
    Accession No. : 84
    		• CaM
    Pathway No. : 1014    		0125.7No
    CaM-Ca4
  • Ajay_Bhalla_
    2007_ReacDiff3
    Accession No. : 84
    		• CaM
    Pathway No. : 1021    		0125.7No
    CaM-Ca4
  • Ajay_Bhalla_
    2007_ReacDiff3
    Accession No. : 84
    		• CaM
    Pathway No. : 1026    		0125.7No
    CaM-Ca4
  • Ajay_Bhalla_
    2007_ReacDiff3
    Accession No. : 84
    		• CaM
    Pathway No. : 1032    		0125.7No
    CaM-Ca4
  • Ajay_Bhalla_
    2007_ReacDiff3
    Accession No. : 84
    		• CaM
    Pathway No. : 1038    		0125.7No
    CaM-Ca4
  • Ajay_Bhalla_
    2007_ReacDiff3
    Accession No. : 84
    		• CaM
    Pathway No. : 1044    		0125.7No
    CaM-Ca4
  • Ajay_Bhalla_
    2007_ReacDiff3
    Accession No. : 84
    		• CaM
    Pathway No. : 1050    		0125.7No
    CaM-Ca4
  • Ajay_Bhalla_
    2007_ReacDiff3
    Accession No. : 84
    		• CaM
    Pathway No. : 1056    		0125.7No
    CaM-Ca4
  • Ajay_Bhalla_
    2007_ReacDiff3
    Accession No. : 84
    		• CaM
    Pathway No. : 1062    		0125.7No
    CaM-Ca4
  • Ajay_Bhalla_
    2007_ReacDiff3
    Accession No. : 84
    		• CaM
    Pathway No. : 1068    		0125.7No

    CaM-Ca4 acting as a Substrate in a reaction in      Ajay_Bhalla_2007_ReacDiff3 Network
    Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.
     NameAccession NamePathway NameKfKbKdtauReagents
    1CaM-bind-GEF
  • Ajay_Bhalla_
    2007_ReacDiff3
    Accession No. : 84
    		• Ras
    Pathway No. : 923    		199.995
    (uM^-1 s^-1)    		1
    (s^-1)    		Kd(bf) = 0.005(uM)-Substrate
    CaM-Ca4
    inact-GEF

    Product
    CaM-GEF
      We have no numbers for this. It is probably between the two extremes represented by the CaMKII phosph states, and I have used guesses based on this. kf=1e-4 kb=1 The reaction is based on Farnsworth et al Nature 376 524-527 1995 28 Feb 2006: Increased affinity 36-fold to account for Ca input to MAPK cascade, possibly folding in other pathway inputs. 21 April 2006: Altered affinity to same level as pkm_mapk21.g model to prevent spontaneous turnon. Kf = 200, Kb = 1.
    2diff
  • Ajay_Bhalla_
    2007_ReacDiff3
    Accession No. : 84
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff3
    Pathway No. : 918
    		• 0.001
    (s^-1)    		0.001
    (s^-1)    		Keq = 1(uM)500secSubstrate
    CaM-Ca4

    Product
    CaM-Ca4
    3CaM-bind-GEF
  • Ajay_Bhalla_
    2007_ReacDiff3
    Accession No. : 84
    		• Ras
    Pathway No. : 929    		199.995
    (uM^-1 s^-1)    		1
    (s^-1)    		Kd(bf) = 0.005(uM)-Substrate
    CaM-Ca4
    inact-GEF

    Product
    CaM-GEF
      We have no numbers for this. It is probably between the two extremes represented by the CaMKII phosph states, and I have used guesses based on this. kf=1e-4 kb=1 The reaction is based on Farnsworth et al Nature 376 524-527 1995 28 Feb 2006: Increased affinity 36-fold to account for Ca input to MAPK cascade, possibly folding in other pathway inputs. 21 April 2006: Altered affinity to same level as pkm_mapk21.g model to prevent spontaneous turnon. Kf = 200, Kb = 1.
    4diff
  • Ajay_Bhalla_
    2007_ReacDiff3
    Accession No. : 84
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff3
    Pathway No. : 918
    		• 0.001
    (s^-1)    		0.001
    (s^-1)    		Keq = 1(uM)500secSubstrate
    CaM-Ca4

    Product
    CaM-Ca4
    5CaM-bind-GEF
  • Ajay_Bhalla_
    2007_ReacDiff3
    Accession No. : 84
    		• Ras
    Pathway No. : 935    		199.995
    (uM^-1 s^-1)    		1
    (s^-1)    		Kd(bf) = 0.005(uM)-Substrate
    CaM-Ca4
    inact-GEF

    Product
    CaM-GEF
      We have no numbers for this. It is probably between the two extremes represented by the CaMKII phosph states, and I have used guesses based on this. kf=1e-4 kb=1 The reaction is based on Farnsworth et al Nature 376 524-527 1995 28 Feb 2006: Increased affinity 36-fold to account for Ca input to MAPK cascade, possibly folding in other pathway inputs. 21 April 2006: Altered affinity to same level as pkm_mapk21.g model to prevent spontaneous turnon. Kf = 200, Kb = 1.
    6diff
  • Ajay_Bhalla_
    2007_ReacDiff3
    Accession No. : 84
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff3
    Pathway No. : 918
    		• 0.001
    (s^-1)    		0.001
    (s^-1)    		Keq = 1(uM)500secSubstrate
    CaM-Ca4

    Product
    CaM-Ca4
    7CaM-bind-GEF
  • Ajay_Bhalla_
    2007_ReacDiff3
    Accession No. : 84
    		• Ras
    Pathway No. : 959    		199.995
    (uM^-1 s^-1)    		1
    (s^-1)    		Kd(bf) = 0.005(uM)-Substrate
    CaM-Ca4
    inact-GEF

    Product
    CaM-GEF
      We have no numbers for this. It is probably between the two extremes represented by the CaMKII phosph states, and I have used guesses based on this. kf=1e-4 kb=1 The reaction is based on Farnsworth et al Nature 376 524-527 1995 28 Feb 2006: Increased affinity 36-fold to account for Ca input to MAPK cascade, possibly folding in other pathway inputs. 21 April 2006: Altered affinity to same level as pkm_mapk21.g model to prevent spontaneous turnon. Kf = 200, Kb = 1.
    8CaM-bind-GEF
  • Ajay_Bhalla_
    2007_ReacDiff3
    Accession No. : 84
    		• Ras
    Pathway No. : 941    		199.995
    (uM^-1 s^-1)    		1
    (s^-1)    		Kd(bf) = 0.005(uM)-Substrate
    CaM-Ca4
    inact-GEF

