| | Name | Kf | Kb | Kd | tau | Substrate | Product |
| 1 |
AV_degdra | 0
(s^-1) | 0
(s^-1) | - | - | AV
| AV_degraded
|
| | Degaradation reaction of AV kf = 0.00001/sec kb = 0/sec Appendix, Satoshi Yamada et al 2003 FEBS Letters 534:190-196. |
| 2 |
AV_formation | 0.002
(s^-1) | 0
(s^-1) | - | - | mRNAVc_dupli
| AV
|
| | Fromation of AV kf = 0.002/sec kb = 0/sec Appendix, Satoshi Yamada et al 2003 FEBS Letters 534:190-196. |
| 3 |
cyto_trans2 | 0.001
(s^-1) | 0
(s^-1) | - | - | mRNAVn
| mRNAVc
|
| | cytoplasmic transport of the mRNAV from nucleus to cytoplasm. kf = 0.001/sec kb = 0/sec Appendix, Satoshi Yamada et al 2003 FEBS Letters 534:190-196. |
| 4 |
degradation | 0.0005
(s^-1) | 0
(s^-1) | - | - | SOCS1
| SOCS1_Deg
|
| | Degdration of SOCS1 kf = 0.0005/sec kb = 0/sec Appendix, Satoshi Yamada et al 2003 FEBS Letters 534:190-196 |
| 5 |
dephospo_
IFNRJ2* | 0.003
(s^-1) | 0
(uM^-2 s^-1) | - | - | IFNRJ2*-STAT1c-S
HP2
| IFNRJ2
STAT1c
SHP-2
|
| 6 |
Disso_
SOCS1-IFNRJ2*-SH
P2 | 0.003
(s^-1) | 0
(uM^-2 s^-1) | - | - | SOCS1-IFNRJ2*-SH
P2
| SOCS1
IFNRJ2
SHP-2
|
| | Dissociation reaction of SOCS1-IFNRJ2*-SHP2. kf = 0.003/sec kb = 0/sec/uM^2 Appendix, Satoshi Yamada et al 2003 FEBS Letters 534:190-196. |
| 7 |
IFN-R_bind | 20
(uM^-1 s^-1) | 0.02
(s^-1) | Kd(bf) = 0.001(uM) | - | IFN
R
| IFNR
|
| | Binding reaction of IFN + R. kf = 20/sec/uM kb = 0.02/sec Appendix, Satoshi Yamada et al 2003 FEBS Letters 534:190-196. |
| 8 |
IFNR-JAK_bind | 100
(uM^-1 s^-1) | 0.05
(s^-1) | Kd(bf) = 0.0005(uM) | - | IFNR
JAK
| IFNRJ_
|
| 9 |
IFNRJ2*-STAT1c_
bind_SHP2 | 1
(uM^-1 s^-1) | 0.2
(s^-1) | Kd(bf) = 0.2(uM) | - | SHP-2
IFNRJ2*-STAT1c
| IFNRJ2*-STAT1c-S
HP2
|
| | Binding of IFNRJ2*-STAT1c to SHP2 kf = 1/sec/uM kb = 0.2/sec Appendix, Satoshi Yamada 2003 FEBS Letters 534:190-196. |
| 10 |
IFNRJ2*_dephosp | 0.003
(s^-1) | 0
(uM^-1 s^-1) | - | - | IFNRJ2*-SHP-2
| SHP-2
IFNRJ2
|
| | SHP-2 dephosphorylates JAK-IFNR dimer Kf = 0.003 /sec Kb = 0 /sec/uM Appendix, Satoshi Yamada et al 2003 FEBS Letters 534:190-196 |
| 11 |
IFNRJ2*_
dephospo | 0.003
(s^-1) | 0
(uM^-3 s^-1) | - | - | SOCS1-IFNRJ2*-ST
AT1c-SHP-2
| SOCS1
IFNRJ2
SHP-2
STAT1c
|
| | SHP-2 dephosphorylates JAK-IFNR dimer complexed with SOCS1 and STAT1c Kf = 0.003 /sec Kb = 0 /sec Appendix, Satoshi Yamada et al 2003 FEBS Letters 534:190-196 |
| 12 |
IFNRJ_
activation | 0.005
(s^-1) | 0
(s^-1) | - | - | IFNRJ2
| IFNRJ2*
|
