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Parameters for CaMKII (Pathway Number 145) Pathway Layout
Pathway Basic Parameters | Pathway Name | CaMKII | | Pathway Entry Number | 145 | | Accession Number | 31 | | Accession Name | NonOsc_Ca_IP3metabolism | | Species | Generic mammalian | | Tissue | Brain - Neuronal | | CellCompartment | Cytosol | | Related Pathways | 13,
26,
80,
106,
121,
159,
174,
202,
216,
235,
245,
258,
264,
272,
282,
322,
339,
357
| | Notes | Main reference here is the review by Hanson and Schulman, Ann Rev Biochem 1992 vol 61 pp 559-601. Most of the mechanistic details and a few constants are derived from there. Many kinetics are from Hanson and Schulman JBC 267:24 17216-17224 1992. The enzymes look a bit complicated. Actually it is just 3 reactions for different sites, by 4 states of CaMKII, defined by the phosphorylation state. This model approximates the fact that the enzyme is actually present as a decamer/dodecamer. It does so by treating the autophosphorylation reactions as being independent of the concentration of CaMKII. Also the rates for the autophosphorylation steps have been scaled to fit this approximation.
| Statistics Conversion formatThis pathway is part of accession 31 and is completely specified in the file acc31.g.
There is no separate files for just this pathway. |
| Format | File | | Native Format (GENESIS format) | acc31.g | | GENESIS Format (Annotated version) | Anno_acc31.g |
Pathway Detail Molecule List Enzyme List Reaction List
| Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
This Copyright is applied to ensure that the contents of this database remain freely available. Please see FAQ for details. |
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