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Reaction List for pathway MAPK (Pathway Number 61) in Accession MAPK_MKP1_oscillation (Accession Number 9)

Entries are grouped according to Pathway Number and they are alternately color coded using

and

color.
Further ordering can be done to the table header.

indicates that ordering is done according to ascending or descending order.
Keq is calculated only for first order reactions.
Kd is calculated only for second order reactions. [nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules]

	Reaction Name	Pathway Name / Pathway No.	Kf	Kb	Kd	tau	Reagents
1	turnover_MKP1	MAPK Pathway No. 61	0.0004 (s^-1)	0 (s^-1)	-	-	Substrate: MKP-1 Products: Ubiquitination
	3 Feb 2000. Rate of turnover of non-phosph form of MKP1 is from Brondello et al Science 286:2514 1999. Tau is about 45 min.
2	MKP-1-basal-synt h	MAPK Pathway No. 61	0 (s^-1)	0 (s^-1)	-	-	Substrate: MKP-1-gene Products: MKP-1
	3 Feb 2000. The levels of basal MAPK are so low that we need to have a basal mechanism for making MKP-1. This is easy, as the degradation tau is 45 min and basal MKP-1 levels are 2.4 nM in our model. x * 1 uM = 2.4e-3 * 0.37e-3 = 8.9e-7 May 30 2k. Basal levels shifted up a bit. kf now 1.0e-6 Jun 3 2k: kf now 8e-7 Jun 4 2k: kf = 7e-7
3	turnover_MKP1**	MAPK Pathway No. 61	0.0001 (s^-1)	0 (s^-1)	-	-	Substrate: MKP-1 Products:** Ubiquitination
	3 Feb 2000. Rate of turnover of phosph form of MKP1 is from Brondello et al Science 286:2514 1999. Tau is about 150 min though it is not a clean exp falloff.
4	turnover_MKP1*	MAPK Pathway No. 61	0.0001 (s^-1)	0 (s^-1)	-	-	Substrate: MKP-1-ser359* Products: Ubiquitination
	3 Feb 2000. Rate of turnover of phosph form of MKP1 is from Brondello et al Science 286:2514 1999. Tau is about 150 min though it is not a clean exp falloff.
5	MKP-1*dephosph	MAPK Pathway No. 61	0.01 (s^-1)	0 (s^-1)	-	-	Substrate: MKP-1-ser359* Products: MKP-1
	24 Apr 2K: Based on 12 Feb 2K: Scaled up 10x so kf=0.01, kb=0
6	MKP-1**dephosph	MAPK Pathway No. 61	0.01 (s^-1)	0 (s^-1)	-	-	Substrate: MKP-1 Products:** MKP-1-ser359*
	24 Apr 2K, based on 12 Feb 2K: Scaled up 10x to kf=0.01, kb=0
7	translocation	MAPK Pathway No. 61	0 (s^-1)	0.0001 (s^-1)	Keq = 5(uM)	-	Substrate: MAPK* Products: nuc_MAPK*
	5 Feb 2000. A nuclear translocation step. The rates are set up so that not too much MAPK gets siphoned off. 24 Apr 2000. Based on 12 Feb model. Rates slowed down x 0.02 to kf=2e-5 kb=1e-4

Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
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