 |  |  CaRegulation |
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Molecule List for pathway IP3-3K (Pathway Number 124) | | Name | Initial Conc. (uM) | Volume (fL) | Buffered | | 1 | IP3_3K | 0.3853 | 1000 | No | | | from Johanson et al, JBC, 1988, Vol. 263, No.16, pp 7465-7471 this is the predominant isoform in brain ie IP3-3kinaseA: BiochemJ, 1995, 306, 429-435 | | 2 | IP3_3K* | 0 | 1000 | No | | | phosphorylation at thr311 Communi et al, EMBO J 16; 1997 | | 3 | IP3_3K*1 | 0 | 1000 | No | | | Sim et al; JBC 265(18) June 25; 1990: pp 10367-10372 Phos. at 2 major sites = Ser109 & Ser 175; but there is a possibility that inactivation is due to combined effect of multiple phosphorylations activity suppressed by 75% | | 4 | IP3_3K_CaM | 0 | 1000 | No | | | 2-2.5 fold increase in enzyme activity due to CaM binding CaM binding involves Trp165 Erneux et al; Biochem 214, 497-501 (1993) | | 5 | IP3_3K_CaM* | 0 | 1000 | No | | | 8-10 fold activation with both CaM bound and CaMKII phosphorylation (phos at thr311) Communi et al; EMBO J 16 (8), pp 1943-1952, 1997 | | 6 | IP4(1345) | 1 | 1000 | No | | | Inositol(1345)tetrakisphosphate |
Pathway Details Molecule List Enzyme List Reaction List
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