    Product
    CaM-GEF
      We have no numbers for this. It is probably between the two extremes represented by the CaMKII phosph states, and I have used guesses based on this. kf=1e-4 kb=1 The reaction is based on Farnsworth et al Nature 376 524-527 1995 28 Feb 2006: Increased affinity 36-fold to account for Ca input to MAPK cascade, possibly folding in other pathway inputs. 21 April 2006: Altered affinity to same level as pkm_mapk21.g model to prevent spontaneous turnon. Kf = 200, Kb = 1.
    9diff
  • Ajay_Bhalla_
    2007_ReacDiff3
    Accession No. : 84
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff3
    Pathway No. : 918
    		• 0.001
    (s^-1)    		0.001
    (s^-1)    		Keq = 1(uM)500secSubstrate
    CaM-Ca4

    Product
    CaM-Ca4
    10CaM-bind-GEF
  • Ajay_Bhalla_
    2007_ReacDiff3
    Accession No. : 84
    		• Ras
    Pathway No. : 947    		199.995
    (uM^-1 s^-1)    		1
    (s^-1)    		Kd(bf) = 0.005(uM)-Substrate
    CaM-Ca4
    inact-GEF

    Product
    CaM-GEF
      We have no numbers for this. It is probably between the two extremes represented by the CaMKII phosph states, and I have used guesses based on this. kf=1e-4 kb=1 The reaction is based on Farnsworth et al Nature 376 524-527 1995 28 Feb 2006: Increased affinity 36-fold to account for Ca input to MAPK cascade, possibly folding in other pathway inputs. 21 April 2006: Altered affinity to same level as pkm_mapk21.g model to prevent spontaneous turnon. Kf = 200, Kb = 1.
    11diff
  • Ajay_Bhalla_
    2007_ReacDiff3
    Accession No. : 84
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff3
    Pathway No. : 918
    		• 0.001
    (s^-1)    		0.001
    (s^-1)    		Keq = 1(uM)500secSubstrate
    CaM-Ca4

    Product
    CaM-Ca4
    12CaM-bind-GEF
  • Ajay_Bhalla_
    2007_ReacDiff3
    Accession No. : 84
    		• Ras
    Pathway No. : 953    		199.995
    (uM^-1 s^-1)    		1
    (s^-1)    		Kd(bf) = 0.005(uM)-Substrate
    CaM-Ca4
    inact-GEF

    Product
    CaM-GEF
      We have no numbers for this. It is probably between the two extremes represented by the CaMKII phosph states, and I have used guesses based on this. kf=1e-4 kb=1 The reaction is based on Farnsworth et al Nature 376 524-527 1995 28 Feb 2006: Increased affinity 36-fold to account for Ca input to MAPK cascade, possibly folding in other pathway inputs. 21 April 2006: Altered affinity to same level as pkm_mapk21.g model to prevent spontaneous turnon. Kf = 200, Kb = 1.
    13diff
  • Ajay_Bhalla_
    2007_ReacDiff3
    Accession No. : 84
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff3
    Pathway No. : 918
    		• 0.001
    (s^-1)    		0.001
    (s^-1)    		Keq = 1(uM)500secSubstrate
    CaM-Ca4

    Product
    CaM-Ca4
    14diff
  • Ajay_Bhalla_
    2007_ReacDiff3
    Accession No. : 84
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff3
    Pathway No. : 918
    		• 0.001
    (s^-1)    		0.001
    (s^-1)    		Keq = 1(uM)500secSubstrate
    CaM-Ca4

    Product
    CaM-Ca4
    15CaM-bind-GEF
  • Ajay_Bhalla_
    2007_ReacDiff3
    Accession No. : 84
    		• Ras
    Pathway No. : 966    		199.995
    (uM^-1 s^-1)    		1
    (s^-1)    		Kd(bf) = 0.005(uM)-Substrate
    CaM-Ca4
    inact-GEF

    Product
    CaM-GEF
      We have no numbers for this. It is probably between the two extremes represented by the CaMKII phosph states, and I have used guesses based on this. kf=1e-4 kb=1 The reaction is based on Farnsworth et al Nature 376 524-527 1995 28 Feb 2006: Increased affinity 36-fold to account for Ca input to MAPK cascade, possibly folding in other pathway inputs. 21 April 2006: Altered affinity to same level as pkm_mapk21.g model to prevent spontaneous turnon. Kf = 200, Kb = 1.
    16diff
  • Ajay_Bhalla_
    2007_ReacDiff3
    Accession No. : 84
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff3
    Pathway No. : 918
    		• 0.001
    (s^-1)    		0.001
    (s^-1)    		Keq = 1(uM)500secSubstrate
    CaM-Ca4

    Product
    CaM-Ca4
    17CaM-bind-GEF
  • Ajay_Bhalla_
    2007_ReacDiff3
    Accession No. : 84
    		• Ras
    Pathway No. : 972    		199.995
    (uM^-1 s^-1)    		1
    (s^-1)    		Kd(bf) = 0.005(uM)-Substrate
    CaM-Ca4
    inact-GEF

    Product
    CaM-GEF
      We have no numbers for this. It is probably between the two extremes represented by the CaMKII phosph states, and I have used guesses based on this. kf=1e-4 kb=1 The reaction is based on Farnsworth et al Nature 376 524-527 1995 28 Feb 2006: Increased affinity 36-fold to account for Ca input to MAPK cascade, possibly folding in other pathway inputs. 21 April 2006: Altered affinity to same level as pkm_mapk21.g model to prevent spontaneous turnon. Kf = 200, Kb = 1.
    18diff
  • Ajay_Bhalla_
    2007_ReacDiff3
    Accession No. : 84
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff3
    Pathway No. : 918
    		• 0.001
    (s^-1)    		0.001
    (s^-1)    		Keq = 1(uM)500secSubstrate
    CaM-Ca4

    Product
    CaM-Ca4
    19CaM-bind-GEF
  • Ajay_Bhalla_
    2007_ReacDiff3
    Accession No. : 84
    		• Ras
    Pathway No. : 978    		199.995
    (uM^-1 s^-1)    		1
    (s^-1)    		Kd(bf) = 0.005(uM)-Substrate
    CaM-Ca4
    inact-GEF

