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Molecule List for pathway CaMKII (Pathway Number 264) in Accession CaMKII_model3 (Accession Number 63) | Default ordering is done according to Pathway Number. Table headers can be used for changing the default ordering.
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The entries are grouped according to Pathway Number and are alternately color coded using  and  color. |
| |
Name | Accession
Type | Initial
Conc.
(uM) | Volume
(fL) | Buffered | Sum Total Of | | 1 | tot_CaM_CaMKII | Network | 0 | 0 | No | CaMKII-CaM
CaMKII-thr286*-C
aM
| | 2 | tot_autonomous_
CaMKII | Network | 2 | 0 | No | CaMKII-thr286
CaMKII***
basal_CaMKII_
cyt
| | 3 | CaMKII-thr286*-C
aM | Network | 0 | 0 | No | - | | | From Hanson and Schulman, the thr286 is responsible for autonomous activation of CaMKII. | | 4 | CaMKII-thr286 | Network | 0 | 0 | No | - | | | I am not sure if we need to endow this one with a lot of enzs. It is likely to be a short-lived intermediate, since it will be phosphorylated further as soon as the CAM falls off. | | 5 | CaMKII-CaM | Network | 0 | 0 | No | - | | 6 | CaMKII*** | Network | 0 | 0 | No | - | | | From Hanson and Schulman, the CaMKII does a lot of autophosphorylation just after the CaM is released. This prevents further CaM binding and renders the enzyme quite independent of Ca. | | 7 | CaMKII | Network | 20 | 0 | No | - | | | Huge conc of CaMKII. In PSD it is 20-40% of protein, so we assume it is around 2.5% of protein in spine as a whole. This level is so high it is unlikely to matter much if we are off a bit. | | 8 | CaMK-thr305 | Network | 0 | 0 | No | - | | | This forms due to basal autophosphorylation, but I think it has to be considered as a pathway even if some CaM is floating around. In either case it will tend to block further binding of CaM, and will not display any enzyme activity. See Hanson and Schulman JBC 267:24 pp17216-17224 1992 |
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