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Molecule Parameter List for I1

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by color.
Statistics
I1 participated asMoleculeSum total ofEnzymeSubstrate of an enzymeProduct of an enzymeSubstrate in ReactionProduct in Reaction
No. of occurrences1001301

Accession and Pathway Details
Accession NameAccession No.Accession TypePathway Link
fig3_CaMKII2Network
Shared_Object_fig3_CaMKII CaMKII CaM 
PP1 PP2B PKA 
AC 
This is the model file for figure 3 from Bhalla US and Iyengar R. Science (1999) 283(5400):381-7. It is a model of the Ca activation of CaMKII and other CaM-activated enzymes. It includes the regulatory phosphatases PP1 and PP2B (Calcineurin) acting on CaMKII and also includes CaM-activated adenylyl cyclase and PKA in the synapse.
Demonstration script files for generating the figures in the paper, including figure 3, are available here.

I1 acting as a Molecule in  
fig3_CaMKII Network
NameAccession NamePathway NameInitial Conc.
(uM)
Volume
(fL)
Buffered
I1fig3_CaMKII
Accession No. : 2
PP1
Pathway No. : 15
1.81000No

I1 acting as a Substrate for an Enzyme in  
fig3_CaMKII Network
Enzyme Molecule /
Enzyme Activity
Accession NamePathway NameKm (uM)kcat (s^-1)RatioEnzyme TypeReagents
PKA-active  /
PKA-phosph-I1
fig3_CaMKII
Accession No. : 2
  • Shared_Object_
    fig3_CaMKII

    Pathway No. : 12
  • 7.594explicit E-S complexSubstrate
    I1

    Product
    I1*

    I1 acting as a Product of an Enzyme in  
    fig3_CaMKII Network
     Enzyme Molecule /
    Enzyme Activity
    Accession NamePathway NameKm (uM)kcat (s^-1)RatioEnzyme TypeReagents
    1CaM(Ca)n-CaNAB  /
    dephosph_inhib1
    fig3_CaMKII
    Accession No. : 2
  • Shared_Object_
    fig3_CaMKII

    Pathway No. : 12
  • 4.970760.344explicit E-S complexSubstrate
    I1*

    Product
    I1
    2PP2A  /
  • PP2A-dephosph-I1
  • fig3_CaMKII
    Accession No. : 2
  • Shared_Object_
    fig3_CaMKII

    Pathway No. : 12
  • 7.8282864.16667explicit E-S complexSubstrate
    I1*

    Product
    I1
    3CaNAB-Ca4  /
  • dephosph_
    inhib1_noCaM
  • fig3_CaMKII
    Accession No. : 2
  • Shared_Object_
    fig3_CaMKII

    Pathway No. : 12
  • 4.970760.0344explicit E-S complexSubstrate
    I1*

    Product
    I1

    I1 acting as a Product in a reaction in  
    fig3_CaMKII Network
    Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.
    NameAccession NamePathway NameKfKbKdtauReagents
    dissoc-PP1-I1fig3_CaMKII
    Accession No. : 2
    PP1
    Pathway No. : 15
    1
    (s^-1)
    0
    (uM^-1 s^-1)
    --Substrate
    PP1-I1

    Product
    I1
    PP1-active



    Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
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