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Reaction List for pathway IP4-system (Pathway Number 115) |
| Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reactions is not considered. |
| Name | Kf | Kb | Kd | tau | Substrate | Product | |
| 1 | 5kinase | 0.0132 (s^-1) | 0 (uM^-1 s^-1) | - | - | IP3-56Kcmplx | IP4(1345) IP3-56K |
| Kf = 0.274 times Vmax of IP3 56-K as product ratio of Ins(1345)P4 : Ins(1346)P4 is 1 : 2.3-5 from Wilson and Majerus, JBC 271; 1996 | |||||||
| 2 | 6kinase | 0.048 (s^-1) | 0 (uM^-1 s^-1) | - | - | IP3-56Kcmplx | IP4(1346) IP3-56K |
| Kf = Vmax for IP3 56K from Wilson and Majerus, JBC 271; 1996 | |||||||
| 3 | ip3-inhib-1k | 1 (uM^-1 s^-1) | 0.2 (s^-1) | Kd(bf) = 0.2(uM) | - | IP4-1K IP3(134) | IP3-1Kcmplx |
| from Tan et al, JBC 272; 1997 | |||||||
| 4 | IP3-Kcmplx-on | 3 (uM^-1 s^-1) | 0.192 (s^-1) | Kd(bf) = 0.064(uM) | - | IP3(134) IP3-56K | IP3-56Kcmplx |
| Kf and Kb are equivalent to k1 and k2 for InsP3 56-K, calculated from Km and Vmax values provided by Wilson and Majerus, JBC 271; 1996 | |||||||
| 5 | ip4-5K | 0.008 (s^-1) | 0 (s^-1) | - | - | IP4(1346) | IP5(13456) |
| rate based on basal levels of Ins(1346)P4 | |||||||
| 6 | ip4-6pase | 0.01 (s^-1) | 0 (s^-1) | - | - | IP4(1456) | IP3(145) |
| this step is essential to maintain flux around the network, rate adjusted accordingly | |||||||
| 7 | ip4-inhib-56k | 1 (uM^-1 s^-1) | 0.2 (s^-1) | Kd(bf) = 0.2(uM) | - | IP4(3456) IP3-56Kcmplx | plx |
| from Hughes et al, JBC 264(33); 1989: 19871-78 | |||||||
| 8 | ip4-inhib-56k[1] | 1 (uM^-1 s^-1) | 6.3 (s^-1) | Kd(bf) = 6.3(uM) | - | IP3-56Kcmplx IP4(1345) | plx |
| from Shears, JBC 264(33); 1989: 19879-86 | |||||||
| 9 | ip5-1-pase | 0.0031 (s^-1) | 0 (s^-1) | - | - | IP5(13456) | IP4(3456) |
| most probable reaction for Ins(3456)P4 synthesis as per Yang et al, JBC 274(27); 1999: 18973-80 | |||||||
| 10 | ip5-inhib-1k | 1 (uM^-1 s^-1) | 15 (s^-1) | Kd(bf) = 15(uM) | - | IP4-1K IP5(13456) | IP5-1Kcmplx |
| from Tan et al, JBC 272; 1997 | |||||||
| 11 | ip5_3pase | 0.0005 (s^-1) | 0 (s^-1) | - | - | IP5(13456) | IP4(1456) |
| Ins(13456)P5 3-phosphatase from Nogimori et al, JBC 266; 1991 | |||||||
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