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Accession Type:
Network
CaMKII_model3
Shared_Object_
CaMKII_model3
CaMKII
CaM
PP1
PP2B
PP1_PSD
 Molecule
 Reaction
AC
PKA

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Parameters for PP1_PSD (Pathway Number 268)

Pathway Layout

Pathway Basic Parameters

Pathway NamePP1_PSD
Pathway Entry Number 268
Accession Number 63
Accession Name CaMKII_model3
Species General Mammalian
Tissue Neuronal
CellCompartmentSynaptic Spine, Postsynaptic Density
Related Pathways 239, 249, 262, 279, 286
Notes  This is the complete model of CaMKII bistability, model 3. It exhibits bistability in CaMKII activation due to autophosphorylation at the PSD and local saturation of PP1. This version of model 3 includes PKA regulatory input. This has little effect on the deterministic calculations, but the PKA pathway introduces a lot of noise which causes a difference in stochastic runs.

Statistics

Enzyme sites
4
0
1

Conversion format

This pathway is part of accession 63 and is completely specified in the file acc63.g.
There is no separate files for just this pathway.
FormatFile
Native Format (GENESIS format)    acc63.g   
MATLAB format    acc63.m   
SBML format    acc63.xml   


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Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
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