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Molecule Parameter List for MAPK-tyr

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by color.
Statistics
MAPK-tyr participated asMoleculeSum total ofEnzymeSubstrate of an enzymeProduct of an enzymeSubstrate in ReactionProduct in Reaction
No. of occurrences250050502424

Accession and Pathway Details
Accession NameAccession No.Accession TypePathway Link
  • Ajay_Bhalla_
    2007_ReacDiff3
  • 84NetworkShared_Object_Ajay_Bhalla_2007_ReacDiff3 PKC PLA2 
    MAPK PLA2 Ras CaM chain kinetics PKC MAPK Ras CaM kinetics[1] 
    PKC PLA2 MAPK Ras CaM kinetics[2] PKC PLA2 MAPK Ras CaM kinetics[3] 
    PKC PLA2 MAPK Ras CaM kinetics[4] PKC PLA2 MAPK Ras CaM kinetics[5] 
    PKC PLA2 MAPK Ras MAPK CaM kinetics[6] PKC PLA2 MAPK Ras 
    CaM kinetics[7] PKC PLA2 MAPK Ras CaM PKC kinetics[8] PLA2 
    MAPK Ras CaM kinetics[9] PKC PLA2 MAPK Ras CaM kinetics[10] 
    PKC PLA2 MAPK Ras CaM kinetics[11] PKC PLA2 MAPK Ras CaM 
    kinetics[12] PKC PLA2 Ras CaM kinetics[13] PKC PLA2 MAPK 
    Ras CaM kinetics[14] PKC PLA2 MAPK Ras CaM kinetics[15] 
    PKC PLA2 MAPK Ras kinetics[16] CaM PKC PLA2 MAPK Ras CaM 
    kinetics[17] PKC PLA2 MAPK Ras CaM kinetics[18] PKC PLA2 
    MAPK Ras CaM kinetics[19] PKC PLA2 MAPK Ras CaM kinetics[20] 
    PKC PLA2 MAPK Ras CaM kinetics[21] PKC PLA2 MAPK Ras CaM 
    kinetics[22] PKC PLA2 MAPK Ras CaM kinetics[23] PKC PLA2 
    MAPK Ras CaM 
    This is a 25-compartment reaction-diffusion version of the Ajay_Bhalla_2007_bistable model. The original single-compartment model is repeated 25 times.
    In addition, a subset (33 out of 50) molecules can diffuse between compartments. Diffusion is implemented as a reaction between corresponding molecules in neighboring compartments. Here D = 1e-13 m^2/sec (i.e., 0.1 micron^2/sec ) so the kf and kb of this reaction for these 10 micron compartments are both 0.001/sec.
    The basal calcium level in this model is held at 95 nM which is rather close to threshold for the flip to the active state. This is necessary to sustain active propagation of activation.
    The stimulus file bis6-propgn_D1e-13_FigEF which was used for the model to replicate Figure 4E and 4F from the paper.

    MAPK-tyr acting as a Molecule in  
    Ajay_Bhalla_2007_ReacDiff3 Network
    NameAccession NamePathway NameInitial Conc.
    (uM)
    Volume
    (fL)
    Buffered
    MAPK-tyr
  • Ajay_Bhalla_
    2007_ReacDiff3

    Accession No. : 84
  • MAPK
    Pathway No. : 921
    0125.7No
    Haystead et al FEBS Lett. 306(1) pp 17-22 show that phosphorylation is strictly sequential, first tyr185 then thr183.
    MAPK-tyr
  • Ajay_Bhalla_
    2007_ReacDiff3

    Accession No. : 84
  • MAPK
    Pathway No. : 928
    0125.7No
    Haystead et al FEBS Lett. 306(1) pp 17-22 show that phosphorylation is strictly sequential, first tyr185 then thr183.
    MAPK-tyr
  • Ajay_Bhalla_
    2007_ReacDiff3

    Accession No. : 84
  • MAPK
    Pathway No. : 934
    0125.7No
    Haystead et al FEBS Lett. 306(1) pp 17-22 show that phosphorylation is strictly sequential, first tyr185 then thr183.
    MAPK-tyr
  • Ajay_Bhalla_
    2007_ReacDiff3

    Accession No. : 84
  • MAPK
    Pathway No. : 940
    0125.7No
    Haystead et al FEBS Lett. 306(1) pp 17-22 show that phosphorylation is strictly sequential, first tyr185 then thr183.
    MAPK-tyr
  • Ajay_Bhalla_
    2007_ReacDiff3

    Accession No. : 84
  • MAPK
    Pathway No. : 946
    0125.7No
    Haystead et al FEBS Lett. 306(1) pp 17-22 show that phosphorylation is strictly sequential, first tyr185 then thr183.
    MAPK-tyr
  • Ajay_Bhalla_
    2007_ReacDiff3

    Accession No. : 84
  • MAPK
    Pathway No. : 952
    0125.7No
    Haystead et al FEBS Lett. 306(1) pp 17-22 show that phosphorylation is strictly sequential, first tyr185 then thr183.
    MAPK-tyr
  • Ajay_Bhalla_
    2007_ReacDiff3

    Accession No. : 84
  • MAPK
    Pathway No. : 958
    0125.7No
    Haystead et al FEBS Lett. 306(1) pp 17-22 show that phosphorylation is strictly sequential, first tyr185 then thr183.
    MAPK-tyr
  • Ajay_Bhalla_
    2007_ReacDiff3

    Accession No. : 84
  • MAPK
    Pathway No. : 965
    0125.7No
    Haystead et al FEBS Lett. 306(1) pp 17-22 show that phosphorylation is strictly sequential, first tyr185 then thr183.
    MAPK-tyr
  • Ajay_Bhalla_
    2007_ReacDiff3

    Accession No. : 84
  • MAPK
    Pathway No. : 971
    0125.7No
    Haystead et al FEBS Lett. 306(1) pp 17-22 show that phosphorylation is strictly sequential, first tyr185 then thr183.
    MAPK-tyr
  • Ajay_Bhalla_
    2007_ReacDiff3

    Accession No. : 84
  • MAPK
    Pathway No. : 977
    0125.7No
    Haystead et al FEBS Lett. 306(1) pp 17-22 show that phosphorylation is strictly sequential, first tyr185 then thr183.
    MAPK-tyr
  • Ajay_Bhalla_
    2007_ReacDiff3

    Accession No. : 84
  • MAPK
    Pathway No. : 983
    0125.7No
    Haystead et al FEBS Lett. 306(1) pp 17-22 show that phosphorylation is strictly sequential, first tyr185 then thr183.
    MAPK-tyr
  • Ajay_Bhalla_
    2007_ReacDiff3

    Accession No. : 84
  • MAPK
    Pathway No. : 989
    0125.7No
    Haystead et al FEBS Lett. 306(1) pp 17-22 show that phosphorylation is strictly sequential, first tyr185 then thr183.
    MAPK-tyr
  • Ajay_Bhalla_
    2007_ReacDiff3

    Accession No. : 84
  • MAPK
    Pathway No. : 995
    0125.7No
    Haystead et al FEBS Lett. 306(1) pp 17-22 show that phosphorylation is strictly sequential, first tyr185 then thr183.
    MAPK-tyr
  • Ajay_Bhalla_
    2007_ReacDiff3

    Accession No. : 84
  • MAPK
    Pathway No. : 960
    0125.7No
    Haystead et al FEBS Lett. 306(1) pp 17-22 show that phosphorylation is strictly sequential, first tyr185 then thr183.
    MAPK-tyr
  • Ajay_Bhalla_
    2007_ReacDiff3

    Accession No. : 84
  • MAPK
    Pathway No. : 1006
    0125.7No
    Haystead et al FEBS Lett. 306(1) pp 17-22 show that phosphorylation is strictly sequential, first tyr185 then thr183.
    MAPK-tyr
  • Ajay_Bhalla_
    2007_ReacDiff3

    Accession No. : 84
  • MAPK
    Pathway No. : 1012
    0125.7No
    Haystead et al FEBS Lett. 306(1) pp 17-22 show that phosphorylation is strictly sequential, first tyr185 then thr183.
    MAPK-tyr
  • Ajay_Bhalla_
    2007_ReacDiff3

    Accession No. : 84
  • MAPK
    Pathway No. : 1018
    0125.7No
    Haystead et al FEBS Lett. 306(1) pp 17-22 show that phosphorylation is strictly sequential, first tyr185 then thr183.
    MAPK-tyr
  • Ajay_Bhalla_
    2007_ReacDiff3

    Accession No. : 84
  • MAPK
    Pathway No. : 1024
    0125.7No
    Haystead et al FEBS Lett. 306(1) pp 17-22 show that phosphorylation is strictly sequential, first tyr185 then thr183.
    MAPK-tyr
  • Ajay_Bhalla_
    2007_ReacDiff3

    Accession No. : 84
  • MAPK
    Pathway No. : 1030
    0125.7No
    Haystead et al FEBS Lett. 306(1) pp 17-22 show that phosphorylation is strictly sequential, first tyr185 then thr183.
    MAPK-tyr
  • Ajay_Bhalla_
    2007_ReacDiff3

    Accession No. : 84
  • MAPK
    Pathway No. : 1036
    0125.7No
    Haystead et al FEBS Lett. 306(1) pp 17-22 show that phosphorylation is strictly sequential, first tyr185 then thr183.
    MAPK-tyr
  • Ajay_Bhalla_
    2007_ReacDiff3

    Accession No. : 84
  • MAPK
    Pathway No. : 1042
    0125.7No
    Haystead et al FEBS Lett. 306(1) pp 17-22 show that phosphorylation is strictly sequential, first tyr185 then thr183.
    MAPK-tyr
  • Ajay_Bhalla_
    2007_ReacDiff3

    Accession No. : 84
  • MAPK
    Pathway No. : 1048
    0125.7No
    Haystead et al FEBS Lett. 306(1) pp 17-22 show that phosphorylation is strictly sequential, first tyr185 then thr183.
    MAPK-tyr
  • Ajay_Bhalla_
    2007_ReacDiff3

    Accession No. : 84
  • MAPK
    Pathway No. : 1054
    0125.7No
    Haystead et al FEBS Lett. 306(1) pp 17-22 show that phosphorylation is strictly sequential, first tyr185 then thr183.
    MAPK-tyr
  • Ajay_Bhalla_
    2007_ReacDiff3

    Accession No. : 84
  • MAPK
    Pathway No. : 1060
    0125.7No
    Haystead et al FEBS Lett. 306(1) pp 17-22 show that phosphorylation is strictly sequential, first tyr185 then thr183.
    MAPK-tyr
  • Ajay_Bhalla_
    2007_ReacDiff3

    Accession No. : 84
  • MAPK
    Pathway No. : 1066
    0125.7No
    Haystead et al FEBS Lett. 306(1) pp 17-22 show that phosphorylation is strictly sequential, first tyr185 then thr183.

