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Enzyme List for pathway PKA (Pathway Number 288) in Accession AMPAR_CaMKII_weak_coupling (Accession Number 65) |
Entries are grouped according to Pathway Number and they are alternately color coded using  and  color.Further ordering can be done according to header.   arrow indicates that ordering is done according to ascending or descending order. |
| Enzyme Molecule / Enzyme Activity | Pathway Name / Pathway No. | Km (uM) | kcat (s^-1) | Ratio (k2/k3) | Enzyme Type | Reagents | ||
| 1 | PKA-active / phosph-PDE | PKA Pathway No. 288 | 7.50008 | 9 | 4 | explicit E-S complex | Substrate: cAMP-PDE Product : cAMP-PDE* | |
| Same rates as PKA-phosph-I1 | ||||||||
| 2 | PKA-active / PKA-phosph-I1 | PKA Pathway No. 288 | 7.50008 | 9 | 4 | explicit E-S complex | Substrate: I1 Product : I1* | |
| #s from Bramson et al CRC crit rev Biochem 15:2 93-124. They have a huge list of peptide substrates and I have chosen high-ish rates. These consts give too much PKA activity, so lower Vmax 1/3. Now, k1 = 3e-5, k2 = 36, k3 = 9 (still pretty fast). Also lower Km 1/3 so k1 = 1e-5 Cohen et al FEBS Lett 76:182-86 1977 say rate =30% PKA act on phosphokinase beta. | ||||||||
| 3 | PKA-active / PSD | PKA Pathway No. 288 | 7.50008 | 9 | 4 | explicit E-S complex | Substrate: I1 Product : I1* | |
| 4 | PKA-active / PKA[17] | PKA Pathway No. 288 | 7.50021 | 6 | 4 | explicit E-S complex | Substrate: A_B Product : A845*_B | |
| 5 | PKA-active / PKA[16] | PKA Pathway No. 288 | 7.50021 | 6 | 4 | explicit E-S complex | Substrate: A831*_B Product : A831*845*_B | |
| 6 | PKA-active / PKA[18] | PKA Pathway No. 288 | 7.50021 | 6 | 4 | explicit E-S complex | Substrate: A_B831* Product : A845*_B831* | |
| 7 | PKA-active / PKA[19] | PKA Pathway No. 288 | 7.50021 | 6 | 4 | explicit E-S complex | Substrate: A831*_B831* Product : A831*845*_B831* | |
| 8 | PKA-active / PKA[20] | PKA Pathway No. 288 | 7.50021 | 6 | 4 | explicit E-S complex | Substrate: A_B Product : A_B845* | |
| 9 | PKA-active / PKA[21] | PKA Pathway No. 288 | 7.50021 | 6 | 4 | explicit E-S complex | Substrate: A831*_B Product : A831*_B845* | |
| 10 | PKA-active / PKA[22] | PKA Pathway No. 288 | 7.50021 | 6 | 4 | explicit E-S complex | Substrate: A_B831* Product : A_B831*845* | |
| 11 | PKA-active / PKA[23] | PKA Pathway No. 288 | 7.50021 | 6 | 4 | explicit E-S complex | Substrate: A831*_B831* Product : A831*_B831*845* | |
| 12 | PKA-active / PKA[24] | PKA Pathway No. 288 | 7.50021 | 6 | 4 | explicit E-S complex | Substrate: A_B845* Product : A845*_B845* | |
| 13 | PKA-active / PKA[25] | PKA Pathway No. 288 | 7.50021 | 6 | 4 | explicit E-S complex | Substrate: A831*_B845* Product : A831*845*_B845* | |
| 14 | PKA-active / PKA[26] | PKA Pathway No. 288 | 7.50021 | 6 | 4 | explicit E-S complex | Substrate: A_B831*845* Product : A845*_B831*845* | |
| 15 | PKA-active / PKA[27] | PKA Pathway No. 288 | 7.50021 | 6 | 4 | explicit E-S complex | Substrate: A831*_B831*845* Product : A835*845*_ B835*845* | |
| 16 | PKA-active / PKA[28] | PKA Pathway No. 288 | 7.50021 | 6 | 4 | explicit E-S complex | Substrate: A845*_B Product : A845*_B845* | |
| 17 | PKA-active / PKA[29] | PKA Pathway No. 288 | 7.50021 | 6 | 4 | explicit E-S complex | Substrate: A831*845*_B Product : A831*845*_B845* | |
| 18 | PKA-active / PKA[30] | PKA Pathway No. 288 | 7.50021 | 6 | 4 | explicit E-S complex | Substrate: A845*_B831* Product : A845*_B831*845* | |
| 19 | PKA-active / PKA[31] | PKA Pathway No. 288 | 7.50021 | 6 | 4 | explicit E-S complex | Substrate: A831*845*_B831* Product : A835*845*_ B835*845* | |
| 20 | PKA-active / PKA | PKA Pathway No. 288 | 7.50021 | 6 | 4 | explicit E-S complex | Substrate: A_B845* Product : A845*_B845* | |