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Molecule Parameter List for 3kCaM*_ip3_cmplx

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by color.
Statistics
3kCaM*_ip3_cmplx participated asMoleculeSum total ofEnzymeSubstrate of an enzymeProduct of an enzymeSubstrate in ReactionProduct in Reaction
No. of occurrences1000011

Accession and Pathway Details
Accession NameAccession No.Accession TypePathway Link
  • Osc_Ca_
    IP3metabolism
  • 32Network
    MIPP CaMKII CaM 
    PKC IP3-3K Gq 
    PLCbeta 134_dephos 145_dephos 
    IP4-system IHP-system 1345_dephos 
    CaRegulation Othmer-Tang-model 
    This network models an oscillatory calcium response to GPCR mediated PLCbeta activation, alongwith detailed InsP3 metabolism in the neuron. It is similar to the Osc_Ca_IP3metab model (accession 24) except that some enzymes in the InsP3 metabolism network have been modified to have reversible kinetics rather than Michaelis-Menten kinetics. The modified enzymes belong to the groups: IP4-system, IP3-3K, 145_dephos and 134_dephos. Mishra J, Bhalla US. Biophys J. 2002 Sep;83(3):1298-316.

    3kCaM*_ip3_cmplx acting as a Molecule in  
    Osc_Ca_IP3metabolism Network
    NameAccession NamePathway NameInitial Conc.
    (uM)
    Volume
    (fL)
    Buffered
    3kCaM*_ip3_cmplx
  • Osc_Ca_
    IP3metabolism

    Accession No. : 32
  • IP3-3K
    Pathway No. : 162
    01000No
    Enzyme complex exclusively modeled as M-M kinetics do not hold. Enzyme is reversible as per free energy calculations that yield a a significant back flux.

    3kCaM*_ip3_cmplx acting as a Substrate in a reaction in  
    Osc_Ca_IP3metabolism Network
    Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.
    NameAccession NamePathway NameKfKbKdtauReagents
    3k-CaM*-off
  • Osc_Ca_
    IP3metabolism

    Accession No. : 32
  • IP3-3K
    Pathway No. : 162
    45
    (s^-1)
    0.4148
    (uM^-1 s^-1)
    Kd(cb) = 0.0092(uM)-Substrate
  • 3kCaM*_ip3_
    cmplx


    Product
    IP3_3K_CaM*
    IP4(1345)
  • Kf = Vmax for enzyme (Communi et al, EMBO J 16(8)) Vmax is such that enzyme activity is 9 fold above basal. Kb derived from Keq value when reaction free energy = -10 kJ/mol

    3kCaM*_ip3_cmplx acting as a Product in a reaction in  
    Osc_Ca_IP3metabolism Network
    Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.
    NameAccession NamePathway NameKfKbKdtauReagents
    3k-CaM*-on
  • Osc_Ca_
    IP3metabolism

    Accession No. : 32
  • IP3-3K
    Pathway No. : 162
    80.358
    (uM^-1 s^-1)
    180
    (s^-1)
    Kd(bf) = 2.24(uM)-Substrate
    IP3(145)
    IP3_3K_CaM*

    Product
  • 3kCaM*_ip3_
    cmplx

  • Rates from Km of enzyme Communi et al, EMBO J 16(8)



    Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
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