    MAPK-tyr acting as a Substrate for an Enzyme in  
    Ajay_Bhalla_2007_ReacDiff3 Network
     Enzyme Molecule /
    Enzyme Activity
    Accession NamePathway NameKm (uM)kcat (s^-1)RatioEnzyme TypeReagents
    1MAPKK*  /
    MAPKKthr
  • Ajay_Bhalla_
    2007_ReacDiff3

    Accession No. : 84
  • MAPK
    Pathway No. : 921
    0.04629640.34explicit E-S complexSubstrate
    MAPK-tyr

    Product
    MAPK*
        Rate consts same as for MAPKKtyr.
    2MKP-1  /
    MKP1-tyr-deph
  • Ajay_Bhalla_
    2007_ReacDiff3

    Accession No. : 84
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff3

    Pathway No. : 918
  • 0.13333344explicit E-S complexSubstrate
    MAPK-tyr

    Product
    MAPK
        The original kinetics have been modified to obey the k2 = 4 * k3 rule, while keeping kcat and Km fixed. As noted in the NOTES, the only constraining data point is the time course of MAPK dephosphorylation, which this model satisfies. It would be nice to have more accurate estimates of rate consts and MKP-1 levels from the literature. Effective Km : 67 nM kcat = 1.43 umol/min/mg
    3MAPKK*  /
    MAPKKthr
  • Ajay_Bhalla_
    2007_ReacDiff3

    Accession No. : 84
  • MAPK
    Pathway No. : 928
    0.04629640.34explicit E-S complexSubstrate
    MAPK-tyr

    Product
    MAPK*
        Rate consts same as for MAPKKtyr.
    4MKP-1  /
    MKP1-tyr-deph
  • Ajay_Bhalla_
    2007_ReacDiff3

    Accession No. : 84
  • kinetics
    Pathway No. : 926
    0.13333344explicit E-S complexSubstrate
    MAPK-tyr

    Product
    MAPK
        The original kinetics have been modified to obey the k2 = 4 * k3 rule, while keeping kcat and Km fixed. As noted in the NOTES, the only constraining data point is the time course of MAPK dephosphorylation, which this model satisfies. It would be nice to have more accurate estimates of rate consts and MKP-1 levels from the literature. Effective Km : 67 nM kcat = 1.43 umol/min/mg
    5MAPKK*  /
    MAPKKthr
  • Ajay_Bhalla_
    2007_ReacDiff3

    Accession No. : 84
  • MAPK
    Pathway No. : 934
    0.04629640.34explicit E-S complexSubstrate
    MAPK-tyr

    Product
    MAPK*
        Rate consts same as for MAPKKtyr.
    6MKP-1  /
    MKP1-tyr-deph
  • Ajay_Bhalla_
    2007_ReacDiff3

    Accession No. : 84
  • kinetics[1]
    Pathway No. : 931
    0.13333344explicit E-S complexSubstrate
    MAPK-tyr

    Product
    MAPK
        The original kinetics have been modified to obey the k2 = 4 * k3 rule, while keeping kcat and Km fixed. As noted in the NOTES, the only constraining data point is the time course of MAPK dephosphorylation, which this model satisfies. It would be nice to have more accurate estimates of rate consts and MKP-1 levels from the literature. Effective Km : 67 nM kcat = 1.43 umol/min/mg
    7MAPKK*  /
    MAPKKthr
  • Ajay_Bhalla_
    2007_ReacDiff3

    Accession No. : 84
  • MAPK
    Pathway No. : 940
    0.04629640.34explicit E-S complexSubstrate
    MAPK-tyr

    Product
    MAPK*
        Rate consts same as for MAPKKtyr.
    8MKP-1  /
    MKP1-tyr-deph
  • Ajay_Bhalla_
    2007_ReacDiff3

    Accession No. : 84
  • kinetics[2]
    Pathway No. : 937
    0.13333344explicit E-S complexSubstrate
    MAPK-tyr

    Product
    MAPK
        The original kinetics have been modified to obey the k2 = 4 * k3 rule, while keeping kcat and Km fixed. As noted in the NOTES, the only constraining data point is the time course of MAPK dephosphorylation, which this model satisfies. It would be nice to have more accurate estimates of rate consts and MKP-1 levels from the literature. Effective Km : 67 nM kcat = 1.43 umol/min/mg
    9MAPKK*  /
    MAPKKthr
  • Ajay_Bhalla_
    2007_ReacDiff3

    Accession No. : 84
  • MAPK
    Pathway No. : 946
    0.04629640.34explicit E-S complexSubstrate
    MAPK-tyr

    Product
    MAPK*
        Rate consts same as for MAPKKtyr.
    10MKP-1  /
    MKP1-tyr-deph
  • Ajay_Bhalla_
    2007_ReacDiff3

    Accession No. : 84
  • kinetics[3]
    Pathway No. : 943
    0.13333344explicit E-S complexSubstrate
    MAPK-tyr

    Product
    MAPK
        The original kinetics have been modified to obey the k2 = 4 * k3 rule, while keeping kcat and Km fixed. As noted in the NOTES, the only constraining data point is the time course of MAPK dephosphorylation, which this model satisfies. It would be nice to have more accurate estimates of rate consts and MKP-1 levels from the literature. Effective Km : 67 nM kcat = 1.43 umol/min/mg
    11MAPKK*  /
    MAPKKthr
  • Ajay_Bhalla_
    2007_ReacDiff3

    Accession No. : 84
  • MAPK
    Pathway No. : 952
    0.04629640.34explicit E-S complexSubstrate
    MAPK-tyr

    Product
    MAPK*
        Rate consts same as for MAPKKtyr.
    12MKP-1  /
    MKP1-tyr-deph
  • Ajay_Bhalla_
    2007_ReacDiff3

    Accession No. : 84
  • kinetics[4]
    Pathway No. : 949
    0.13333344explicit E-S complexSubstrate
    MAPK-tyr

    Product
    MAPK
        The original kinetics have been modified to obey the k2 = 4 * k3 rule, while keeping kcat and Km fixed. As noted in the NOTES, the only constraining data point is the time course of MAPK dephosphorylation, which this model satisfies. It would be nice to have more accurate estimates of rate consts and MKP-1 levels from the literature. Effective Km : 67 nM kcat = 1.43 umol/min/mg
    13MAPKK*  /
    MAPKKthr
  • Ajay_Bhalla_
    2007_ReacDiff3

    Accession No. : 84
  • MAPK
    Pathway No. : 958
    0.04629640.34explicit E-S complexSubstrate
    MAPK-tyr

    Product
    MAPK*
        Rate consts same as for MAPKKtyr.
    14MKP-1  /
    MKP1-tyr-deph
  • Ajay_Bhalla_
    2007_ReacDiff3

    Accession No. : 84
  • kinetics[5]
    Pathway No. : 955
    0.13333344explicit E-S complexSubstrate
    MAPK-tyr

    Product
    MAPK
        The original kinetics have been modified to obey the k2 = 4 * k3 rule, while keeping kcat and Km fixed. As noted in the NOTES, the only constraining data point is the time course of MAPK dephosphorylation, which this model satisfies. It would be nice to have more accurate estimates of rate consts and MKP-1 levels from the literature. Effective Km : 67 nM kcat = 1.43 umol/min/mg
    15MAPKK*  /
    MAPKKthr
  • Ajay_Bhalla_
    2007_ReacDiff3

    Accession No. : 84
  • MAPK
    Pathway No. : 965
    0.04629640.34explicit E-S complexSubstrate
    MAPK-tyr

    Product
    MAPK*
        Rate consts same as for MAPKKtyr.
    16MKP-1  /
    MKP1-tyr-deph
  • Ajay_Bhalla_
    2007_ReacDiff3

    Accession No. : 84
  • kinetics[6]
    Pathway No. : 962
    0.13333344explicit E-S complexSubstrate
    MAPK-tyr

    Product
    MAPK
        The original kinetics have been modified to obey the k2 = 4 * k3 rule, while keeping kcat and Km fixed. As noted in the NOTES, the only constraining data point is the time course of MAPK dephosphorylation, which this model satisfies. It would be nice to have more accurate estimates of rate consts and MKP-1 levels from the literature. Effective Km : 67 nM kcat = 1.43 umol/min/mg
    17MAPKK*  /
    MAPKKthr
  • Ajay_Bhalla_
    2007_ReacDiff3

