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Accession Type:
Network
AMPAR_traff_
model1
Shared_Object_
AMPAR_traff_
model1
CaMKII
 Molecule
 Enzyme
 Reaction
CaM
PP1
PP2B
PP1_PSD
PKA
AC
AMPAR
AMPAR_memb

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Enzyme List for pathway CaMKII (Pathway Number 245)

 Molecule Name/
Site Name 		Km (uM) kcat (1/s)Ratio
(k2/k3)		Enzyme TypeSubstrate Product
1 Enzyme Activity:
auton-286-PSD

Enzyme Molecule:
tot-auto-PSD		125.0010.54explicit E-S complexCaMKII-CaM-PSD
  • CaMKII-thr286-Ca
    M-PSD
    • 2 Enzyme Activity:
    auton-305-PSD

    Enzyme Molecule:
    tot-auto-PSD    		12564explicit E-S complex
  • CaMKII-thr286-PS
    D
    		• CaMKII***-PSD
    3 Enzyme Activity:
    auton_286

    Enzyme Molecule:
    tot_autonomous_
    CaMKII    		174.9940.54explicit E-S complexCaMKII-CaM
  • CaMKII-thr286*-C
    aM
    • 4 Enzyme Activity:
    auton_305

    Enzyme Molecule:
    tot_autonomous_
    CaMKII    		17564explicit E-S complexCaMKII-thr286
    		CaMKII***
      See Hanson and Schulman again, for afterburst rates of phosph.
    5 Enzyme Activity:
    CaM-act-286-PSD

    Enzyme Molecule:
    tot-CaM-CaMKII-P
    SD    		81.16940.54explicit E-S complexCaMKII-CaM-PSD
  • CaMKII-thr286-Ca
    M-PSD
    • 6 Enzyme Activity:
    CaM-act-305-PSD

    Enzyme Molecule:
    tot-CaM-CaMKII-P
    SD    		81.170164explicit E-S complex
  • CaMKII-thr286-PS
    D
    		• CaMKII***-PSD
    7 Enzyme Activity:
    CaMKII

    Enzyme Molecule:
    actCaMKII-PSD    		90.00060.54explicit E-S complexA845*_B845*
    		A831*845*_B845*
    8 Enzyme Activity:
    CaMKII[10]

    Enzyme Molecule:
    actCaMKII-PSD    		90.00060.54explicit E-S complexA845*_B831*
    		A831*845*_B831*
    9 Enzyme Activity:
    CaMKII[11]

    Enzyme Molecule:
    actCaMKII-PSD    		90.00060.54explicit E-S complexA_B831*
    		A831*_B831*
    10 Enzyme Activity:
    CaMKII[12]

    Enzyme Molecule:
    actCaMKII-PSD    		90.00060.54explicit E-S complexA831*845*_B845*
  • A835*845*_
    B835*845*
    • 11 Enzyme Activity:
    CaMKII[13]

    Enzyme Molecule:
    actCaMKII-PSD    		90.00060.54explicit E-S complexA831*_B845*
    		A831*_B831*845*
    12 Enzyme Activity:
    CaMKII[14]

    Enzyme Molecule:
    actCaMKII-PSD    		90.00060.54explicit E-S complexA831*845*_B
    		A831*845*_B831*
    13 Enzyme Activity:
    CaMKII[15]

    Enzyme Molecule:
    actCaMKII-PSD    		90.00060.54explicit E-S complexA831*_B
    		A831*_B831*
    14 Enzyme Activity:
    CaMKII[1]

    Enzyme Molecule:
    actCaMKII-PSD    		90.00060.54explicit E-S complexA_B845*
    		A831*_B845*
    15 Enzyme Activity:
    CaMKII[2]

    Enzyme Molecule:
    actCaMKII-PSD    		90.00060.54explicit E-S complexA845*_B
    		A831*845*_B
    16 Enzyme Activity:
    CaMKII[3]

    Enzyme Molecule:
    actCaMKII-PSD    		90.00060.54explicit E-S complexA_B
    		A831*_B
    17 Enzyme Activity:
    CaMKII[4]

    Enzyme Molecule:
    actCaMKII-PSD    		90.00060.54explicit E-S complexA845*_B845*
    		A845*_B831*845*
    18 Enzyme Activity:
    CaMKII[5]

    Enzyme Molecule:
    actCaMKII-PSD    		90.00060.54explicit E-S complexA_B845*
    		A_B831*845*
    19 Enzyme Activity:
    CaMKII[6]

    Enzyme Molecule:
    actCaMKII-PSD    		90.00060.54explicit E-S complexA845*_B
    		A845*_B831*
    20 Enzyme Activity:
    CaMKII[7]

    Enzyme Molecule:
    actCaMKII-PSD    		90.00060.54explicit E-S complexA_B
    		A_B831*
    21 Enzyme Activity:
    CaMKII[8]

    Enzyme Molecule:
    actCaMKII-PSD    		90.00060.54explicit E-S complexA845*_B831*845*
  • A835*845*_
    B835*845*
    • 22 Enzyme Activity:
    CaMKII[9]

    Enzyme Molecule:
    actCaMKII-PSD    		90.00060.54explicit E-S complexA_B831*845*
    		A831*_B831*845*
    23 Enzyme Activity:
    CaM_act_286

    Enzyme Molecule:
    tot_CaM_CaMKII    		113.6020.54explicit E-S complexCaMKII-CaM
  • CaMKII-thr286*-C
    aM
    • 24 Enzyme Activity:
    CaM_act_305

    Enzyme Molecule:
    tot_CaM_CaMKII    		113.60164explicit E-S complexCaMKII-thr286
    		CaMKII***
      Rates from autocamtide phosphorylation, from Hanson and Schulman JBC 267:24 17216-17224 1992. Jan 1 1998: Speed up 12x to match fig 5.


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