| | Dimerisation of the RJ complex leads to the phosphorylation of several tyrosine residues by JAK Kf = 0.005*10e+06 /M/sec = 0.005/uM/sec Kb = 0 /sec Appendix, Satoshi Yamada et al 2003 FEBS Letters 534:190-196 |
| 13 |
IFNRJ_
dimerisation | 40
(uM^-1 s^-1) | 0.2
(s^-1) | Kd(bf) = 0.005(uM) | - | IFNRJ
IFNRJ_
| IFNRJ2
|
| | Dimerisation of the RJ complex Kf = 40*10e+06 /M/sec = 40/uM/sec Kb = 0.2 /sec Appendix, Satoshi Yamada et al 2003 FEBS Letters 534:190-196 |
| 14 |
IFN_binding | 20
(uM^-1 s^-1) | 0.02
(s^-1) | Kd(bf) = 0.001(uM) | - | RJ
IFN
| IFNRJ
|
| | Binding of JAK to the intracellular domain of the IFN gamma receptor Kf = 20*10e+06 /M/sec = 20/uM/sec Kb = 0.02 /sec Appendix, Satoshi Yamada et al 2003 FEBS Letters 534:190-196 |
| 15 |
JAK_binding | 100
(uM^-1 s^-1) | 0.05
(s^-1) | Kd(bf) = 0.0005(uM) | - | R
JAK
| RJ
|
| | Binding of JAK to the intracellular domain of the IFN gamma receptor Kf = 100*10e+06 /M/sec = 100/uM/sec Kb = 0.05 /sec Appendix, Satoshi Yamada et al 2003 FEBS Letters 534:190-196 |
| 16 |
mRNAn_cyto_
tran1 | 0.001
(s^-1) | 0
(s^-1) | - | - | mRNASn
| mRNASc
|
| | Transport of nucleoplasmic mRNA to the cytoplasm Kf = 0.001 /sec Kb = 0 /sec Appendix, Satoshi Yamada et al 2003 FEBS Letters 534:190-196 |
| 17 |
mRNAVc_deg | 0.002
(s^-1) | 0
(s^-1) | - | - | mRNAVc
| mRNAVc_remain
|
| | mRNAVc degradation reaction. kf = 0.002/sec kb = 0/sec Appendix, Satoshi Yamada et al 2003 FEBS Letters 534:190-196. |
| 18 |
mRNA_deg | 0.0005
(s^-1) | 0
(s^-1) | - | - | mRNASc
| mRNA_remain
|
| | Degradation of mRNAc in the cytoplasm. kf = 0.0005/sec kb = 0/sec Appendix, Satoshi Yamada et al 2003 FEBS Letters 534:190-196 |
| 19 |
PPN_binding | 1
(uM^-1 s^-1) | 0.2
(s^-1) | Kd(bf) = 0.2(uM) | - | STAT1n*
PPN
| PPN-STAT1n*
|
| | Binding of PPN to phosphorylated STAT1n Kf = 1*10e+06 /M/sec = 1/uM/sec Kb = 0.2 /sec Appendix, Satoshi Yamada et al 2003 FEBS Letters 534:190-196 |
| 20 |
PPN_binding[1] | 1
(uM^-1 s^-1) | 0.2
(s^-1) | Kd(bf) = 0.2(uM) | - | PPN
STAT1n*-STAT1n*
| PPN-STAT1n*-STAT
1n*
|
| | Binding of PPN to phosphorylated STAT1n dimer Kf = 1*10e+06 /M/sec = 1/uM/sec Kb = 0.2 /sec Appendix, Satoshi Yamada et al 2003 FEBS Letters 534:190-196 |
| 21 |
PPX_binding[1] | 1
(uM^-1 s^-1) | 0.2
(s^-1) | Kd(bf) = 0.2(uM) | - | STAT1c*
PPX
| PPX-STAT1c*
|
| | Binding of PPX to phosphorylated STAT1c Kf = 1*10e+06 /M/sec = 1/uM/sec Kb = 0.2 /sec Appendix, Satoshi Yamada et al 2003 FEBS Letters 534:190-196 |
