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Accession Type:
Pathway
SOCS1_knockout
SOCS1_knockout
 Molecule
 Enzyme
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Reaction List for pathway SOCS1_knockout (Pathway Number 294)

Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reactions is not considered.
  Name KfKbKdtauSubstrateProduct
1 AV_degdra0
(s^-1)		0
(s^-1)		--AV
AV_degraded
  Degradation reaction of AV kf = 0.00005/sec kb = 0/sec Appendix, Satoshi Yamada et al 2003 FEBS Letters 534:190-196.
2 AV_formation0.002
(s^-1)		0
(s^-1)		--mRNAVc_dupli
AV
  Formation reaction of AV kf = 0.002/sec kb = 0/sec Appendix, Satoshi Yamada et al 2003 FEBS Letters 534;190-196.
3 cyto_trans20.001
(s^-1)		0
(s^-1)		--mRNAVn
mRNAVc
  Cytoplasmic transport of mRNAVn kf = 0.001/sec kb = 0/sec Appendix, Satoshi Yamada et al 2003 FEBS Letters 534:190-196.
4 degradation0.0005
(s^-1)		0
(s^-1)		--SOCS1
SOCS1_Deg
  Degdration of SOCS1 kf = 0.0005 uM kb = 0 Appendix, Satoshi Yamada et al 2003 FEBS Letters 534:190-196
5 dephospo_
IFNRJ2*		0.003
(s^-1)		0
(uM^-2 s^-1)		--
  • IFNRJ2*-STAT1c-S
    HP2
    		• IFNRJ2
    STAT1c
    SHP-2
      Dephosphoryaltion of IFNRJ2* kf = 0.003/sec kb = 0/sec/uM^2 Appendix, Satoshi Yamada et al 2003 FEBS Letters 534:190-196.
    6 Disso_
    SOCS1-IFNRJ2*-SH
    P2    		0.003
    (s^-1)    		0
    (uM^-2 s^-1)    		--
  • SOCS1-IFNR2*-SHP
    2
    		• SOCS1
    IFNRJ2
    SHP-2
      Dissociation reaction of SOCS1-IFNRJ2*-SHP2 kf = 0.003/sec kb = 0/sec/uM^2 Appendix, Satoshi Yamada et al 2003 FEBS Letters 534:190-196.
    7 IFN-R_bind20
    (uM^-1 s^-1)    		0.02
    (s^-1)    		Kd(bf) = 0.001(uM)-IFN
    R
    		IFNR
      Binding reaction of IFN + R kf = 20/sec/uM kb = 0.02/sec Appendix, Satoshi Yamada et al 2003 FEBS Letters 534:190-196.
    8 IFNR-JAK_bind100
    (uM^-1 s^-1)    		0.05
    (s^-1)    		Kd(bf) = 0.0005(uM)-IFNR
    JAK
    		IFNRJ_
      Binding reaction of IFNR + JAK kf = 100/sec/uM kb = 0.05/sec Appendix, Satoshi Yamada et al 2003 FEBS Letters 534:190-196.
    9 IFNRJ2*-STAT1c_
    bind_SHP2    		1
    (uM^-1 s^-1)    		0.2
    (s^-1)    		Kd(bf) = 0.2(uM)-SHP-2
    IFNRJ2*-STAT1c
  • IFNRJ2*-STAT1c-S
    HP2
    •   Binding of IFNRJ2*-STAT1c to SHP2 kf = 1/sec/uM kb = 0.2/sec Appendix, Satoshi Yamada 2003 FEBS Letters 534:190-196.
