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Enzyme List for pathway MAPK (Pathway Number 139)
| Molecule Name/ Site Name | Km (uM) | kcat (1/s) | Ratio (k2/k3) | Enzyme Type | Substrate | Product | |
| 1 | Enzyme Activity: 1 Enzyme Molecule: Ras-MKKKK | 0.01 | 2.5 | 4 | Classical Michaelis-Menten V = Etot.S.Kcat/Km+S | MKKK | MKKK-P |
| The Km is 10nM and Vmax is 2.5nM sec^-1. We assume that there is 1 nM of the Ras-MKKKK. From Kholodenko, 2000. If the enzymes are not flagged as Available, then this Km should be set to 0.1 to obtain oscillations. | |||||||
| 2 | Enzyme Activity: 10 Enzyme Molecule: int5 | 0.015 | 0.5 | 4 | Classical Michaelis-Menten V = Etot.S.Kcat/Km+S | MAPK-P | MAPK |
| The Km is 15nM and Vmax is 0.5nM.s-1 from Kholodenko, 2000 | |||||||
| 3 | Enzyme Activity: 2 Enzyme Molecule: int1 | 0.008 | 0.25 | 4 | Classical Michaelis-Menten V = Etot.S.Kcat/Km+S | MKKK-P | MKKK |
| Km is 8nM and Vmax is 0.25nM.s-1 from Kholodenko, 2000. | |||||||
| 4 | Enzyme Activity: 3 Enzyme Molecule: MKKK-P | 0.015 | 0.025 | 4 | Classical Michaelis-Menten V = Etot.S.Kcat/Km+S | MKK | MKK-P |
| Km is 15 nM and Vmax is 0.025s-1 from Kholodenko, 2000 | |||||||
| 5 | Enzyme Activity: 4 Enzyme Molecule: MKKK-P | 0.015 | 0.025 | 4 | Classical Michaelis-Menten V = Etot.S.Kcat/Km+S | MKK-P | MKK-PP |
| Km is 15nM and Vmax is 0.025s-1 from Kholodenko, 2000. | |||||||
| 6 | Enzyme Activity: 5 Enzyme Molecule: int2 | 0.015 | 0.75 | 4 | Classical Michaelis-Menten V = Etot.S.Kcat/Km+S | MKK-PP | MKK-P |
| The Km is 15nM and Vmax is 0.75nM.s-1 from Kholodenko, 2000 | |||||||
| 7 | Enzyme Activity: 6 Enzyme Molecule: int3 | 0.015 | 0.75 | 4 | Classical Michaelis-Menten V = Etot.S.Kcat/Km+S | MKK-P | MKK |
| The Km is 15nM and the Vmax is 0.75nM.s-1 from Kholodenko 2000. | |||||||
| 8 | Enzyme Activity: 7 Enzyme Molecule: MKK-PP | 0.015 | 0.025 | 4 | Classical Michaelis-Menten V = Etot.S.Kcat/Km+S | MAPK | MAPK-P |
| The Km is 15nM which is 0.015uM Vmax is 0.025s-1 from Kholodenko, 2000. | |||||||
| 9 | Enzyme Activity: 8 Enzyme Molecule: MKK-PP | 0.015 | 0.025 | 4 | Classical Michaelis-Menten V = Etot.S.Kcat/Km+S | MAPK-P | MAPK-PP |
| The Km is 15nM which is 0.015uM and Vmax is 0.025s-1 from Kholodenko, 2000 | |||||||
| 10 | Enzyme Activity: 9 Enzyme Molecule: int4 | 0.015 | 0.5 | 4 | Classical Michaelis-Menten V = Etot.S.Kcat/Km+S | MAPK-PP | MAPK-P |
| The Km is 15nM and Vmax is 0.5nM.s-1 from Kholodenko, 2000 | |||||||
| Pathway Detail | Molecule List | Enzyme List | Reaction List |