    Product
    CaM-GEF
      We have no numbers for this. It is probably between the two extremes represented by the CaMKII phosph states, and I have used guesses based on this. kf=1e-4 kb=1 The reaction is based on Farnsworth et al Nature 376 524-527 1995 28 Feb 2006: Increased affinity 36-fold to account for Ca input to MAPK cascade, possibly folding in other pathway inputs. 21 April 2006: Altered affinity to same level as pkm_mapk21.g model to prevent spontaneous turnon. Kf = 200, Kb = 1.
    20diff
  • Ajay_Bhalla_
    2007_ReacDiff3
    Accession No. : 84
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff3
    Pathway No. : 918
    		• 0.001
    (s^-1)    		0.001
    (s^-1)    		Keq = 1(uM)500secSubstrate
    CaM-Ca4

    Product
    CaM-Ca4
    21CaM-bind-GEF
  • Ajay_Bhalla_
    2007_ReacDiff3
    Accession No. : 84
    		• Ras
    Pathway No. : 984    		199.995
    (uM^-1 s^-1)    		1
    (s^-1)    		Kd(bf) = 0.005(uM)-Substrate
    CaM-Ca4
    inact-GEF

    Product
    CaM-GEF
      We have no numbers for this. It is probably between the two extremes represented by the CaMKII phosph states, and I have used guesses based on this. kf=1e-4 kb=1 The reaction is based on Farnsworth et al Nature 376 524-527 1995 28 Feb 2006: Increased affinity 36-fold to account for Ca input to MAPK cascade, possibly folding in other pathway inputs. 21 April 2006: Altered affinity to same level as pkm_mapk21.g model to prevent spontaneous turnon. Kf = 200, Kb = 1.
    22diff
  • Ajay_Bhalla_
    2007_ReacDiff3
    Accession No. : 84
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff3
    Pathway No. : 918
    		• 0.001
    (s^-1)    		0.001
    (s^-1)    		Keq = 1(uM)500secSubstrate
    CaM-Ca4

    Product
    CaM-Ca4
    23CaM-bind-GEF
  • Ajay_Bhalla_
    2007_ReacDiff3
    Accession No. : 84
    		• Ras
    Pathway No. : 990    		199.995
    (uM^-1 s^-1)    		1
    (s^-1)    		Kd(bf) = 0.005(uM)-Substrate
    CaM-Ca4
    inact-GEF

    Product
    CaM-GEF
      We have no numbers for this. It is probably between the two extremes represented by the CaMKII phosph states, and I have used guesses based on this. kf=1e-4 kb=1 The reaction is based on Farnsworth et al Nature 376 524-527 1995 28 Feb 2006: Increased affinity 36-fold to account for Ca input to MAPK cascade, possibly folding in other pathway inputs. 21 April 2006: Altered affinity to same level as pkm_mapk21.g model to prevent spontaneous turnon. Kf = 200, Kb = 1.
    24diff
  • Ajay_Bhalla_
    2007_ReacDiff3
    Accession No. : 84
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff3
    Pathway No. : 918
    		• 0.001
    (s^-1)    		0.001
    (s^-1)    		Keq = 1(uM)500secSubstrate
    CaM-Ca4

    Product
    CaM-Ca4
    25CaM-bind-GEF
  • Ajay_Bhalla_
    2007_ReacDiff3
    Accession No. : 84
    		• Ras
    Pathway No. : 996    		199.995
    (uM^-1 s^-1)    		1
    (s^-1)    		Kd(bf) = 0.005(uM)-Substrate
    CaM-Ca4
    inact-GEF

    Product
    CaM-GEF
      We have no numbers for this. It is probably between the two extremes represented by the CaMKII phosph states, and I have used guesses based on this. kf=1e-4 kb=1 The reaction is based on Farnsworth et al Nature 376 524-527 1995 28 Feb 2006: Increased affinity 36-fold to account for Ca input to MAPK cascade, possibly folding in other pathway inputs. 21 April 2006: Altered affinity to same level as pkm_mapk21.g model to prevent spontaneous turnon. Kf = 200, Kb = 1.
    26diff
  • Ajay_Bhalla_
    2007_ReacDiff3
    Accession No. : 84
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff3
    Pathway No. : 918
    		• 0.001
    (s^-1)    		0.001
    (s^-1)    		Keq = 1(uM)500secSubstrate
    CaM-Ca4

    Product
    CaM-Ca4
    27CaM-bind-GEF
  • Ajay_Bhalla_
    2007_ReacDiff3
    Accession No. : 84
    		• Ras
    Pathway No. : 1001    		199.995
    (uM^-1 s^-1)    		1
    (s^-1)    		Kd(bf) = 0.005(uM)-Substrate
    CaM-Ca4
    inact-GEF

    Product
    CaM-GEF
      We have no numbers for this. It is probably between the two extremes represented by the CaMKII phosph states, and I have used guesses based on this. kf=1e-4 kb=1 The reaction is based on Farnsworth et al Nature 376 524-527 1995 28 Feb 2006: Increased affinity 36-fold to account for Ca input to MAPK cascade, possibly folding in other pathway inputs. 21 April 2006: Altered affinity to same level as pkm_mapk21.g model to prevent spontaneous turnon. Kf = 200, Kb = 1.
    28diff
  • Ajay_Bhalla_
    2007_ReacDiff3
    Accession No. : 84
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff3
    Pathway No. : 918
    		• 0.001
    (s^-1)    		0.001
    (s^-1)    		Keq = 1(uM)500secSubstrate
    CaM-Ca4

    Product
    CaM-Ca4
    29CaM-bind-GEF
  • Ajay_Bhalla_
    2007_ReacDiff3
    Accession No. : 84
    		• Ras
    Pathway No. : 1007    		199.995
    (uM^-1 s^-1)    		1
    (s^-1)    		Kd(bf) = 0.005(uM)-Substrate
    CaM-Ca4
    inact-GEF

    Product
    CaM-GEF
      We have no numbers for this. It is probably between the two extremes represented by the CaMKII phosph states, and I have used guesses based on this. kf=1e-4 kb=1 The reaction is based on Farnsworth et al Nature 376 524-527 1995 28 Feb 2006: Increased affinity 36-fold to account for Ca input to MAPK cascade, possibly folding in other pathway inputs. 21 April 2006: Altered affinity to same level as pkm_mapk21.g model to prevent spontaneous turnon. Kf = 200, Kb = 1.
    30diff
  • Ajay_Bhalla_
    2007_ReacDiff3
    Accession No. : 84
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff3
    Pathway No. : 918
    		• 0.001
    (s^-1)    		0.001
    (s^-1)    		Keq = 1(uM)500secSubstrate
    CaM-Ca4

