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Accession Type:
Network
Osc_Ca_
IP3metabolism
MIPP
CaMKII
CaM
PKC
IP3-3K
 Molecule
 Enzyme
 Reaction
Gq
PLCbeta
134_dephos
145_dephos
IP4-system
IHP-system
1345_dephos
CaRegulation
Othmer-Tang-mode
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Enzyme List for pathway IP3-3K (Pathway Number 124)

 Molecule Name/
Site Name
Km (uM) kcat (1/s)Ratio
(k2/k3)
Enzyme TypeSubstrate Product
1 Enzyme Activity:
ip3-3k

Enzyme Molecule:
IP3_3K
1.400013.04754explicit E-S complexIP3(145)
IP4(1345)
  from Johanson et al, JBC 263; 1988 Original Vmax scaled up by 50% to obtain value at 37C, as enzyme assay was done at 30C Km increased from 0.2 to 1.4 as per various other reports (Shears Review, BiochemJ 260; 1989)
2 Enzyme Activity:
ip3-3k*

Enzyme Molecule:
IP3_3K*
1.400013.04754explicit E-S complexIP3(145)
IP4(1345)
  from Communi et al, EMBO J 16; 1997 In absence of CaM binding, activity same as that of non-phosphorylated enzyme
3 Enzyme Activity:
ip3-3k*1

Enzyme Molecule:
IP3_3K*1
1.400040.761874.00003explicit E-S complexIP3(145)
IP4(1345)
  from Sim et al, JBC 265; 1990
4 Enzyme Activity:
ip3-3k-CaM

Enzyme Molecule:
IP3_3K_CaM
2.800110.54.0001explicit E-S complexIP3(145)
IP4(1345)
  from Erneux et al, Biochem 214; 1993 2-2.5 fold more active than ip3-3k but Km is doubled, hence Vmax adjusted accordingly.
5 Enzyme Activity:
ip3-3k-CaM*

Enzyme Molecule:
IP3_3K_CaM*
2.80002454explicit E-S complexIP3(145)
IP4(1345)
  from Communi et al, EMBO J 16; 1997 Vmax adjusted to obtain 9-fold greater activity than ip3-3k


Pathway Details   Molecule List  Enzyme List   Reaction List  


Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
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