    10 IFNRJ2*_
    dephosphorylatio
    n    		0.003
    (s^-1)    		0
    (uM^-1 s^-1)    		--IFNRJ2*-SHP-2
    		SHP-2
    IFNRJ2
      SHP-2 dephosphorylates JAK-IFNR dimer Kf = 0.003 /sec Kb = 0 /uM/sec Appendix, Satoshi Yamada et al 2003 FEBS Letters 534:190-196
    11 IFNRJ2*_
    dephospo    		0.003
    (s^-1)    		0
    (uM^-3 s^-1)    		--
  • SOCS1-IFNRJ2*-ST
    AT1c-SHP-2
    		• SOCS1
    IFNRJ2
    SHP-2
    STAT1c
      SHP-2 dephosphorylates JAK-IFNR dimer complexed with SOCS1 and STAT1c Kf = 0.003 /sec Kb = 0 /sec Appendix, Satoshi Yamada et al 2003 FEBS Letters 534:190-196
    12 IFNRJ_
    activation    		0.005
    (s^-1)    		0
    (s^-1)    		--IFNRJ2
    		IFNRJ2*
      Dimerisation of the RJ complex leads to the phosphorylation of several tyrosine residues by JAK Kf = 0.005*10e+06 /M/sec = 0.005/uM/sec Kb = 0 /sec Appendix, Satoshi Yamada et al 2003 FEBS Letters 534:190-196
    13 IFNRJ_
    dimerisation    		40
    (uM^-1 s^-1)    		0.2
    (s^-1)    		Kd(bf) = 0.005(uM)-IFNRJ
    IFNRJ_
    		IFNRJ2
      Dimerisation of the RJ complex Kf = 40*10e+06 /M/sec = 40/uM/sec Kb = 0.2 /sec Appendix, Satoshi Yamada et al 2003 FEBS Letters 534:190-196
    14 IFN_binding20
    (uM^-1 s^-1)    		0.02
    (s^-1)    		Kd(bf) = 0.001(uM)-RJ
    IFN
    		IFNRJ
      Binding of JAK to the intracellular domain of the IFN gamma receptor Kf = 20*10e+06 /M/sec = 20/uM/sec Kb = 0.02 /sec Appendix, Satoshi Yamada et al 2003 FEBS Letters 534:190-196
    15 JAK_binding100
    (uM^-1 s^-1)    		0.05
    (s^-1)    		Kd(bf) = 0.0005(uM)-R
    JAK
    		RJ
      Binding of JAK to the intracellular domain of the IFN gamma receptor Kf = 100*10e+06 /M/sec = 100/uM/sec Kb = 0.05 /sec Appendix, Satoshi Yamada et al 2003 FEBS Letters 534:190-196
    16 mRNAn_
    cytoplasmic_
    transport    		0.001
    (s^-1)    		0
    (s^-1)    		--mRNASn
    		mRNASc
      Transport of nucleoplasmic mRNA to the cytoplasm Kf = 0.001 /sec Kb = 0 /sec Appendix, Satoshi Yamada et al 2003 FEBS Letters 534:190-196
    17 mRNAVc_deg0.002
    (s^-1)    		0
    (s^-1)    		--mRNAVc
    		mRNAVc_remain
      Degdration reaction of mRNAVc kf = 0.002/sec kb = 0/sec Appendix, Satoshi Yamada et al 2003 FEBS Letters 534;190-196
    18 mRNA_deg0.0005
    (s^-1)    		0
    (s^-1)    		--mRNASc
    		mRNA_remain
      Degradation of mRNAc in the cytoplasm. kf = 0.0005uM kb = 0 Appendix, Satoshi Yamada et al 2003 FEBS Letters 534:190-196
    19 PPN_binding1
    (uM^-1 s^-1)    		0.2
    (s^-1)    		Kd(bf) = 0.2(uM)-STAT1n*
    PPN
    		PPN-STAT1n*
      Binding of PPN to phosphorylated STAT1n Kf = 1*10e+06 /M/sec = 1/uM/sec Kb = 0.2 /sec Appendix, Satoshi Yamada et al 2003 FEBS Letters 534:190-196
    20 PPN_binding[1]1
    (uM^-1 s^-1)    		0.2
    (s^-1)    		Kd(bf) = 0.2(uM)-PPN
    STAT1n*-STAT1n*
  • PPN-STAT1n*-STAT
    1n*
