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Reaction List for pathway IHP-system (Pathway Number 116)

Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reactions is not considered.
  Name KfKbKdtauSubstrateProduct
1 dipp_ip60
(s^-1)		0
(s^-1)		--PP-IP4
IP5(13456)
  rate based on basal levels of PP-InsP4
2 IP5-dipp-inhib1
(uM^-1 s^-1)		1.6
(s^-1)		Kd(bf) = 1.6(uM)-DIPP1
IP5(13456)
IP5-DIPPcmplx
  IC50=1.6uM from Safrany et al, EMBO J 17(22); 1998
3 ip5-kinase-pase1
(s^-1)		1.92
(s^-1)		Keq = 1.92(uM)0.342secIP5(13456)
IP6
  Kf represents InsP5 2-kinase and Kb represents InsP6 2-phosphatase Although InsP5 2-kinases in yeast and plant systems have been characterized (Ives et al, JBC 275; 2000: 36575-83), the mammalian counterpart is still to be worked out. Rates calculated to maintain InsP5 and InsP6 levels
4 IP6-dipp-inhib1
(uM^-1 s^-1)		0.2
(s^-1)		Kd(bf) = 0.2(uM)-IP6
DIPP1
IP6-DIPPcmplx
  IC50=0.2uM from Safrany et al, EMBO J 17(22); 1998
5 IP6cmplx-off1.26
(s^-1)		0.0012
(uM^-2 s^-1)		--IP6-K-complex
PP-IP5
ADP
IP6-K
  from Voglmaier et al, PNAS 93; 1996 Kf = Vmax of forward reaction Kb calculated from Km for InsP6 and ATP, and Vmax of forward and backward reactions
6 IP6cmplx-on0.0038
(uM^-2 s^-1)		2.376
(s^-1)		--IP6
ATP
IP6-K
IP6-K-complex
  from Voglmaier et al, PNAS 93; 1996 Kf calculated from Km for InsP6 and ATP, and Vmax for forward and backward reactions Kb = Vmax of backward reaction
7 PP-IP5cmplx-off1
(s^-1)		0.0013
(uM^-2 s^-1)		--
  • PP-IP5-K-complex
    		• ADP
    bisPP-IP4
    PP-IP5-K
      from Huang et al, Biochem 37; 1998 Kf = Vmax of forward reaction Kb calculated using Km for PP-InsP5 and ATP, and Vmax of forward and backward reactions
    8 PP-IP5cmplx-on0.0027
    (uM^-2 s^-1)    		2.5
    (s^-1)    		--ATP
    PP-IP5
    PP-IP5-K
  • PP-IP5-K-complex
    •   from Huang et al, Biochem 37; 1998 Kf calculated using Km for PP-InsP5 and ATP, and Vmax of forward and backward reactions. Kb = Vmax of backward reaction
    Pathway DetailMolecule ListEnzyme ListReaction List