| Pathway Name | CaMKII |
| Pathway Entry Number | 145 |
| Accession Number | 31 |
| Accession Name | NonOsc_Ca_IP3metabolism |
| Species | Generic mammalian |
| Tissue | Brain - Neuronal |
| CellCompartment | Cytosol |
| Related Pathways | 13,
26,
80,
106,
121,
159,
174,
202,
216,
235,
245,
258,
264,
272,
282,
322,
339,
357
|
| Notes | Main reference here is the review by Hanson and Schulman, Ann Rev Biochem 1992 vol 61 pp 559-601. Most of the mechanistic details and a few constants are derived from there. Many kinetics are from Hanson and Schulman JBC 267:24 17216-17224 1992. The enzymes look a bit complicated. Actually it is just 3 reactions for different sites, by 4 states of CaMKII, defined by the phosphorylation state. This model approximates the fact that the enzyme is actually present as a decamer/dodecamer. It does so by treating the autophosphorylation reactions as being independent of the concentration of CaMKII. Also the rates for the autophosphorylation steps have been scaled to fit this approximation.
|
