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Molecule List for pathway CaMKII (Pathway Number 245) in Accession AMPAR_traff_model1 (Accession Number 60)

Default ordering is done according to Pathway Number. Table headers can be used for changing the default ordering.
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The entries are grouped according to Pathway Number and are alternately color coded using  and  color.
  NameAccession
Type
Initial
Conc.

(uM)
Volume
(fL)
BufferedSum Total Of
1 286P-PSDNetwork00.01No
  •  CaMKII-thr286-Ca
    M-PSD

  •  CaMKII-thr286-PS
    D

  • 2 actCaMKII-PSDNetwork20.01No
  •  CaMKII-thr286-Ca
    M-PSD

     CaMKII-CaM-PSD
     tot-auto-PSD
  • 3 act_CaMKII_cytNetwork20.09No tot_CaM_CaMKII
  •  tot_autonomous_
    CaMKII

  • 4 
  • basal_CaMKII_
    cyt
  • Network20.09Yes
    5 
  • basal_CaMKII_
    PSD
  • Network20.01No
    6 
  • basal_CaMKII_
    PSD_control
  • Network20.01Yes
    7 CaMK-thr305Network00.09No
        This forms due to basal autophosphorylation, but I think it has to be considered as a pathway even if some CaM is floating around. In either case it will tend to block further binding of CaM, and will not display any enzyme activity. See Hanson and Schulman JBC 267:24 pp17216-17224 1992
    8 CaMKIINetwork200.09No
        Huge conc of CaMKII. In PSD it is 20-40% of protein, so we assume it is around 2.5% of protein in spine as a whole. This level is so high it is unlikely to matter much if we are off a bit. This comes to about 70 uM.
    9 CaMKII***Network00.09No
        From Hanson and Schulman, the CaMKII does a lot of autophosphorylation just after the CaM is released. This prevents further CaM binding and renders the enzyme quite independent of Ca.
    10 CaMKII***-PSDNetwork00.01No
    11 CaMKII-CaMNetwork00.09No
    12 CaMKII-CaM-PSDNetwork00.01No
    13 CaMKII-PSDNetwork00.01No
    14 CaMKII-thr286Network00.09No
        I am not sure if we need to endow this one with a lot of enzs. It is likely to be a short-lived intermediate, since it will be phosphorylated further as soon as the CAM falls off.
    15 
  • CaMKII-thr286*-C
    aM
  • Network00.09No
        From Hanson and Schulman, the thr286 is responsible for autonomous activation of CaMKII.
    16 
  • CaMKII-thr286-Ca
    M-PSD
  • Network00.01No
    17 
  • CaMKII-thr286-PS
    D
  • Network00.01No
    18 
  • CaMKII-thr305-PS
    D
  • Network00.01No
    19 NMDARNetwork1200.01No
        The stochiometry is a bit off here. Each NMDAR actually binds to a holoenzyme, about 12 CaMKII subunits. But our CaMKII calculations are in terms of individual subunits. So as a hack, we put in much more NMDAR than is actually there.
    20 tot-auto-PSDNetwork20.01No
  •  CaMKII-thr286-PS
    D

     CaMKII***-PSD
  •  basal_CaMKII_
    PSD


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