| 22 |
PPX_binding[2] | 1
(uM^-1 s^-1) | 0.2
(s^-1) | Kd(bf) = 0.2(uM) | - | PPX
STAT1c*-STAT1c*
| PPX-STAT1c*-STAT
1c*
|
| | Binding of PPX to phosphorylated STAT1c dimer Kf = 1*10e+06 /M/sec = 1/uM/sec Kb = 0.2 /sec Appendix, Satoshi Yamada et al 2003 FEBS Letters 534:190-196 |
| 23 |
SHP-2_
binding[1] | 1
(uM^-1 s^-1) | 0.2
(s^-1) | Kd(bf) = 0.2(uM) | - | SOCS1-IFNRJ2*-ST
AT1c
SHP-2
| SOCS1-IFNRJ2*-ST
AT1c-SHP-2
|
| | Binding of SHP-2 to JAK-IFNR phosphorylated dimer complexed with SOCS1 and STAT1c Kf = 1*10e+06 /M/sec = 1/uM/sec Kb = 0.2 /sec Appendix, Satoshi Yamada et al 2003 FEBS Letters 534:190-196 |
| 24 |
SHP-2_
binding[3] | 1
(uM^-1 s^-1) | 0.2
(s^-1) | Kd(bf) = 0.2(uM) | - | IFNRJ2*
SHP-2
| IFNRJ2*-SHP-2
|
| | Binding of SHP-2 to JAK-IFNR phosphorylated dimer Kf = 1*10e+06 /M/sec = 1/uM/sec Kb = 0.2 /sec Appendix, Satoshi Yamada et al 2003 FEBS Letters 534:190-196 |
| 25 |
SHP2_binding[2] | 1
(uM^-1 s^-1) | 0.2
(s^-1) | Kd(bf) = 0.2(uM) | - | SHP-2
SOCS1-IFNRJ2*
| SOCS1-IFNRJ2*-SH
P2
|
| | SHP2 binding reaction to SOCS1-IFNRJ2* kf = 1/sec/uM kb = 0.2/sec Appendix,Satoshi Yamada et al 2003 FEBS LEtters 534:190-196. |
| 26 |
SOCS1c_
binding[2] | 20
(uM^-1 s^-1) | 0.1
(s^-1) | Kd(bf) = 0.005(uM) | - | SOCS1
IFNRJ2*-STAT1c
| SOCS1-IFNRJ2*-ST
AT1c
|
| | Binding reaction of SOCS1+IFNRJ2*-STAT1c kf = 20/sec/uM kb = 0.1/sec Appendix,Satoshi Yamada et al 2003 FEBS Letters 534:190-196. |
| 27 |
SOCS1c_
binding[4] | 20
(uM^-1 s^-1) | 0.1
(s^-1) | Kd(bf) = 0.005(uM) | - | SOCS1
IFNRJ2*-STAT1c-S
HP2
| SOCS1-IFNRJ2*-ST
AT1c-SHP-2
|
| | SOCS1 binding to IFNRJ2*-STAT1c-SHP2 kf = 20/sec/uM kb = 0.1/sec Appendix, Satoshi Yamada et al 2003 FEBS Letters 534:190-196 |
| 28 |
SOCS1_
binding[1] | 20
(uM^-1 s^-1) | 0.1
(s^-1) | Kd(bf) = 0.005(uM) | - | IFNRJ2*
SOCS1
| SOCS1-IFNRJ2*
|
| | Binding of SOCS1 to phosphorylated dimer of IFN gamma liganding to the IFN gamma receptor that has JAK bound to its intracellular domain Kf = 20*10e+06 /M/sec = 20/uM/sec Kb = 0.1 /sec Appendix, Satoshi Yamada et al 2003 FEBS Letters 534:190-196 |
| 29 |
SOCS1_
binding[3] | 20
(uM^-1 s^-1) | 0.1
(s^-1) | Kd(bf) = 0.005(uM) | - | SOCS1
IFNRJ2*-SHP-2
| SOCS1-IFNRJ2*-SH
P2
|
| | SOCS1 binding reaction of SOCS1+IFNRJ2*-SHP2 kf = 20/sec/uM kb = 0.1/sec Appendix, Satoshi Yamada et al 2003 FEBS Letters 534:190-196. |
| 30 |
