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Molecule Parameter List for I1*

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by color.
Statistics
I1* participated asMoleculeSum total ofEnzymeSubstrate of an enzymeProduct of an enzymeSubstrate in ReactionProduct in Reaction
No. of occurrences1003110

Accession and Pathway Details
Accession NameAccession No.Accession TypePathway Link
fig4_synapse3Network
Shared_Object_fig4_synapse PKC PLA2 
PLCbeta Gq MAPK 
Ras CaMKII CaM 
PP1 PP2B PKA 
AC 
This is the composite model of 4 kinases: PKC, MAPK, PKA and CaMKII and numerous regulatory pathways involved in synaptic signaling. From Bhalla US and Iyengar R. Science (1999) 283(5400):381-7.This model comes from figure 4 of that paper.
Demonstration script files for generating the figures in the paper, including figure 4, are available here.

I1* acting as a Molecule in  
fig4_synapse Network
NameAccession NamePathway NameInitial Conc.
(uM)
Volume
(fL)
Buffered
I1*fig4_synapse
Accession No. : 3
PP1
Pathway No. : 28
0.0011000No

I1* acting as a Substrate for an Enzyme in  
fig4_synapse Network
 Enzyme Molecule /
Enzyme Activity
Accession NamePathway NameKm (uM)kcat (s^-1)RatioEnzyme TypeReagents
1CaM(Ca)n-CaNAB  /
dephosph_inhib1
fig4_synapse
Accession No. : 3
  • Shared_Object_
    fig4_synapse

    Pathway No. : 19
  • 4.970760.344explicit E-S complexSubstrate
    I1*

    Product
    I1
    2PP2A  /
  • PP2A-dephosph-I1
  • fig4_synapse
    Accession No. : 3
  • Shared_Object_
    fig4_synapse

    Pathway No. : 19
  • 7.8282864.16667explicit E-S complexSubstrate
    I1*

    Product
    I1
    3CaNAB-Ca4  /
  • dephosph_
    inhib1_noCaM
  • fig4_synapse
    Accession No. : 3
  • Shared_Object_
    fig4_synapse

    Pathway No. : 19
  • 4.970760.0344explicit E-S complexSubstrate
    I1*

    Product
    I1

    I1* acting as a Product of an Enzyme in  
    fig4_synapse Network
    Enzyme Molecule /
    Enzyme Activity
    Accession NamePathway NameKm (uM)kcat (s^-1)RatioEnzyme TypeReagents
    PKA-active  /
    PKA-phosph-I1
    fig4_synapse
    Accession No. : 3
  • Shared_Object_
    fig4_synapse

    Pathway No. : 19
  • 7.594explicit E-S complexSubstrate
    I1

    Product
    I1*

    I1* acting as a Substrate in a reaction in  
    fig4_synapse Network
    Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.
    NameAccession NamePathway NameKfKbKdtauReagents
    Inact-PP1fig4_synapse
    Accession No. : 3
    PP1
    Pathway No. : 28
    499.98
    (uM^-1 s^-1)
    0.1
    (s^-1)
    Kd(bf) = 0.0002(uM)-Substrate
    I1*
    PP1-active

    Product
    PP1-I1*



    Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
    This Copyright is applied to ensure that the contents of this database remain freely available. Please see FAQ for details.