    Product
    CaM-Ca4
    31CaM-bind-GEF
  • Ajay_Bhalla_
    2007_ReacDiff3
    Accession No. : 84
    		• Ras
    Pathway No. : 1013    		199.995
    (uM^-1 s^-1)    		1
    (s^-1)    		Kd(bf) = 0.005(uM)-Substrate
    CaM-Ca4
    inact-GEF

    Product
    CaM-GEF
      We have no numbers for this. It is probably between the two extremes represented by the CaMKII phosph states, and I have used guesses based on this. kf=1e-4 kb=1 The reaction is based on Farnsworth et al Nature 376 524-527 1995 28 Feb 2006: Increased affinity 36-fold to account for Ca input to MAPK cascade, possibly folding in other pathway inputs. 21 April 2006: Altered affinity to same level as pkm_mapk21.g model to prevent spontaneous turnon. Kf = 200, Kb = 1.
    32diff
  • Ajay_Bhalla_
    2007_ReacDiff3
    Accession No. : 84
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff3
    Pathway No. : 918
    		• 0.001
    (s^-1)    		0.001
    (s^-1)    		Keq = 1(uM)500secSubstrate
    CaM-Ca4

    Product
    CaM-Ca4
    33CaM-bind-GEF
  • Ajay_Bhalla_
    2007_ReacDiff3
    Accession No. : 84
    		• Ras
    Pathway No. : 1019    		199.995
    (uM^-1 s^-1)    		1
    (s^-1)    		Kd(bf) = 0.005(uM)-Substrate
    CaM-Ca4
    inact-GEF

    Product
    CaM-GEF
      We have no numbers for this. It is probably between the two extremes represented by the CaMKII phosph states, and I have used guesses based on this. kf=1e-4 kb=1 The reaction is based on Farnsworth et al Nature 376 524-527 1995 28 Feb 2006: Increased affinity 36-fold to account for Ca input to MAPK cascade, possibly folding in other pathway inputs. 21 April 2006: Altered affinity to same level as pkm_mapk21.g model to prevent spontaneous turnon. Kf = 200, Kb = 1.
    34diff
  • Ajay_Bhalla_
    2007_ReacDiff3
    Accession No. : 84
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff3
    Pathway No. : 918
    		• 0.001
    (s^-1)    		0.001
    (s^-1)    		Keq = 1(uM)500secSubstrate
    CaM-Ca4

    Product
    CaM-Ca4
    35CaM-bind-GEF
  • Ajay_Bhalla_
    2007_ReacDiff3
    Accession No. : 84
    		• Ras
    Pathway No. : 1025    		199.995
    (uM^-1 s^-1)    		1
    (s^-1)    		Kd(bf) = 0.005(uM)-Substrate
    CaM-Ca4
    inact-GEF

    Product
    CaM-GEF
      We have no numbers for this. It is probably between the two extremes represented by the CaMKII phosph states, and I have used guesses based on this. kf=1e-4 kb=1 The reaction is based on Farnsworth et al Nature 376 524-527 1995 28 Feb 2006: Increased affinity 36-fold to account for Ca input to MAPK cascade, possibly folding in other pathway inputs. 21 April 2006: Altered affinity to same level as pkm_mapk21.g model to prevent spontaneous turnon. Kf = 200, Kb = 1.
    36diff
  • Ajay_Bhalla_
    2007_ReacDiff3
    Accession No. : 84
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff3
    Pathway No. : 918
    		• 0.001
    (s^-1)    		0.001
    (s^-1)    		Keq = 1(uM)500secSubstrate
    CaM-Ca4

    Product
    CaM-Ca4
    37CaM-bind-GEF
  • Ajay_Bhalla_
    2007_ReacDiff3
    Accession No. : 84
    		• Ras
    Pathway No. : 1031    		199.995
    (uM^-1 s^-1)    		1
    (s^-1)    		Kd(bf) = 0.005(uM)-Substrate
    CaM-Ca4
    inact-GEF

    Product
    CaM-GEF
      We have no numbers for this. It is probably between the two extremes represented by the CaMKII phosph states, and I have used guesses based on this. kf=1e-4 kb=1 The reaction is based on Farnsworth et al Nature 376 524-527 1995 28 Feb 2006: Increased affinity 36-fold to account for Ca input to MAPK cascade, possibly folding in other pathway inputs. 21 April 2006: Altered affinity to same level as pkm_mapk21.g model to prevent spontaneous turnon. Kf = 200, Kb = 1.
    38diff
  • Ajay_Bhalla_
    2007_ReacDiff3
    Accession No. : 84
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff3
    Pathway No. : 918
    		• 0.001
    (s^-1)    		0.001
    (s^-1)    		Keq = 1(uM)500secSubstrate
    CaM-Ca4

    Product
    CaM-Ca4
    39CaM-bind-GEF
  • Ajay_Bhalla_
    2007_ReacDiff3
    Accession No. : 84
    		• Ras
    Pathway No. : 1037    		199.995
    (uM^-1 s^-1)    		1
    (s^-1)    		Kd(bf) = 0.005(uM)-Substrate
    CaM-Ca4
    inact-GEF

    Product
    CaM-GEF
      We have no numbers for this. It is probably between the two extremes represented by the CaMKII phosph states, and I have used guesses based on this. kf=1e-4 kb=1 The reaction is based on Farnsworth et al Nature 376 524-527 1995 28 Feb 2006: Increased affinity 36-fold to account for Ca input to MAPK cascade, possibly folding in other pathway inputs. 21 April 2006: Altered affinity to same level as pkm_mapk21.g model to prevent spontaneous turnon. Kf = 200, Kb = 1.
    40diff
  • Ajay_Bhalla_
    2007_ReacDiff3
    Accession No. : 84
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff3
    Pathway No. : 918
    		• 0.001
    (s^-1)    		0.001
    (s^-1)    		Keq = 1(uM)500secSubstrate
    CaM-Ca4

    Product
    CaM-Ca4
    41CaM-bind-GEF
  • Ajay_Bhalla_
    2007_ReacDiff3
    Accession No. : 84
    		• Ras
    Pathway No. : 1043    		199.995
    (uM^-1 s^-1)    		1
    (s^-1)    		Kd(bf) = 0.005(uM)-Substrate
    CaM-Ca4
    inact-GEF

    Product
    CaM-GEF
      We have no numbers for this. It is probably between the two extremes represented by the CaMKII phosph states, and I have used guesses based on this. kf=1e-4 kb=1 The reaction is based on Farnsworth et al Nature 376 524-527 1995 28 Feb 2006: Increased affinity 36-fold to account for Ca input to MAPK cascade, possibly folding in other pathway inputs. 21 April 2006: Altered affinity to same level as pkm_mapk21.g model to prevent spontaneous turnon. Kf = 200, Kb = 1.
    42diff
  • Ajay_Bhalla_
    2007_ReacDiff3
    Accession No. : 84
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff3
    Pathway No. : 918
    		• 0.001
    (s^-1)    		0.001
    (s^-1)    		Keq = 1(uM)500secSubstrate
    CaM-Ca4