    Accession No. : 84
  • MAPK
    Pathway No. : 971
    0.04629640.34explicit E-S complexSubstrate
    MAPK-tyr

    Product
    MAPK*
        Rate consts same as for MAPKKtyr.
    18MKP-1  /
    MKP1-tyr-deph
  • Ajay_Bhalla_
    2007_ReacDiff3

    Accession No. : 84
  • kinetics[7]
    Pathway No. : 968
    0.13333344explicit E-S complexSubstrate
    MAPK-tyr

    Product
    MAPK
        The original kinetics have been modified to obey the k2 = 4 * k3 rule, while keeping kcat and Km fixed. As noted in the NOTES, the only constraining data point is the time course of MAPK dephosphorylation, which this model satisfies. It would be nice to have more accurate estimates of rate consts and MKP-1 levels from the literature. Effective Km : 67 nM kcat = 1.43 umol/min/mg
    19MAPKK*  /
    MAPKKthr
  • Ajay_Bhalla_
    2007_ReacDiff3

    Accession No. : 84
  • MAPK
    Pathway No. : 977
    0.04629640.34explicit E-S complexSubstrate
    MAPK-tyr

    Product
    MAPK*
        Rate consts same as for MAPKKtyr.
    20MKP-1  /
    MKP1-tyr-deph
  • Ajay_Bhalla_
    2007_ReacDiff3

    Accession No. : 84
  • kinetics[8]
    Pathway No. : 975
    0.13333344explicit E-S complexSubstrate
    MAPK-tyr

    Product
    MAPK
        The original kinetics have been modified to obey the k2 = 4 * k3 rule, while keeping kcat and Km fixed. As noted in the NOTES, the only constraining data point is the time course of MAPK dephosphorylation, which this model satisfies. It would be nice to have more accurate estimates of rate consts and MKP-1 levels from the literature. Effective Km : 67 nM kcat = 1.43 umol/min/mg
    21MAPKK*  /
    MAPKKthr
  • Ajay_Bhalla_
    2007_ReacDiff3

    Accession No. : 84
  • MAPK
    Pathway No. : 983
    0.04629640.34explicit E-S complexSubstrate
    MAPK-tyr

    Product
    MAPK*
        Rate consts same as for MAPKKtyr.
    22MKP-1  /
    MKP1-tyr-deph
  • Ajay_Bhalla_
    2007_ReacDiff3

    Accession No. : 84
  • kinetics[9]
    Pathway No. : 980
    0.13333344explicit E-S complexSubstrate
    MAPK-tyr

    Product
    MAPK
        The original kinetics have been modified to obey the k2 = 4 * k3 rule, while keeping kcat and Km fixed. As noted in the NOTES, the only constraining data point is the time course of MAPK dephosphorylation, which this model satisfies. It would be nice to have more accurate estimates of rate consts and MKP-1 levels from the literature. Effective Km : 67 nM kcat = 1.43 umol/min/mg
    23MAPKK*  /
    MAPKKthr
  • Ajay_Bhalla_
    2007_ReacDiff3

    Accession No. : 84
  • MAPK
    Pathway No. : 989
    0.04629640.34explicit E-S complexSubstrate
    MAPK-tyr

    Product
    MAPK*
        Rate consts same as for MAPKKtyr.
    24MKP-1  /
    MKP1-tyr-deph
  • Ajay_Bhalla_
    2007_ReacDiff3

    Accession No. : 84
  • kinetics[10]
    Pathway No. : 986
    0.13333344explicit E-S complexSubstrate
    MAPK-tyr

    Product
    MAPK
        The original kinetics have been modified to obey the k2 = 4 * k3 rule, while keeping kcat and Km fixed. As noted in the NOTES, the only constraining data point is the time course of MAPK dephosphorylation, which this model satisfies. It would be nice to have more accurate estimates of rate consts and MKP-1 levels from the literature. Effective Km : 67 nM kcat = 1.43 umol/min/mg
    25MAPKK*  /
    MAPKKthr
  • Ajay_Bhalla_
    2007_ReacDiff3

    Accession No. : 84
  • MAPK
    Pathway No. : 995
    0.04629640.34explicit E-S complexSubstrate
    MAPK-tyr

    Product
    MAPK*
        Rate consts same as for MAPKKtyr.
    26MKP-1  /
    MKP1-tyr-deph
  • Ajay_Bhalla_
    2007_ReacDiff3

    Accession No. : 84
  • kinetics[11]
    Pathway No. : 992
    0.13333344explicit E-S complexSubstrate
    MAPK-tyr

    Product
    MAPK
        The original kinetics have been modified to obey the k2 = 4 * k3 rule, while keeping kcat and Km fixed. As noted in the NOTES, the only constraining data point is the time course of MAPK dephosphorylation, which this model satisfies. It would be nice to have more accurate estimates of rate consts and MKP-1 levels from the literature. Effective Km : 67 nM kcat = 1.43 umol/min/mg
    27MAPKK*  /
    MAPKKthr
  • Ajay_Bhalla_
    2007_ReacDiff3

    Accession No. : 84
  • MAPK
    Pathway No. : 960
    0.04629640.34explicit E-S complexSubstrate
    MAPK-tyr

    Product
    MAPK*
        Rate consts same as for MAPKKtyr.
    28MKP-1  /
    MKP1-tyr-deph
  • Ajay_Bhalla_
    2007_ReacDiff3

    Accession No. : 84
  • kinetics[12]
    Pathway No. : 998
    0.13333344explicit E-S complexSubstrate
    MAPK-tyr

    Product
    MAPK
        The original kinetics have been modified to obey the k2 = 4 * k3 rule, while keeping kcat and Km fixed. As noted in the NOTES, the only constraining data point is the time course of MAPK dephosphorylation, which this model satisfies. It would be nice to have more accurate estimates of rate consts and MKP-1 levels from the literature. Effective Km : 67 nM kcat = 1.43 umol/min/mg
    29MAPKK*  /
    MAPKKthr
  • Ajay_Bhalla_
    2007_ReacDiff3

    Accession No. : 84
  • MAPK
    Pathway No. : 1006
    0.04629640.34explicit E-S complexSubstrate
    MAPK-tyr

    Product
    MAPK*
        Rate consts same as for MAPKKtyr.
    30MKP-1  /
    MKP1-tyr-deph
  • Ajay_Bhalla_
    2007_ReacDiff3

    Accession No. : 84
  • kinetics[13]
    Pathway No. : 1003
    0.13333344explicit E-S complexSubstrate
    MAPK-tyr

    Product
    MAPK
        The original kinetics have been modified to obey the k2 = 4 * k3 rule, while keeping kcat and Km fixed. As noted in the NOTES, the only constraining data point is the time course of MAPK dephosphorylation, which this model satisfies. It would be nice to have more accurate estimates of rate consts and MKP-1 levels from the literature. Effective Km : 67 nM kcat = 1.43 umol/min/mg
    31MAPKK*  /
    MAPKKthr
  • Ajay_Bhalla_
    2007_ReacDiff3

    Accession No. : 84
  • MAPK
    Pathway No. : 1012
    0.04629640.34explicit E-S complexSubstrate
    MAPK-tyr

    Product
    MAPK*
        Rate consts same as for MAPKKtyr.
    32MKP-1  /
    MKP1-tyr-deph
  • Ajay_Bhalla_
    2007_ReacDiff3

    Accession No. : 84
  • kinetics[14]
    Pathway No. : 1009
    0.13333344explicit E-S complexSubstrate
    MAPK-tyr

    Product
    MAPK
        The original kinetics have been modified to obey the k2 = 4 * k3 rule, while keeping kcat and Km fixed. As noted in the NOTES, the only constraining data point is the time course of MAPK dephosphorylation, which this model satisfies. It would be nice to have more accurate estimates of rate consts and MKP-1 levels from the literature. Effective Km : 67 nM kcat = 1.43 umol/min/mg
    33MAPKK*  /
    MAPKKthr
  • Ajay_Bhalla_
    2007_ReacDiff3

    Accession No. : 84
  • MAPK
    Pathway No. : 1018
    0.04629640.34explicit E-S complexSubstrate
    MAPK-tyr

    Product
    MAPK*
        Rate consts same as for MAPKKtyr.
    34MKP-1  /
    MKP1-tyr-deph
  • Ajay_Bhalla_
    2007_ReacDiff3

    Accession No. : 84
  • kinetics[15]
    Pathway No. : 1015
    0.13333344explicit E-S complexSubstrate
    MAPK-tyr

    Product
    MAPK
        The original kinetics have been modified to obey the k2 = 4 * k3 rule, while keeping kcat and Km fixed. As noted in the NOTES, the only constraining data point is the time course of MAPK dephosphorylation, which this model satisfies. It would be nice to have more accurate estimates of rate consts and MKP-1 levels from the literature. Effective Km : 67 nM kcat = 1.43 umol/min/mg
    35MAPKK*  /
    MAPKKthr
  • Ajay_Bhalla_
    2007_ReacDiff3

    Accession No. : 84
  • MAPK
    Pathway No. : 1024
    0.04629640.34explicit E-S complexSubstrate
    MAPK-tyr

    Product
    MAPK*
        Rate consts same as for MAPKKtyr.
    36MKP-1  /
    MKP1-tyr-deph
  • Ajay_Bhalla_
    2007_ReacDiff3