SOCS1_synthesis | 0.01
(s^-1) | 0
(s^-1) | - | - | dup_mRNASc
| SOCS1
|
| | SOCS1 synthesis from duplicate mRNAc kf = 0.01/sec kb = 0/sec Appendix, Satoshi Yamada FEBS Letters 534:190-196 |
| 31 |
SOCS1_unbind | 0.0005
(s^-1) | 0
(s^-1) | - | - | SOCS1-IFNRJ2*-ST
AT1c
| IFNRJ2*-STAT1c
|
| | Unbinding reaction of the SOCS1 from SOCS1-IFNRJ2*-STAT1c kf = 0.0005/sec kb =0/sec Appendix, Satoshi Yamada et al 2003 FEBS Letters 534:190-196. |
| 32 |
SOCS1_unbind[1] | 0.0005
(s^-1) | 0
(s^-1) | - | - | SOCS1-IFNRJ2*-SH
P2
| IFNRJ2*-SHP-2
|
| | Unbinding reaction of SOCS1 from SOCS1-IFNRJ2*-SHP2 kf = 0.0005/sec kb = 0/sec Appendix, Satoshi Yamada et al 2003 FEBS Letters 534:190-196. |
| 33 |
STAT1c*_binding | 5
(uM^-1 s^-1) | 0.5
(s^-1) | Kd(bf) = 0.1(uM) | - | STAT1c*
IFNRJ2*
| IFNRJ2*-STAT1c*
|
| | Binding of phosphorylated STAT1c to JAK-IFNR phosphorylated dimer Kf = 5*10e+06 /M/sec = 5/uM/sec Kb = 0.5 /sec Appendix, Satoshi Yamada et al 2003 FEBS Letters 534:190-196 |
| 34 |
STAT1c*_dephosp | 0.003
(s^-1) | 0
(uM^-1 s^-1) | - | - | PPX-STAT1c*
| STAT1c
PPX
|
| | Cytoplasmic phosphatase (PPX) dephosphorylates STAT1c Kf = 0.003/sec Kb = 0/sec/uM Appendix, Satoshi Yamada et al 2003 FEBS Letters 534:190-196 |
| 35 |
STAT1c*_
dephosphorylatio
n[1] | 0.003
(s^-1) | 0
(uM^-2 s^-1) | - | - | PPX-STAT1c*-STAT
1c*
| PPX
STAT1c
STAT1c*
|
| | Cytoplasmic phosphatase (PPX) dephosphorylates STAT1c dimer Kf = 0.003/sec Kb = 0/sec/uM^2 Appendix, Satoshi Yamada et al 2003 FEBS Letters 534:190-196 |
| 36 |
STAT1c*_
dimerisation | 20
(uM^-1 s^-1) | 0.1
(s^-1) | Keq = 0.005(uM) | - | STAT1c*
STAT1c*
| STAT1c*-STAT1c*
|
| | Dimerisation of phosphorylated STAT1c Kf = 20*10e+06 /M/sec = 20/uM/sec Kb = 0.1 /sec Appendix, Satoshi Yamada et al 2003 FEBS Letters 534:190-196 |
| 37 |
STAT1c_
activation | 0.4
(s^-1) | 0
(uM^-1 s^-1) | - | - | IFNRJ2*-STAT1c
| IFNRJ2*
STAT1c*
|
| | Dimerisation of the RJ complex leads to the phosphorylation of several tyrosine residues by JAK Kf = 0.4 /sec Kb = 0 /M/sec Appendix, Satoshi Yamada et al 2003 FEBS Letters 534:190-196 |
| 38 |
STAT1c_
binding[1] | 8
(uM^-1 s^-1) | 0.8
(s^-1) | Kd(bf) = 0.1(uM) | - | IFNRJ2*
STAT1c
| IFNRJ2*-STAT1c
|
| | Binding of STAT1c to JAK-IFNR phosphorylated dimer Kf = 8*10e+06 /M/sec = 8/uM/sec Kb = 0.8 /sec Appendix, Satoshi Yamada et al 2003 FEBS Letters 534:190-196 |
| 39 |
STAT1c_
binding[2] | 8
(uM^-1 s^-1) | 0.8
