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Parameters for PKC (Pathway Number 108)
Pathway Layout
Pathway Basic Parameters
| Pathway Name | PKC |
| Pathway Entry Number | 108 |
| Accession Number | 23 |
| Accession Name | NonOsc_Ca_IP3metabolism |
| Species | Generic mammalian |
| Tissue | Brain - Neuronal |
| CellCompartment | Cytosol |
| Related Pathways | 2, 20, 34, 55, 60, 71, 123, 138, 147, 161, 181, 200, 207, 313, 330, 348, 364, 370, 376, 383, 389, 395, 401, 408, 414, 420, 426, 431, 437, 443, 449, 455, 461, 467, 473, 479, 485, 491, 497, 503, 509, 515, 521, 527, 534, 540, 546, 552, 558, 564, 570, 576, 582, 588, 594, 600, 606, 612, 618, 624, 630, 636, 642, 648, 654, 660, 666, 672, 678, 685, 691, 698, 703, 709, 715, 721, 727, 733, 739, 745, 751, 757, 763, 769, 775, 781, 787, 793, 799, 805, 811, 817, 823, 829, 835, 841, 847, 853, 859, 865, 871, 877, 883, 889, 895, 901, 907, 913, 919, 927, 932, 938, 944, 950, 956, 963, 969, 974, 981, 987, 993, 999, 1004, 1010, 1016, 1022, 1028, 1034, 1040, 1046, 1052, 1058, 1064, 1104 |
| Notes | Protein Kinase C. This module represents a weighted average of the alpha, beta and gamma isoforms. It takes inputs from Ca, DAG (Diacyl Glycerol) and AA (arachidonic acid). Regulation parameters are largely from Schaechter JD, Benowitz LI J Neurosci. 1993 Oct;13(10):4361-71 who use synaptosomes from mammalian brain and in one paper look at all three inputs. Shinomura T et al Proc Natl Acad Sci U S A. 1991 Jun 15;88(12):5149-53 is also a useful source of data and helps to tighten the DAG inputs. General reviews include Azzi A et. al Eur J Biochem. 1992 Sep 15;208(3):547-57 and Nishizuka Y.Nature. 1988 Aug 25;334(6184):661-5. Concentration info from Kikkawa U.et al J Biol Chem. 1982 Nov 25;257(22):13341-8. The process of parameterization is described in detail in several places. See Supplementary notes to Weng G et al, Science. 1999 Apr 2;284(5411):92-6 available at the site http://www.ncbs.res.in/~bhalla/ltploop/ltploop/pkc_example.html. The parameterization is also described in a book chapter: Bhalla, 2000: Simulations of Biochemical Signaling in Computational Neuroscience: Realistic Modeling for Experimentalists. Ed. E. De Schutter. CRC Press. |
Statistics
13 | 1 | 10 |
Conversion format
| This pathway is part of accession 23 and is completely specified in the file acc23.g. There is no separate files for just this pathway. |
| Format | File |
| Native Format (GENESIS format) | acc23.g |
| GENESIS Format (Annotated version) | Anno_acc23.g |
| Pathway Detail | Molecule List | Enzyme List | Reaction List |