    Accession No. : 84
  • kinetics[16]
    Pathway No. : 1020
    0.13333344explicit E-S complexSubstrate
    MAPK-tyr

    Product
    MAPK
        The original kinetics have been modified to obey the k2 = 4 * k3 rule, while keeping kcat and Km fixed. As noted in the NOTES, the only constraining data point is the time course of MAPK dephosphorylation, which this model satisfies. It would be nice to have more accurate estimates of rate consts and MKP-1 levels from the literature. Effective Km : 67 nM kcat = 1.43 umol/min/mg
    37MAPKK*  /
    MAPKKthr
  • Ajay_Bhalla_
    2007_ReacDiff3

    Accession No. : 84
  • MAPK
    Pathway No. : 1030
    0.04629640.34explicit E-S complexSubstrate
    MAPK-tyr

    Product
    MAPK*
        Rate consts same as for MAPKKtyr.
    38MKP-1  /
    MKP1-tyr-deph
  • Ajay_Bhalla_
    2007_ReacDiff3

    Accession No. : 84
  • kinetics[17]
    Pathway No. : 1027
    0.13333344explicit E-S complexSubstrate
    MAPK-tyr

    Product
    MAPK
        The original kinetics have been modified to obey the k2 = 4 * k3 rule, while keeping kcat and Km fixed. As noted in the NOTES, the only constraining data point is the time course of MAPK dephosphorylation, which this model satisfies. It would be nice to have more accurate estimates of rate consts and MKP-1 levels from the literature. Effective Km : 67 nM kcat = 1.43 umol/min/mg
    39MAPKK*  /
    MAPKKthr
  • Ajay_Bhalla_
    2007_ReacDiff3

    Accession No. : 84
  • MAPK
    Pathway No. : 1036
    0.04629640.34explicit E-S complexSubstrate
    MAPK-tyr

    Product
    MAPK*
        Rate consts same as for MAPKKtyr.
    40MKP-1  /
    MKP1-tyr-deph
  • Ajay_Bhalla_
    2007_ReacDiff3

    Accession No. : 84
  • kinetics[18]
    Pathway No. : 1033
    0.13333344explicit E-S complexSubstrate
    MAPK-tyr

    Product
    MAPK
        The original kinetics have been modified to obey the k2 = 4 * k3 rule, while keeping kcat and Km fixed. As noted in the NOTES, the only constraining data point is the time course of MAPK dephosphorylation, which this model satisfies. It would be nice to have more accurate estimates of rate consts and MKP-1 levels from the literature. Effective Km : 67 nM kcat = 1.43 umol/min/mg
    41MAPKK*  /
    MAPKKthr
  • Ajay_Bhalla_
    2007_ReacDiff3

    Accession No. : 84
  • MAPK
    Pathway No. : 1042
    0.04629640.34explicit E-S complexSubstrate
    MAPK-tyr

    Product
    MAPK*
        Rate consts same as for MAPKKtyr.
    42MKP-1  /
    MKP1-tyr-deph
  • Ajay_Bhalla_
    2007_ReacDiff3

    Accession No. : 84
  • kinetics[19]
    Pathway No. : 1039
    0.13333344explicit E-S complexSubstrate
    MAPK-tyr

    Product
    MAPK
        The original kinetics have been modified to obey the k2 = 4 * k3 rule, while keeping kcat and Km fixed. As noted in the NOTES, the only constraining data point is the time course of MAPK dephosphorylation, which this model satisfies. It would be nice to have more accurate estimates of rate consts and MKP-1 levels from the literature. Effective Km : 67 nM kcat = 1.43 umol/min/mg
    43MAPKK*  /
    MAPKKthr
  • Ajay_Bhalla_
    2007_ReacDiff3

    Accession No. : 84
  • MAPK
    Pathway No. : 1048
    0.04629640.34explicit E-S complexSubstrate
    MAPK-tyr

    Product
    MAPK*
        Rate consts same as for MAPKKtyr.
    44MKP-1  /
    MKP1-tyr-deph
  • Ajay_Bhalla_
    2007_ReacDiff3

    Accession No. : 84
  • kinetics[20]
    Pathway No. : 1045
    0.13333344explicit E-S complexSubstrate
    MAPK-tyr

    Product
    MAPK
        The original kinetics have been modified to obey the k2 = 4 * k3 rule, while keeping kcat and Km fixed. As noted in the NOTES, the only constraining data point is the time course of MAPK dephosphorylation, which this model satisfies. It would be nice to have more accurate estimates of rate consts and MKP-1 levels from the literature. Effective Km : 67 nM kcat = 1.43 umol/min/mg
    45MAPKK*  /
    MAPKKthr
  • Ajay_Bhalla_
    2007_ReacDiff3

    Accession No. : 84
  • MAPK
    Pathway No. : 1054
    0.04629640.34explicit E-S complexSubstrate
    MAPK-tyr

    Product
    MAPK*
        Rate consts same as for MAPKKtyr.
    46MKP-1  /
    MKP1-tyr-deph
  • Ajay_Bhalla_
    2007_ReacDiff3

    Accession No. : 84
  • kinetics[21]
    Pathway No. : 1051
    0.13333344explicit E-S complexSubstrate
    MAPK-tyr

    Product
    MAPK
        The original kinetics have been modified to obey the k2 = 4 * k3 rule, while keeping kcat and Km fixed. As noted in the NOTES, the only constraining data point is the time course of MAPK dephosphorylation, which this model satisfies. It would be nice to have more accurate estimates of rate consts and MKP-1 levels from the literature. Effective Km : 67 nM kcat = 1.43 umol/min/mg
    47MAPKK*  /
    MAPKKthr
  • Ajay_Bhalla_
    2007_ReacDiff3

    Accession No. : 84
  • MAPK
    Pathway No. : 1060
    0.04629640.34explicit E-S complexSubstrate
    MAPK-tyr

    Product
    MAPK*
        Rate consts same as for MAPKKtyr.
    48MKP-1  /
    MKP1-tyr-deph
  • Ajay_Bhalla_
    2007_ReacDiff3

    Accession No. : 84
  • kinetics[22]
    Pathway No. : 1057
    0.13333344explicit E-S complexSubstrate
    MAPK-tyr

    Product
    MAPK
        The original kinetics have been modified to obey the k2 = 4 * k3 rule, while keeping kcat and Km fixed. As noted in the NOTES, the only constraining data point is the time course of MAPK dephosphorylation, which this model satisfies. It would be nice to have more accurate estimates of rate consts and MKP-1 levels from the literature. Effective Km : 67 nM kcat = 1.43 umol/min/mg
    49MAPKK*  /
    MAPKKthr
  • Ajay_Bhalla_
    2007_ReacDiff3

    Accession No. : 84
  • MAPK
    Pathway No. : 1066
    0.04629640.34explicit E-S complexSubstrate
    MAPK-tyr

    Product
    MAPK*
        Rate consts same as for MAPKKtyr.
    50MKP-1  /
    MKP1-tyr-deph
  • Ajay_Bhalla_
    2007_ReacDiff3

    Accession No. : 84
  • kinetics[23]
    Pathway No. : 1063
    0.13333344explicit E-S complexSubstrate
    MAPK-tyr

    Product
    MAPK
        The original kinetics have been modified to obey the k2 = 4 * k3 rule, while keeping kcat and Km fixed. As noted in the NOTES, the only constraining data point is the time course of MAPK dephosphorylation, which this model satisfies. It would be nice to have more accurate estimates of rate consts and MKP-1 levels from the literature. Effective Km : 67 nM kcat = 1.43 umol/min/mg

    MAPK-tyr acting as a Product of an Enzyme in  
    Ajay_Bhalla_2007_ReacDiff3 Network
     Enzyme Molecule /
    Enzyme Activity
    Accession NamePathway NameKm (uM)kcat (s^-1)RatioEnzyme TypeReagents
    1MAPKK*  /
    MAPKKtyr
  • Ajay_Bhalla_
    2007_ReacDiff3

    Accession No. : 84
  • MAPK
    Pathway No. : 921
    0.04629640.34explicit E-S complexSubstrate
    MAPK

    Product
    MAPK-tyr
        The actual MAPKK is 2 forms from Seger et al JBC 267:20 14373(1992) Vmax = 150nmol/min/mg From Haystead et al FEBS 306(1):17-22 we get Km=46.6nM for at least one of the phosphs. Putting these together: k3=0.15/sec, scale to get k2=0.6. k1=0.75/46.6nM=2.7e-5
    2MKP-1  /
    MKP1-thr-deph
  • Ajay_Bhalla_
    2007_ReacDiff3

    Accession No. : 84
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff3

    Pathway No. : 918
  • 0.13333344explicit E-S complexSubstrate
    MAPK*

    Product
    MAPK-tyr
        See MKP1-tyr-deph
    3MAPKK*  /
    MAPKKtyr
  • Ajay_Bhalla_
    2007_ReacDiff3

    Accession No. : 84
  • MAPK
    Pathway No. : 928
    0.04629640.34explicit E-S complexSubstrate
    MAPK

    Product
    MAPK-tyr
        The actual MAPKK is 2 forms from Seger et al JBC 267:20 14373(1992) Vmax = 150nmol/min/mg From Haystead et al FEBS 306(1):17-22 we get Km=46.6nM for at least one of the phosphs. Putting these together: k3=0.15/sec, scale to get k2=0.6. k1=0.75/46.6nM=2.7e-5
    4MKP-1  /
    MKP1-thr-deph
  • Ajay_Bhalla_
    2007_ReacDiff3