(s^-1) | Kd(bf) = 0.1(uM) | - | STAT1c
SOCS1-IFNRJ2*
| SOCS1-IFNRJ2*-ST
AT1c
|
| | Binding of STAT1c to JAK-IFNR phosphorylated dimer complexed with SOCS1 Kf = 8*10e+06 /M/sec = 8/uM/sec Kb = 0.8 /sec Appendix, Satoshi Yamada et al 2003 FEBS Letters 534:190-196 |
| 40 |
STAT1c_
binding[3] | 8
(uM^-1 s^-1) | 0.8
(s^-1) | Kd(bf) = 0.1(uM) | - | STAT1c
SOCS1-IFNRJ2*-SH
P2
| SOCS1-IFNRJ2*-ST
AT1c-SHP-2
|
| | Binding reaction of STAT1c + SOCS1-IFNRJ2*-SHP2. kf = 8/sec/uM kb = 0.8/sec Appendix, Satoshi Yamada et al 2003 FEBS Letters 534:190-196. |
| 41 |
STAT1c_nuclear_
trans | 0.005
(s^-1) | 0
(s^-1) | - | - | STAT1c*-STAT1c*
| STAT1n*-STAT1n*
|
| | Transport of cytoplasmic, phosphorylated STAT1 dimers to the nucleus Kf = 0.005 /sec Kb = 0 /sec Appendix, Satoshi Yamada et al 2003 FEBS Letters 534:190-196 |
| 42 |
STAT1n*_
dephosphorylatio
n | 0.005
(s^-1) | 0
(uM^-1 s^-1) | - | - | PPN-STAT1n*
| PPN
STAT1n
|
| | Nucleoplasmic phosphatase (PPN) dephosphorylates STAT1n Kf = 0.005 /sec Kb = 0 /uM/sec Appendix, Satoshi Yamada et al 2003 FEBS Letters 534:190-196 |
| 43 |
STAT1n*_
dephosphorylatio
n[1] | 0.005
(s^-1) | 0
(uM^-2 s^-1) | - | - | PPN-STAT1n*-STAT
1n*
| PPN
STAT1n
STAT1n*
|
| | Nucleoplasmic phosphatase (PPN) dephosphorylates STAT1n Kf = 0.005 /sec Kb = 0 /uM/sec Appendix, Satoshi Yamada et al 2003 FEBS Letters 534:190-196 |
| 44 |
STAT1n*_
dimerisation | 20
(uM^-1 s^-1) | 0.1
(s^-1) | Keq = 0.005(uM) | - | STAT1n*
STAT1n*
| STAT1n*-STAT1n*
|
| | Dimerisation of phosphorylated STAT1n Kf = 20/sec/uM Kb = 0.1/sec Notes : These values of kf and kb are put according to the data sheet provided by the authour. Appendix, Satoshi Yamada et al 2003 FEBS Letters 534:190-196 |
| 45 |
STAT1n_cyto_
trans | 0.05
(s^-1) | 0
(s^-1) | - | - | STAT1n
| STAT1c
|
| | Transport of nucleoplasmic STAT1 to the cytoplasm Kf = 0.05 /sec Kb = 0 /sec Appendix, Satoshi Yamada et al 2003 FEBS Letters 534:190-196 |
| 46 |
unbind_SOCS1[1] | 0.0005
(s^-1) | 0
(s^-1) | - | - | SOCS1-IFNRJ2*
| IFNRJ2*
|
| | The unbinding reactoion of SOCS1 from SOCS1-IFNRJ2* kf = 0.0005/sec kb = 0/sec Appendix, Satoshi Yamada et al 2003 FEBS Letters 534:190-196. |
| 47 |
unbind_SOCS1[2] | 0.0005
(s^-1) | 0
(s^-1) | - | - | SOCS1-IFNRJ2*-ST
AT1c-SHP-2
| IFNRJ2*-STAT1c-S
HP2
|
| | IFNRJ2*-STAT1c-SHP2 formation reaction kf = 0.0005/sec kb = 0/sec Appendix, Satoshi Yamada et al 2003 FEBS Letters 534:190-196. |
