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Accession Type:
Network
mkp1_feedback_
effects
Shared_Object_
mkp1_feedback_
effects
Sos
PKC
MAPK
PLA2
Ras
PDGFR

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Accession information for mkp1_feedback_effects (Accession Number 4)

Reaction Scheme

Accession Basic Parameters

Name mkp1_feedback_effects
Accession Type Network
Transcriber Upinder S. Bhalla, NCBS
Developer Upinder S. Bhalla, NCBS
Entry Date (YYYY-MM-DD) 2001-11-07
Species Generic mammalian
Tissue NIH 3T3 Expression
Cell Compartment Surface - nucleus
Source Bhalla US et al. Science (2002) 297(5583):1018-23. ( peer-reviewed publication )
Methodology Quantitative match to experiments
Model Implementation Exact GENESIS implementation
Model Validation Replicates orginal data, Quantitatively predicts new data
Notes This is a network involving the MAPK-PKC feedback loop with input from the PDGFR in the synapse. The distinctive feature of this model is that it includes MKP-1 induction by MAPK, and the consequent inhibitory regulation of MAPK and the feedback loop. Lots of interesting dynamics arise from this. This link provides supplementary material for the paper Bhalla US et al. Science (2002) 297(5583):1018-23. In the form of several example simulations and demos for the figures in the paper.

Conversion formats

FormatFile
Native Format (GENESIS format)    acc4.g   
GENESIS Format (Annotated version)    Anno_acc4.g   
MATLAB format    acc4.m   
SBML format    acc4.xml   



Database compilation and code copyright (C) 2005, Upinder S. Bhalla and NCBS/TIFR
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