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Parameters for Shared_Object_mkp1_feedback_effects (Pathway Number 32) Pathway Layout
Pathway Basic Parameters | Pathway Name | Shared_Object_mkp1_feedback_effects | | Pathway Entry Number | 32 | | Accession Number | 4 | | Accession Name | mkp1_feedback_effects | | Species | Generic mammalian | | Tissue | NIH 3T3 Expression | | CellCompartment | Surface - nucleus | | Related Pathways |
| | Notes | This is a network involving the MAPK-PKC feedback loop with input from the PDGFR in the synapse. The distinctive feature of this model is that it includes MKP-1 induction by MAPK, and the consequent inhibitory regulation of MAPK and the feedback loop. Lots of interesting dynamics arise from this. This link provides supplementary material for the paper Bhalla US et al. Science (2002) 297(5583):1018-23. In the form of several example simulations and demos for the figures in the paper.
| Statistics Conversion formatThis pathway is part of accession 4 and is completely specified in the file acc4.g.
There is no separate files for just this pathway. |
Pathway Detail Molecule List Enzyme List Reaction List
| Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
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