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Enzyme List for pathway PP2B (Pathway Number 248)

 Molecule Name/
Site Name 		Km (uM) kcat (1/s)Ratio
(k2/k3)		Enzyme TypeSubstrate Product
1 Enzyme Activity:
dephosph-PP1-I*

Enzyme Molecule:
CaM_Ca_n-CaNAB		4.97080.344explicit E-S complexPP1-I1*
PP1-I1
2 Enzyme Activity:

dephosph-PP1-I*_
PSD

Enzyme Molecule:
CaM_Ca_n-CaNAB		4.97070.344explicit E-S complexPP1-I1*
PP1-I1
3 Enzyme Activity:
dephosph_inhib1

Enzyme Molecule:
CaM_Ca_n-CaNAB		4.97080.344explicit E-S complexI1*
I1
4 Enzyme Activity:
dephosph_
inhib1_noCaM

Enzyme Molecule:
CaNAB-Ca4		4.97080.0344explicit E-S complexI1*
I1
  The rates here are so slow I do not know if we should even bother with this enz reacn. These numbers are from Liu and Storm. Other refs suggest that the Km stays the same but the Vmax goes to 10% of the CaM stim levels. Prev: k1=2.2e-9, k2 = 0.0052, k3 = 0.0013 New : k1=5.7e-8, k2=.136, k3=.034
5 Enzyme Activity:
dephosph_
inhib1_noCaM_
PSD

Enzyme Molecule:
CaNAB-Ca4		4.97070.0344explicit E-S complexI1*
I1
  The rates here are so slow I do not know if we should even bother with this enz reacn. These numbers are from Liu and Storm. Other refs suggest that the Km stays the same but the Vmax goes to 10% of the CaM stim levels. Prev: k1=2.2e-9, k2 = 0.0052, k3 = 0.0013 New : k1=5.7e-8, k2=.136, k3=.034
6 Enzyme Activity:
dephosph_
inhib1_PSD

Enzyme Molecule:
CaM_Ca_n-CaNAB		4.97070.344explicit E-S complexI1*
I1
7 Enzyme Activity:
dephosph_
neurogranin

Enzyme Molecule:
CaM_Ca_n-CaNAB		10.0120.673.98507explicit E-S complexneurogranin*
neurogranin
  From Seki et al ABB 316(2):673-679
8 Enzyme Activity:
dephosph_
neurogranin_PSD

Enzyme Molecule:
CaM_Ca_n-CaNAB		10.0120.673.98507explicit E-S complex
  • neurogranin*_
    PSD
    		• neurogranin_PSD
      From Seki et al ABB 316(2):673-679
    9 Enzyme Activity:
    PP2B

    Enzyme Molecule:
    CaM_Ca_n-CaNAB    		4.970624explicit E-S complexA845*_B845*
    		A_B845*
    10 Enzyme Activity:
    PP2B[10]

    Enzyme Molecule:
    CaM_Ca_n-CaNAB    		4.970624explicit E-S complexA_B831*845*
    		A_B831*
    11 Enzyme Activity:
    PP2B[11]

    Enzyme Molecule:
    CaM_Ca_n-CaNAB    		4.970624explicit E-S complexA845*_B831*
    		A_B831*
    12 Enzyme Activity:
    PP2B[12]

    Enzyme Molecule:
    CaM_Ca_n-CaNAB    		4.970624explicit E-S complex
  • A835*845*_
    B835*845*
    		• A831*_B831*845*
    13 Enzyme Activity:
    PP2B[13]

    Enzyme Molecule:
    CaM_Ca_n-CaNAB    		4.970624explicit E-S complex
  • A835*845*_
    B835*845*
    		• A831*845*_B831*
    14 Enzyme Activity:
    PP2B[14]

    Enzyme Molecule:
    CaM_Ca_n-CaNAB    		4.970624explicit E-S complexA831*845*_B831*
    		A831*_B831*
    15 Enzyme Activity:
    PP2B[15]

    Enzyme Molecule:
    CaM_Ca_n-CaNAB    		4.970624explicit E-S complexA831*_B831*845*
    		A831*_B831*
    16 Enzyme Activity:
    PP2B[17]

    Enzyme Molecule:
    CaM_Ca_n-CaNAB    		4.970624explicit E-S complexA845*_B
    		A_B
    17 Enzyme Activity:
    PP2B[18]

    Enzyme Molecule:
    CaM_Ca_n-CaNAB    		4.970624explicit E-S complexA831*845*_B
    		A831*_B
    18 Enzyme Activity:
    PP2B[19]