    Accession No. : 84
  • kinetics
    Pathway No. : 926
    0.13333344explicit E-S complexSubstrate
    MAPK*

    Product
    MAPK-tyr
        See MKP1-tyr-deph
    5MAPKK*  /
    MAPKKtyr
  • Ajay_Bhalla_
    2007_ReacDiff3

    Accession No. : 84
  • MAPK
    Pathway No. : 934
    0.04629640.34explicit E-S complexSubstrate
    MAPK

    Product
    MAPK-tyr
        The actual MAPKK is 2 forms from Seger et al JBC 267:20 14373(1992) Vmax = 150nmol/min/mg From Haystead et al FEBS 306(1):17-22 we get Km=46.6nM for at least one of the phosphs. Putting these together: k3=0.15/sec, scale to get k2=0.6. k1=0.75/46.6nM=2.7e-5
    6MKP-1  /
    MKP1-thr-deph
  • Ajay_Bhalla_
    2007_ReacDiff3

    Accession No. : 84
  • kinetics[1]
    Pathway No. : 931
    0.13333344explicit E-S complexSubstrate
    MAPK*

    Product
    MAPK-tyr
        See MKP1-tyr-deph
    7MAPKK*  /
    MAPKKtyr
  • Ajay_Bhalla_
    2007_ReacDiff3

    Accession No. : 84
  • MAPK
    Pathway No. : 940
    0.04629640.34explicit E-S complexSubstrate
    MAPK

    Product
    MAPK-tyr
        The actual MAPKK is 2 forms from Seger et al JBC 267:20 14373(1992) Vmax = 150nmol/min/mg From Haystead et al FEBS 306(1):17-22 we get Km=46.6nM for at least one of the phosphs. Putting these together: k3=0.15/sec, scale to get k2=0.6. k1=0.75/46.6nM=2.7e-5
    8MKP-1  /
    MKP1-thr-deph
  • Ajay_Bhalla_
    2007_ReacDiff3

    Accession No. : 84
  • kinetics[2]
    Pathway No. : 937
    0.13333344explicit E-S complexSubstrate
    MAPK*

    Product
    MAPK-tyr
        See MKP1-tyr-deph
    9MAPKK*  /
    MAPKKtyr
  • Ajay_Bhalla_
    2007_ReacDiff3

    Accession No. : 84
  • MAPK
    Pathway No. : 946
    0.04629640.34explicit E-S complexSubstrate
    MAPK

    Product
    MAPK-tyr
        The actual MAPKK is 2 forms from Seger et al JBC 267:20 14373(1992) Vmax = 150nmol/min/mg From Haystead et al FEBS 306(1):17-22 we get Km=46.6nM for at least one of the phosphs. Putting these together: k3=0.15/sec, scale to get k2=0.6. k1=0.75/46.6nM=2.7e-5
    10MKP-1  /
    MKP1-thr-deph
  • Ajay_Bhalla_
    2007_ReacDiff3

    Accession No. : 84
  • kinetics[3]
    Pathway No. : 943
    0.13333344explicit E-S complexSubstrate
    MAPK*

    Product
    MAPK-tyr
        See MKP1-tyr-deph
    11MAPKK*  /
    MAPKKtyr
  • Ajay_Bhalla_
    2007_ReacDiff3

    Accession No. : 84
  • MAPK
    Pathway No. : 952
    0.04629640.34explicit E-S complexSubstrate
    MAPK

    Product
    MAPK-tyr
        The actual MAPKK is 2 forms from Seger et al JBC 267:20 14373(1992) Vmax = 150nmol/min/mg From Haystead et al FEBS 306(1):17-22 we get Km=46.6nM for at least one of the phosphs. Putting these together: k3=0.15/sec, scale to get k2=0.6. k1=0.75/46.6nM=2.7e-5
    12MKP-1  /
    MKP1-thr-deph
  • Ajay_Bhalla_
    2007_ReacDiff3

    Accession No. : 84
  • kinetics[4]
    Pathway No. : 949
    0.13333344explicit E-S complexSubstrate
    MAPK*

    Product
    MAPK-tyr
        See MKP1-tyr-deph
    13MAPKK*  /
    MAPKKtyr
  • Ajay_Bhalla_
    2007_ReacDiff3

    Accession No. : 84
  • MAPK
    Pathway No. : 958
    0.04629640.34explicit E-S complexSubstrate
    MAPK

    Product
    MAPK-tyr
        The actual MAPKK is 2 forms from Seger et al JBC 267:20 14373(1992) Vmax = 150nmol/min/mg From Haystead et al FEBS 306(1):17-22 we get Km=46.6nM for at least one of the phosphs. Putting these together: k3=0.15/sec, scale to get k2=0.6. k1=0.75/46.6nM=2.7e-5
    14MKP-1  /
    MKP1-thr-deph
  • Ajay_Bhalla_
    2007_ReacDiff3

    Accession No. : 84
  • kinetics[5]
    Pathway No. : 955
    0.13333344explicit E-S complexSubstrate
    MAPK*

    Product
    MAPK-tyr
        See MKP1-tyr-deph
    15MAPKK*  /
    MAPKKtyr
  • Ajay_Bhalla_
    2007_ReacDiff3

    Accession No. : 84
  • MAPK
    Pathway No. : 965
    0.04629640.34explicit E-S complexSubstrate
    MAPK

    Product
    MAPK-tyr
        The actual MAPKK is 2 forms from Seger et al JBC 267:20 14373(1992) Vmax = 150nmol/min/mg From Haystead et al FEBS 306(1):17-22 we get Km=46.6nM for at least one of the phosphs. Putting these together: k3=0.15/sec, scale to get k2=0.6. k1=0.75/46.6nM=2.7e-5
    16MKP-1  /
    MKP1-thr-deph
  • Ajay_Bhalla_
    2007_ReacDiff3

    Accession No. : 84
  • kinetics[6]
    Pathway No. : 962
    0.13333344explicit E-S complexSubstrate
    MAPK*

    Product
    MAPK-tyr
        See MKP1-tyr-deph
    17MAPKK*  /
    MAPKKtyr
  • Ajay_Bhalla_
    2007_ReacDiff3

    Accession No. : 84
  • MAPK
    Pathway No. : 971
    0.04629640.34explicit E-S complexSubstrate
    MAPK

    Product
    MAPK-tyr
        The actual MAPKK is 2 forms from Seger et al JBC 267:20 14373(1992) Vmax = 150nmol/min/mg From Haystead et al FEBS 306(1):17-22 we get Km=46.6nM for at least one of the phosphs. Putting these together: k3=0.15/sec, scale to get k2=0.6. k1=0.75/46.6nM=2.7e-5
    18MKP-1  /
    MKP1-thr-deph
  • Ajay_Bhalla_
    2007_ReacDiff3

    Accession No. : 84
  • kinetics[7]
    Pathway No. : 968
    0.13333344explicit E-S complexSubstrate
    MAPK*

    Product
    MAPK-tyr
        See MKP1-tyr-deph
    19MAPKK*  /
    MAPKKtyr
  • Ajay_Bhalla_
    2007_ReacDiff3

    Accession No. : 84
  • MAPK
    Pathway No. : 977
    0.04629640.34explicit E-S complexSubstrate
    MAPK

    Product
    MAPK-tyr
        The actual MAPKK is 2 forms from Seger et al JBC 267:20 14373(1992) Vmax = 150nmol/min/mg From Haystead et al FEBS 306(1):17-22 we get Km=46.6nM for at least one of the phosphs. Putting these together: k3=0.15/sec, scale to get k2=0.6. k1=0.75/46.6nM=2.7e-5
    20MKP-1  /
    MKP1-thr-deph
  • Ajay_Bhalla_
    2007_ReacDiff3

    Accession No. : 84
  • kinetics[8]
    Pathway No. : 975
    0.13333344explicit E-S complexSubstrate
    MAPK*

    Product
    MAPK-tyr
        See MKP1-tyr-deph
    21MAPKK*  /
    MAPKKtyr
  • Ajay_Bhalla_
    2007_ReacDiff3

    Accession No. : 84
  • MAPK
    Pathway No. : 983
    0.04629640.34explicit E-S complexSubstrate
    MAPK

    Product
    MAPK-tyr
        The actual MAPKK is 2 forms from Seger et al JBC 267:20 14373(1992) Vmax = 150nmol/min/mg From Haystead et al FEBS 306(1):17-22 we get Km=46.6nM for at least one of the phosphs. Putting these together: k3=0.15/sec, scale to get k2=0.6. k1=0.75/46.6nM=2.7e-5
    22MKP-1  /
    MKP1-thr-deph
  • Ajay_Bhalla_
    2007_ReacDiff3

    Accession No. : 84
  • kinetics[9]
    Pathway No. : 980
    0.13333344explicit E-S complexSubstrate
    MAPK*

    Product
    MAPK-tyr
        See MKP1-tyr-deph
    23MAPKK*  /
    MAPKKtyr
  • Ajay_Bhalla_
    2007_ReacDiff3

    Accession No. : 84
  • MAPK
    Pathway No. : 989
    0.04629640.34explicit E-S complexSubstrate
    MAPK

    Product
    MAPK-tyr
        The actual MAPKK is 2 forms from Seger et al JBC 267:20 14373(1992) Vmax = 150nmol/min/mg From Haystead et al FEBS 306(1):17-22 we get Km=46.6nM for at least one of the phosphs. Putting these together: k3=0.15/sec, scale to get k2=0.6. k1=0.75/46.6nM=2.7e-5
    24MKP-1  /
    MKP1-thr-deph
  • Ajay_Bhalla_
    2007_ReacDiff3