    •   Binding of PPN to phosphorylated STAT1n dimer Kf = 1*10e+06 /M/sec = 1/uM/sec Kb = 0.2 /sec Appendix, Satoshi Yamada et al 2003 FEBS Letters 534:190-196
    21 PPX_binding[1]1
    (uM^-1 s^-1)    		0.2
    (s^-1)    		Kd(bf) = 0.2(uM)-STAT1c*
    PPX
    		PPX-STAT1c*
      Binding of PPX to phosphorylated STAT1c Kf = 1*10e+06 /M/sec = 1/sec/uM Kb = 0.2 /sec Appendix, Satoshi Yamada et al 2003 FEBS Letters 534:190-196
    22 PPX_binding[2]1
    (uM^-1 s^-1)    		0.2
    (s^-1)    		Kd(bf) = 0.2(uM)-PPX
    STAT1c*-STAT1c*
  • PPX-STAT1c*-STAT
    1c*
    •   Binding of PPX to phosphorylated STAT1c dimer Kf = 1*10e+06 /M/sec = 1/uM/sec Kb = 0.2 /sec Appendix, Satoshi Yamada et al 2003 FEBS Letters 534:190-196
    23 SHP-2_
    binding[1]    		1
    (uM^-1 s^-1)    		0.2
    (s^-1)    		Kd(bf) = 0.2(uM)-
  • SOCS1-IFNRJ2*-ST
    AT1c
    SHP-2
  • SOCS1-IFNRJ2*-ST
    AT1c-SHP-2
    •   Binding of SHP-2 to JAK-IFNR phosphorylated dimer complexed with SOCS1 and STAT1c Kf = 1*10e+06 /M/sec = 1/uM/sec Kb = 0.2 /sec Appendix, Satoshi Yamada et al 2003 FEBS Letters 534:190-196
    24 SHP-2_
    binding[3]    		1
    (uM^-1 s^-1)    		0.2
    (s^-1)    		Kd(bf) = 0.2(uM)-IFNRJ2*
    SHP-2
    		IFNRJ2*-SHP-2
      Binding of SHP-2 to JAK-IFNR phosphorylated dimer Kf = 1*10e+06 /M/sec = 1/uM/sec Kb = 0.2 /sec Appendix, Satoshi Yamada et al 2003 FEBS Letters 534:190-196
    25 SHP2_binding[2]1
    (uM^-1 s^-1)    		0.2
    (s^-1)    		Kd(bf) = 0.2(uM)-SHP-2
    SOCS1-IFNRJ2*
  • SOCS1-IFNR2*-SHP
    2
    •   SHP2 binding reaction kf = 1/sec/uM kb = 0.2/sec Appendix, Satoshi Yamada et al 2003 FEBS Letters 534;190-196.
    26 SOCS1c_
    binding[2]    		20
    (uM^-1 s^-1)    		0.1
    (s^-1)    		Kd(bf) = 0.005(uM)-SOCS1
    IFNRJ2*-STAT1c
  • SOCS1-IFNRJ2*-ST
    AT1c
    •   Binding reaction of SOCS1 kf = 20/sec/uM kb = 0.1/sec Appendix, Satoshi Yamada et al 2003 FEBS Letters 534:190-196.
    27 SOCS1c_
    binding[4]    		20
    (uM^-1 s^-1)    		0.1
    (s^-1)    		Kd(bf) = 0.005(uM)-SOCS1
  • IFNRJ2*-STAT1c-S
    HP2
  • SOCS1-IFNRJ2*-ST
    AT1c-SHP-2
    •   SOCS1 binding reaction kf = 20/sec/uM kb = 0.1/sec Appendix, Satoshi Yamada et al 2003 FEBS Letters 534;190-196.
    28 SOCS1_
    binding[1]    		20
    (uM^-1 s^-1)    		0.1
    (s^-1)    		Kd(bf) = 0.005(uM)-IFNRJ2*
    SOCS1
    		SOCS1-IFNRJ2*
      Binding of SOCS1 to phosphorylated dimer of IFN gamma liganding to the IFN gamma receptor that has JAK bound to its intracellular domain Kf = 20*10e+06 /M/sec = 20/uM/sec Kb = 0.1 /sec Appendix, Satoshi Yamada et al 2003 FEBS Letters 534:190-196
    29 SOCS1_
    binding[3]    		20
    (uM^-1 s^-1)    		0.1
    (s^-1)    		Kd(bf) = 0.005(uM)-SOCS1
    IFNRJ2*-SHP-2
  • SOCS1-IFNR2*-SHP
    2
    •   Binding reaction of SOCS1 kf = 20/sec/uM kb = 0.1/sec Appendix, Satoshi Yamada et al 2003 FEBS Letters 534:190-194.
