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Reaction List for pathway AMPAR (Pathway Number 252)

Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reactions is not considered.
  Name KfKbKdtauSubstrateProduct
1 degrade**0
(s^-1)		0
(s^-1)		--
  • A835*845*_
    B835*845*
    		• AMPAR_deg
    2 degrade*_0
    (s^-1)    		0
    (s^-1)    		--A831*845*_B845*
    		AMPAR_deg
    3 degrade_*0
    (s^-1)    		0
    (s^-1)    		--A845*_B831*845*
    		AMPAR_deg
    4 degrade__0
    (s^-1)    		0
    (s^-1)    		--A845*_B845*
    		AMPAR_deg
    5 endo_const0.0004
    (s^-1)    		0.0014
    (s^-1)    		Not applicable**-GluR23_M
    		GluR23_I
    6 exo_reg**0.0002
    (#^-1 s^-1)    		0.008
    (s^-1)    		Not applicable**-
  • A835*845*_
    B835*845*
    Anchor
  • A835*845*_
    B835*845*
    • 7 exo_reg*_0.0002
    (#^-1 s^-1)    		0.008
    (s^-1)    		Not applicable**-A831*845*_B845*
    Anchor
    		A831*845*_B845*
    8 exo_reg_*0.0002
    (#^-1 s^-1)    		0.008
    (s^-1)    		Not applicable**-A845*_B831*845*
    Anchor
    		A845*_B831*845*
    9 exo_reg__0.0002
    (#^-1 s^-1)    		0.008
    (s^-1)    		Not applicable**-A845*_B845*
    Anchor
    		A845*_B845*
      Exo rates are scaled from earlier model versions to account for binding of anchor. We have about 200 molecules of anchor in the whole model. Here we select rates to give us a max of about 150 molecules of GluR at the synapse.
    10 recycle**0.0008
    (s^-1)    		0
    (#^-1 s^-1)    		Not applicable**-A831*_B831*
    		A831*_B831*
    Anchor
    11 recycle*_0.0008
    (s^-1)    		0
    (#^-1 s^-1)    		Not applicable**-A831*_B
    		A831*_B
    Anchor
    12 recycle_*0.0008
    (s^-1)    		0
    (#^-1 s^-1)    		Not applicable**-A_B831*
    		A_B831*
    Anchor
    13 recycle__0.0008
    (s^-1)    		0
    (#^-1 s^-1)    		Not applicable**-A_B
    		A_B
    Anchor
    14 turnover0.018
    (s^-1)    		1
    (s^-1)    		Not applicable**-AMPAR_bulk
    		A_B
      Represents both synthesis and degradation of the receptor. The rate is set to be rather fast for now. The forward rate also includes scaling terms because the AMPAR_bulk is in the dendritic volume of 5e-18. This means that we need to lower Kf to account for the difference in volumes. Effectively Kf is 1/sec, but the scaled version becomes 9e-20/5e-18 = 0.018
    ** This is a trasport reation between compartments of different volumes. Therefore Kd is not applicable. Please Note Kf, Kb units are in number of molecules instead of concentration.
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