    Accession No. : 84
  • kinetics[10]
    Pathway No. : 986
    0.13333344explicit E-S complexSubstrate
    MAPK*

    Product
    MAPK-tyr
        See MKP1-tyr-deph
    25MAPKK*  /
    MAPKKtyr
  • Ajay_Bhalla_
    2007_ReacDiff3

    Accession No. : 84
  • MAPK
    Pathway No. : 995
    0.04629640.34explicit E-S complexSubstrate
    MAPK

    Product
    MAPK-tyr
        The actual MAPKK is 2 forms from Seger et al JBC 267:20 14373(1992) Vmax = 150nmol/min/mg From Haystead et al FEBS 306(1):17-22 we get Km=46.6nM for at least one of the phosphs. Putting these together: k3=0.15/sec, scale to get k2=0.6. k1=0.75/46.6nM=2.7e-5
    26MKP-1  /
    MKP1-thr-deph
  • Ajay_Bhalla_
    2007_ReacDiff3

    Accession No. : 84
  • kinetics[11]
    Pathway No. : 992
    0.13333344explicit E-S complexSubstrate
    MAPK*

    Product
    MAPK-tyr
        See MKP1-tyr-deph
    27MAPKK*  /
    MAPKKtyr
  • Ajay_Bhalla_
    2007_ReacDiff3

    Accession No. : 84
  • MAPK
    Pathway No. : 960
    0.04629640.34explicit E-S complexSubstrate
    MAPK

    Product
    MAPK-tyr
        The actual MAPKK is 2 forms from Seger et al JBC 267:20 14373(1992) Vmax = 150nmol/min/mg From Haystead et al FEBS 306(1):17-22 we get Km=46.6nM for at least one of the phosphs. Putting these together: k3=0.15/sec, scale to get k2=0.6. k1=0.75/46.6nM=2.7e-5
    28MKP-1  /
    MKP1-thr-deph
  • Ajay_Bhalla_
    2007_ReacDiff3

    Accession No. : 84
  • kinetics[12]
    Pathway No. : 998
    0.13333344explicit E-S complexSubstrate
    MAPK*

    Product
    MAPK-tyr
        See MKP1-tyr-deph
    29MAPKK*  /
    MAPKKtyr
  • Ajay_Bhalla_
    2007_ReacDiff3

    Accession No. : 84
  • MAPK
    Pathway No. : 1006
    0.04629640.34explicit E-S complexSubstrate
    MAPK

    Product
    MAPK-tyr
        The actual MAPKK is 2 forms from Seger et al JBC 267:20 14373(1992) Vmax = 150nmol/min/mg From Haystead et al FEBS 306(1):17-22 we get Km=46.6nM for at least one of the phosphs. Putting these together: k3=0.15/sec, scale to get k2=0.6. k1=0.75/46.6nM=2.7e-5
    30MKP-1  /
    MKP1-thr-deph
  • Ajay_Bhalla_
    2007_ReacDiff3

    Accession No. : 84
  • kinetics[13]
    Pathway No. : 1003
    0.13333344explicit E-S complexSubstrate
    MAPK*

    Product
    MAPK-tyr
        See MKP1-tyr-deph
    31MAPKK*  /
    MAPKKtyr
  • Ajay_Bhalla_
    2007_ReacDiff3

    Accession No. : 84
  • MAPK
    Pathway No. : 1012
    0.04629640.34explicit E-S complexSubstrate
    MAPK

    Product
    MAPK-tyr
        The actual MAPKK is 2 forms from Seger et al JBC 267:20 14373(1992) Vmax = 150nmol/min/mg From Haystead et al FEBS 306(1):17-22 we get Km=46.6nM for at least one of the phosphs. Putting these together: k3=0.15/sec, scale to get k2=0.6. k1=0.75/46.6nM=2.7e-5
    32MKP-1  /
    MKP1-thr-deph
  • Ajay_Bhalla_
    2007_ReacDiff3

    Accession No. : 84
  • kinetics[14]
    Pathway No. : 1009
    0.13333344explicit E-S complexSubstrate
    MAPK*

    Product
    MAPK-tyr
        See MKP1-tyr-deph
    33MAPKK*  /
    MAPKKtyr
  • Ajay_Bhalla_
    2007_ReacDiff3

    Accession No. : 84
  • MAPK
    Pathway No. : 1018
    0.04629640.34explicit E-S complexSubstrate
    MAPK

    Product
    MAPK-tyr
        The actual MAPKK is 2 forms from Seger et al JBC 267:20 14373(1992) Vmax = 150nmol/min/mg From Haystead et al FEBS 306(1):17-22 we get Km=46.6nM for at least one of the phosphs. Putting these together: k3=0.15/sec, scale to get k2=0.6. k1=0.75/46.6nM=2.7e-5
    34MKP-1  /
    MKP1-thr-deph
  • Ajay_Bhalla_
    2007_ReacDiff3

    Accession No. : 84
  • kinetics[15]
    Pathway No. : 1015
    0.13333344explicit E-S complexSubstrate
    MAPK*

    Product
    MAPK-tyr
        See MKP1-tyr-deph
    35MAPKK*  /
    MAPKKtyr
  • Ajay_Bhalla_
    2007_ReacDiff3

    Accession No. : 84
  • MAPK
    Pathway No. : 1024
    0.04629640.34explicit E-S complexSubstrate
    MAPK

    Product
    MAPK-tyr
        The actual MAPKK is 2 forms from Seger et al JBC 267:20 14373(1992) Vmax = 150nmol/min/mg From Haystead et al FEBS 306(1):17-22 we get Km=46.6nM for at least one of the phosphs. Putting these together: k3=0.15/sec, scale to get k2=0.6. k1=0.75/46.6nM=2.7e-5
    36MKP-1  /
    MKP1-thr-deph
  • Ajay_Bhalla_
    2007_ReacDiff3

    Accession No. : 84
  • kinetics[16]
    Pathway No. : 1020
    0.13333344explicit E-S complexSubstrate
    MAPK*

    Product
    MAPK-tyr
        See MKP1-tyr-deph
    37MAPKK*  /
    MAPKKtyr
  • Ajay_Bhalla_
    2007_ReacDiff3

    Accession No. : 84
  • MAPK
    Pathway No. : 1030
    0.04629640.34explicit E-S complexSubstrate
    MAPK

    Product
    MAPK-tyr
        The actual MAPKK is 2 forms from Seger et al JBC 267:20 14373(1992) Vmax = 150nmol/min/mg From Haystead et al FEBS 306(1):17-22 we get Km=46.6nM for at least one of the phosphs. Putting these together: k3=0.15/sec, scale to get k2=0.6. k1=0.75/46.6nM=2.7e-5
    38MKP-1  /
    MKP1-thr-deph
  • Ajay_Bhalla_
    2007_ReacDiff3

    Accession No. : 84
  • kinetics[17]
    Pathway No. : 1027
    0.13333344explicit E-S complexSubstrate
    MAPK*

    Product
    MAPK-tyr
        See MKP1-tyr-deph
    39MAPKK*  /
    MAPKKtyr
  • Ajay_Bhalla_
    2007_ReacDiff3

    Accession No. : 84
  • MAPK
    Pathway No. : 1036
    0.04629640.34explicit E-S complexSubstrate
    MAPK

    Product
    MAPK-tyr
        The actual MAPKK is 2 forms from Seger et al JBC 267:20 14373(1992) Vmax = 150nmol/min/mg From Haystead et al FEBS 306(1):17-22 we get Km=46.6nM for at least one of the phosphs. Putting these together: k3=0.15/sec, scale to get k2=0.6. k1=0.75/46.6nM=2.7e-5
    40MKP-1  /
    MKP1-thr-deph
  • Ajay_Bhalla_
    2007_ReacDiff3

    Accession No. : 84
  • kinetics[18]
    Pathway No. : 1033
    0.13333344explicit E-S complexSubstrate
    MAPK*

    Product
    MAPK-tyr
        See MKP1-tyr-deph
    41MAPKK*  /
    MAPKKtyr
  • Ajay_Bhalla_
    2007_ReacDiff3

    Accession No. : 84
  • MAPK
    Pathway No. : 1042
    0.04629640.34explicit E-S complexSubstrate
    MAPK

    Product
    MAPK-tyr
        The actual MAPKK is 2 forms from Seger et al JBC 267:20 14373(1992) Vmax = 150nmol/min/mg From Haystead et al FEBS 306(1):17-22 we get Km=46.6nM for at least one of the phosphs. Putting these together: k3=0.15/sec, scale to get k2=0.6. k1=0.75/46.6nM=2.7e-5
    42MKP-1  /
    MKP1-thr-deph
  • Ajay_Bhalla_
    2007_ReacDiff3

    Accession No. : 84
  • kinetics[19]
    Pathway No. : 1039
    0.13333344explicit E-S complexSubstrate
    MAPK*

    Product
    MAPK-tyr
        See MKP1-tyr-deph
    43MAPKK*  /
    MAPKKtyr
  • Ajay_Bhalla_
    2007_ReacDiff3

    Accession No. : 84
  • MAPK
    Pathway No. : 1048
    0.04629640.34explicit E-S complexSubstrate
    MAPK

