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Accession Type:
Network

AMPAR_traff_
model0

Shared_Object_
AMPAR_traff_
model0

CaMKII

CaM

PP1

		PP2B
		Molecule
		Enzyme
		Reaction

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Enzyme List for pathway PP2B (Pathway Number 238)

	Molecule Name/ Site Name	Km (uM)	kcat (1/s)	Ratio (k2/k3)	Enzyme Type	Substrate	Product
1	Enzyme Activity: dephosph-PP1-I* Enzyme Molecule: CaM_Ca_n-CaNAB	4.97079	0.34	4	explicit E-S complex	PP1-I1*	PP1-I1
2	Enzyme Activity: dephosph-PP1-I_ PSD Enzyme Molecule:* CaM_Ca_n-CaNAB	4.97071	0.34	4	explicit E-S complex	PP1-I1*	PP1-I1
3	Enzyme Activity: dephosph_inhib1 Enzyme Molecule: CaM_Ca_n-CaNAB	4.97079	0.34	4	explicit E-S complex	I1*	I1
4	Enzyme Activity: dephosph_ inhib1_noCaM Enzyme Molecule: CaNAB-Ca4	4.97079	0.034	4	explicit E-S complex	I1*	I1
	The rates here are so slow I do not know if we should even bother with this enz reacn. These numbers are from Liu and Storm. Other refs suggest that the Km stays the same but the Vmax goes to 10% of the CaM stim levels. Prev: k1=2.2e-9, k2 = 0.0052, k3 = 0.0013 New : k1=5.7e-8, k2=.136, k3=.034
5	Enzyme Activity: dephosph_ inhib1_noCaM_ PSD Enzyme Molecule: CaNAB-Ca4	4.97071	0.034	4	explicit E-S complex	I1*	I1
	The rates here are so slow I do not know if we should even bother with this enz reacn. These numbers are from Liu and Storm. Other refs suggest that the Km stays the same but the Vmax goes to 10% of the CaM stim levels. Prev: k1=2.2e-9, k2 = 0.0052, k3 = 0.0013 New : k1=5.7e-8, k2=.136, k3=.034
6	Enzyme Activity: dephosph_ inhib1_PSD Enzyme Molecule: CaM_Ca_n-CaNAB	4.97071	0.34	4	explicit E-S complex	I1*	I1
7	Enzyme Activity: dephosph_ neurogranin Enzyme Molecule: CaM_Ca_n-CaNAB	10.012	0.67	3.98507	explicit E-S complex	neurogranin*	neurogranin
	From Seki et al ABB 316(2):673-679
8	Enzyme Activity: dephosph_ neurogranin_PSD Enzyme Molecule: CaM_Ca_n-CaNAB	10.012	0.67	3.98507	explicit E-S complex	neurogranin*_ PSD	neurogranin_PSD
	From Seki et al ABB 316(2):673-679
9	Enzyme Activity: PP2B Enzyme Molecule: CaM_Ca_n-CaNAB	4.97061	2	4	explicit E-S complex	A845_B845	A_B845*
10	Enzyme Activity: PP2B[10] Enzyme Molecule: CaM_Ca_n-CaNAB	4.97061	2	4	explicit E-S complex	A_B831845	A_B831*
11	Enzyme Activity: PP2B[11] Enzyme Molecule: CaM_Ca_n-CaNAB	4.97061	2	4	explicit E-S complex	A845_B831	A_B831*
12	Enzyme Activity: PP2B[12] Enzyme Molecule: CaM_Ca_n-CaNAB	4.97061	2	4	explicit E-S complex	A835845_ B835845	A831_B831845*
13	Enzyme Activity: PP2B[13] Enzyme Molecule: CaM_Ca_n-CaNAB	4.97061	2	4	explicit E-S complex	A835845_ B835845	A831845_B831*
14	Enzyme Activity: PP2B[14] Enzyme Molecule: CaM_Ca_n-CaNAB	4.97061	2	4	explicit E-S complex	A831845_B831*	A831_B831
15	Enzyme Activity: PP2B[15] Enzyme Molecule: CaM_Ca_n-CaNAB	4.97061	2	4	explicit E-S complex	A831_B831845*	A831_B831
16	Enzyme Activity: PP2B[17] Enzyme Molecule: CaM_Ca_n-CaNAB	4.97061	2	4	explicit E-S complex	A845*_B	A_B
