| | Molecule Name/
Site Name | Km (uM) | kcat (1/s) | Ratio
(k2/k3) | Enzyme Type | Substrate | Product |
| 1 |
Enzyme Activity:
Deph-thr286
Enzyme Molecule:
PP1-active | 5.09905 | 2.5 | 4 | explicit E-S complex | CaMKII-thr286*-C
aM
| CaMKII-CaM
|
| 2 |
Enzyme Activity:
Deph-thr286b
Enzyme Molecule:
PP1-active | 5.09905 | 2.5 | 4 | explicit E-S complex | CaMKII-thr286
| CaMKII
|
| 3 |
Enzyme Activity:
Deph-thr286c
Enzyme Molecule:
PP1-active | 5.09905 | 2.5 | 4 | explicit E-S complex | CaMKII***
| CaMK-thr305
|
| 4 |
Enzyme Activity:
Deph-thr305
Enzyme Molecule:
PP1-active | 5.09905 | 2.5 | 4 | explicit E-S complex | CaMKII***
| CaMKII-thr286
|
| 5 |
Enzyme Activity:
Deph-thr305a
Enzyme Molecule:
PP1-active | 5.09905 | 2.5 | 4 | explicit E-S complex | CaMK-thr305
| CaMKII
|
| 6 |
Enzyme Activity:
PP2A-dephosph-I1
Enzyme Molecule:
PP2A | 15.9999 | 2 | 4.1667 | explicit E-S complex | I1*
| I1
|
| | PP2A does most of the dephosph of I1 at basal Ca levels. See the review by Cohen in Ann Rev Biochem 1989. For now, lets halve Km. k1 was 3.3e-6, now 6.6e-6 |
| 7 |
Enzyme Activity:
PP2A-dephosph-I1
_
PSD
Enzyme Molecule:
PP2A | 15.9999 | 2 | 4.1667 | explicit E-S complex | I1*
| I1
|
| | PP2A does most of the dephosph of I1 at basal Ca levels. See the review by Cohen in Ann Rev Biochem 1989. For now, lets halve Km. k1 was 3.3e-6, now 6.6e-6 |
| 8 |
Enzyme Activity:
PP2A-dephosph-PP
1-I*
Enzyme Molecule:
PP2A | 15.9999 | 2 | 4.1667 | explicit E-S complex | PP1-I1*
| PP1-I1
|
| | k1 changed from 3.3e-6 to 6.6e-6 |
| 9 |
Enzyme Activity:
PP2A-dephosph-PP
1-I*_
PSD
Enzyme Molecule:
PP2A | 15.9999 | 2 | 4.1667 | explicit E-S complex | PP1-I1*
| PP1-I1
|
| | k1 changed from 3.3e-6 to 6.6e-6 |