    Product
    MAPK-tyr
        The actual MAPKK is 2 forms from Seger et al JBC 267:20 14373(1992) Vmax = 150nmol/min/mg From Haystead et al FEBS 306(1):17-22 we get Km=46.6nM for at least one of the phosphs. Putting these together: k3=0.15/sec, scale to get k2=0.6. k1=0.75/46.6nM=2.7e-5
    44MKP-1  /
    MKP1-thr-deph
  • Ajay_Bhalla_
    2007_ReacDiff3

    Accession No. : 84
  • kinetics[20]
    Pathway No. : 1045
    0.13333344explicit E-S complexSubstrate
    MAPK*

    Product
    MAPK-tyr
        See MKP1-tyr-deph
    45MAPKK*  /
    MAPKKtyr
  • Ajay_Bhalla_
    2007_ReacDiff3

    Accession No. : 84
  • MAPK
    Pathway No. : 1054
    0.04629640.34explicit E-S complexSubstrate
    MAPK

    Product
    MAPK-tyr
        The actual MAPKK is 2 forms from Seger et al JBC 267:20 14373(1992) Vmax = 150nmol/min/mg From Haystead et al FEBS 306(1):17-22 we get Km=46.6nM for at least one of the phosphs. Putting these together: k3=0.15/sec, scale to get k2=0.6. k1=0.75/46.6nM=2.7e-5
    46MKP-1  /
    MKP1-thr-deph
  • Ajay_Bhalla_
    2007_ReacDiff3

    Accession No. : 84
  • kinetics[21]
    Pathway No. : 1051
    0.13333344explicit E-S complexSubstrate
    MAPK*

    Product
    MAPK-tyr
        See MKP1-tyr-deph
    47MAPKK*  /
    MAPKKtyr
  • Ajay_Bhalla_
    2007_ReacDiff3

    Accession No. : 84
  • MAPK
    Pathway No. : 1060
    0.04629640.34explicit E-S complexSubstrate
    MAPK

    Product
    MAPK-tyr
        The actual MAPKK is 2 forms from Seger et al JBC 267:20 14373(1992) Vmax = 150nmol/min/mg From Haystead et al FEBS 306(1):17-22 we get Km=46.6nM for at least one of the phosphs. Putting these together: k3=0.15/sec, scale to get k2=0.6. k1=0.75/46.6nM=2.7e-5
    48MKP-1  /
    MKP1-thr-deph
  • Ajay_Bhalla_
    2007_ReacDiff3

    Accession No. : 84
  • kinetics[22]
    Pathway No. : 1057
    0.13333344explicit E-S complexSubstrate
    MAPK*

    Product
    MAPK-tyr
        See MKP1-tyr-deph
    49MAPKK*  /
    MAPKKtyr
  • Ajay_Bhalla_
    2007_ReacDiff3

    Accession No. : 84
  • MAPK
    Pathway No. : 1066
    0.04629640.34explicit E-S complexSubstrate
    MAPK

    Product
    MAPK-tyr
        The actual MAPKK is 2 forms from Seger et al JBC 267:20 14373(1992) Vmax = 150nmol/min/mg From Haystead et al FEBS 306(1):17-22 we get Km=46.6nM for at least one of the phosphs. Putting these together: k3=0.15/sec, scale to get k2=0.6. k1=0.75/46.6nM=2.7e-5
    50MKP-1  /
    MKP1-thr-deph
  • Ajay_Bhalla_
    2007_ReacDiff3

    Accession No. : 84
  • kinetics[23]
    Pathway No. : 1063
    0.13333344explicit E-S complexSubstrate
    MAPK*

    Product
    MAPK-tyr
        See MKP1-tyr-deph

    MAPK-tyr acting as a Substrate in a reaction in  
    Ajay_Bhalla_2007_ReacDiff3 Network
    Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.
     NameAccession NamePathway NameKfKbKdtauReagents
    1diff
  • Ajay_Bhalla_
    2007_ReacDiff3

    Accession No. : 84
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff3

    Pathway No. : 918
  • 0.001
    (s^-1)
    0.001
    (s^-1)
    Keq = 1(uM)500secSubstrate
    MAPK-tyr

    Product
    MAPK-tyr
    2diff
  • Ajay_Bhalla_
    2007_ReacDiff3

    Accession No. : 84
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff3

    Pathway No. : 918
  • 0.001
    (s^-1)
    0.001
    (s^-1)
    Keq = 1(uM)500secSubstrate
    MAPK-tyr

    Product
    MAPK-tyr
    3diff
  • Ajay_Bhalla_
    2007_ReacDiff3

    Accession No. : 84
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff3

    Pathway No. : 918
  • 0.001
    (s^-1)
    0.001
    (s^-1)
    Keq = 1(uM)500secSubstrate
    MAPK-tyr

    Product
    MAPK-tyr
    4diff
  • Ajay_Bhalla_
    2007_ReacDiff3

    Accession No. : 84
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff3

    Pathway No. : 918
  • 0.001
    (s^-1)
    0.001
    (s^-1)
    Keq = 1(uM)500secSubstrate
    MAPK-tyr

    Product
    MAPK-tyr
    5diff
  • Ajay_Bhalla_
    2007_ReacDiff3

    Accession No. : 84
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff3

    Pathway No. : 918
  • 0.001
    (s^-1)
    0.001
    (s^-1)
    Keq = 1(uM)500secSubstrate
    MAPK-tyr

    Product
    MAPK-tyr
    6diff
  • Ajay_Bhalla_
    2007_ReacDiff3

    Accession No. : 84
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff3

    Pathway No. : 918
  • 0.001
    (s^-1)
    0.001
    (s^-1)
    Keq = 1(uM)500secSubstrate
    MAPK-tyr

    Product
    MAPK-tyr
    7diff
  • Ajay_Bhalla_
    2007_ReacDiff3

    Accession No. : 84
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff3

    Pathway No. : 918
  • 0.001
    (s^-1)
    0.001
    (s^-1)
    Keq = 1(uM)500secSubstrate
    MAPK-tyr

    Product
    MAPK-tyr
    8diff
  • Ajay_Bhalla_
    2007_ReacDiff3

    Accession No. : 84
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff3

    Pathway No. : 918
  • 0.001
    (s^-1)
    0.001
    (s^-1)
    Keq = 1(uM)500secSubstrate
    MAPK-tyr

    Product
    MAPK-tyr
    9diff
  • Ajay_Bhalla_
    2007_ReacDiff3

    Accession No. : 84
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff3

    Pathway No. : 918
  • 0.001
    (s^-1)
    0.001
    (s^-1)
    Keq = 1(uM)500secSubstrate
    MAPK-tyr

    Product
    MAPK-tyr
    10diff
  • Ajay_Bhalla_
    2007_ReacDiff3

    Accession No. : 84
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff3

    Pathway No. : 918
  • 0.001
    (s^-1)
    0.001
    (s^-1)
    Keq = 1(uM)500secSubstrate
    MAPK-tyr

    Product
    MAPK-tyr
    11diff
  • Ajay_Bhalla_
    2007_ReacDiff3

    Accession No. : 84
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff3

    Pathway No. : 918
  • 0.001
    (s^-1)
    0.001
    (s^-1)
    Keq = 1(uM)500secSubstrate
    MAPK-tyr

    Product
    MAPK-tyr
    12diff
  • Ajay_Bhalla_
    2007_ReacDiff3

    Accession No. : 84
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff3

    Pathway No. : 918
  • 0.001
    (s^-1)
    0.001
    (s^-1)
    Keq = 1(uM)500secSubstrate
    MAPK-tyr

    Product
    MAPK-tyr
    13diff
  • Ajay_Bhalla_
    2007_ReacDiff3

    Accession No. : 84
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff3

    Pathway No. : 918
  • 0.001
    (s^-1)
    0.001
    (s^-1)
    Keq = 1(uM)500secSubstrate
    MAPK-tyr

    Product
    MAPK-tyr
    14diff
  • Ajay_Bhalla_
    2007_ReacDiff3

    Accession No. : 84
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff3

    Pathway No. : 918
  • 0.001
    (s^-1)
    0.001
    (s^-1)
    Keq = 1(uM)500secSubstrate
    MAPK-tyr

    Product
    MAPK-tyr
    15diff
  • Ajay_Bhalla_
    2007_ReacDiff3

    Accession No. : 84
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff3

    Pathway No. : 918
  • 0.001
    (s^-1)
    0.001
    (s^-1)
    Keq = 1(uM)500secSubstrate
    MAPK-tyr

    Product
    MAPK-tyr
    16diff
  • Ajay_Bhalla_
    2007_ReacDiff3

    Accession No. : 84
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff3

    Pathway No. : 918
  • 0.001
    (s^-1)
    0.001
    (s^-1)
    Keq = 1(uM)500secSubstrate
    MAPK-tyr

    Product
    MAPK-tyr
    17diff
  • Ajay_Bhalla_
    2007_ReacDiff3

    Accession No. : 84
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff3

    Pathway No. : 918
  • 0.001
    (s^-1)
    0.001
    (s^-1)
    Keq = 1(uM)500secSubstrate
    MAPK-tyr

    Product
    MAPK-tyr
    18diff
  • Ajay_Bhalla_
    2007_ReacDiff3

    Accession No. : 84
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff3

    Pathway No. : 918
  • 0.001
    (s^-1)
    0.001
    (s^-1)
    Keq = 1(uM)500secSubstrate
    MAPK-tyr

    Product
    MAPK-tyr
    19diff
  • Ajay_Bhalla_
    2007_ReacDiff3

    Accession No. : 84
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff3

    Pathway No. : 918
  • 0.001
    (s^-1)
    0.001
    (s^-1)
    Keq = 1(uM)500secSubstrate
    MAPK-tyr