    Enzyme Molecule:
    CaM_Ca_n-CaNAB    		4.970624explicit E-S complexA845*_B831*
    		A_B831*
    19 Enzyme Activity:
    PP2B[1]

    Enzyme Molecule:
    CaM_Ca_n-CaNAB    		4.970624explicit E-S complexA845*_B845*
    		A845*_B
    20 Enzyme Activity:
    PP2B[20]

    Enzyme Molecule:
    CaM_Ca_n-CaNAB    		4.970624explicit E-S complexA831*845*_B831*
    		A831*_B831*
    21 Enzyme Activity:
    PP2B[21]

    Enzyme Molecule:
    CaM_Ca_n-CaNAB    		4.970624explicit E-S complexA_B845*
    		A_B
    22 Enzyme Activity:
    PP2B[22]

    Enzyme Molecule:
    CaM_Ca_n-CaNAB    		4.970624explicit E-S complexA831*_B845*
    		A831*_B
    23 Enzyme Activity:
    PP2B[23]

    Enzyme Molecule:
    CaM_Ca_n-CaNAB    		4.970624explicit E-S complexA_B831*845*
    		A_B831*
    24 Enzyme Activity:
    PP2B[24]

    Enzyme Molecule:
    CaM_Ca_n-CaNAB    		4.970624explicit E-S complexA831*_B831*845*
    		A831*_B831*
    25 Enzyme Activity:
    PP2B[25]

    Enzyme Molecule:
    CaM_Ca_n-CaNAB    		4.970624explicit E-S complexA845*_B845*
    		A_B845*
    26 Enzyme Activity:
    PP2B[26]

    Enzyme Molecule:
    CaM_Ca_n-CaNAB    		4.970624explicit E-S complexA831*845*_B845*
    		A831*_B845*
    27 Enzyme Activity:
    PP2B[27]

    Enzyme Molecule:
    CaM_Ca_n-CaNAB    		4.970624explicit E-S complexA845*_B831*845*
    		A_B831*845*
    28 Enzyme Activity:
    PP2B[28]

    Enzyme Molecule:
    CaM_Ca_n-CaNAB    		4.970624explicit E-S complex
  • A835*845*_
    B835*845*
    		• A831*_B831*845*
    29 Enzyme Activity:
    PP2B[29]

    Enzyme Molecule:
    CaM_Ca_n-CaNAB    		4.970624explicit E-S complexA845*_B845*
    		A845*_B
    30 Enzyme Activity:
    PP2B[2]

    Enzyme Molecule:
    CaM_Ca_n-CaNAB    		4.970624explicit E-S complexA_B845*
    		A_B
    31 Enzyme Activity:
    PP2B[30]

    Enzyme Molecule:
    CaM_Ca_n-CaNAB    		4.970624explicit E-S complexA831*845*_B845*
    		A831*845*_B
    32 Enzyme Activity:
    PP2B[31]

    Enzyme Molecule:
    CaM_Ca_n-CaNAB    		4.970624explicit E-S complexA845*_B831*845*
    		A845*_B831*
    33 Enzyme Activity:
    PP2B[32]

    Enzyme Molecule:
    CaM_Ca_n-CaNAB    		4.970624explicit E-S complex
  • A835*845*_
    B835*845*
    		• A831*845*_B831*
    34 Enzyme Activity:
    PP2B[3]

    Enzyme Molecule:
    CaM_Ca_n-CaNAB    		4.970624explicit E-S complexA845*_B
    		A_B
    35 Enzyme Activity:
    PP2B[4]

    Enzyme Molecule:
    CaM_Ca_n-CaNAB    		4.970624explicit E-S complexA831*845*_B845*
    		A831*_B845*
    36 Enzyme Activity:
    PP2B[5]

    Enzyme Molecule:
    CaM_Ca_n-CaNAB    		4.970624explicit E-S complexA831*845*_B845*
    		A831*845*_B
    37 Enzyme Activity:
    PP2B[6]

    Enzyme Molecule:
    CaM_Ca_n-CaNAB    		4.970624explicit E-S complexA831*_B845*
    		A831*_B
    38 Enzyme Activity:
    PP2B[7]

    Enzyme Molecule:
    CaM_Ca_n-CaNAB    		4.970624explicit E-S complexA831*845*_B
    		A831*_B
    39 Enzyme Activity:
    PP2B[8]

    Enzyme Molecule:
    CaM_Ca_n-CaNAB    		4.970624explicit E-S complexA845*_B831*845*
    		A_B831*845*
    40 Enzyme Activity:
    PP2B[9]

    Enzyme Molecule:
    CaM_Ca_n-CaNAB    		4.970624explicit E-S complexA845*_B831*845*
    		A845*_B831*
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