    30 SOCS1_synthesis0.01
    (s^-1)    		0
    (s^-1)    		--dup_mRNASc
    		SOCS1
      SOCS1 synthesis from duplicate mRNAc kf = 0.01/sec kb = 0/sec Appendix, Satoshi Yamada et al 2003 FEBS Letters 534:190-196
    31 SOCS1_unbind0.0005
    (s^-1)    		0
    (s^-1)    		--
  • SOCS1-IFNRJ2*-ST
    AT1c
    		• IFNRJ2*-STAT1c
      Ubinding reaction of SOCS1 kf = 0.0005/sec kb = 0/sec Appendix, Satoshi Yamada et al 2003 FEBS Letters, 534:190-196.
    32 SOCS1_unbind[1]0.0005
    (s^-1)    		0
    (s^-1)    		--
  • SOCS1-IFNR2*-SHP
    2
    		• IFNRJ2*-SHP-2
      Unbinding reaction of SOCS1 kf = 0.0005/sec kb = 0/sec Appendix, Satoshi Yamada et al 2003 FEBS Letters 534:190-196.
    33 STAT1c*_binding5
    (uM^-1 s^-1)    		0.5
    (s^-1)    		Kd(bf) = 0.1(uM)-STAT1c*
    IFNRJ2*
    		IFNRJ2*-STAT1c*
      Binding of phosphorylated STAT1c to JAK-IFNR phosphorylated dimer Kf = 5*10e+06 /M/sec = 5/uM/sec Kb = 0.5 /sec Appendix, Satoshi Yamada et al 2003 FEBS Letters 534:190-196
    34 STAT1c*_
    dephosphorylatio
    n    		0.003
    (s^-1)    		0
    (uM^-1 s^-1)    		--PPX-STAT1c*
    		STAT1c
    PPX
      Cytoplasmic phosphatase (PPX) dephosphorylates STAT1c Kf = 0.003/sec Kb = 0/sec/uM Appendix, Satoshi Yamada et al 2003 FEBS Letters 534:190-196
    35 STAT1c*_
    dephosphorylatio
    n[1]    		0.003
    (s^-1)    		0
    (uM^-2 s^-1)    		--
  • PPX-STAT1c*-STAT
    1c*
    		• PPX
    STAT1c
    STAT1c*
      Cytoplasmic phosphatase (PPX) dephosphorylates STAT1c dimer Kf = 0.003 Kb = 0 Appendix, Satoshi Yamada et al 2003 FEBS Letters 534:190-196
    36 STAT1c*_
    dimerisation    		20
    (uM^-1 s^-1)    		0.1
    (s^-1)    		Keq = 0.005(uM)-STAT1c*
    STAT1c*
    		STAT1c*-STAT1c*
      Dimerisation of phosphorylated STAT1c Kf = 20*10e+06 /M/sec = 20/uM/sec Kb = 0.1 /sec Appendix, Satoshi Yamada et al 2003 FEBS Letters 534:190-196
    37 STAT1c_
    activation    		0.4
    (s^-1)    		0
    (uM^-1 s^-1)    		--IFNRJ2*-STAT1c
    		IFNRJ2*
    STAT1c*
      Dimerisation of the RJ complex leads to the phosphorylation of several tyrosine residues by JAK Kf = 0.4 /sec Kb = 0 /M/sec Appendix, Satoshi Yamada et al 2003 FEBS Letters 534:190-196
    38 STAT1c_
    binding[1]    		8
    (uM^-1 s^-1)    		0.8
    (s^-1)    		Kd(bf) = 0.1(uM)-IFNRJ2*
    STAT1c
    		IFNRJ2*-STAT1c
      Binding of STAT1c to JAK-IFNR phosphorylated dimer Kf = 8*10e+06 /M/sec = 8/uM/sec Kb = 0.8 /sec Appendix, Satoshi Yamada et al 2003 FEBS Letters 534:190-196
    39 STAT1c_
    binding[2]    		8
    (uM^-1 s^-1)    		0.8
    (s^-1)    		Kd(bf) = 0.1(uM)-STAT1c
    SOCS1-IFNRJ2*
  • SOCS1-IFNRJ2*-ST
    AT1c
    •   Binding of STAT1c to JAK-IFNR phosphorylated dimer complexed with SOCS1 Kf = 8*10e+06 /M/sec = 8/uM/sec Kb = 0.8 /sec Appendix, Satoshi Yamada et al 2003 FEBS Letters 534:190-196
    40 STAT1c_
    binding[3]    		8
    (uM^-1 s^-1)    		0.8
    (s^-1)    		Kd(bf) = 0.1(uM)-STAT1c
  • SOCS1-IFNR2*-SHP
    2
  • SOCS1-IFNRJ2*-ST
    AT1c-SHP-2
    •   Binding reaction of STAT1c kf = 8/sec/uM kb = 0.8/sec Appendix, Satoshi Yamada et al 2003 FEBS Letters 534;190-196.