    Product
    MAPK-tyr
    20diff
  • Ajay_Bhalla_
    2007_ReacDiff3

    Accession No. : 84
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff3

    Pathway No. : 918
  • 0.001
    (s^-1)
    0.001
    (s^-1)
    Keq = 1(uM)500secSubstrate
    MAPK-tyr

    Product
    MAPK-tyr
    21diff
  • Ajay_Bhalla_
    2007_ReacDiff3

    Accession No. : 84
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff3

    Pathway No. : 918
  • 0.001
    (s^-1)
    0.001
    (s^-1)
    Keq = 1(uM)500secSubstrate
    MAPK-tyr

    Product
    MAPK-tyr
    22diff
  • Ajay_Bhalla_
    2007_ReacDiff3

    Accession No. : 84
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff3

    Pathway No. : 918
  • 0.001
    (s^-1)
    0.001
    (s^-1)
    Keq = 1(uM)500secSubstrate
    MAPK-tyr

    Product
    MAPK-tyr
    23diff
  • Ajay_Bhalla_
    2007_ReacDiff3

    Accession No. : 84
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff3

    Pathway No. : 918
  • 0.001
    (s^-1)
    0.001
    (s^-1)
    Keq = 1(uM)500secSubstrate
    MAPK-tyr

    Product
    MAPK-tyr
    24diff
  • Ajay_Bhalla_
    2007_ReacDiff3

    Accession No. : 84
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff3

    Pathway No. : 918
  • 0.001
    (s^-1)
    0.001
    (s^-1)
    Keq = 1(uM)500secSubstrate
    MAPK-tyr

    Product
    MAPK-tyr

    MAPK-tyr acting as a Product in a reaction in  
    Ajay_Bhalla_2007_ReacDiff3 Network
    Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.
     NameAccession NamePathway NameKfKbKdtauReagents
    1diff
  • Ajay_Bhalla_
    2007_ReacDiff3

    Accession No. : 84
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff3

    Pathway No. : 918
  • 0.001
    (s^-1)
    0.001
    (s^-1)
    Keq = 1(uM)500secSubstrate
    MAPK-tyr

    Product
    MAPK-tyr
    2diff
  • Ajay_Bhalla_
    2007_ReacDiff3

    Accession No. : 84
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff3

    Pathway No. : 918
  • 0.001
    (s^-1)
    0.001
    (s^-1)
    Keq = 1(uM)500secSubstrate
    MAPK-tyr

    Product
    MAPK-tyr
    3diff
  • Ajay_Bhalla_
    2007_ReacDiff3

    Accession No. : 84
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff3

    Pathway No. : 918
  • 0.001
    (s^-1)
    0.001
    (s^-1)
    Keq = 1(uM)500secSubstrate
    MAPK-tyr

    Product
    MAPK-tyr
    4diff
  • Ajay_Bhalla_
    2007_ReacDiff3

    Accession No. : 84
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff3

    Pathway No. : 918
  • 0.001
    (s^-1)
    0.001
    (s^-1)
    Keq = 1(uM)500secSubstrate
    MAPK-tyr

    Product
    MAPK-tyr
    5diff
  • Ajay_Bhalla_
    2007_ReacDiff3

    Accession No. : 84
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff3

    Pathway No. : 918
  • 0.001
    (s^-1)
    0.001
    (s^-1)
    Keq = 1(uM)500secSubstrate
    MAPK-tyr

    Product
    MAPK-tyr
    6diff
  • Ajay_Bhalla_
    2007_ReacDiff3

    Accession No. : 84
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff3

    Pathway No. : 918
  • 0.001
    (s^-1)
    0.001
    (s^-1)
    Keq = 1(uM)500secSubstrate
    MAPK-tyr

    Product
    MAPK-tyr
    7diff
  • Ajay_Bhalla_
    2007_ReacDiff3

    Accession No. : 84
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff3

    Pathway No. : 918
  • 0.001
    (s^-1)
    0.001
    (s^-1)
    Keq = 1(uM)500secSubstrate
    MAPK-tyr

    Product
    MAPK-tyr
    8diff
  • Ajay_Bhalla_
    2007_ReacDiff3

    Accession No. : 84
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff3

    Pathway No. : 918
  • 0.001
    (s^-1)
    0.001
    (s^-1)
    Keq = 1(uM)500secSubstrate
    MAPK-tyr

    Product
    MAPK-tyr
    9diff
  • Ajay_Bhalla_
    2007_ReacDiff3

    Accession No. : 84
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff3

    Pathway No. : 918
  • 0.001
    (s^-1)
    0.001
    (s^-1)
    Keq = 1(uM)500secSubstrate
    MAPK-tyr

    Product
    MAPK-tyr
    10diff
  • Ajay_Bhalla_
    2007_ReacDiff3

    Accession No. : 84
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff3

    Pathway No. : 918
  • 0.001
    (s^-1)
    0.001
    (s^-1)
    Keq = 1(uM)500secSubstrate
    MAPK-tyr

    Product
    MAPK-tyr
    11diff
  • Ajay_Bhalla_
    2007_ReacDiff3

    Accession No. : 84
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff3

    Pathway No. : 918
  • 0.001
    (s^-1)
    0.001
    (s^-1)
    Keq = 1(uM)500secSubstrate
    MAPK-tyr

    Product
    MAPK-tyr
    12diff
  • Ajay_Bhalla_
    2007_ReacDiff3

    Accession No. : 84
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff3

    Pathway No. : 918
  • 0.001
    (s^-1)
    0.001
    (s^-1)
    Keq = 1(uM)500secSubstrate
    MAPK-tyr

    Product
    MAPK-tyr
    13diff
  • Ajay_Bhalla_
    2007_ReacDiff3

    Accession No. : 84
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff3

    Pathway No. : 918
  • 0.001
    (s^-1)
    0.001
    (s^-1)
    Keq = 1(uM)500secSubstrate
    MAPK-tyr

    Product
    MAPK-tyr
    14diff
  • Ajay_Bhalla_
    2007_ReacDiff3

    Accession No. : 84
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff3

    Pathway No. : 918
  • 0.001
    (s^-1)
    0.001
    (s^-1)
    Keq = 1(uM)500secSubstrate
    MAPK-tyr

    Product
    MAPK-tyr
    15diff
  • Ajay_Bhalla_
    2007_ReacDiff3

    Accession No. : 84
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff3

    Pathway No. : 918
  • 0.001
    (s^-1)
    0.001
    (s^-1)
    Keq = 1(uM)500secSubstrate
    MAPK-tyr

    Product
    MAPK-tyr
    16diff
  • Ajay_Bhalla_
    2007_ReacDiff3

    Accession No. : 84
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff3

    Pathway No. : 918
  • 0.001
    (s^-1)
    0.001
    (s^-1)
    Keq = 1(uM)500secSubstrate
    MAPK-tyr

    Product
    MAPK-tyr
    17diff
  • Ajay_Bhalla_
    2007_ReacDiff3

    Accession No. : 84
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff3

    Pathway No. : 918
  • 0.001
    (s^-1)
    0.001
    (s^-1)
    Keq = 1(uM)500secSubstrate
    MAPK-tyr

    Product
    MAPK-tyr
    18diff
  • Ajay_Bhalla_
    2007_ReacDiff3

    Accession No. : 84
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff3

    Pathway No. : 918
  • 0.001
    (s^-1)
    0.001
    (s^-1)
    Keq = 1(uM)500secSubstrate
    MAPK-tyr

    Product
    MAPK-tyr
    19diff
  • Ajay_Bhalla_
    2007_ReacDiff3

    Accession No. : 84
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff3

    Pathway No. : 918
  • 0.001
    (s^-1)
    0.001
    (s^-1)
    Keq = 1(uM)500secSubstrate
    MAPK-tyr

    Product
    MAPK-tyr
    20diff
  • Ajay_Bhalla_
    2007_ReacDiff3

    Accession No. : 84
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff3

    Pathway No. : 918
  • 0.001
    (s^-1)
    0.001
    (s^-1)
    Keq = 1(uM)500secSubstrate
    MAPK-tyr

    Product
    MAPK-tyr
    21diff
  • Ajay_Bhalla_
    2007_ReacDiff3

    Accession No. : 84
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff3

    Pathway No. : 918
  • 0.001
    (s^-1)
    0.001
    (s^-1)
    Keq = 1(uM)500secSubstrate
    MAPK-tyr

    Product
    MAPK-tyr
    22diff
  • Ajay_Bhalla_
    2007_ReacDiff3

    Accession No. : 84
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff3

    Pathway No. : 918
  • 0.001
    (s^-1)
    0.001
    (s^-1)
    Keq = 1(uM)500secSubstrate
    MAPK-tyr

    Product
    MAPK-tyr
    23diff
  • Ajay_Bhalla_
    2007_ReacDiff3

    Accession No. : 84
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff3

    Pathway No. : 918
  • 0.001
    (s^-1)
    0.001
    (s^-1)
    Keq = 1(uM)500secSubstrate
    MAPK-tyr

    Product
    MAPK-tyr
    24diff
  • Ajay_Bhalla_
    2007_ReacDiff3

    Accession No. : 84
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff3

    Pathway No. : 918
  • 0.001
    (s^-1)
    0.001
    (s^-1)
    Keq = 1(uM)500secSubstrate
    MAPK-tyr

    Product
    MAPK-tyr



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