17	Enzyme Activity: PP2B[18] Enzyme Molecule: CaM_Ca_n-CaNAB	4.97061	2	4	explicit E-S complex	A831845_B	A831*_B
18	Enzyme Activity: PP2B[19] Enzyme Molecule: CaM_Ca_n-CaNAB	4.97061	2	4	explicit E-S complex	A845_B831	A_B831*
19	Enzyme Activity: PP2B[1] Enzyme Molecule: CaM_Ca_n-CaNAB	4.97061	2	4	explicit E-S complex	A845_B845	A845*_B
20	Enzyme Activity: PP2B[20] Enzyme Molecule: CaM_Ca_n-CaNAB	4.97061	2	4	explicit E-S complex	A831845_B831*	A831_B831
21	Enzyme Activity: PP2B[21] Enzyme Molecule: CaM_Ca_n-CaNAB	4.97061	2	4	explicit E-S complex	A_B845*	A_B
22	Enzyme Activity: PP2B[22] Enzyme Molecule: CaM_Ca_n-CaNAB	4.97061	2	4	explicit E-S complex	A831_B845	A831*_B
23	Enzyme Activity: PP2B[23] Enzyme Molecule: CaM_Ca_n-CaNAB	4.97061	2	4	explicit E-S complex	A_B831845	A_B831*
24	Enzyme Activity: PP2B[24] Enzyme Molecule: CaM_Ca_n-CaNAB	4.97061	2	4	explicit E-S complex	A831_B831845*	A831_B831
25	Enzyme Activity: PP2B[25] Enzyme Molecule: CaM_Ca_n-CaNAB	4.97061	2	4	explicit E-S complex	A845_B845	A_B845*
26	Enzyme Activity: PP2B[26] Enzyme Molecule: CaM_Ca_n-CaNAB	4.97061	2	4	explicit E-S complex	A831845_B845*	A831_B845
27	Enzyme Activity: PP2B[27] Enzyme Molecule: CaM_Ca_n-CaNAB	4.97061	2	4	explicit E-S complex	A845_B831845*	A_B831845
28	Enzyme Activity: PP2B[28] Enzyme Molecule: CaM_Ca_n-CaNAB	4.97061	2	4	explicit E-S complex	A835845_ B835845	A831_B831845*
29	Enzyme Activity: PP2B[29] Enzyme Molecule: CaM_Ca_n-CaNAB	4.97061	2	4	explicit E-S complex	A845_B845	A845*_B
30	Enzyme Activity: PP2B[2] Enzyme Molecule: CaM_Ca_n-CaNAB	4.97061	2	4	explicit E-S complex	A_B845*	A_B
31	Enzyme Activity: PP2B[30] Enzyme Molecule: CaM_Ca_n-CaNAB	4.97061	2	4	explicit E-S complex	A831845_B845*	A831845_B
32	Enzyme Activity: PP2B[31] Enzyme Molecule: CaM_Ca_n-CaNAB	4.97061	2	4	explicit E-S complex	A845_B831845*	A845_B831
33	Enzyme Activity: PP2B[32] Enzyme Molecule: CaM_Ca_n-CaNAB	4.97061	2	4	explicit E-S complex	A835845_ B835845	A831845_B831*
34	Enzyme Activity: PP2B[3] Enzyme Molecule: CaM_Ca_n-CaNAB	4.97061	2	4	explicit E-S complex	A845*_B	A_B
35	Enzyme Activity: PP2B[4] Enzyme Molecule: CaM_Ca_n-CaNAB	4.97061	2	4	explicit E-S complex	A831845_B845*	A831_B845
36	Enzyme Activity: PP2B[5] Enzyme Molecule: CaM_Ca_n-CaNAB	4.97061	2	4	explicit E-S complex	A831845_B845*	A831845_B
37	Enzyme Activity: PP2B[6] Enzyme Molecule: CaM_Ca_n-CaNAB	4.97061	2	4	explicit E-S complex	A831_B845	A831*_B
38	Enzyme Activity: PP2B[7] Enzyme Molecule: CaM_Ca_n-CaNAB	4.97061	2	4	explicit E-S complex	A831845_B	A831*_B
39	Enzyme Activity: PP2B[8] Enzyme Molecule: CaM_Ca_n-CaNAB	4.97061	2	4	explicit E-S complex	A845_B831845*	A_B831845
40	Enzyme Activity: PP2B[9] Enzyme Molecule: CaM_Ca_n-CaNAB	4.97061	2	4	explicit E-S complex	A845_B831845*	A845_B831

Pathway Details Molecule List Enzyme List Reaction List

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