    41 STAT1c_nuclear_
    transport    		0.005
    (s^-1)    		0
    (s^-1)    		--STAT1c*-STAT1c*
    		STAT1n*-STAT1n*
      Transport of cytoplasmic, phosphorylated STAT1 dimers to the nucleus Kf = 0.005 /sec Kb = 0 /sec Appendix, Satoshi Yamada et al 2003 FEBS Letters 534:190-196
    42 STAT1n*_
    dephosphorylatio
    n    		0.005
    (s^-1)    		0
    (uM^-1 s^-1)    		--PPN-STAT1n*
    		PPN
    STAT1n
      Nucleoplasmic phosphatase (PPN) dephosphorylates STAT1n Kf = 0.005 /sec Kb = 0 /uM/sec Appendix, Satoshi Yamada et al 2003 FEBS Letters 534:190-196
    43 STAT1n*_
    dephosphorylatio
    n[1]    		0.005
    (s^-1)    		0
    (uM^-2 s^-1)    		--
  • PPN-STAT1n*-STAT
    1n*
    		• PPN
    STAT1n
    STAT1n*
      Nucleoplasmic phosphatase (PPN) dephosphorylates STAT1n Kf = 0.005 /sec Kb = 0 /uM/sec Appendix, Satoshi Yamada et al 2003 FEBS Letters 534:190-196
    44 STAT1n*_
    dimerisation    		20
    (uM^-1 s^-1)    		0.1
    (s^-1)    		Keq = 0.005(uM)-STAT1n*
    STAT1n*
    		STAT1n*-STAT1n*
      Dimerisation of phosphorylated STAT1n Kf = 20/sec/uM Kb = 0.1/sec Note: These values have been out according to the DATA sheet provided by author. Appendix, Satoshi Yamada et al 2003 FEBS Letters 534:190-196
    45 STAT1n_
    cytoplasmic_
    transport    		0.05
    (s^-1)    		0
    (s^-1)    		--STAT1n
    		STAT1c
      Transport of nucleoplasmic STAT1 to the cytoplasm Kf = 0.05 /sec/uM Kb = 0 /sec Appendix, Satoshi Yamada et al 2003 FEBS Letters 534:190-196
    46 unbind_SOCS1[1]0.0005
    (s^-1)    		0
    (s^-1)    		--SOCS1-IFNRJ2*
    		IFNRJ2*
      Unbinding reaction of SOCS1 kf = 0.0005/sec kb = 0/sec Appendix, Satoshi Yamada et al 2003 FEBS Letters 534:190-196.
    47 unbind_SOCS1[2]0.0005
    (s^-1)    		0
    (s^-1)    		--
  • SOCS1-IFNRJ2*-ST
    AT1c-SHP-2
  • IFNRJ2*-STAT1c-S
    HP2
    •   IFNRJ2*-STAT1c-SHP2 formation reaction. kf = 0.0005/sec kb = 0/sec Appendix, Satoshi Yamada et al 2003 FEBS Letters 534:190-196.


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