    Product
    CaM-Ca4
    43CaM-bind-GEF
  • Ajay_Bhalla_
    2007_ReacDiff3
    Accession No. : 84
    		• Ras
    Pathway No. : 1049    		199.995
    (uM^-1 s^-1)    		1
    (s^-1)    		Kd(bf) = 0.005(uM)-Substrate
    CaM-Ca4
    inact-GEF

    Product
    CaM-GEF
      We have no numbers for this. It is probably between the two extremes represented by the CaMKII phosph states, and I have used guesses based on this. kf=1e-4 kb=1 The reaction is based on Farnsworth et al Nature 376 524-527 1995 28 Feb 2006: Increased affinity 36-fold to account for Ca input to MAPK cascade, possibly folding in other pathway inputs. 21 April 2006: Altered affinity to same level as pkm_mapk21.g model to prevent spontaneous turnon. Kf = 200, Kb = 1.
    44diff
  • Ajay_Bhalla_
    2007_ReacDiff3
    Accession No. : 84
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff3
    Pathway No. : 918
    		• 0.001
    (s^-1)    		0.001
    (s^-1)    		Keq = 1(uM)500secSubstrate
    CaM-Ca4

    Product
    CaM-Ca4
    45CaM-bind-GEF
  • Ajay_Bhalla_
    2007_ReacDiff3
    Accession No. : 84
    		• Ras
    Pathway No. : 1055    		199.995
    (uM^-1 s^-1)    		1
    (s^-1)    		Kd(bf) = 0.005(uM)-Substrate
    CaM-Ca4
    inact-GEF

    Product
    CaM-GEF
      We have no numbers for this. It is probably between the two extremes represented by the CaMKII phosph states, and I have used guesses based on this. kf=1e-4 kb=1 The reaction is based on Farnsworth et al Nature 376 524-527 1995 28 Feb 2006: Increased affinity 36-fold to account for Ca input to MAPK cascade, possibly folding in other pathway inputs. 21 April 2006: Altered affinity to same level as pkm_mapk21.g model to prevent spontaneous turnon. Kf = 200, Kb = 1.
    46diff
  • Ajay_Bhalla_
    2007_ReacDiff3
    Accession No. : 84
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff3
    Pathway No. : 918
    		• 0.001
    (s^-1)    		0.001
    (s^-1)    		Keq = 1(uM)500secSubstrate
    CaM-Ca4

    Product
    CaM-Ca4
    47CaM-bind-GEF
  • Ajay_Bhalla_
    2007_ReacDiff3
    Accession No. : 84
    		• Ras
    Pathway No. : 1061    		199.995
    (uM^-1 s^-1)    		1
    (s^-1)    		Kd(bf) = 0.005(uM)-Substrate
    CaM-Ca4
    inact-GEF

    Product
    CaM-GEF
      We have no numbers for this. It is probably between the two extremes represented by the CaMKII phosph states, and I have used guesses based on this. kf=1e-4 kb=1 The reaction is based on Farnsworth et al Nature 376 524-527 1995 28 Feb 2006: Increased affinity 36-fold to account for Ca input to MAPK cascade, possibly folding in other pathway inputs. 21 April 2006: Altered affinity to same level as pkm_mapk21.g model to prevent spontaneous turnon. Kf = 200, Kb = 1.
    48diff
  • Ajay_Bhalla_
    2007_ReacDiff3
    Accession No. : 84
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff3
    Pathway No. : 918
    		• 0.001
    (s^-1)    		0.001
    (s^-1)    		Keq = 1(uM)500secSubstrate
    CaM-Ca4

    Product
    CaM-Ca4
    49CaM-bind-GEF
  • Ajay_Bhalla_
    2007_ReacDiff3
    Accession No. : 84
    		• Ras
    Pathway No. : 1067    		199.995
    (uM^-1 s^-1)    		1
    (s^-1)    		Kd(bf) = 0.005(uM)-Substrate
    CaM-Ca4
    inact-GEF

    Product
    CaM-GEF
      We have no numbers for this. It is probably between the two extremes represented by the CaMKII phosph states, and I have used guesses based on this. kf=1e-4 kb=1 The reaction is based on Farnsworth et al Nature 376 524-527 1995 28 Feb 2006: Increased affinity 36-fold to account for Ca input to MAPK cascade, possibly folding in other pathway inputs. 21 April 2006: Altered affinity to same level as pkm_mapk21.g model to prevent spontaneous turnon. Kf = 200, Kb = 1.

    CaM-Ca4 acting as a Product in a reaction in      Ajay_Bhalla_2007_ReacDiff3 Network
    Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.
     NameAccession NamePathway NameKfKbKdtauReagents
    1CaM-Ca3-bind-Ca
  • Ajay_Bhalla_
    2007_ReacDiff3
    Accession No. : 84
    		• CaM
    Pathway No. : 924    		0.465
    (uM^-1 s^-1)    		10
    (s^-1)    		Kd(bf) = 21.5051(uM)-Substrate
    Ca
    CaM-Ca3

    Product
    CaM-Ca4
      Use K3 = 21.5 uM here from Stemmer and Klee table 3. kb/kf =21.5 * 6e5 so kf = 7.75e-7, kb = 10
    2diff
  • Ajay_Bhalla_
    2007_ReacDiff3
    Accession No. : 84
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff3
    Pathway No. : 918
    		• 0.001
    (s^-1)    		0.001
    (s^-1)    		Keq = 1(uM)500secSubstrate
    CaM-Ca4

    Product
    CaM-Ca4
    3CaM-Ca3-bind-Ca
  • Ajay_Bhalla_
    2007_ReacDiff3
    Accession No. : 84
    		• CaM
    Pathway No. : 930    		0.465
    (uM^-1 s^-1)    		10
    (s^-1)    		Kd(bf) = 21.5051(uM)-Substrate
    Ca
    CaM-Ca3

    Product
    CaM-Ca4
      Use K3 = 21.5 uM here from Stemmer and Klee table 3. kb/kf =21.5 * 6e5 so kf = 7.75e-7, kb = 10
    4diff
  • Ajay_Bhalla_
    2007_ReacDiff3
    Accession No. : 84
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff3
    Pathway No. : 918
    		• 0.001
    (s^-1)    		0.001
    (s^-1)    		Keq = 1(uM)500secSubstrate
    CaM-Ca4

