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Molecule Parameter List for IP6-K

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by color.
Statistics
IP6-K participated asMoleculeSum total ofEnzymeSubstrate of an enzymeProduct of an enzymeSubstrate in ReactionProduct in Reaction
No. of occurrences1020011

Accession and Pathway Details
Accession NameAccession No.Accession TypePathway Link
  • Osc_Ca_
    IP3metabolism
  • 32Network
    MIPP CaMKII CaM 
    PKC IP3-3K Gq 
    PLCbeta 134_dephos 145_dephos 
    IP4-system IHP-system 1345_dephos 
    CaRegulation Othmer-Tang-model 
    This network models an oscillatory calcium response to GPCR mediated PLCbeta activation, alongwith detailed InsP3 metabolism in the neuron. It is similar to the Osc_Ca_IP3metab model (accession 24) except that some enzymes in the InsP3 metabolism network have been modified to have reversible kinetics rather than Michaelis-Menten kinetics. The modified enzymes belong to the groups: IP4-system, IP3-3K, 145_dephos and 134_dephos. Mishra J, Bhalla US. Biophys J. 2002 Sep;83(3):1298-316.

    IP6-K acting as a Molecule in  
    Osc_Ca_IP3metabolism Network
    NameAccession NamePathway NameInitial Conc.
    (uM)
    Volume
    (fL)
    Buffered
    IP6-K
  • Osc_Ca_
    IP3metabolism

    Accession No. : 32
  • IHP-system
    Pathway No. : 168
    0.0081000No
    from Voglmaier et al, PNAS 93; 1996: 4305-10 has InsP5 kinase/ PP-InsP4 synthase and PP-InsP4 kinase apart from InsP6 kinase activity (Saiardi et al, JBC 275(32); 2000: 24686-92)

    IP6-K acting as an Enzyme in  
    Osc_Ca_IP3metabolism Network
     Enzyme Molecule /
    Enzyme Activity
    Accession NamePathway NameKm (uM)kcat (s^-1)RatioEnzyme TypeReagents
    1IP6-K /
    ip5_k1
  • Osc_Ca_
    IP3metabolism

    Accession No. : 32
  • IHP-system
    Pathway No. : 168
    6.699990.2344explicit E-S complexSubstrate
    IP5(13456)

    Product
    PP-IP4
        from Saiardi et al, JBC 275(32); 2000: 24686-92
    2IP6-K /
    pp-ip4-k1
  • Osc_Ca_
    IP3metabolism

    Accession No. : 32
  • IHP-system
    Pathway No. : 168
    23.00030.054explicit E-S complexSubstrate
    PP-IP4

    Product
    bisPP-IP3
        from Saiardi et al, JBC 275; 2000 approx Km and Vmax calculated from first order rate constants

    IP6-K acting as a Substrate in a reaction in  
    Osc_Ca_IP3metabolism Network
    Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.
    NameAccession NamePathway NameKfKbKdtauReagents
    IP6cmplx-on
  • Osc_Ca_
    IP3metabolism

    Accession No. : 32
  • IHP-system
    Pathway No. : 168
    0.0038
    (uM^-2 s^-1)
    2.376
    (s^-1)
    --Substrate
    ATP
    IP6
    IP6-K

    Product
    IP6-K-complex
    from Voglmaier et al, PNAS 93; 1996 Kf calculated from Km for InsP6 and ATP, and Vmax for forward and backward reactions Kb = Vmax of backward reaction

    IP6-K acting as a Product in a reaction in  
    Osc_Ca_IP3metabolism Network
    Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.
    NameAccession NamePathway NameKfKbKdtauReagents
    IP6cmplx-off
  • Osc_Ca_
    IP3metabolism

    Accession No. : 32
  • IHP-system
    Pathway No. : 168
    1.26
    (s^-1)
    0.0012
    (uM^-2 s^-1)
    --Substrate
    IP6-K-complex

    Product
    ADP
    IP6-K
    PP-IP5
    from Voglmaier et al, PNAS 93; 1996 Kf = Vmax of forward reaction Kb calculated from Km for InsP6 and ATP, and Vmax of forward and backward reactions



    Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
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