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Reaction List for pathway Ras (Pathway Number 378) in Accession Ajay_bhalla_2007_ReacDiff1_1e-12 (Accession Number 81)

Entries are grouped according to Pathway Number and they are alternately color coded using  and  color.
Further ordering can be done to the table header.  indicates that ordering is done according to ascending or descending order.
Keq is calculated only for first order reactions.
Kd is calculated only for second order reactions. [nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules]
  Reaction
Name
Pathway Name / 
Pathway No.
KfKbKdtauReagents
1 dephosph-GEFRas

Pathway No. 378
1
(s^-1)
0
(s^-1)
--  Substrate:
 GEF*

 Products:
 inact-GEF
2 
  • Ras-intrinsic-GT
    Pase
  • Ras

    Pathway No. 378
    0.0001
    (s^-1)
    0
    (s^-1)
    --  Substrate:
     GTP-Ras

     Products:
     GDP-Ras
      This is extremely slow (1e-4), but it is significant as so little GAP actually gets complexed with it that the total GTP turnover rises only by 2-3 X (see Gibbs et al, JBC 265(33) 20437-20422) and Eccleston et al JBC 268(36) 27012-27019 kf = 1e-4
    3 dephosph-GAPRas

    Pathway No. 378
    0.1
    (s^-1)
    0
    (s^-1)
    --  Substrate:
     GAP*

     Products:
     GAP
      Assume a reasonably good rate for dephosphorylating it, 1/sec
    4 CaM-bind-GEFRas

    Pathway No. 378
    199.995
    (uM^-1 s^-1)
    1
    (s^-1)
    Kd(bf) = 0.005(uM)-  Substrate:
     inact-GEF
     CaM-Ca4

     Products:
     CaM-GEF
      We have no numbers for this. It is probably between the two extremes represented by the CaMKII phosph states, and I have used guesses based on this. kf=1e-4 kb=1 The reaction is based on Farnsworth et al Nature 376 524-527 1995

     
    Result: 1 - 4 of 4 rows are displayed



    Database compilation and code copyright (C) 2005, Upinder S. Bhalla and NCBS/TIFR
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