    Product
    CaM-Ca4
    5CaM-Ca3-bind-Ca
  • Ajay_Bhalla_
    2007_ReacDiff3
    Accession No. : 84
    		• CaM
    Pathway No. : 936    		0.465
    (uM^-1 s^-1)    		10
    (s^-1)    		Kd(bf) = 21.5051(uM)-Substrate
    Ca
    CaM-Ca3

    Product
    CaM-Ca4
      Use K3 = 21.5 uM here from Stemmer and Klee table 3. kb/kf =21.5 * 6e5 so kf = 7.75e-7, kb = 10
    6diff
  • Ajay_Bhalla_
    2007_ReacDiff3
    Accession No. : 84
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff3
    Pathway No. : 918
    		• 0.001
    (s^-1)    		0.001
    (s^-1)    		Keq = 1(uM)500secSubstrate
    CaM-Ca4

    Product
    CaM-Ca4
    7CaM-Ca3-bind-Ca
  • Ajay_Bhalla_
    2007_ReacDiff3
    Accession No. : 84
    		• CaM
    Pathway No. : 942    		0.465
    (uM^-1 s^-1)    		10
    (s^-1)    		Kd(bf) = 21.5051(uM)-Substrate
    Ca
    CaM-Ca3

    Product
    CaM-Ca4
      Use K3 = 21.5 uM here from Stemmer and Klee table 3. kb/kf =21.5 * 6e5 so kf = 7.75e-7, kb = 10
    8diff
  • Ajay_Bhalla_
    2007_ReacDiff3
    Accession No. : 84
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff3
    Pathway No. : 918
    		• 0.001
    (s^-1)    		0.001
    (s^-1)    		Keq = 1(uM)500secSubstrate
    CaM-Ca4

    Product
    CaM-Ca4
    9CaM-Ca3-bind-Ca
  • Ajay_Bhalla_
    2007_ReacDiff3
    Accession No. : 84
    		• CaM
    Pathway No. : 948    		0.465
    (uM^-1 s^-1)    		10
    (s^-1)    		Kd(bf) = 21.5051(uM)-Substrate
    Ca
    CaM-Ca3

    Product
    CaM-Ca4
      Use K3 = 21.5 uM here from Stemmer and Klee table 3. kb/kf =21.5 * 6e5 so kf = 7.75e-7, kb = 10
    10diff
  • Ajay_Bhalla_
    2007_ReacDiff3
    Accession No. : 84
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff3
    Pathway No. : 918
    		• 0.001
    (s^-1)    		0.001
    (s^-1)    		Keq = 1(uM)500secSubstrate
    CaM-Ca4

    Product
    CaM-Ca4
    11CaM-Ca3-bind-Ca
  • Ajay_Bhalla_
    2007_ReacDiff3
    Accession No. : 84
    		• CaM
    Pathway No. : 954    		0.465
    (uM^-1 s^-1)    		10
    (s^-1)    		Kd(bf) = 21.5051(uM)-Substrate
    Ca
    CaM-Ca3

    Product
    CaM-Ca4
      Use K3 = 21.5 uM here from Stemmer and Klee table 3. kb/kf =21.5 * 6e5 so kf = 7.75e-7, kb = 10
    12diff
  • Ajay_Bhalla_
    2007_ReacDiff3
    Accession No. : 84
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff3
    Pathway No. : 918
    		• 0.001
    (s^-1)    		0.001
    (s^-1)    		Keq = 1(uM)500secSubstrate
    CaM-Ca4

    Product
    CaM-Ca4
    13CaM-Ca3-bind-Ca
  • Ajay_Bhalla_
    2007_ReacDiff3
    Accession No. : 84
    		• CaM
    Pathway No. : 961    		0.465
    (uM^-1 s^-1)    		10
    (s^-1)    		Kd(bf) = 21.5051(uM)-Substrate
    Ca
    CaM-Ca3

    Product
    CaM-Ca4
      Use K3 = 21.5 uM here from Stemmer and Klee table 3. kb/kf =21.5 * 6e5 so kf = 7.75e-7, kb = 10
    14diff
  • Ajay_Bhalla_
    2007_ReacDiff3
    Accession No. : 84
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff3
    Pathway No. : 918
    		• 0.001
    (s^-1)    		0.001
    (s^-1)    		Keq = 1(uM)500secSubstrate
    CaM-Ca4

    Product
    CaM-Ca4
    15CaM-Ca3-bind-Ca
  • Ajay_Bhalla_
    2007_ReacDiff3
    Accession No. : 84
    		• CaM
    Pathway No. : 967    		0.465
    (uM^-1 s^-1)    		10
    (s^-1)    		Kd(bf) = 21.5051(uM)-Substrate
    Ca
    CaM-Ca3

    Product
    CaM-Ca4
      Use K3 = 21.5 uM here from Stemmer and Klee table 3. kb/kf =21.5 * 6e5 so kf = 7.75e-7, kb = 10
    16diff
  • Ajay_Bhalla_
    2007_ReacDiff3
    Accession No. : 84
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff3
    Pathway No. : 918
    		• 0.001
    (s^-1)    		0.001
    (s^-1)    		Keq = 1(uM)500secSubstrate
    CaM-Ca4

    Product
    CaM-Ca4
    17CaM-Ca3-bind-Ca
  • Ajay_Bhalla_
    2007_ReacDiff3
    Accession No. : 84
    		• CaM
    Pathway No. : 973    		0.465
    (uM^-1 s^-1)    		10
    (s^-1)    		Kd(bf) = 21.5051(uM)-Substrate
    Ca
    CaM-Ca3

    Product
    CaM-Ca4
      Use K3 = 21.5 uM here from Stemmer and Klee table 3. kb/kf =21.5 * 6e5 so kf = 7.75e-7, kb = 10
    18diff
  • Ajay_Bhalla_
    2007_ReacDiff3
    Accession No. : 84
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff3
    Pathway No. : 918
    		• 0.001
    (s^-1)    		0.001
    (s^-1)    		Keq = 1(uM)500secSubstrate
    CaM-Ca4

    Product
    CaM-Ca4
    19CaM-Ca3-bind-Ca
  • Ajay_Bhalla_
    2007_ReacDiff3
    Accession No. : 84
    		• CaM
    Pathway No. : 979    		0.465
    (uM^-1 s^-1)    		10
    (s^-1)    		Kd(bf) = 21.5051(uM)-Substrate
    Ca
    CaM-Ca3

    Product
    CaM-Ca4
      Use K3 = 21.5 uM here from Stemmer and Klee table 3. kb/kf =21.5 * 6e5 so kf = 7.75e-7, kb = 10
    20diff
  • Ajay_Bhalla_
    2007_ReacDiff3
    Accession No. : 84
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff3
    Pathway No. : 918
    		• 0.001
    (s^-1)    		0.001
    (s^-1)    		Keq = 1(uM)500secSubstrate
    CaM-Ca4

    Product
    CaM-Ca4
    21CaM-Ca3-bind-Ca
  • Ajay_Bhalla_
    2007_ReacDiff3
    Accession No. : 84
    		• CaM
    Pathway No. : 985    		0.465
    (uM^-1 s^-1)    		10
    (s^-1)    		Kd(bf) = 21.5051(uM)-Substrate
    Ca
    CaM-Ca3

    Product
    CaM-Ca4
      Use K3 = 21.5 uM here from Stemmer and Klee table 3. kb/kf =21.5 * 6e5 so kf = 7.75e-7, kb = 10
    22diff
  • Ajay_Bhalla_
    2007_ReacDiff3
    Accession No. : 84
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff3
    Pathway No. : 918
    		• 0.001
    (s^-1)    		0.001
    (s^-1)    		Keq = 1(uM)500secSubstrate
    CaM-Ca4

    Product
    CaM-Ca4
    23CaM-Ca3-bind-Ca
  • Ajay_Bhalla_
    2007_ReacDiff3
    Accession No. : 84
    		• CaM
    Pathway No. : 991    		0.465
    (uM^-1 s^-1)    		10
    (s^-1)    		Kd(bf) = 21.5051(uM)-Substrate
    Ca
    CaM-Ca3

    Product
    CaM-Ca4
      Use K3 = 21.5 uM here from Stemmer and Klee table 3. kb/kf =21.5 * 6e5 so kf = 7.75e-7, kb = 10
    24diff
  • Ajay_Bhalla_
    2007_ReacDiff3
    Accession No. : 84
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff3
    Pathway No. : 918
    		• 0.001
    (s^-1)    		0.001
    (s^-1)    		Keq = 1(uM)500secSubstrate
    CaM-Ca4

    Product
    CaM-Ca4
    25CaM-Ca3-bind-Ca
  • Ajay_Bhalla_
    2007_ReacDiff3
    Accession No. : 84
    		• CaM
    Pathway No. : 997    		0.465
    (uM^-1 s^-1)    		10
    (s^-1)    		Kd(bf) = 21.5051(uM)-Substrate
    Ca
    CaM-Ca3

    Product
    CaM-Ca4
      Use K3 = 21.5 uM here from Stemmer and Klee table 3. kb/kf =21.5 * 6e5 so kf = 7.75e-7, kb = 10
    26diff
  • Ajay_Bhalla_
    2007_ReacDiff3
    Accession No. : 84
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff3
    Pathway No. : 918
    		• 0.001
    (s^-1)    		0.001
    (s^-1)    		Keq = 1(uM)500secSubstrate
    CaM-Ca4

    Product
    CaM-Ca4
    27CaM-Ca3-bind-Ca
  • Ajay_Bhalla_
    2007_ReacDiff3
    Accession No. : 84
    		• CaM
    Pathway No. : 1002    		0.465
    (uM^-1 s^-1)    		10
    (s^-1)    		Kd(bf) = 21.5051(uM)-Substrate
    Ca
    CaM-Ca3

    Product
    CaM-Ca4
      Use K3 = 21.5 uM here from Stemmer and Klee table 3. kb/kf =21.5 * 6e5 so kf = 7.75e-7, kb = 10
    28diff
  • Ajay_Bhalla_
    2007_ReacDiff3
    Accession No. : 84
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff3
    Pathway No. : 918
    		• 0.001
    (s^-1)    		0.001
    (s^-1)    		Keq = 1(uM)500secSubstrate
    CaM-Ca4

    Product
    CaM-Ca4
    29CaM-Ca3-bind-Ca
  • Ajay_Bhalla_
    2007_ReacDiff3
    Accession No. : 84
    		• CaM
    Pathway No. : 1008    		0.465
    (uM^-1 s^-1)    		10
    (s^-1)    		Kd(bf) = 21.5051(uM)-Substrate
    Ca
    CaM-Ca3

    Product
    CaM-Ca4
      Use K3 = 21.5 uM here from Stemmer and Klee table 3. kb/kf =21.5 * 6e5 so kf = 7.75e-7, kb = 10
    30diff
  • Ajay_Bhalla_
    2007_ReacDiff3
    Accession No. : 84
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff3
    Pathway No. : 918
    		• 0.001
    (s^-1)    		0.001
    (s^-1)    		Keq = 1(uM)500secSubstrate
    CaM-Ca4

    Product
    CaM-Ca4
    31CaM-Ca3-bind-Ca
  • Ajay_Bhalla_
    2007_ReacDiff3
    Accession No. : 84
    		• CaM
    Pathway No. : 1014    		0.465
    (uM^-1 s^-1)    		10
    (s^-1)    		Kd(bf) = 21.5051(uM)-Substrate
    Ca
    CaM-Ca3

    Product
    CaM-Ca4
      Use K3 = 21.5 uM here from Stemmer and Klee table 3. kb/kf =21.5 * 6e5 so kf = 7.75e-7, kb = 10
    32diff
  • Ajay_Bhalla_
    2007_ReacDiff3
    Accession No. : 84
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff3
    Pathway No. : 918
    		• 0.001
    (s^-1)    		0.001
    (s^-1)    		Keq = 1(uM)500secSubstrate
    CaM-Ca4

    Product
    CaM-Ca4
    33CaM-Ca3-bind-Ca
  • Ajay_Bhalla_
    2007_ReacDiff3
    Accession No. : 84
    		• CaM
    Pathway No. : 1021    		0.465
    (uM^-1 s^-1)    		10
    (s^-1)    		Kd(bf) = 21.5051(uM)-Substrate
    Ca
    CaM-Ca3

    Product
    CaM-Ca4
      Use K3 = 21.5 uM here from Stemmer and Klee table 3. kb/kf =21.5 * 6e5 so kf = 7.75e-7, kb = 10
    34diff
  • Ajay_Bhalla_
    2007_ReacDiff3
    Accession No. : 84
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff3
    Pathway No. : 918
    		• 0.001
    (s^-1)    		0.001
    (s^-1)    		Keq = 1(uM)500secSubstrate
    CaM-Ca4

    Product
    CaM-Ca4
    35CaM-Ca3-bind-Ca
  • Ajay_Bhalla_
    2007_ReacDiff3
    Accession No. : 84
    		• CaM
    Pathway No. : 1026    		0.465
    (uM^-1 s^-1)    		10
    (s^-1)    		Kd(bf) = 21.5051(uM)-Substrate
    Ca
    CaM-Ca3

    Product
    CaM-Ca4
      Use K3 = 21.5 uM here from Stemmer and Klee table 3. kb/kf =21.5 * 6e5 so kf = 7.75e-7, kb = 10
    36diff
  • Ajay_Bhalla_
    2007_ReacDiff3
    Accession No. : 84
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff3
    Pathway No. : 918
    		• 0.001
    (s^-1)    		0.001
    (s^-1)    		Keq = 1(uM)500secSubstrate
    CaM-Ca4

    Product
    CaM-Ca4
    37CaM-Ca3-bind-Ca
  • Ajay_Bhalla_
    2007_ReacDiff3
    Accession No. : 84
    		• CaM
    Pathway No. : 1032    		0.465
    (uM^-1 s^-1)    		10
    (s^-1)    		Kd(bf) = 21.5051(uM)-Substrate
    Ca
    CaM-Ca3

    Product
    CaM-Ca4
      Use K3 = 21.5 uM here from Stemmer and Klee table 3. kb/kf =21.5 * 6e5 so kf = 7.75e-7, kb = 10
    38diff
  • Ajay_Bhalla_
    2007_ReacDiff3
    Accession No. : 84
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff3
    Pathway No. : 918
    		• 0.001
    (s^-1)    		0.001
    (s^-1)    		Keq = 1(uM)500secSubstrate
    CaM-Ca4

    Product
    CaM-Ca4
    39CaM-Ca3-bind-Ca
  • Ajay_Bhalla_
    2007_ReacDiff3
    Accession No. : 84
    		• CaM
    Pathway No. : 1038    		0.465
    (uM^-1 s^-1)    		10
    (s^-1)    		Kd(bf) = 21.5051(uM)-Substrate
    Ca
    CaM-Ca3

    Product
    CaM-Ca4
      Use K3 = 21.5 uM here from Stemmer and Klee table 3. kb/kf =21.5 * 6e5 so kf = 7.75e-7, kb = 10
    40diff
  • Ajay_Bhalla_
    2007_ReacDiff3
    Accession No. : 84
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff3
    Pathway No. : 918
    		• 0.001
    (s^-1)    		0.001
    (s^-1)    		Keq = 1(uM)500secSubstrate
    CaM-Ca4

    Product
    CaM-Ca4
    41CaM-Ca3-bind-Ca
  • Ajay_Bhalla_
    2007_ReacDiff3
    Accession No. : 84
    		• CaM
    Pathway No. : 1044    		0.465
    (uM^-1 s^-1)    		10
    (s^-1)    		Kd(bf) = 21.5051(uM)-Substrate
    Ca
    CaM-Ca3

    Product
    CaM-Ca4
      Use K3 = 21.5 uM here from Stemmer and Klee table 3. kb/kf =21.5 * 6e5 so kf = 7.75e-7, kb = 10
    42diff
  • Ajay_Bhalla_
    2007_ReacDiff3
    Accession No. : 84
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff3
    Pathway No. : 918
    		• 0.001
    (s^-1)    		0.001
    (s^-1)    		Keq = 1(uM)500secSubstrate
    CaM-Ca4

    Product
    CaM-Ca4
    43CaM-Ca3-bind-Ca
  • Ajay_Bhalla_
    2007_ReacDiff3
    Accession No. : 84
    		• CaM
    Pathway No. : 1050    		0.465
    (uM^-1 s^-1)    		10
    (s^-1)    		Kd(bf) = 21.5051(uM)-Substrate
    Ca
    CaM-Ca3

    Product
    CaM-Ca4
      Use K3 = 21.5 uM here from Stemmer and Klee table 3. kb/kf =21.5 * 6e5 so kf = 7.75e-7, kb = 10
    44diff
  • Ajay_Bhalla_
    2007_ReacDiff3
    Accession No. : 84
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff3
    Pathway No. : 918
    		• 0.001
    (s^-1)    		0.001
    (s^-1)    		Keq = 1(uM)500secSubstrate
    CaM-Ca4

    Product
    CaM-Ca4
    45CaM-Ca3-bind-Ca
  • Ajay_Bhalla_
    2007_ReacDiff3
    Accession No. : 84
    		• CaM
    Pathway No. : 1056    		0.465
    (uM^-1 s^-1)    		10
    (s^-1)    		Kd(bf) = 21.5051(uM)-Substrate
    Ca
    CaM-Ca3

    Product
    CaM-Ca4
      Use K3 = 21.5 uM here from Stemmer and Klee table 3. kb/kf =21.5 * 6e5 so kf = 7.75e-7, kb = 10
    46diff
  • Ajay_Bhalla_
    2007_ReacDiff3
    Accession No. : 84
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff3
    Pathway No. : 918
    		• 0.001
    (s^-1)    		0.001
    (s^-1)    		Keq = 1(uM)500secSubstrate
    CaM-Ca4

    Product
    CaM-Ca4
    47CaM-Ca3-bind-Ca
  • Ajay_Bhalla_
    2007_ReacDiff3
    Accession No. : 84
    		• CaM
    Pathway No. : 1062    		0.465
    (uM^-1 s^-1)    		10
    (s^-1)    		Kd(bf) = 21.5051(uM)-Substrate
    Ca
    CaM-Ca3

    Product
    CaM-Ca4
      Use K3 = 21.5 uM here from Stemmer and Klee table 3. kb/kf =21.5 * 6e5 so kf = 7.75e-7, kb = 10
    48diff
  • Ajay_Bhalla_
    2007_ReacDiff3
    Accession No. : 84
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff3
    Pathway No. : 918
    		• 0.001
    (s^-1)    		0.001
    (s^-1)    		Keq = 1(uM)500secSubstrate
    CaM-Ca4

    Product
    CaM-Ca4
    49CaM-Ca3-bind-Ca
  • Ajay_Bhalla_
    2007_ReacDiff3
    Accession No. : 84
    		• CaM
    Pathway No. : 1068    		0.465
    (uM^-1 s^-1)    		10
    (s^-1)    		Kd(bf) = 21.5051(uM)-Substrate
    Ca
    CaM-Ca3

    Product
    CaM-Ca4
      Use K3 = 21.5 uM here from Stemmer and Klee table 3. kb/kf =21.5 * 6e5 so kf = 7.75e-7, kb = 10


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